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Items: 1 to 50 of 134

1.

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation.

Zhao X, Hamidinia M, Choo JAL, Too CT, Ho ZZ, Ren EC, Bertoletti A, MacAry PA, Gould KG, Brzostek J, Gascoigne NRJ.

J Vis Exp. 2019 Feb 28;(144). doi: 10.3791/59126.

2.

Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01.

Gu Y, Wong YH, Liew CW, Chan CEZ, Murali TM, Yap J, Too CT, Purushotorman K, Hamidinia M, El Sahili A, Goh ATH, Teo RZC, Wood KJ, Hanson BJ, Gascoigne NRJ, Lescar J, Vathsala A, MacAry PA.

Nat Commun. 2019 Feb 21;10(1):893. doi: 10.1038/s41467-019-08790-1.

3.

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries.

Chen EW, Ke CY, Brzostek J, Gascoigne NRJ, Rybakin V.

J Vis Exp. 2019 Jan 22;(143). doi: 10.3791/58946.

PMID:
30735195
4.

Themis-associated phosphatase activity controls signaling in T cell development.

Mehta M, Brzostek J, Chen EW, Tung DWH, Chen S, Sankaran S, Yap J, Rybakin V, Gascoigne NRJ.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11331-E11340. doi: 10.1073/pnas.1720209115. Epub 2018 Nov 9.

5.

CD8+ T cells have commitment issues.

Balyan R, Brzostek J, Gascoigne NRJ.

Nat Immunol. 2018 Aug;19(8):797-799. doi: 10.1038/s41590-018-0169-0. No abstract available.

PMID:
30013145
6.

Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling.

Zhao X, Sankaran S, Yap J, Too CT, Ho ZZ, Dolton G, Legut M, Ren EC, Sewell AK, Bertoletti A, MacAry PA, Brzostek J, Gascoigne NRJ.

Nat Commun. 2018 Jul 13;9(1):2716. doi: 10.1038/s41467-018-05288-0.

7.

Development of a screening strategy for new modulators of T cell receptor signaling and T cell activation.

Chen EW, Brzostek J, Gascoigne NRJ, Rybakin V.

Sci Rep. 2018 Jul 3;8(1):10046. doi: 10.1038/s41598-018-28106-5.

8.

Monomeric TCRs drive T cell antigen recognition.

Brameshuber M, Kellner F, Rossboth BK, Ta H, Alge K, Sevcsik E, Göhring J, Axmann M, Baumgart F, Gascoigne NRJ, Davis SJ, Stockinger H, Schütz GJ, Huppa JB.

Nat Immunol. 2018 May;19(5):487-496. doi: 10.1038/s41590-018-0092-4. Epub 2018 Apr 16.

PMID:
29662172
9.

A high content imaging flow cytometry approach to study mitochondria in T cells: MitoTracker Green FM dye concentration optimization.

Gautam N, Sankaran S, Yason JA, Tan KSW, Gascoigne NRJ.

Methods. 2018 Feb 1;134-135:11-19. doi: 10.1016/j.ymeth.2017.11.015. Epub 2017 Dec 2.

PMID:
29198814
10.

CD40L Expression Allows CD8+ T Cells to Promote Their Own Expansion and Differentiation through Dendritic Cells.

Tay NQ, Lee DCP, Chua YL, Prabhu N, Gascoigne NRJ, Kemeny DM.

Front Immunol. 2017 Nov 6;8:1484. doi: 10.3389/fimmu.2017.01484. eCollection 2017.

11.

TCR-like antibodies mediate complement and antibody-dependent cellular cytotoxicity against Epstein-Barr virus-transformed B lymphoblastoid cells expressing different HLA-A*02 microvariants.

Lai J, Choo JAL, Tan WJ, Too CT, Oo MZ, Suter MA, Mustafa FB, Srinivasan N, Chan CEZ, Lim AGX, Zhong Y, Chan SH, Hanson BJ, Gascoigne NRJ, MacAry PA.

Sci Rep. 2017 Aug 30;7(1):9923. doi: 10.1038/s41598-017-10265-6.

12.

Thymic Origins of T Cell Receptor Alloreactivity.

Brzostek J, Gascoigne NRJ.

Transplantation. 2017 Jul;101(7):1535-1541. doi: 10.1097/TP.0000000000001654. Review.

PMID:
28114168
13.

Molecular engineering of a therapeutic antibody for Blo t 5-induced allergic asthma.

Chan JHS, Chua YL, Peh HY, Jovanovic V, Gascoigne NRJ, Wong WSF, Chew FT, Hanson BJ, Kemeny DM, MacAry PA.

J Allergy Clin Immunol. 2017 May;139(5):1705-1708.e6. doi: 10.1016/j.jaci.2016.10.028. Epub 2016 Dec 5. No abstract available.

14.

TCR Signal Strength and T Cell Development.

