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Items: 1 to 50 of 126

1.

Differential regulation of LncRNA-SARCC suppresses VHL-mutant RCC cell proliferation yet promotes VHL-normal RCC cell proliferation via modulating androgen receptor/HIF-2α/C-MYC axis under hypoxia.

Zhai W, Sun Y, Jiang M, Wang M, Gasiewicz TA, Zheng J, Chang C.

Oncogene. 2017 Aug;36(31):4525. doi: 10.1038/onc.2016.514. Epub 2017 Apr 3.

PMID:
28368407
2.

Aryl Hydrocarbon Receptor and Stem Cells.

Gasiewicz TA, Singh KP, Casado FL.

Stem Cells Int. 2017;2017:4602854. doi: 10.1155/2017/4602854. Epub 2017 Jan 9. No abstract available.

3.

Aryl Hydrocarbon Receptor Deficiency in an Exon 3 Deletion Mouse Model Promotes Hematopoietic Stem Cell Proliferation and Impacts Endosteal Niche Cells.

Unnisa Z, Singh KP, Henry EC, Donegan CL, Bennett JA, Gasiewicz TA.

Stem Cells Int. 2016;2016:4536187. doi: 10.1155/2016/4536187. Epub 2016 Jun 16.

4.

Differential regulation of LncRNA-SARCC suppresses VHL-mutant RCC cell proliferation yet promotes VHL-normal RCC cell proliferation via modulating androgen receptor/HIF-2α/C-MYC axis under hypoxia.

Zhai W, Sun Y, Jiang M, Wang M, Gasiewicz TA, Zheng J, Chang C.

Oncogene. 2016 Sep 15;35(37):4866-80. doi: 10.1038/onc.2016.19. Epub 2016 Mar 14.

PMID:
26973243
5.

Deficiency in Aryl Hydrocarbon Receptor (AHR) Expression throughout Aging Alters Gene Expression Profiles in Murine Long-Term Hematopoietic Stem Cells.

Bennett JA, Singh KP, Unnisa Z, Welle SL, Gasiewicz TA.

PLoS One. 2015 Jul 24;10(7):e0133791. doi: 10.1371/journal.pone.0133791. eCollection 2015.

6.

The heat shock protein 90 inhibitor, (-)-epigallocatechin gallate, has anticancer activity in a novel human prostate cancer progression model.

Moses MA, Henry EC, Ricke WA, Gasiewicz TA.

Cancer Prev Res (Phila). 2015 Mar;8(3):249-57. doi: 10.1158/1940-6207.CAPR-14-0224. Epub 2015 Jan 20.

7.

Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors.

Bhat R, Adam AT, Lee JJ, Gasiewicz TA, Henry EC, Rotella DP.

Bioorg Med Chem Lett. 2014 May 15;24(10):2263-6. doi: 10.1016/j.bmcl.2014.03.088. Epub 2014 Apr 4.

PMID:
24745965
8.

The Ah receptor in stem cell cycling, regulation, and quiescence.

Gasiewicz TA, Singh KP, Bennett JA.

Ann N Y Acad Sci. 2014 Mar;1310:44-50. doi: 10.1111/nyas.12361. Epub 2014 Feb 3. Review.

9.

Loss of aryl hydrocarbon receptor promotes gene changes associated with premature hematopoietic stem cell exhaustion and development of a myeloproliferative disorder in aging mice.

Singh KP, Bennett JA, Casado FL, Walrath JL, Welle SL, Gasiewicz TA.

Stem Cells Dev. 2014 Jan 15;23(2):95-106. doi: 10.1089/scd.2013.0346. Epub 2013 Oct 19.

10.
11.

Aryl hydrocarbon receptor-null allele mice have hematopoietic stem/progenitor cells with abnormal characteristics and functions.

Singh KP, Garrett RW, Casado FL, Gasiewicz TA.

Stem Cells Dev. 2011 May;20(5):769-84. doi: 10.1089/scd.2010.0333. Epub 2010 Nov 9.

12.

Neural precursor cell proliferation is disrupted through activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Latchney SE, Lioy DT, Henry EC, Gasiewicz TA, Strathmann FG, Mayer-Pröschel M, Opanashuk LA.

Stem Cells Dev. 2011 Feb;20(2):313-26. doi: 10.1089/scd.2009.0529. Epub 2010 Aug 31.

13.

The aryl hydrocarbon receptor: regulation of hematopoiesis and involvement in the progression of blood diseases.

Casado FL, Singh KP, Gasiewicz TA.

Blood Cells Mol Dis. 2010 Apr 15;44(4):199-206. doi: 10.1016/j.bcmd.2010.01.005. Epub 2010 Feb 19. Review.

