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Items: 48


BRCA-1 depletion impairs pro-inflammatory polarization and activation of RAW 264.7 macrophages in a NF-κB-dependent mechanism.

Morrone MDS, Somensi N, Franz L, Ramos VM, Gasparotto J, da Rosa HT, Sartori M, Figueiró F, Gelain DP, Zanotto-Filho A, Moreira JCF.

Mol Cell Biochem. 2019 Aug 24. doi: 10.1007/s11010-019-03605-9. [Epub ahead of print]


Obesity associated with coal ash inhalation triggers systemic inflammation and oxidative damage in the hippocampus of rats.

Gasparotto J, Chaves PR, da Boit Martinello K, Silva Oliveira LF, Gelain DP, Fonseca Moreira JC.

Food Chem Toxicol. 2019 Nov;133:110766. doi: 10.1016/j.fct.2019.110766. Epub 2019 Aug 17.


Retinoic acid downregulates thiol antioxidant defences and homologous recombination while promotes A549 cells sensitization to cisplatin.

de Miranda Ramos V, Gasparotto J, Figueiró F, de Fraga Dias A, Rostirolla DC, Somensi N, da Rosa HT, Grun LK, Barbé-Tuana FM, Gelain DP, Moreira JCF.

Cell Signal. 2019 Oct;62:109356. doi: 10.1016/j.cellsig.2019.109356. Epub 2019 Jul 6.


Anti-NMDA Receptor Autoantibody Is an Independent Predictor of Hospital Mortality but Not Brain Dysfunction in Septic Patients.

Malfussi H, Santana IV, Gasparotto J, Righy C, Tomasi CD, Gelain DP, Bozza FA, Walz R, Dal-Pizzol F, Ritter C.

Front Neurol. 2019 Mar 15;10:221. doi: 10.3389/fneur.2019.00221. eCollection 2019.


Guarana supplementation attenuated obesity, insulin resistance, and adipokines dysregulation induced by a standardized human Western diet via brown adipose tissue activation.

Bortolin RC, Vargas AR, de Miranda Ramos V, Gasparotto J, Chaves PR, Schnorr CE, da Boit Martinello K, Silveira AK, Gomes HM, Rabelo TK, Grunwald MS, Ligabue-Braun R, Gelain DP, Moreira JCF.

Phytother Res. 2019 May;33(5):1394-1403. doi: 10.1002/ptr.6330. Epub 2019 Mar 13.


Oral administration of carvacrol/β-cyclodextrin complex protects against 6-hydroxydopamine-induced dopaminergic denervation.

Tiefensee Ribeiro C, Gasparotto J, Petiz LL, Brum PO, Peixoto DO, Kunzler A, da Rosa Silva HT, Bortolin RC, Almeida RF, Quintans-Junior LJ, Araújo AA, Moreira JCF, Gelain DP.

Neurochem Int. 2019 Jun;126:27-35. doi: 10.1016/j.neuint.2019.02.021. Epub 2019 Mar 5.


The effects of retinol oral supplementation in 6-hydroxydopamine dopaminergic denervation model in Wistar rats.

Kunzler A, Ribeiro CT, Gasparotto J, Petiz LL, da Rosa Silva HT, da Silva JD Jr, Bortolin R, de Souza PO, Barreto F, Espitia-Perez P, Schnorr CE, Somensi N, Moreira JCF, Gelain DP.

Neurochem Int. 2019 May;125:25-34. doi: 10.1016/j.neuint.2019.02.002. Epub 2019 Feb 7.


Peripheral perfusion index does not accurately reflect hypoperfusion in healthy dogs undergoing elective ovariohysterectomy.

Teixeira LG, Martins LR, Schimites PI, de Oliveira RB, Bonella J, Campos RV, Mangini LT, Gasparotto JC, Soares AV.

Vet J. 2018 Oct;240:27-30. doi: 10.1016/j.tvjl.2018.09.003. Epub 2018 Sep 5.


Obese rats are more vulnerable to inflammation, genotoxicity and oxidative stress induced by coal dust inhalation than non-obese rats.

Gasparotto J, Chaves PR, da Boit Martinello K, da Rosa-Siva HT, Bortolin RC, Silva LFO, Rabelo TK, da Silva J, da Silva FR, Nordin AP, Soares K, Borges MS, Gelain DP, Moreira JCF.

Ecotoxicol Environ Saf. 2018 Dec 15;165:44-51. doi: 10.1016/j.ecoenv.2018.08.097. Epub 2018 Sep 1.


Systemic Inflammation Changes the Site of RAGE Expression from Endothelial Cells to Neurons in Different Brain Areas.

