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The multifaceted contribution of α-ketoglutarate to tumor progression: An opportunity to exploit?

Abla H, Sollazzo M, Gasparre G, Iommarini L, Porcelli AM.

Semin Cell Dev Biol. 2019 Jun 10. pii: S1084-9521(18)30171-X. doi: 10.1016/j.semcdb.2019.05.031. [Epub ahead of print] Review.


Potential Prognostic Role of 18F-FDG PET/CT in Invasive Epithelial Ovarian Cancer Relapse. A Preliminary Study.

Perrone AM, Dondi G, Lima GM, Castellucci P, Tesei M, Coluccelli S, Gasparre G, Porcelli AM, Nanni C, Fanti S, De Iaco P.

Cancers (Basel). 2019 May 23;11(5). pii: E713. doi: 10.3390/cancers11050713.


Synergistic Effect of Mitochondrial and Lysosomal Dysfunction in Parkinson's Disease.

Guerra F, Girolimetti G, Beli R, Mitruccio M, Pacelli C, Ferretta A, Gasparre G, Cocco T, Bucci C.

Cells. 2019 May 14;8(5). pii: E452. doi: 10.3390/cells8050452.


The multifaceted effects of metformin on tumor microenvironment.

Kurelac I, Umesh Ganesh N, Iorio M, Porcelli AM, Gasparre G.

Semin Cell Dev Biol. 2019 May 22. pii: S1084-9521(19)30077-1. doi: 10.1016/j.semcdb.2019.05.010. [Epub ahead of print] Review.


Contribution of ultrarare variants in mTOR pathway genes to sporadic focal epilepsies.

Pippucci T, Licchetta L, Baldassari S, Marconi C, De Luise M, Myers C, Nardi E, Provini F, Cameli C, Minardi R, Bacchelli E, Giordano L, Crichiutti G, d'Orsi G, Seri M, Gasparre G, Mefford HC, Tinuper P, Bisulli F; Collaborative Group of Italian League Against Epilepsy (LICE) Genetic Commission.

Ann Clin Transl Neurol. 2019 Feb 25;6(3):475-485. doi: 10.1002/acn3.722. eCollection 2019 Mar.


Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses.

Kurelac I, Iommarini L, Vatrinet R, Amato LB, De Luise M, Leone G, Girolimetti G, Umesh Ganesh N, Bridgeman VL, Ombrato L, Columbaro M, Ragazzi M, Gibellini L, Sollazzo M, Feichtinger RG, Vidali S, Baldassarre M, Foriel S, Vidone M, Cossarizza A, Grifoni D, Kofler B, Malanchi I, Porcelli AM, Gasparre G.

Nat Commun. 2019 Feb 22;10(1):903. doi: 10.1038/s41467-019-08839-1.


A Nonsense Mitochondrial DNA Mutation Associates with Dysfunction of HIF1α in a Von Hippel-Lindau Renal Oncocytoma.

De Luise M, Guarnieri V, Ceccarelli C, D'Agruma L, Porcelli AM, Gasparre G.

Oxid Med Cell Longev. 2019 Jan 9;2019:8069583. doi: 10.1155/2019/8069583. eCollection 2019.


A Preventive Program for Work-related Musculoskeletal Disorders Among Surgeons: Outcomes of a Randomized Controlled Clinical Trial.

Giagio S, Volpe G, Pillastrini P, Gasparre G, Frizziero A, Squizzato F.

Ann Surg. 2019 Jan 18. doi: 10.1097/SLA.0000000000003199. [Epub ahead of print]


Modulation of RAB7A Protein Expression Determines Resistance to Cisplatin through Late Endocytic Pathway Impairment and Extracellular Vesicular Secretion.

Guerra F, Paiano A, Migoni D, Girolimetti G, Perrone AM, De Iaco P, Fanizzi FP, Gasparre G, Bucci C.

Cancers (Basel). 2019 Jan 8;11(1). pii: E52. doi: 10.3390/cancers11010052.


Mice harbouring a SCA28 patient mutation in AFG3L2 develop late-onset ataxia associated with enhanced mitochondrial proteotoxicity.