14.

Identification of stage-specific gene modulation during early thymocyte development by whole-genome profiling analysis after aryl hydrocarbon receptor activation.

Laiosa MD, Mills JH, Lai ZW, Singh KP, Middleton FA, Gasiewicz TA, Silverstone AE.

Mol Pharmacol. 2010 May;77(5):773-83. doi: 10.1124/mol.109.062497. Epub 2010 Feb 16.

15.

TCDD and a putative endogenous AhR ligand, ITE, elicit the same immediate changes in gene expression in mouse lung fibroblasts.

Henry EC, Welle SL, Gasiewicz TA.

Toxicol Sci. 2010 Mar;114(1):90-100. doi: 10.1093/toxsci/kfp285. Epub 2009 Nov 19.

16.

The aryl hydrocarbon receptor has an important role in the regulation of hematopoiesis: implications for benzene-induced hematopoietic toxicity.

Gasiewicz TA, Singh KP, Casado FL.

Chem Biol Interact. 2010 Mar 19;184(1-2):246-51. doi: 10.1016/j.cbi.2009.10.019. Epub 2009 Nov 5. Review.

17.

(-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitor.

Yin Z, Henry EC, Gasiewicz TA.

Biochemistry. 2009 Jan 20;48(2):336-45. doi: 10.1021/bi801637q.

18.

The aryl hydrocarbon receptor has a normal function in the regulation of hematopoietic and other stem/progenitor cell populations.

Singh KP, Casado FL, Opanashuk LA, Gasiewicz TA.

Biochem Pharmacol. 2009 Feb 15;77(4):577-87. doi: 10.1016/j.bcp.2008.10.001. Epub 2008 Oct 15. Review.

19.

Treatment of mice with the Ah receptor agonist and human carcinogen dioxin results in altered numbers and function of hematopoietic stem cells.

Singh KP, Wyman A, Casado FL, Garrett RW, Gasiewicz TA.

Carcinogenesis. 2009 Jan;30(1):11-9. doi: 10.1093/carcin/bgn224. Epub 2008 Sep 26.

20.

Dioxin causes ventral prostate agenesis by disrupting dorsoventral patterning in developing mouse prostate.

Vezina CM, Allgeier SH, Moore RW, Lin TM, Bemis JC, Hardin HA, Gasiewicz TA, Peterson RE.

Toxicol Sci. 2008 Dec;106(2):488-96. doi: 10.1093/toxsci/kfn183. Epub 2008 Sep 8.

21.

The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB.

Baglole CJ, Maggirwar SB, Gasiewicz TA, Thatcher TH, Phipps RP, Sime PJ.

J Biol Chem. 2008 Oct 24;283(43):28944-57. doi: 10.1074/jbc.M800685200. Epub 2008 Aug 12.

22.

Expression and activity of aryl hydrocarbon receptors in development and cancer.

Gasiewicz TA, Henry EC, Collins LL.

Crit Rev Eukaryot Gene Expr. 2008;18(4):279-321. Review.

PMID:
18652561
23.

Molecular determinants of species-specific agonist and antagonist activity of a substituted flavone towards the aryl hydrocarbon receptor.

Henry EC, Gasiewicz TA.

Arch Biochem Biophys. 2008 Apr 15;472(2):77-88. doi: 10.1016/j.abb.2008.02.005. Epub 2008 Feb 13.

24.

2,3,7,8-Tetracholorodibenzo-p-dioxin exposure disrupts granule neuron precursor maturation in the developing mouse cerebellum.

Collins LL, Williamson MA, Thompson BD, Dever DP, Gasiewicz TA, Opanashuk LA.

Toxicol Sci. 2008 May;103(1):125-36. doi: 10.1093/toxsci/kfn017. Epub 2008 Jan 27.

PMID:
18227101
25.

Environmental toxicants may modulate osteoblast differentiation by a mechanism involving the aryl hydrocarbon receptor.

Ryan EP, Holz JD, Mulcahey M, Sheu TJ, Gasiewicz TA, Puzas JE.

J Bone Miner Res. 2007 Oct;22(10):1571-80.

26.
27.

TCDD-induced alterations in gene expression profiles of the developing mouse paw do not influence morphological differentiation of this potential target tissue.

Bemis JC, Alejandro NF, Nazarenko DA, Brooks AI, Baggs RB, Gasiewicz TA.

Toxicol Sci. 2007 Jan;95(1):240-8. Epub 2006 Oct 11.

PMID:
17035482
29.

A potential endogenous ligand for the aryl hydrocarbon receptor has potent agonist activity in vitro and in vivo.

