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Items: 18

1.

Natural product libraries to accelerate the high-throughput discovery of therapeutic leads.

Johnson TA, Sohn J, Inman WD, Estee SA, Loveridge ST, Vervoort HC, Tenney K, Liu J, Ang KK, Ratnam J, Bray WM, Gassner NC, Shen YY, Lokey RS, McKerrow JH, Boundy-Mills K, Nukanto A, Kanti A, Julistiono H, Kardono LB, Bjeldanes LF, Crews P.

J Nat Prod. 2011 Dec 27;74(12):2545-55. doi: 10.1021/np200673b. Epub 2011 Nov 30.

2.

An image-based 384-well high-throughput screening method for the discovery of biofilm inhibitors in Vibrio cholerae.

Peach KC, Bray WM, Shikuma NJ, Gassner NC, Lokey RS, Yildiz FH, Linington RG.

Mol Biosyst. 2011 Apr;7(4):1176-84. doi: 10.1039/c0mb00276c. Epub 2011 Jan 18.

PMID:
21246108
3.

Biostructural features of additional jasplakinolide (jaspamide) analogues.

Watts KR, Morinaka BI, Amagata T, Robinson SJ, Tenney K, Bray WM, Gassner NC, Lokey RS, Media J, Valeriote FA, Crews P.

J Nat Prod. 2011 Mar 25;74(3):341-51. doi: 10.1021/np100721g. Epub 2011 Jan 11.

4.

New structures and bioactivity properties of jasplakinolide (jaspamide) analogues from marine sponges.

Robinson SJ, Morinaka BI, Amagata T, Tenney K, Bray WM, Gassner NC, Lokey RS, Crews P.

J Med Chem. 2010 Feb 25;53(4):1651-61. doi: 10.1021/jm9013554.

5.

HALO384: a halo-based potency prediction algorithm for high-throughput detection of antimicrobial agents.

Woehrmann MH, Gassner NC, Bray WM, Stuart JM, Lokey S.

J Biomol Screen. 2010 Feb;15(2):196-205. doi: 10.1177/1087057109355060. Epub 2010 Jan 19.

PMID:
20086209
6.

A beta-carboline alkaloid from the Papua New Guinea marine sponge hyrtios reticulatus.

Inman WD, Bray WM, Gassner NC, Lokey RS, Tenney K, Shen YY, Tendyke K, Suh T, Crews P.

J Nat Prod. 2010 Feb 26;73(2):255-7. doi: 10.1021/np9005426.

7.

Pinpointing pseurotins from a marine-derived Aspergillus as tools for chemical genetics using a synthetic lethality yeast screen.

Boot CM, Gassner NC, Compton JE, Tenney K, Tamble CM, Lokey RS, Holman TR, Crews P.

J Nat Prod. 2007 Oct;70(10):1672-5. Epub 2007 Oct 12.

PMID:
17929896
8.

Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.

Deschamps JD, Gautschi JT, Whitman S, Johnson TA, Gassner NC, Crews P, Holman TR.

Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. Epub 2007 Aug 22.

9.

Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay.

Gassner NC, Tamble CM, Bock JE, Cotton N, White KN, Tenney K, St Onge RP, Proctor MJ, Giaever G, Nislow C, Davis RW, Crews P, Holman TR, Lokey RS.

J Nat Prod. 2007 Mar;70(3):383-90. Epub 2007 Feb 10.

10.

Pyrroloacridine alkaloids from Plakortis quasiamphiaster: structures and bioactivity.

Ralifo P, Sanchez L, Gassner NC, Tenney K, Lokey RS, Holman TR, Valeriote FA, Crews P.

J Nat Prod. 2007 Jan;70(1):95-9.

11.

Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability.

Gassner NC, Baase WA, Mooers BH, Busam RD, Weaver LH, Lindstrom JD, Quillin ML, Matthews BW.

Biophys Chem. 2003;100(1-3):325-40.

PMID:
12646375
12.

Use of differentially substituted selenomethionine proteins in X-ray structure determination.

Gassner NC, Matthews BW.

Acta Crystallogr D Biol Crystallogr. 1999 Dec;55(Pt 12):1967-70.

PMID:
10666571
13.

Substitution with selenomethionine can enhance the stability of methionine-rich proteins.

Gassner NC, Baase WA, Hausrath AC, Matthews BW.

J Mol Biol. 1999 Nov 19;294(1):17-20.

PMID:
10556025
14.

Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.

Gassner NC, Baase WA, Lindstrom JD, Lu J, Dahlquist FW, Matthews BW.

Biochemistry. 1999 Nov 2;38(44):14451-60.

PMID:
10545167
15.
16.

Context-dependent protein stabilization by methionine-to-leucine substitution shown in T4 lysozyme.

Lipscomb LA, Gassner NC, Snow SD, Eldridge AM, Baase WA, Drew DL, Matthews BW.

Protein Sci. 1998 Mar;7(3):765-73. Erratum in: Protein Sci 1998 Jun;7(6):1481.

17.
18.

The enthalpy of transfer of unfolded proteins into solutions of urea and guanidinium chloride.

Schellman JA, Gassner NC.

Biophys Chem. 1996 Apr 16;59(3):259-75.

PMID:
8672715

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