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Items: 1 to 50 of 192

1.

Polymeric Encapsulation of Novel Homoleptic Bis(dipyrrinato) Zinc(II) Complexes with Long Lifetimes for Applications as Photodynamic Therapy Photosensitisers.

Karges J, Basu U, Blacque O, Chao H, Gasser G.

Angew Chem Int Ed Engl. 2019 Aug 6. doi: 10.1002/anie.201907856. [Epub ahead of print]

PMID:
31386250
2.

Synthesis and Characterization of an Epidermal Growth Factor Receptor selective Ru(II) Polypyridyl-Nanobody Conjugate as a Photosensitizer for Photodynamic Therapy.

Karges J, Jakubaszek M, Mari C, Zarschler K, Goud B, Stephan H, Gasser G.

Chembiochem. 2019 Jul 24. doi: 10.1002/cbic.201900419. [Epub ahead of print]

PMID:
31339225
3.

Systematic investigation of the antiproliferative activity of a series of ruthenium terpyridine complexes.

Karges J, Blacque O, Jakubaszek M, Goud B, Goldner P, Gasser G.

J Inorg Biochem. 2019 Sep;198:110752. doi: 10.1016/j.jinorgbio.2019.110752. Epub 2019 Jun 17.

PMID:
31242458
4.

A Ru(II) polypyridyl complex bearing aldehyde functions as a versatile synthetic precursor for long-wavelength absorbing photodynamic therapy photosensitizers.

Karges J, Heinemann F, Maschietto F, Patra M, Blacque O, Ciofini I, Spingler B, Gasser G.

Bioorg Med Chem. 2019 Jun 15;27(12):2666-2675. doi: 10.1016/j.bmc.2019.05.011. Epub 2019 May 10.

PMID:
31103403
5.

Towards Light Activated Ruthenium-Arene (RAPTA-type) Prodrug Candidates.

Renfrew AK, Karges J, Scopelliti R, Bobbink FD, Nowak-Sliwinska P, Gasser G, Dyson P.

Chembiochem. 2019 May 18. doi: 10.1002/cbic.201900236. [Epub ahead of print]

PMID:
31102568
6.

Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model.

Putra M, Sharma S, Gage M, Gasser G, Hinojo-Perez A, Olson A, Gregory-Flores A, Puttachary S, Wang C, Anantharam V, Thippeswamy T.

Neurobiol Dis. 2019 Mar 30. pii: S0969-9961(19)30082-8. doi: 10.1016/j.nbd.2019.03.031. [Epub ahead of print]

PMID:
30940499
7.

Targeting of the mitochondrion by dinuclear thiolato-bridged arene ruthenium complexes in cancer cells and in the apicomplexan parasite Neospora caninum.

Basto AP, Anghel N, Rubbiani R, Müller J, Stibal D, Giannini F, Süss-Fink G, Balmer V, Gasser G, Furrer J, Hemphill A.

Metallomics. 2019 Feb 20;11(2):462-474. doi: 10.1039/c8mt00307f.

8.

Synthesis, characterization and biological activity of organometallic derivatives of the antimalarial drug mefloquine as new antischistosomal drug candidates.

d'Orchymont F, Hess J, Panic G, Jakubaszek M, Gemperle L, Keiser J, Gasser G.

Medchemcomm. 2018 Oct 10;9(11):1905-1909. doi: 10.1039/c8md00396c. eCollection 2018 Nov 1.

PMID:
30568758
9.

Metal Compounds against Neglected Tropical Diseases.

Ong YC, Roy S, Andrews PC, Gasser G.

Chem Rev. 2019 Jan 23;119(2):730-796. doi: 10.1021/acs.chemrev.8b00338. Epub 2018 Dec 3.

PMID:
30507157
11.

Mechanisms of action of Ru(ii) polypyridyl complexes in living cells upon light irradiation.

Jakubaszek M, Goud B, Ferrari S, Gasser G.

Chem Commun (Camb). 2018 Nov 20;54(93):13040-13059. doi: 10.1039/c8cc05928d. Review.

PMID:
30398487
12.

Mesoporous silica nanoparticles functionalised with a photoactive ruthenium(ii) complex: exploring the formulation of a metal-based photodynamic therapy photosensitiser.

Ellahioui Y, Patra M, Mari C, Kaabi R, Karges J, Gasser G, Gómez-Ruiz S.

Dalton Trans. 2019 May 7;48(18):5940-5951. doi: 10.1039/c8dt02392a.

PMID:
30209497
13.

ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links.

Mutreja K, Krietsch J, Hess J, Ursich S, Berti M, Roessler FK, Zellweger R, Patra M, Gasser G, Lopes M.

Cell Rep. 2018 Sep 4;24(10):2629-2642.e5. doi: 10.1016/j.celrep.2018.08.019.