Mancini C, Hoxha E, Iommarini L, Brussino A, Richter U, Montarolo F, Cagnoli C, Parolisi R, Gondor Morosini DI, Nicolò V, Maltecca F, Muratori L, Ronchi G, Geuna S, Arnaboldi F, Donetti E, Giorgio E, Cavalieri S, Di Gregorio E, Pozzi E, Ferrero M, Riberi E, Casari G, Altruda F, Turco E, Gasparre G, Battersby BJ, Porcelli AM, Ferrero E, Brusco A, Tempia F.

Neurobiol Dis. 2019 Apr;124:14-28. doi: 10.1016/j.nbd.2018.10.018. Epub 2018 Oct 30.


HmtVar: a new resource for human mitochondrial variations and pathogenicity data.

Preste R, Vitale O, Clima R, Gasparre G, Attimonelli M.

Nucleic Acids Res. 2019 Jan 8;47(D1):D1202-D1210. doi: 10.1093/nar/gky1024.


Potential for Mitochondrial DNA Sequencing in the Differential Diagnosis of Gynaecological Malignancies.

Perrone AM, Girolimetti G, Procaccini M, Marchio L, Livi A, Borghese G, Porcelli AM, De Iaco P, Gasparre G.

Int J Mol Sci. 2018 Jul 13;19(7). pii: E2048. doi: 10.3390/ijms19072048. Review.


Reply to the letter "Is hyaluronic injection really better than shockwave treatment for painful non-calcified rotator cuff tendinopathies? Think again…".

Frizziero A, Vittadini F, Barazzuol M, Gasparre G, Finotti P, Meneghini A, Maffulli N, Masiero S.

J Sports Med Phys Fitness. 2018 Jun;58(6):945-947. doi: 10.23736/S0022-4707.17.07721-0. No abstract available.


The Oncojanus Paradigm of Respiratory Complex I.

Leone G, Abla H, Gasparre G, Porcelli AM, Iommarini L.

Genes (Basel). 2018 May 7;9(5). pii: E243. doi: 10.3390/genes9050243. Review.


Unravelling the Effects of the Mutation m.3571insC/MT-ND1 on Respiratory Complexes Structural Organization.

Iommarini L, Ghelli A, Tropeano CV, Kurelac I, Leone G, Vidoni S, Lombes A, Zeviani M, Gasparre G, Porcelli AM.

Int J Mol Sci. 2018 Mar 7;19(3). pii: E764. doi: 10.3390/ijms19030764.


Pathological and molecular diagnosis of bilateral inguinal lymph nodes metastases from low-grade endometrial adenocarcinoma: a case report with review of the literature.

Perrone AM, Girolimetti G, Cima S, Kurelac I, Livi A, Caprara G, Santini D, Castellucci P, Morganti AG, Gasparre G, De Iaco P.

BMC Cancer. 2018 Jan 2;18(1):7. doi: 10.1186/s12885-017-3944-7. Review.


Renal oncocytoma characterized by the defective complex I of the respiratory chain boosts the synthesis of the ROS scavenger glutathione.

Kürschner G, Zhang Q, Clima R, Xiao Y, Busch JF, Kilic E, Jung K, Berndt N, Bulik S, Holzhütter HG, Gasparre G, Attimonelli M, Babu M, Meierhofer D.

Oncotarget. 2017 Nov 11;8(62):105882-105904. doi: 10.18632/oncotarget.22413. eCollection 2017 Dec 1.


Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer.

Iommarini L, Porcelli AM, Gasparre G, Kurelac I.

Front Oncol. 2017 Nov 27;7:286. doi: 10.3389/fonc.2017.00286. eCollection 2017. Review.


Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer.

Sansone P, Savini C, Kurelac I, Chang Q, Amato LB, Strillacci A, Stepanova A, Iommarini L, Mastroleo C, Daly L, Galkin A, Thakur BK, Soplop N, Uryu K, Hoshino A, Norton L, Bonafé M, Cricca M, Gasparre G, Lyden D, Bromberg J.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9066-E9075. doi: 10.1073/pnas.1704862114. Epub 2017 Oct 11. Erratum in: Proc Natl Acad Sci U S A. 2017 Nov 13;:.


Mild phenotypes and proper supercomplex assembly in human cells carrying the homoplasmic m.15557G > A mutation in cytochrome b gene.

Iommarini L, Ghelli A, Leone G, Tropeano CV, Kurelac I, Amato LB, Gasparre G, Porcelli AM.

Hum Mutat. 2018 Jan;39(1):92-102. doi: 10.1002/humu.23350. Epub 2017 Oct 12.


