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The Sir4 H-BRCT domain interacts with phospho-proteins to sequester and repress yeast heterochromatin.

Deshpande I, Keusch JJ, Challa K, Iesmantavicius V, Gasser SM, Gut H.

EMBO J. 2019 Oct 15;38(20):e101744. doi: 10.15252/embj.2019101744. Epub 2019 Sep 12.


Srs2 helicase prevents the formation of toxic DNA damage during late prophase I of yeast meiosis.

Sasanuma H, Sakurai HSM, Furihata Y, Challa K, Palmer L, Gasser SM, Shinohara M, Shinohara A.

Chromosoma. 2019 Sep;128(3):453-471. doi: 10.1007/s00412-019-00709-5. Epub 2019 Jun 6.


Active chromatin marks drive spatial sequestration of heterochromatin in C. elegans nuclei.

Cabianca DS, Muñoz-Jiménez C, Kalck V, Gaidatzis D, Padeken J, Seeber A, Askjaer P, Gasser SM.

Nature. 2019 May;569(7758):734-739. doi: 10.1038/s41586-019-1243-y. Epub 2019 May 22.


The study of protein recruitment to laser-induced DNA lesions can be distorted by photoconversion of the DNA binding dye Hoechst.

Hurst V, Gasser SM.

Version 2. F1000Res. 2019 Jan 25 [revised 2019 Jan 1];8:104. doi: 10.12688/f1000research.17865.2. eCollection 2019.


Nuclear Actin and Actin-Binding Proteins in DNA Repair.

Hurst V, Shimada K, Gasser SM.

Trends Cell Biol. 2019 Jun;29(6):462-476. doi: 10.1016/j.tcb.2019.02.010. Epub 2019 Apr 4. Review.


Synergistic lethality between BRCA1 and H3K9me2 loss reflects satellite derepression.

Padeken J, Zeller P, Towbin B, Katic I, Kalck V, Methot SP, Gasser SM.

Genes Dev. 2019 Apr 1;33(7-8):436-451. doi: 10.1101/gad.322495.118. Epub 2019 Feb 25.


Heterochromatic foci and transcriptional repression by an unstructured MET-2/SETDB1 co-factor LIN-65.

Delaney CE, Methot SP, Guidi M, Katic I, Gasser SM, Padeken J.

J Cell Biol. 2019 Mar 4;218(3):820-838. doi: 10.1083/jcb.201811038. Epub 2019 Feb 8.


Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways.

Klein HL, Bačinskaja G, Che J, Cheblal A, Elango R, Epshtein A, Fitzgerald DM, Gómez-González B, Khan SR, Kumar S, Leland BA, Marie L, Mei Q, Miné-Hattab J, Piotrowska A, Polleys EJ, Putnam CD, Radchenko EA, Saada AA, Sakofsky CJ, Shim EY, Stracy M, Xia J, Yan Z, Yin Y, Aguilera A, Argueso JL, Freudenreich CH, Gasser SM, Gordenin DA, Haber JE, Ira G, Jinks-Robertson S, King MC, Kolodner RD, Kuzminov A, Lambert SA, Lee SE, Miller KM, Mirkin SM, Petes TD, Rosenberg SM, Rothstein R, Symington LS, Zawadzki P, Kim N, Lisby M, Malkova A.

Microb Cell. 2019 Jan 7;6(1):1-64. doi: 10.15698/mic2019.01.664. Review.


Meiosis-specific prophase-like pathway controls cleavage-independent release of cohesin by Wapl phosphorylation.

Challa K, Fajish V G, Shinohara M, Klein F, Gasser SM, Shinohara A.

PLoS Genet. 2019 Jan 3;15(1):e1007851. doi: 10.1371/journal.pgen.1007851. eCollection 2019 Jan.


Challenges and guidelines toward 4D nucleome data and model standards.

Marti-Renom MA, Almouzni G, Bickmore WA, Bystricky K, Cavalli G, Fraser P, Gasser SM, Giorgetti L, Heard E, Nicodemi M, Nollmann M, Orozco M, Pombo A, Torres-Padilla ME.