14.

Applications of Ruthenium Complexes Covalently Linked to Nucleic Acid Derivatives.

Flamme M, Clarke E, Gasser G, Hollenstein M.

Molecules. 2018 Jun 22;23(7). pii: E1515. doi: 10.3390/molecules23071515. Review.

15.

An Overview of PET Radiochemistry, Part 2: Radiometals.

Brandt M, Cardinale J, Aulsebrook ML, Gasser G, Mindt TL.

J Nucl Med. 2018 Oct;59(10):1500-1506. doi: 10.2967/jnumed.117.190801. Epub 2018 May 10. Review.

PMID:
29748237
16.

A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models.

Krishnan N, Konidaris KF, Gasser G, Tonks NK.

J Biol Chem. 2018 Feb 2;293(5):1517-1525. doi: 10.1074/jbc.C117.819110. Epub 2017 Dec 7.

17.

A solid phase-assisted approach for the facile synthesis of a highly water-soluble zirconium-89 chelator for radiopharmaceutical development.

Briand M, Aulsebrook ML, Mindt TL, Gasser G.

Dalton Trans. 2017 Dec 21;46(47):16387-16389. doi: 10.1039/c7dt03639f. Epub 2017 Nov 13.

PMID:
29130082
18.

Modeling sewage leakage and transport in carbonate aquifer using carbamazepine as an indicator.

Dvory NZ, Kuznetsov M, Livshitz Y, Gasser G, Pankratov I, Lev O, Adar E, Yakirevich A.

Water Res. 2018 Jan 1;128:157-170. doi: 10.1016/j.watres.2017.10.044. Epub 2017 Oct 31.

PMID:
29102695
19.

Critical Overview of the Use of Ru(II) Polypyridyl Complexes as Photosensitizers in One-Photon and Two-Photon Photodynamic Therapy.

Heinemann F, Karges J, Gasser G.

Acc Chem Res. 2017 Nov 21;50(11):2727-2736. doi: 10.1021/acs.accounts.7b00180. Epub 2017 Oct 23. Review.

PMID:
29058879
20.

Monomeric and dimeric coordinatively saturated and substitutionally inert Ru(ii) polypyridyl complexes as anticancer drug candidates.

Notaro A, Gasser G.

Chem Soc Rev. 2017 Nov 27;46(23):7317-7337. doi: 10.1039/c7cs00356k. Review.

PMID:
29027562
21.

Sensitive Analysis of Nitroguanidine in Aqueous and Soil Matrices by LC-MS.

Voloshenko Rossin A, Sladkevich S, Gasser G, Melman A, Lev O.

Anal Chem. 2017 Sep 19;89(18):9990-9996. doi: 10.1021/acs.analchem.7b02364. Epub 2017 Aug 3.

PMID:
28721718
22.

Ferrocenyl, Ruthenocenyl, and Benzyl Oxamniquine Derivatives with Cross-Species Activity against Schistosoma mansoni and Schistosoma haematobium.

Hess J, Panic G, Patra M, Mastrobuoni L, Spingler B, Roy S, Keiser J, Gasser G.

ACS Infect Dis. 2017 Sep 8;3(9):645-652. doi: 10.1021/acsinfecdis.7b00054. Epub 2017 Jul 18.

PMID:
28686009
23.

Extending the Excitation Wavelength of Potential Photosensitizers via Appendage of a Kinetically Stable Terbium(III) Macrocyclic Complex for Applications in Photodynamic Therapy.

Ung P, Clerc M, Huang H, Qiu K, Chao H, Seitz M, Boyd B, Graham B, Gasser G.

Inorg Chem. 2017 Jul 17;56(14):7960-7974. doi: 10.1021/acs.inorgchem.7b00677. Epub 2017 Jul 6.

PMID:
28682604
24.

Characterization of the Activities of Dinuclear Thiolato-Bridged Arene Ruthenium Complexes against Toxoplasma gondii.

Basto AP, Müller J, Rubbiani R, Stibal D, Giannini F, Süss-Fink G, Balmer V, Hemphill A, Gasser G, Furrer J.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e01031-17. doi: 10.1128/AAC.01031-17. Print 2017 Sep.

25.

Evaluation of the Medicinal Potential of Two Ruthenium(II) Polypyridine Complexes as One- and Two-Photon Photodynamic Therapy Photosensitizers.

Hess J, Huang H, Kaiser A, Pierroz V, Blacque O, Chao H, Gasser G.

Chemistry. 2017 Jul 21;23(41):9888-9896. doi: 10.1002/chem.201701392. Epub 2017 Jun 29.

PMID:
28509422
26.

Combining imaging and anticancer properties with new heterobimetallic Pt(ii)/M(i) (M = Re, 99mTc) complexes.