Gasparotto J, Ribeiro CT, da Rosa-Silva HT, Bortolin RC, Rabelo TK, Peixoto DO, Moreira JCF, Gelain DP.

Mol Neurobiol. 2019 May;56(5):3079-3089. doi: 10.1007/s12035-018-1291-6. Epub 2018 Aug 9.


Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures.

de Araújo FM, Ferreira RS, Souza CS, Dos Santos CC, Rodrigues TLRS, E Silva JHC, Gasparotto J, Gelain DP, El-Bachá RS, D Costa MF, Fonseca JCM, Segura-Aguilar J, Costa SL, Silva VDA.

Neurotoxicology. 2018 May;66:98-106. doi: 10.1016/j.neuro.2018.03.009. Epub 2018 Mar 26.


Immune neutralization of the receptor for advanced glycation end products reduce liver oxidative damage induced by an acute systemic injection of lipopolysaccharide.

Tiefensee Ribeiro C, Gasparotto J, Teixeira AA, Portela LVC, Flores VNL, Moreira JCF, Gelain DP.

J Biochem. 2018 Jun 1;163(6):515-523. doi: 10.1093/jb/mvy013.


Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment.

Gasparotto J, Girardi CS, Somensi N, Ribeiro CT, Moreira JCF, Michels M, Sonai B, Rocha M, Steckert AV, Barichello T, Quevedo J, Dal-Pizzol F, Gelain DP.

J Biol Chem. 2018 Jan 5;293(1):226-244. doi: 10.1074/jbc.M117.786756. Epub 2017 Nov 10.


A new animal diet based on human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption.

Bortolin RC, Vargas AR, Gasparotto J, Chaves PR, Schnorr CE, Martinello KB, Silveira AK, Rabelo TK, Gelain DP, Moreira JCF.

Int J Obes (Lond). 2018 Mar;42(3):525-534. doi: 10.1038/ijo.2017.225. Epub 2017 Sep 12.


Extracellular HSP70 Activates ERK1/2, NF-kB and Pro-Inflammatory Gene Transcription Through Binding with RAGE in A549 Human Lung Cancer Cells.

Somensi N, Brum PO, de Miranda Ramos V, Gasparotto J, Zanotto-Filho A, Rostirolla DC, da Silva Morrone M, Moreira JCF, Pens Gelain D.

Cell Physiol Biochem. 2017;42(6):2507-2522. doi: 10.1159/000480213. Epub 2017 Aug 22.


Targeted inhibition of RAGE in substantia nigra of rats blocks 6-OHDA-induced dopaminergic denervation.

Gasparotto J, Ribeiro CT, Bortolin RC, Somensi N, Rabelo TK, Kunzler A, Souza NC, Pasquali MAB, Moreira JCF, Gelain DP.

Sci Rep. 2017 Aug 18;7(1):8795. doi: 10.1038/s41598-017-09257-3.


Role of vitamin A oral supplementation on oxidative stress and inflammatory response in the liver of trained rats.

Petiz LL, Kunzler A, Bortolin RC, Gasparotto J, Matté C, Moreira JCF, Gelain DP.

Appl Physiol Nutr Metab. 2017 Nov;42(11):1192-1200. doi: 10.1139/apnm-2017-0193. Epub 2017 Jun 28.


Retinol (Vitamin A) Increases α-Synuclein, β-Amyloid Peptide, Tau Phosphorylation and RAGE Content in Human SH-SY5Y Neuronal Cell Line.

Kunzler A, Kolling EA, da Silva JD Jr, Gasparotto J, de Bittencourt Pasquali MA, Moreira JCF, Gelain DP.

Neurochem Res. 2017 Oct;42(10):2788-2797. doi: 10.1007/s11064-017-2292-y. Epub 2017 May 11.


Genetic variability of populations of Nyssomyia neivai in the Northern State of Paraná, Brazil.

Gasparotto JC, Costa-Ribeiro MC, Thomaz-Soccol V, Liebel SM, Neitzke-Abreu HC, Reinhold-Castro KR, Cristovão EC, Teodoro U.

Rev Inst Med Trop Sao Paulo. 2017 Apr 3;59:e10. doi: 10.1590/S1678-9946201759010.


Vitamin A Oral Supplementation Induces Oxidative Stress and Suppresses IL-10 and HSP70 in Skeletal Muscle of Trained Rats.

Petiz LL, Girardi CS, Bortolin RC, Kunzler A, Gasparotto J, Rabelo TK, Matté C, Moreira JC, Gelain DP.

Nutrients. 2017 Apr 2;9(4). pii: E353. doi: 10.3390/nu9040353.