Nat Genet. 2018 Oct;50(10):1352-1358. doi: 10.1038/s41588-018-0236-3. Epub 2018 Sep 27. Review.


Chromosome Dynamics in Response to DNA Damage.

Seeber A, Hauer MH, Gasser SM.

Annu Rev Genet. 2018 Nov 23;52:295-319. doi: 10.1146/annurev-genet-120417-031334. Epub 2018 Sep 12. Review.


Asymmetric Processing of DNA Ends at a Double-Strand Break Leads to Unconstrained Dynamics and Ectopic Translocation.

Marcomini I, Shimada K, Delgoshaie N, Yamamoto I, Seeber A, Cheblal A, Horigome C, Naumann U, Gasser SM.

Cell Rep. 2018 Sep 4;24(10):2614-2628.e4. doi: 10.1016/j.celrep.2018.07.102.


A memetic optimization algorithm for multi-constrained multicast routing in ad hoc networks.

Ramadan RM, Gasser SM, El-Mahallawy MS, Hammad K, El Bakly AM.

PLoS One. 2018 Mar 6;13(3):e0193142. doi: 10.1371/journal.pone.0193142. eCollection 2018.


Repressive Chromatin in Caenorhabditis elegans: Establishment, Composition, and Function.

Ahringer J, Gasser SM.

Genetics. 2018 Feb;208(2):491-511. doi: 10.1534/genetics.117.300386. Review.


Chromatin and nucleosome dynamics in DNA damage and repair.

Hauer MH, Gasser SM.

Genes Dev. 2017 Nov 15;31(22):2204-2221. doi: 10.1101/gad.307702.117. Review.


The Importance of Satellite Sequence Repression for Genome Stability.

Zeller P, Gasser SM.

Cold Spring Harb Symp Quant Biol. 2017;82:15-24. doi: 10.1101/sqb.2017.82.033662. Epub 2017 Nov 13.


Structural Basis of Mec1-Ddc2-RPA Assembly and Activation on Single-Stranded DNA at Sites of Damage.

Deshpande I, Seeber A, Shimada K, Keusch JJ, Gut H, Gasser SM.

Mol Cell. 2017 Oct 19;68(2):431-445.e5. doi: 10.1016/j.molcel.2017.09.019. Epub 2017 Oct 12.


The INO80 remodeller in transcription, replication and repair.

Poli J, Gasser SM, Papamichos-Chronakis M.

Philos Trans R Soc Lond B Biol Sci. 2017 Oct 5;372(1731). pii: 20160290. doi: 10.1098/rstb.2016.0290. Review.


Chromatin modifiers and remodellers in DNA repair and signalling.

Jeggo PA, Downs JA, Gasser SM.

Philos Trans R Soc Lond B Biol Sci. 2017 Oct 5;372(1731). pii: 20160279. doi: 10.1098/rstb.2016.0279. No abstract available.


A game of musical chairs: Pro- and anti-resection factors compete for TOPBP1 binding after DNA damage.

Shimada K, Gasser SM.

J Cell Biol. 2017 Mar 6;216(3):535-537. doi: 10.1083/jcb.201701038. Epub 2017 Feb 24.


Visualization of Chromatin Decompaction and Break Site Extrusion as Predicted by Statistical Polymer Modeling of Single-Locus Trajectories.

Amitai A, Seeber A, Gasser SM, Holcman D.

Cell Rep. 2017 Jan 31;18(5):1200-1214. doi: 10.1016/j.celrep.2017.01.018.


Selfish DNA and Epigenetic Repression Revisited.

Gasser SM.

Genetics. 2016 Nov;204(3):837-839. doi: 10.1534/genetics.116.196287. No abstract available.


Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates.

Hauer MH, Seeber A, Singh V, Thierry R, Sack R, Amitai A, Kryzhanovska M, Eglinger J, Holcman D, Owen-Hughes T, Gasser SM.

Nat Struct Mol Biol. 2017 Feb;24(2):99-107. doi: 10.1038/nsmb.3347. Epub 2017 Jan 9.


RPA Mediates Recruitment of MRX to Forks and Double-Strand Breaks to Hold Sister Chromatids Together.