Quental L, Raposinho P, Mendes F, Santos I, Navarro-Ranninger C, Alvarez-Valdes A, Huang H, Chao H, Rubbiani R, Gasser G, Quiroga AG, Paulo A.

Dalton Trans. 2017 Oct 31;46(42):14523-14536. doi: 10.1039/c7dt00043j.

PMID:
28164201
27.

Organometallic Derivatization of the Nematocidal Drug Monepantel Leads to Promising Antiparasitic Drug Candidates.

Hess J, Patra M, Rangasamy L, Konatschnig S, Blacque O, Jabbar A, Mac P, Jorgensen EM, Gasser RB, Gasser G.

Chemistry. 2016 Nov 7;22(46):16602-16612. doi: 10.1002/chem.201602851. Epub 2016 Oct 5.

PMID:
27706843
28.

Assessment of the nematocidal activity of metallocenyl analogues of monepantel.

Hess J, Patra M, Jabbar A, Pierroz V, Konatschnig S, Spingler B, Ferrari S, Gasser RB, Gasser G.

Dalton Trans. 2016 Nov 28;45(44):17662-17671. Epub 2016 Oct 17.

29.

New insights into the pretargeting approach to image and treat tumours.

Patra M, Zarschler K, Pietzsch HJ, Stephan H, Gasser G.

Chem Soc Rev. 2016 Nov 21;45(23):6415-6431. Review.

PMID:
27722526
30.

Dual mode of cell death upon the photo-irradiation of a RuII polypyridyl complex in interphase or mitosis.

Pierroz V, Rubbiani R, Gentili C, Patra M, Mari C, Gasser G, Ferrari S.

Chem Sci. 2016 Aug 16;7(9):6115-6124.

31.

Comparison of the octadentate bifunctional chelator DFO*-pPhe-NCS and the clinically used hexadentate bifunctional chelator DFO-pPhe-NCS for 89Zr-immuno-PET.

Vugts DJ, Klaver C, Sewing C, Poot AJ, Adamzek K, Huegli S, Mari C, Visser GWM, Valverde IE, Gasser G, Mindt TL, van Dongen GAMS.

Eur J Nucl Med Mol Imaging. 2017 Feb;44(2):286-295. doi: 10.1007/s00259-016-3499-x. Epub 2016 Aug 30.

32.

N-Heterocyclic Carbene-Polyethylenimine Platinum Complexes with Potent in Vitro and in Vivo Antitumor Efficacy.

Chekkat N, Dahm G, Chardon E, Wantz M, Sitz J, Decossas M, Lambert O, Frisch B, Rubbiani R, Gasser G, Guichard G, Fournel S, Bellemin-Laponnaz S.

Bioconjug Chem. 2016 Aug 17;27(8):1942-8. doi: 10.1021/acs.bioconjchem.6b00320. Epub 2016 Aug 8.

PMID:
27459208
33.

A Disassembly Strategy for Imaging Endogenous Pyrophosphate in Mitochondria by Using an Fe(III) -salen Complex.

Kumari N, Huang H, Chao H, Gasser G, Zelder F.

Chembiochem. 2016 Jul 1;17(13):1211-5. doi: 10.1002/cbic.201600195. Epub 2016 May 24.

PMID:
27124688
34.

Towards (99m)Tc-based imaging agents with effective doxorubicin mimetics: a molecular and cellular study.

Imstepf S, Pierroz V, Raposinho P, Felber M, Fox T, Fernandes C, Gasser G, Santos IR, Alberto R.

Dalton Trans. 2016 Aug 16;45(33):13025-33. doi: 10.1039/c6dt00871b.

35.

Bimodal X-ray and Infrared Imaging of an Organometallic Derivative of Praziquantel in Schistosoma mansoni.

Clède S, Cowan N, Lambert F, Bertrand HC, Rubbiani R, Patra M, Hess J, Sandt C, Trcera N, Gasser G, Keiser J, Policar C.

Chembiochem. 2016 Jun 2;17(11):1004-7. doi: 10.1002/cbic.201500688. Epub 2016 Apr 28.

PMID:
26991635
36.

Sedaxicenes: potential new antifungal ferrocene-based agents?

Rubbiani R, Blacque O, Gasser G.

Dalton Trans. 2016 Apr 21;45(15):6619-26. doi: 10.1039/c5dt04231c.

PMID:
26964501
37.

Cellular Uptake and Photo-Cytotoxicity of a Gadolinium(III)-DOTA-Naphthalimide Complex "Clicked" to a Lipidated Tat Peptide.

O'Malley WI, Rubbiani R, Aulsebrook ML, Grace MR, Spiccia L, Tuck KL, Gasser G, Graham B.

Molecules. 2016 Feb 5;21(2). pii: E194. doi: 10.3390/molecules21020194.