N-acetyl-cysteine inhibits liver oxidative stress markers in BALB/c mice infected with Leishmania amazonensis.

Gasparotto J, Kunzler A, Senger MR, Souza CD, Simone SG, Bortolin RC, Somensi N, Dal-Pizzol F, Moreira JC, Abreu-Silva AL, Calabrese KD, Silva FP Jr, Gelain DP.

Mem Inst Oswaldo Cruz. 2017 Feb;112(2):146-154. doi: 10.1590/0074-02760160403.


Anti-RAGE antibody selectively blocks acute systemic inflammatory responses to LPS in serum, liver, CSF and striatum.

Gasparotto J, Ribeiro CT, Bortolin RC, Somensi N, Fernandes HS, Teixeira AA, Guasselli MOR, Agani CAJO, Souza NC, Grings M, Leipnitz G, Gomes HM, de Bittencourt Pasquali MA, Dunkley PR, Dickson PW, Moreira JCF, Gelain DP.

Brain Behav Immun. 2017 May;62:124-136. doi: 10.1016/j.bbi.2017.01.008. Epub 2017 Jan 11.


Glycine Administration Alters MAPK Signaling Pathways and Causes Neuronal Damage in Rat Brain: Putative Mechanisms Involved in the Neurological Dysfunction in Nonketotic Hyperglycinemia.

Moura AP, Parmeggiani B, Gasparotto J, Grings M, Fernandez Cardoso GM, Seminotti B, Moreira JCF, Gelain DP, Wajner M, Leipnitz G.

Mol Neurobiol. 2018 Jan;55(1):741-750. doi: 10.1007/s12035-016-0319-z. Epub 2017 Jan 3.


NRF2 Mediates Neuroblastoma Proliferation and Resistance to Retinoic Acid Cytotoxicity in a Model of In Vitro Neuronal Differentiation.

de Miranda Ramos V, Zanotto-Filho A, de Bittencourt Pasquali MA, Klafke K, Gasparotto J, Dunkley P, Gelain DP, Moreira JCF.

Mol Neurobiol. 2016 Nov;53(9):6124-6135. doi: 10.1007/s12035-015-9506-6. Epub 2015 Nov 5.


Changes in Cell Cycle and Up-Regulation of Neuronal Markers During SH-SY5Y Neurodifferentiation by Retinoic Acid are Mediated by Reactive Species Production and Oxidative Stress.

Kunzler A, Zeidán-Chuliá F, Gasparotto J, Girardi CS, Klafke K, Petiz LL, Bortolin RC, Rostirolla DC, Zanotto-Filho A, de Bittencourt Pasquali MA, Dickson P, Dunkley P, Moreira JCF, Gelain DP.

Mol Neurobiol. 2017 Nov;54(9):6903-6916. doi: 10.1007/s12035-016-0189-4. Epub 2016 Oct 22.


Effects of Freeze-Thaw and Storage on Enzymatic Activities, Protein Oxidative Damage, and Immunocontent of the Blood, Liver, and Brain of Rats.

Bortolin RC, Gasparotto J, Vargas AR, da Silva Morrone M, Kunzler A, Henkin BS, Chaves PR, Roncato S, Gelain DP, Moreira JCF.

Biopreserv Biobank. 2017 Jun;15(3):182-190. doi: 10.1089/bio.2016.0023. Epub 2016 Sep 23.


Shikimic acid inhibits LPS-induced cellular pro-inflammatory cytokines and attenuates mechanical hyperalgesia in mice.

Rabelo TK, Guimarães AG, Oliveira MA, Gasparotto J, Serafini MR, de Souza Araújo AA, Quintans-Júnior LJ, Moreira JCF, Gelain DP.

Int Immunopharmacol. 2016 Oct;39:97-105. doi: 10.1016/j.intimp.2016.07.016. Epub 2016 Jul 25.


Oral administration of curcumin relieves behavioral alterations and oxidative stress in the frontal cortex, hippocampus, and striatum of ovariectomized Wistar rats.

Da Silva Morrone M, Schnorr CE, Behr GA, Gasparotto J, Bortolin RC, Moresco KS, Bittencourt L, Zanotto-Filho A, Gelain DP, Moreira JC.

J Nutr Biochem. 2016 Jun;32:181-8. doi: 10.1016/j.jnutbio.2016.03.010. Epub 2016 Apr 1.


Curcumin Supplementation Decreases Intestinal Adiposity Accumulation, Serum Cholesterol Alterations, and Oxidative Stress in Ovariectomized Rats.

Morrone Mda S, Schnorr CE, Behr GA, Gasparotto J, Bortolin RC, da Boit Martinello K, Saldanha Henkin B, Rabello TK, Zanotto-Filho A, Gelain DP, Moreira JC.