I.S.Mu.L.T. first-time patellar dislocation guidelines.

Vetrano M, Oliva F, Bisicchia S, Bossa M, De Carli A, Di Lorenzo L, Erroi D, Forte A, Foti C, Frizziero A, Gasparre G, Via AG, Innocenti B, Longo UG, Mahmoud A, Masiero S, Mazza D, Natali S, Notarangelo C, Osti L, Padulo J, Pellicciari L, Perroni F, Piccirilli E, Ramponi C, Salvatore G, Panni AS, Suarez T, Tarantino U, Vittadini F, Vulpiani MC, Ferretti A, Maffulli N.

Muscles Ligaments Tendons J. 2017 May 10;7(1):1-10. doi: 10.11138/mltj/2017.7.1.001. eCollection 2017 Jan-Mar.


Increase in proteins involved in mitochondrial fission, mitophagy, proteolysis and antioxidant response in type I endometrial cancer as an adaptive response to respiratory complex I deficiency.

Cormio A, Musicco C, Gasparre G, Cormio G, Pesce V, Sardanelli AM, Gadaleta MN.

Biochem Biophys Res Commun. 2017 Sep 9;491(1):85-90. doi: 10.1016/j.bbrc.2017.07.047. Epub 2017 Jul 8.


Mitochondria in cancer.

Gasparre G, Rossignol R, Sonveaux P.

Biochim Biophys Acta Bioenerg. 2017 Aug;1858(8):553-555. doi: 10.1016/j.bbabio.2017.05.004. No abstract available.


Platinum-induced mitochondrial DNA mutations confer lower sensitivity to paclitaxel by impairing tubulin cytoskeletal organization.

Girolimetti G, Guerra F, Iommarini L, Kurelac I, Vergara D, Maffia M, Vidone M, Amato LB, Leone G, Dusi S, Tiranti V, Perrone AM, Bucci C, Porcelli AM, Gasparre G.

Hum Mol Genet. 2017 Aug 1;26(15):2961-2974. doi: 10.1093/hmg/ddx186.


The σ1 receptor agonist (+)-pentazocine increases store-operated Ca2+ entry in MCF7σ1 and SK-N-SH cell lines.

Gasparre G, Abate C, Carlucci R, Berardi F, Cassano G.

Pharmacol Rep. 2017 Jun;69(3):542-545. doi: 10.1016/j.pharep.2017.01.022. Epub 2017 Jan 28.


TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours.

Mastropasqua F, Marzano F, Valletti A, Aiello I, Di Tullio G, Morgano A, Liuni S, Ranieri E, Guerrini L, Gasparre G, Sbisà E, Pesole G, Moschetta A, Caratozzolo MF, Tullo A.

Mol Cancer. 2017 Mar 21;16(1):67. doi: 10.1186/s12943-017-0634-7.


Mitochondrial DNA sequencing demonstrates clonality of peritoneal implants of borderline ovarian tumors.

Girolimetti G, De Iaco P, Procaccini M, Panzacchi R, Kurelac I, Amato LB, Dondi G, Caprara G, Ceccarelli C, Santini D, Porcelli AM, Perrone AM, Gasparre G.

Mol Cancer. 2017 Feb 27;16(1):47. doi: 10.1186/s12943-017-0614-y.


Mitochondrial metabolism and energy sensing in tumor progression.

Iommarini L, Ghelli A, Gasparre G, Porcelli AM.

Biochim Biophys Acta Bioenerg. 2017 Aug;1858(8):582-590. doi: 10.1016/j.bbabio.2017.02.006. Epub 2017 Feb 14. Review.


The α-ketoglutarate dehydrogenase complex in cancer metabolic plasticity.

Vatrinet R, Leone G, De Luise M, Girolimetti G, Vidone M, Gasparre G, Porcelli AM.

Cancer Metab. 2017 Feb 2;5:3. doi: 10.1186/s40170-017-0165-0. eCollection 2017. Review.


Molecular and metabolic features of oncocytomas: Seeking the blueprints of indolent cancers.

De Luise M, Girolimetti G, Okere B, Porcelli AM, Kurelac I, Gasparre G.

Biochim Biophys Acta Bioenerg. 2017 Aug;1858(8):591-601. doi: 10.1016/j.bbabio.2017.01.009. Epub 2017 Jan 20. Review.