Gascoigne NR, Rybakin V, Acuto O, Brzostek J.

Annu Rev Cell Dev Biol. 2016 Oct 6;32:327-348. Review.

PMID:
27712102
15.

SHP1-ing thymic selection.

Gascoigne NR, Brzostek J, Mehta M, Acuto O.

Eur J Immunol. 2016 Sep;46(9):2091-4. doi: 10.1002/eji.201646582.

16.

Vive la peptide différence!

Brzostek J, Gascoigne NR.

Nat Immunol. 2016 Jul 19;17(8):896-8. doi: 10.1038/ni.3507. No abstract available.

PMID:
27434001
17.

Targeting Epstein-Barr virus-transformed B lymphoblastoid cells using antibodies with T-cell receptor-like specificities.

Lai J, Tan WJ, Too CT, Choo JA, Wong LH, Mustafa FB, Srinivasan N, Lim AP, Zhong Y, Gascoigne NR, Hanson BJ, Chan SH, Chen J, MacAry PA.

Blood. 2016 Sep 8;128(10):1396-407. doi: 10.1182/blood-2016-03-707836. Epub 2016 Jun 23.

18.

Cell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand Recognition.

Brzostek J, Gascoigne NR, Rybakin V.

Front Immunol. 2016 Feb 4;7:24. doi: 10.3389/fimmu.2016.00024. eCollection 2016. Review.

19.

Identification of a novel lymphoid population in the murine epidermis.

Almeida FF, Tenno M, Brzostek J, Li JL, Allies G, Hoeffel G, See P, Ng LG, Fehling HJ, Gascoigne NR, Taniuchi I, Ginhoux F.

Sci Rep. 2015 Jul 30;5:12554. doi: 10.1038/srep12554.

20.

Virus-specific T lymphocytes home to the skin during natural dengue infection.

Rivino L, Kumaran EA, Thein TL, Too CT, Gan VC, Hanson BJ, Wilder-Smith A, Bertoletti A, Gascoigne NR, Lye DC, Leo YS, Akbar AN, Kemeny DM, MacAry PA.

Sci Transl Med. 2015 Mar 11;7(278):278ra35. doi: 10.1126/scitranslmed.aaa0526.

PMID:
25761891
21.

THEMIS: a critical TCR signal regulator for ligand discrimination.

Gascoigne NR, Acuto O.

Curr Opin Immunol. 2015 Apr;33:86-92. doi: 10.1016/j.coi.2015.01.020. Epub 2015 Feb 18. Review.

PMID:
25700024
22.

A THEMIS:SHP1 complex promotes T-cell survival.

Paster W, Bruger AM, Katsch K, Grégoire C, Roncagalli R, Fu G, Gascoigne NR, Nika K, Cohnen A, Feller SM, Simister PC, Molder KC, Cordoba SP, Dushek O, Malissen B, Acuto O.

EMBO J. 2015 Feb 3;34(3):393-409. doi: 10.15252/embj.201387725. Epub 2014 Dec 22.

23.

Allelic exclusion of TCR α-chains upon severe restriction of Vα repertoire.

Rybakin V, Westernberg L, Fu G, Kim HO, Ampudia J, Sauer K, Gascoigne NR.

PLoS One. 2014 Dec 12;9(12):e114320. doi: 10.1371/journal.pone.0114320. eCollection 2014.

24.

Immunology: Tolerance lies in the timing.

Gascoigne NR.

Nature. 2014 Nov 27;515(7528):502-3. doi: 10.1038/515502a. No abstract available.

PMID:
25428497
25.

Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor.

Casas J, Brzostek J, Zarnitsyna VI, Hong JS, Wei Q, Hoerter JA, Fu G, Ampudia J, Zamoyska R, Zhu C, Gascoigne NR.

Nat Commun. 2014 Nov 27;5:5624. doi: 10.1038/ncomms6624.

26.

Fine-tuning T cell receptor signaling to control T cell development.

Fu G, Rybakin V, Brzostek J, Paster W, Acuto O, Gascoigne NR.

Trends Immunol. 2014 Jul;35(7):311-8. doi: 10.1016/j.it.2014.05.003. Epub 2014 Jun 17. Review.

27.

Protein kinase C-η controls CTLA-4-mediated regulatory T cell function.

Kong KF, Fu G, Zhang Y, Yokosuka T, Casas J, Canonigo-Balancio AJ, Becart S, Kim G, Yates JR 3rd, Kronenberg M, Saito T, Gascoigne NR, Altman A.

Nat Immunol. 2014 May;15(5):465-72. doi: 10.1038/ni.2866. Epub 2014 Apr 6.

28.

Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection.

Nabekura T, Kanaya M, Shibuya A, Fu G, Gascoigne NR, Lanier LL.

Immunity. 2014 Feb 20;40(2):225-34. doi: 10.1016/j.immuni.2013.12.011. Epub 2014 Jan 16.

29.