Henry EC, Bemis JC, Henry O, Kende AS, Gasiewicz TA.

Arch Biochem Biophys. 2006 Jun 1;450(1):67-77. Epub 2006 Mar 3.

PMID:
16545771
30.

Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor.

Kim SH, Henry EC, Kim DK, Kim YH, Shin KJ, Han MS, Lee TG, Kang JK, Gasiewicz TA, Ryu SH, Suh PG.

Mol Pharmacol. 2006 Jun;69(6):1871-8. Epub 2006 Mar 15.

31.

Coplanar polychlorinated biphenyls activate the aryl hydrocarbon receptor in developing tissues of two TCDD-responsive lacZ mouse lines.

Bemis JC, Nazarenko DA, Gasiewicz TA.

Toxicol Sci. 2005 Oct;87(2):529-36. Epub 2005 Jul 20.

PMID:
16033994
32.

The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts.

Martey CA, Baglole CJ, Gasiewicz TA, Sime PJ, Phipps RP.

Am J Physiol Lung Cell Mol Physiol. 2005 Sep;289(3):L391-9. Epub 2005 Apr 29.

33.
34.

Aryl hydrocarbon receptor expression and activity in cerebellar granule neuroblasts: implications for development and dioxin neurotoxicity.

Williamson MA, Gasiewicz TA, Opanashuk LA.

Toxicol Sci. 2005 Feb;83(2):340-8. Epub 2004 Nov 10.

PMID:
15537747
35.

Presence and functional activity of the aryl hydrocarbon receptor in isolated murine cerebral vascular endothelial cells and astrocytes.

Filbrandt CR, Wu Z, Zlokovic B, Opanashuk L, Gasiewicz TA.

Neurotoxicology. 2004 Jun;25(4):605-16.

PMID:
15183014
36.
37.

The Jun N-terminal kinase inhibitor SP600125 is a ligand and antagonist of the aryl hydrocarbon receptor.

Joiakim A, Mathieu PA, Palermo C, Gasiewicz TA, Reiners JJ Jr.

Drug Metab Dispos. 2003 Nov;31(11):1279-82.

38.

Cell proliferation arrest within intrathymic lymphocyte progenitor cells causes thymic atrophy mediated by the aryl hydrocarbon receptor.

Laiosa MD, Wyman A, Murante FG, Fiore NC, Staples JE, Gasiewicz TA, Silverstone AE.

J Immunol. 2003 Nov 1;171(9):4582-91.

39.

Identification of potential aryl hydrocarbon receptor antagonists in green tea.

Palermo CM, Hernando JI, Dertinger SD, Kende AS, Gasiewicz TA.

Chem Res Toxicol. 2003 Jul;16(7):865-72.

PMID:
12870889
41.

Mutational analysis of the mouse aryl hydrocarbon receptor tyrosine residues necessary for recognition of dioxin response elements.

Minsavage GD, Vorojeikina DP, Gasiewicz TA.

Arch Biochem Biophys. 2003 Apr 1;412(1):95-105.

PMID:
12646272
44.

2,3,7,8-tetrachlorodibenzo-p-dioxin causes alterations in lymphocyte development and thymic atrophy in hemopoietic chimeras generated from mice deficient in ARNT2.

Laiosa MD, Lai ZW, Thurmond TS, Fiore NC, DeRossi C, Holdener BC, Gasiewicz TA, Silverstone AE.

Toxicol Sci. 2002 Sep;69(1):117-24.

PMID:
12215665
45.

2,3,7,8-tetrachlorodibenzo-p-dioxin does not directly alter the phenotype of maturing B cells in a murine coculture system.

Wyman A, Lavin AL, Wilding GE, Gasiewicz TA.

Toxicol Appl Pharmacol. 2002 May 1;180(3):164-77.

PMID:
12009856
46.

In vivo antagonism of AhR-mediated gene induction by 3'-methoxy-4'-nitroflavone in TCDD-responsive lacZ mice.

Nazarenko DA, Dertinger SD, Gasiewicz TA.

Toxicol Sci. 2001 Jun;61(2):256-64.

PMID:
11353134
47.

Enhanced detection of beta-galactosidase reporter activation is achieved by a reduction of hemoglobin content in tissue lysates.

Nazarenko DA, Dertinger SD, Gasiewicz TA.

Biotechniques. 2001 Apr;30(4):776-7, 780-1.

PMID:
11314260
48.
49.

Use of bone marrow chimeras to identify cell targets in the immune system for the actions of chemicals.

Gasiewicz TA, Thurmond TS, Staples JE, Murante FG, Silverstone AE.

Ann N Y Acad Sci. 2000;919:300-3. No abstract available.

PMID:
11083120

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