Conservative management of tendinopathies around hip.

Frizziero A, Vittadini F, Pignataro A, Gasparre G, Biz C, Ruggieri P, Masiero S.

Muscles Ligaments Tendons J. 2016 Dec 21;6(3):281-292. doi: 10.11138/mltj/2016.6.3.281. eCollection 2016 Jul-Sep. Review.


HmtDB 2016: data update, a better performing query system and human mitochondrial DNA haplogroup predictor.

Clima R, Preste R, Calabrese C, Diroma MA, Santorsola M, Scioscia G, Simone D, Shen L, Gasparre G, Attimonelli M.

Nucleic Acids Res. 2017 Jan 4;45(D1):D698-D706. doi: 10.1093/nar/gkw1066. Epub 2016 Nov 28.


Eccentric exercise in lower limb tendinopathies: still a long way to go.

Frizziero A, Vittadini F, Fusco A, Giombini A, Gasparre G, Masiero S.

J Sports Med Phys Fitness. 2016 Nov;56(11):1431-1432. No abstract available.


A comprehensive characterization of rare mitochondrial DNA variants in neuroblastoma.

Calabrese FM, Clima R, Pignataro P, Lasorsa VA, Hogarty MD, Castellano A, Conte M, Tonini GP, Iolascon A, Gasparre G, Capasso M.

Oncotarget. 2016 Aug 2;7(31):49246-49258. doi: 10.18632/oncotarget.10271.


A unique combination of rare mitochondrial ribosomal RNA variants affects the kinetics of complex I assembly.

Porcelli AM, Calvaruso MA, Iommarini L, Kurelac I, Zuntini R, Ferrari S, Gasparre G.

Int J Biochem Cell Biol. 2016 Jun;75:117-22. doi: 10.1016/j.biocel.2016.04.007. Epub 2016 Apr 19.


Extracorporeal shockwaves therapy versus hyaluronic acid injection for the treatment of painful non-calcific rotator cuff tendinopathies: preliminary results.

Frizziero A, Vittadini F, Barazzuol M, Gasparre G, Finotti P, Meneghini A, Maffulli N, Masiero S.

J Sports Med Phys Fitness. 2017 Sep;57(9):1162-1168. doi: 10.23736/S0022-4707.16.06408-2. Epub 2016 Apr 12.


The Role of Detraining in Tendon Mechanobiology.

Frizziero A, Salamanna F, Della Bella E, Vittadini F, Gasparre G, Nicoli Aldini N, Masiero S, Fini M.

Front Aging Neurosci. 2016 Feb 29;8:43. doi: 10.3389/fnagi.2016.00043. eCollection 2016. Review.


I.S.Mu.L.T - Rotator Cuff Tears Guidelines.

Oliva F, Piccirilli E, Bossa M, Via AG, Colombo A, Chillemi C, Gasparre G, Pellicciari L, Franceschetti E, Rugiero C, Scialdoni A, Vittadini F, Brancaccio P, Creta D, Buono AD, Garofalo R, Franceschi F, Frizziero A, Mahmoud A, Merolla G, Nicoletti S, Spoliti M, Osti L, Padulo J, Portinaro N, Tajana G, Castagna A, Foti C, Masiero S, Porcellini G, Tarantino U, Maffulli N.

Muscles Ligaments Tendons J. 2016 Feb 13;5(4):227-63. doi: 10.11138/mltj/2015.5.4.227. eCollection 2015 Oct-Dec.


Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer.

Sansone P, Ceccarelli C, Berishaj M, Chang Q, Rajasekhar VK, Perna F, Bowman RL, Vidone M, Daly L, Nnoli J, Santini D, Taffurelli M, Shih NN, Feldman M, Mao JJ, Colameco C, Chen J, DeMichele A, Fabbri N, Healey JH, Cricca M, Gasparre G, Lyden D, Bonafé M, Bromberg J.

Nat Commun. 2016 Feb 9;7:10442. doi: 10.1038/ncomms10442.


A multi-parametric workflow for the prioritization of mitochondrial DNA variants of clinical interest.

Santorsola M, Calabrese C, Girolimetti G, Diroma MA, Gasparre G, Attimonelli M.

Hum Genet. 2016 Jan;135(1):121-36. doi: 10.1007/s00439-015-1615-9. Epub 2015 Nov 30.