Seeber A, Hegnauer AM, Hustedt N, Deshpande I, Poli J, Eglinger J, Pasero P, Gut H, Shinohara M, Hopfner KP, Shimada K, Gasser SM.

Mol Cell. 2016 Dec 1;64(5):951-966. doi: 10.1016/j.molcel.2016.10.032. Epub 2016 Nov 23.


Chromatin organization and dynamics in double-strand break repair.

Seeber A, Gasser SM.

Curr Opin Genet Dev. 2017 Apr;43:9-16. doi: 10.1016/j.gde.2016.10.005. Epub 2016 Oct 31. Review.


Histone H3K9 methylation is dispensable for Caenorhabditis elegans development but suppresses RNA:DNA hybrid-associated repeat instability.

Zeller P, Padeken J, van Schendel R, Kalck V, Tijsterman M, Gasser SM.

Nat Genet. 2016 Nov;48(11):1385-1395. doi: 10.1038/ng.3672. Epub 2016 Sep 26.


Mechanism of chromatin segregation to the nuclear periphery in C. elegans embryos.

Gonzalez-Sandoval A, Gasser SM.

Worm. 2016 May 31;5(3):e1190900. eCollection 2016.


SUMO wrestles breaks to the nuclear ring's edge.

Horigome C, Gasser SM.

Cell Cycle. 2016 Nov 16;15(22):3011-3013. Epub 2016 Aug 2. No abstract available.


On TADs and LADs: Spatial Control Over Gene Expression.

Gonzalez-Sandoval A, Gasser SM.

Trends Genet. 2016 Aug;32(8):485-495. doi: 10.1016/j.tig.2016.05.004. Epub 2016 Jun 13. Review.


Spatial segregation of heterochromatin: Uncovering functionality in a multicellular organism.

Cabianca DS, Gasser SM.

Nucleus. 2016 May 3;7(3):301-7. doi: 10.1080/19491034.2016.1187354. Review.


Nuclear Architecture: Past and Future Tense.

Gasser SM.

Trends Cell Biol. 2016 Jul;26(7):473-475. doi: 10.1016/j.tcb.2016.04.011. Epub 2016 May 10.


PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL.

Horigome C, Bustard DE, Marcomini I, Delgoshaie N, Tsai-Pflugfelder M, Cobb JA, Gasser SM.

Genes Dev. 2016 Apr 15;30(8):931-45. doi: 10.1101/gad.277665.116. Epub 2016 Apr 7.


The MRX Complex Ensures NHEJ Fidelity through Multiple Pathways Including Xrs2-FHA-Dependent Tel1 Activation.

Iwasaki D, Hayashihara K, Shima H, Higashide M, Terasawa M, Gasser SM, Shinohara M.

PLoS Genet. 2016 Mar 18;12(3):e1005942. doi: 10.1371/journal.pgen.1005942. eCollection 2016 Mar.


Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress.

Poli J, Gerhold CB, Tosi A, Hustedt N, Seeber A, Sack R, Herzog F, Pasero P, Shimada K, Hopfner KP, Gasser SM.

Genes Dev. 2016 Feb 1;30(3):337-54. doi: 10.1101/gad.273813.115. Epub 2016 Jan 21.


Histones and histone modifications in perinuclear chromatin anchoring: from yeast to man.

Harr JC, Gonzalez-Sandoval A, Gasser SM.

EMBO Rep. 2016 Feb;17(2):139-55. doi: 10.15252/embr.201541809. Epub 2016 Jan 20. Review.


Perinuclear Anchoring of H3K9-Methylated Chromatin Stabilizes Induced Cell Fate in C. elegans Embryos.

Gonzalez-Sandoval A, Towbin BD, Kalck V, Cabianca DS, Gaidatzis D, Hauer MH, Geng L, Wang L, Yang T, Wang X, Zhao K, Gasser SM.

Cell. 2015 Dec 3;163(6):1333-47. doi: 10.1016/j.cell.2015.10.066. Epub 2015 Nov 19.