38.

Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo.

Pavlovic I, Thakor DT, Vargas JR, McKinlay CJ, Hauke S, Anstaett P, Camuña RC, Bigler L, Gasser G, Schultz C, Wender PA, Jessen HJ.

Nat Commun. 2016 Feb 4;7:10622. doi: 10.1038/ncomms10622.

39.

Luminescent Alkyne-Bearing Terbium(III) Complexes and Their Application to Bioorthogonal Protein Labeling.

O'Malley WI, Abdelkader EH, Aulsebrook ML, Rubbiani R, Loh CT, Grace MR, Spiccia L, Gasser G, Otting G, Tuck KL, Graham B.

Inorg Chem. 2016 Feb 15;55(4):1674-82. doi: 10.1021/acs.inorgchem.5b02605. Epub 2016 Jan 28.

PMID:
26821062
40.

Synthesis, characterization and biological evaluation of novel Ru(II)-arene complexes containing intercalating ligands.

Nikolić S, Rangasamy L, Gligorijević N, Aranđelović S, Radulović S, Gasser G, Grgurić-Šipka S.

J Inorg Biochem. 2016 Jul;160:156-65. doi: 10.1016/j.jinorgbio.2016.01.005. Epub 2016 Jan 11.

PMID:
26818702
41.

Organometallic Rhenium Complexes Divert Doxorubicin to the Mitochondria.

Imstepf S, Pierroz V, Rubbiani R, Felber M, Fox T, Gasser G, Alberto R.

Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2792-5. doi: 10.1002/anie.201511432. Epub 2016 Jan 22.

PMID:
26799241
42.

Lightening up Ruthenium Complexes to Fight Cancer?

Mari C, Gasser G.

Chimia (Aarau). 2015;69(4):176-81. Review.

PMID:
26668934
43.

Metal Complexes and Medicine: A Successful Combination.

Gasser G.

Chimia (Aarau). 2015;69(7-8):442-6. doi: 10.2533/chimia.2015.442.

PMID:
26507597
44.

Nuclear Targeting with an Auger Electron Emitter Potentiates the Action of a Widely Used Antineoplastic Drug.

Imstepf S, Pierroz V, Raposinho P, Bauwens M, Felber M, Fox T, Shapiro AB, Freudenberg R, Fernandes C, Gama S, Gasser G, Motthagy F, Santos IR, Alberto R.

Bioconjug Chem. 2015 Dec 16;26(12):2397-407. doi: 10.1021/acs.bioconjchem.5b00466. Epub 2015 Oct 29.

PMID:
26473388
45.

Highly Charged Ruthenium(II) Polypyridyl Complexes as Lysosome-Localized Photosensitizers for Two-Photon Photodynamic Therapy.

Huang H, Yu B, Zhang P, Huang J, Chen Y, Gasser G, Ji L, Chao H.

Angew Chem Int Ed Engl. 2015 Nov 16;54(47):14049-52. doi: 10.1002/anie.201507800. Epub 2015 Oct 8.

PMID:
26447888
46.

Induction of Cytotoxicity through Photorelease of Aminoferrocene.

Leonidova A, Anstaett P, Pierroz V, Mari C, Spingler B, Ferrari S, Gasser G.

Inorg Chem. 2015 Oct 19;54(20):9740-8. doi: 10.1021/acs.inorgchem.5b01332. Epub 2015 Oct 6.

47.

In vivo demonstration of an active tumor pretargeting approach with peptide nucleic acid bioconjugates as complementary system.

Leonidova A, Foerster C, Zarschler K, Schubert M, Pietzsch HJ, Steinbach J, Bergmann R, Metzler-Nolte N, Stephan H, Gasser G.

Chem Sci. 2015 Oct 1;6(10):5601-5616. doi: 10.1039/c5sc00951k. Epub 2015 Jun 17.

48.

Phototoxic Activity and DNA Interactions of Water-Soluble Porphyrins and Their Rhenium(I) Conjugates.

Mion G, Gianferrara T, Bergamo A, Gasser G, Pierroz V, Rubbiani R, Vilar R, Leczkowska A, Alessio E.

ChemMedChem. 2015 Nov;10(11):1901-14. doi: 10.1002/cmdc.201500288. Epub 2015 Sep 2.

PMID:
26332425
49.

Two-photon uncageable enzyme inhibitors bearing targeting vectors.

Anstaett P, Pierroz V, Ferrari S, Gasser G.

Photochem Photobiol Sci. 2015 Oct;14(10):1821-5. doi: 10.1039/c5pp00245a.

50.

Metal Complexes and Medicine: A Successful Combination.

Gasser G.

Chimia (Aarau). 2015 Aug 19;69(7):442-446. doi: 10.2533/chimia.2015.442.

PMID:
28482977

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