Oxid Med Cell Longev. 2016;2016:5719291. doi: 10.1155/2016/5719291. Epub 2015 Nov 23.


Supplementation with vitamin A enhances oxidative stress in the lungs of rats submitted to aerobic exercise.

Gasparotto J, Petiz LL, Girardi CS, Bortolin RC, de Vargas AR, Henkin BS, Chaves PR, Roncato S, Matté C, Zanotto-Filho A, Moreira JC, Gelain DP.

Appl Physiol Nutr Metab. 2015 Dec;40(12):1253-61. doi: 10.1139/apnm-2015-0218. Epub 2015 Aug 17.


Choline and Cystine Deficient Diets in Animal Models with Hepatocellular Injury: Evaluation of Oxidative Stress and Expression of RAGE, TNF-α, and IL-1β.

Santos JC, de Araújo OR, Valentim IB, de Andrade KQ, Moura FA, Smaniotto S, dos Santos JM, Gasparotto J, Gelain DP, Goulart MO.

Oxid Med Cell Longev. 2015;2015:121925. doi: 10.1155/2015/121925. Epub 2015 Jun 2.


In Vitro Neuroprotective Effect of Shikimic Acid Against Hydrogen Peroxide-Induced Oxidative Stress.

Rabelo TK, Zeidán-Chuliá F, Caregnato FF, Schnorr CE, Gasparotto J, Serafini MR, de Souza Araújo AA, Quintans-Junior LJ, Moreira JCF, Gelain DP.

J Mol Neurosci. 2015 Aug;56(4):956-965. doi: 10.1007/s12031-015-0559-9. Epub 2015 Apr 11.


Production of cellulolytic enzymes and application of crude enzymatic extract for saccharification of lignocellulosic biomass.

Gasparotto JM, Werle LB, Foletto EL, Kuhn RC, Jahn SL, Mazutti MA.

Appl Biochem Biotechnol. 2015 Jan;175(1):560-72. doi: 10.1007/s12010-014-1297-0. Epub 2014 Oct 21.


Effects of different products of peach (Prunus persica L. Batsch) from a variety developed in southern Brazil on oxidative stress and inflammatory parameters in vitro and ex vivo.

Gasparotto J, Somensi N, Bortolin RC, Moresco KS, Girardi CS, Klafke K, Rabelo TK, Morrone Mda S, Vizzotto M, Raseira Mdo C, Moreira JC, Gelain DP.

J Clin Biochem Nutr. 2014 Sep;55(2):110-9. doi: 10.3164/jcbn.13-97. Epub 2014 Sep 1.


Preventive supplementation with fresh and preserved peach attenuates CCl4-induced oxidative stress, inflammation and tissue damage.

Gasparotto J, Somensi N, Bortolin RC, Girardi CS, Kunzler A, Rabelo TK, Schnorr CE, Moresco KS, Bassani VL, Yatsu FK, Vizzotto M, Raseira Mdo C, Zanotto-Filho A, Moreira JC, Gelain DP.

J Nutr Biochem. 2014 Dec;25(12):1282-95. doi: 10.1016/j.jnutbio.2014.07.004. Epub 2014 Sep 16.


Hecogenin acetate inhibits reactive oxygen species production and induces cell cycle arrest and senescence in the A549 human lung cancer cell line.

Gasparotto J, Somensi N, Kunzler A, Girardi CS, de Bittencourt Pasquali MA, Ramos VM, Simoes-Pires A, Quintans-Junior LJ, Branco A, Moreira JC, Gelain DP.

Anticancer Agents Med Chem. 2014;14(8):1128-35.


Increased tau phosphorylation and receptor for advanced glycation endproducts (RAGE) in the brain of mice infected with Leishmania amazonensis.

Gasparotto J, Senger MR, Kunzler A, Degrossoli A, de Simone SG, Bortolin RC, Somensi N, Girardi CS, de Souza Cda S, Calabrese Kda S, Dal-Pizzol F, Moreira JC, Silva FP Jr, Gelain DP.

Brain Behav Immun. 2015 Jan;43:37-45. doi: 10.1016/j.bbi.2014.06.204. Epub 2014 Jul 8.


Mitochondrial bioenergetics deregulation caused by long-chain 3-hydroxy fatty acids accumulating in LCHAD and MTP deficiencies in rat brain: a possible role of mPTP opening as a pathomechanism in these disorders?

Tonin AM, Amaral AU, Busanello EN, Gasparotto J, Gelain DP, Gregersen N, Wajner M.