Heterochromatin Protein 1β (HP1β) has distinct functions and distinct nuclear distribution in pluripotent versus differentiated cells.

Mattout A, Aaronson Y, Sailaja BS, Raghu Ram EV, Harikumar A, Mallm JP, Sim KH, Nissim-Rafinia M, Supper E, Singh PB, Sze SK, Gasser SM, Rippe K, Meshorer E.

Genome Biol. 2015 Sep 28;16:213. doi: 10.1186/s13059-015-0760-8.


Chromatin states and nuclear organization in development--a view from the nuclear lamina.

Mattout A, Cabianca DS, Gasser SM.

Genome Biol. 2015 Aug 25;16:174. doi: 10.1186/s13059-015-0747-5. Review.


Nuclear organization in DNA end processing: Telomeres vs double-strand breaks.

Marcomini I, Gasser SM.

DNA Repair (Amst). 2015 Aug;32:134-140. doi: 10.1016/j.dnarep.2015.04.024. Epub 2015 May 1. Review.


Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability.

Su XA, Dion V, Gasser SM, Freudenreich CH.

Genes Dev. 2015 May 15;29(10):1006-17. doi: 10.1101/gad.256404.114. Epub 2015 May 4.


Repeat DNA in genome organization and stability.

Padeken J, Zeller P, Gasser SM.

Curr Opin Genet Dev. 2015 Apr;31:12-9. doi: 10.1016/j.gde.2015.03.009. Epub 2015 Apr 29. Review.


Visualizing the spatiotemporal dynamics of DNA damage in budding yeast.

Horigome C, Dion V, Seeber A, Gehlen LR, Gasser SM.

Methods Mol Biol. 2015;1292:77-96. doi: 10.1007/978-1-4939-2522-3_6.


Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling.

Hustedt N, Seeber A, Sack R, Tsai-Pflugfelder M, Bhullar B, Vlaming H, van Leeuwen F, Guénolé A, van Attikum H, Srivas R, Ideker T, Shimada K, Gasser SM.

Mol Cell. 2015 Jan 22;57(2):273-89. doi: 10.1016/j.molcel.2014.11.016. Epub 2014 Dec 18.


INO80-C and SWR-C: guardians of the genome.

Gerhold CB, Hauer MH, Gasser SM.

J Mol Biol. 2015 Feb 13;427(3):637-51. doi: 10.1016/j.jmb.2014.10.015. Epub 2014 Oct 30. Review.


INO80 and SWR complexes: relating structure to function in chromatin remodeling.

Gerhold CB, Gasser SM.

Trends Cell Biol. 2014 Nov;24(11):619-31. doi: 10.1016/j.tcb.2014.06.004. Epub 2014 Jul 31. Review.


SWR1 and INO80 chromatin remodelers contribute to DNA double-strand break perinuclear anchorage site choice.

Horigome C, Oma Y, Konishi T, Schmid R, Marcomini I, Hauer MH, Dion V, Harata M, Gasser SM.

Mol Cell. 2014 Aug 21;55(4):626-39. doi: 10.1016/j.molcel.2014.06.027. Epub 2014 Jul 24.


TORC2-a new player in genome stability.

Weisman R, Cohen A, Gasser SM.

EMBO Mol Med. 2014 Aug;6(8):995-1002. doi: 10.15252/emmm.201403959.


Remodelers move chromatin in response to DNA damage.

Seeber A, Dion V, Gasser SM.

Cell Cycle. 2014;13(6):877-8. doi: 10.4161/cc.28200. Epub 2014 Feb 14. No abstract available.


The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear periphery.

Ferreira HC, Towbin BD, Jegou T, Gasser SM.

J Cell Biol. 2013 Dec 9;203(5):727-35. doi: 10.1083/jcb.201307181. Epub 2013 Dec 2.


A Rad53 independent function of Rad9 becomes crucial for genome maintenance in the absence of the Recq helicase Sgs1.

Nielsen I, Bentsen IB, Andersen AH, Gasser SM, Bjergbaek L.

PLoS One. 2013 Nov 20;8(11):e81015. doi: 10.1371/journal.pone.0081015. eCollection 2013.

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