Dysregulation of Parkin-mediated mitophagy in thyroid Hürthle cell tumors.

Lee J, Ham S, Lee MH, Kim SJ, Park JH, Lee SE, Chang JY, Joung KH, Kim TY, Kim JM, Sul HJ, Kweon GR, Jo YS, Kim KS, Shong YK, Gasparre G, Chung JK, Porcelli AM, Shong M.

Carcinogenesis. 2015 Nov;36(11):1407-18. doi: 10.1093/carcin/bgv122. Epub 2015 Sep 8.


Palliative electro-chemotherapy in elderly patients with vulvar cancer: A phase II trial.

Perrone AM, Cima S, Pozzati F, Frakulli R, Cammelli S, Tesei M, Gasparre G, Galuppi A, Morganti AG, De Iaco P.

J Surg Oncol. 2015 Oct;112(5):529-32. doi: 10.1002/jso.24036. Epub 2015 Sep 8.


High-resolution genomic profiling of thyroid lesions uncovers preferential copy number gains affecting mitochondrial biogenesis loci in the oncocytic variants.

Kurelac I, de Biase D, Calabrese C, Ceccarelli C, Ng CK, Lim R, MacKay A, Weigelt B, Porcelli AM, Reis-Filho JS, Tallini G, Gasparre G.

Am J Cancer Res. 2015 May 15;5(6):1954-71. eCollection 2015.


A mutation screening of oncogenes, tumor suppressor gene TP53 and nuclear encoded mitochondrial complex I genes in oncocytic thyroid tumors.

Evangelisti C, de Biase D, Kurelac I, Ceccarelli C, Prokisch H, Meitinger T, Caria P, Vanni R, Romeo G, Tallini G, Gasparre G, Bonora E.

BMC Cancer. 2015 Mar 21;15:157. doi: 10.1186/s12885-015-1122-3.


Homozygous NOTCH3 null mutation and impaired NOTCH3 signaling in recessive early-onset arteriopathy and cavitating leukoencephalopathy.

Pippucci T, Maresca A, Magini P, Cenacchi G, Donadio V, Palombo F, Papa V, Incensi A, Gasparre G, Valentino ML, Preziuso C, Pisano A, Ragno M, Liguori R, Giordano C, Tonon C, Lodi R, Parmeggiani A, Carelli V, Seri M.

EMBO Mol Med. 2015 Jun;7(6):848-58. doi: 10.15252/emmm.201404399.


Targeting respiratory complex I to prevent the Warburg effect.

Vatrinet R, Iommarini L, Kurelac I, De Luise M, Gasparre G, Porcelli AM.

Int J Biochem Cell Biol. 2015 Jun;63:41-5. doi: 10.1016/j.biocel.2015.01.017. Epub 2015 Feb 7. Review.


A comprehensive characterization of mitochondrial DNA mutations in glioblastoma multiforme.

Vidone M, Clima R, Santorsola M, Calabrese C, Girolimetti G, Kurelac I, Amato LB, Iommarini L, Trevisan E, Leone M, Soffietti R, Morra I, Faccani G, Attimonelli M, Porcelli AM, Gasparre G.

Int J Biochem Cell Biol. 2015 Jun;63:46-54. doi: 10.1016/j.biocel.2015.01.027. Epub 2015 Feb 7.


Mitochondrial changes in endometrial carcinoma: possible role in tumor diagnosis and prognosis (review).

Cormio A, Cormio G, Musicco C, Sardanelli AM, Gasparre G, Gadaleta MN.

Oncol Rep. 2015 Mar;33(3):1011-8. doi: 10.3892/or.2014.3690. Epub 2014 Dec 22. Review.


Impact of oestrogen deficiency and aging on tendon: concise review.

Frizziero A, Vittadini F, Gasparre G, Masiero S.

Muscles Ligaments Tendons J. 2014 Nov 17;4(3):324-8. eCollection 2014 Jul. Review.


BRCA-associated ovarian cancer: from molecular genetics to risk management.

Girolimetti G, Perrone AM, Santini D, Barbieri E, Guerra F, Ferrari S, Zamagni C, De Iaco P, Gasparre G, Turchetti D.

Biomed Res Int. 2014;2014:787143. doi: 10.1155/2014/787143. Epub 2014 Jul 22. Review.

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