Biochim Biophys Acta. 2014 Sep;1842(9):1658-67. doi: 10.1016/j.bbadis.2014.06.011. Epub 2014 Jun 16.


The oxidation of HSP70 is associated with functional impairment and lack of stimulatory capacity.

Grunwald MS, Pires AS, Zanotto-Filho A, Gasparotto J, Gelain DP, Demartini DR, Schöler CM, de Bittencourt PI Jr, Moreira JC.

Cell Stress Chaperones. 2014 Nov;19(6):913-25. doi: 10.1007/s12192-014-0516-5. Epub 2014 May 10.


Sulfite disrupts brain mitochondrial energy homeostasis and induces mitochondrial permeability transition pore opening via thiol group modification.

Grings M, Moura AP, Amaral AU, Parmeggiani B, Gasparotto J, Moreira JC, Gelain DP, Wyse AT, Wajner M, Leipnitz G.

Biochim Biophys Acta. 2014 Sep;1842(9):1413-22. doi: 10.1016/j.bbadis.2014.04.022. Epub 2014 May 2.


Redox homeostasis is compromised in vivo by the metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency in rat cerebral cortex and liver.

da Rosa MS, Seminotti B, Amaral AU, Fernandes CG, Gasparotto J, Moreira JC, Gelain DP, Wajner M, Leipnitz G.

Free Radic Res. 2013 Dec;47(12):1066-75. doi: 10.3109/10715762.2013.853876. Epub 2013 Nov 4.


Passiflora manicata (Juss.) aqueous leaf extract protects against reactive oxygen species and protein glycation in vitro and ex vivo models.

da Silva Morrone M, de Assis AM, da Rocha RF, Gasparotto J, Gazola AC, Costa GM, Zucolotto SM, Castellanos LH, Ramos FA, Schenkel EP, Reginatto FH, Gelain DP, Moreira JC.

Food Chem Toxicol. 2013 Oct;60:45-51. doi: 10.1016/j.fct.2013.07.028. Epub 2013 Jul 20.


Coal and tire burning mixtures containing ultrafine and nanoparticulate materials induce oxidative stress and inflammatory activation in macrophages.

Gasparotto J, Somensi N, Caregnato FF, Rabelo TK, DaBoit K, Oliveira ML, Moreira JC, Gelain DP.

Sci Total Environ. 2013 Oct 1;463-464:743-53. doi: 10.1016/j.scitotenv.2013.06.086. Epub 2013 Jul 13.


Effect of N-salicyloyltryptamine (STP), a novel tryptamine analogue, on parameters of cell viability, oxidative stress, and immunomodulation in RAW 264.7 macrophages.

Gasparotto J, de Bittencourt Pasquali MA, Somensi N, Vasques LM, Moreira JC, de Almeida RN, Barbosa-Filho JM, de Fátima Vanderlei de Souza M, Gutierrez SJ, Júnior LJ, Gelain DP.

Cell Biol Toxicol. 2013 Jun;29(3):175-87. doi: 10.1007/s10565-013-9245-2. Epub 2013 Apr 21.


Schistosoma mansoni infection causes oxidative stress and alters receptor for advanced glycation endproduct (RAGE) and tau levels in multiple organs in mice.

de Oliveira RB, Senger MR, Vasques LM, Gasparotto J, dos Santos JP, Pasquali MA, Moreira JC, Silva FP Jr, Gelain DP.

Int J Parasitol. 2013 Apr;43(5):371-9. doi: 10.1016/j.ijpara.2012.12.006. Epub 2013 Jan 29.


Vitamin A (retinol) downregulates the receptor for advanced glycation endproducts (RAGE) by oxidant-dependent activation of p38 MAPK and NF-kB in human lung cancer A549 cells.

de Bittencourt Pasquali MA, Gelain DP, Zeidán-Chuliá F, Pires AS, Gasparotto J, Terra SR, Moreira JC.

Cell Signal. 2013 Apr;25(4):939-54. doi: 10.1016/j.cellsig.2013.01.013. Epub 2013 Jan 16.


L-NAME co-treatment prevent oxidative damage in the lung of adult Wistar rats treated with vitamin A supplementation.

de Bittencourt Pasquali MA, Roberto de Oliveira M, De Bastiani MA, da Rocha RF, Schnorr CE, Gasparotto J, Gelain DP, Moreira JC.

Cell Biochem Funct. 2012 Apr;30(3):256-63.


Gender differences in osteoporosis health beliefs and knowledge and their relation to vigorous physical activity in university students.

Gammage KL, Gasparotto J, Mack DE, Klentrou P.

J Am Coll Health. 2012;60(1):58-64. doi: 10.1080/07448481.2011.570399.


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