Themis sets the signal threshold for positive and negative selection in T-cell development.

Fu G, Casas J, Rigaud S, Rybakin V, Lambolez F, Brzostek J, Hoerter JA, Paster W, Acuto O, Cheroutre H, Sauer K, Gascoigne NR.

Nature. 2013 Dec 19;504(7480):441-5. doi: 10.1038/nature12718. Epub 2013 Nov 13.

30.

Too fast to die.

Brzostek J, Gascoigne NR.

Sci Signal. 2013 Oct 15;6(297):pe33. doi: 10.1126/scisignal.2004753.

PMID:
24129699
31.

In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness.

Mukherjee S, Rigaud S, Seok SC, Fu G, Prochenka A, Dworkin M, Gascoigne NR, Vieland VJ, Sauer K, Das J.

PLoS One. 2013 Sep 16;8(9):e73937. doi: 10.1371/journal.pone.0073937. eCollection 2013. Erratum in: PLoS One. 2014;9(1): 10.1371/annotation/285bb79f-ef1a-467e-9fd3-4e518d65acd3.

32.

Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC.

Hoerter JA, Brzostek J, Artyomov MN, Abel SM, Casas J, Rybakin V, Ampudia J, Lotz C, Connolly JM, Chakraborty AK, Gould KG, Gascoigne NR.

J Exp Med. 2013 Aug 26;210(9):1807-21. doi: 10.1084/jem.20122528. Epub 2013 Aug 12.

33.

GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.

Paster W, Brockmeyer C, Fu G, Simister PC, de Wet B, Martinez-Riaño A, Hoerter JA, Feller SM, Wülfing C, Gascoigne NR, Acuto O.

J Immunol. 2013 Apr 1;190(7):3749-56. doi: 10.4049/jimmunol.1203389. Epub 2013 Mar 4.

34.

Negative selection assay based on stimulation of T cell receptor transgenic thymocytes with peptide-MHC tetramers.

Rybakin V, Gascoigne NR.

PLoS One. 2012;7(8):e43191. doi: 10.1371/journal.pone.0043191. Epub 2012 Aug 10.

35.

The role of protein kinase cη in T cell biology.

Fu G, Gascoigne NR.

Front Immunol. 2012 Jun 27;3:177. doi: 10.3389/fimmu.2012.00177. eCollection 2012.

36.

Tespa1: another gatekeeper for positive selection.

Gascoigne NR, Fu G.

Nat Immunol. 2012 May 18;13(6):530-2. doi: 10.1038/ni.2315. No abstract available.

PMID:
22610243
37.

Protein kinase Cη, an emerging player in T-cell biology.

Fu G, Gascoigne NR.

Cell Cycle. 2012 Mar 1;11(5):837-8. doi: 10.4161/cc.11.5.19677. Epub 2012 Mar 1. No abstract available.

PMID:
22356750
38.

Protein kinase C η is required for T cell activation and homeostatic proliferation.

Fu G, Hu J, Niederberger-Magnenat N, Rybakin V, Casas J, Yachi PP, Feldstein S, Ma B, Hoerter JA, Ampudia J, Rigaud S, Lambolez F, Gavin AL, Sauer K, Cheroutre H, Gascoigne NR.

Sci Signal. 2011 Dec 6;4(202):ra84. doi: 10.1126/scisignal.2002058.

39.

CD8αα and -αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I.

Rybakin V, Clamme JP, Ampudia J, Yachi PP, Gascoigne NR.

EMBO Rep. 2011 Dec 1;12(12):1251-6. doi: 10.1038/embor.2011.209.

40.

T cell receptor structures: three for the price of one.

Gascoigne NR.

Immunity. 2011 Jul 22;35(1):1-3. doi: 10.1016/j.immuni.2011.07.001.

41.

Signaling in thymic selection.

Gascoigne NR, Palmer E.

Curr Opin Immunol. 2011 Apr;23(2):207-12. doi: 10.1016/j.coi.2010.12.017. Epub 2011 Jan 15. Review.

42.

Initiation of TCR phosphorylation and signal transduction.

Gascoigne NR, Casas J, Brzostek J, Rybakin V.

Front Immunol. 2011 Dec 7;2:72. doi: 10.3389/fimmu.2011.00072. eCollection 2011.

43.

T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component.

Brockmeyer C, Paster W, Pepper D, Tan CP, Trudgian DC, McGowan S, Fu G, Gascoigne NR, Acuto O, Salek M.

J Biol Chem. 2011 Mar 4;286(9):7535-47. doi: 10.1074/jbc.M110.201236. Epub 2010 Dec 28.

44.

CD8+ thymocyte differentiation: T cell two-step.

Gascoigne NR.

Nat Immunol. 2010 Mar;11(3):189-90. doi: 10.1038/ni0310-189. No abstract available.

PMID:
20157298
45.

Co-receptors and recognition of self at the immunological synapse.

Gascoigne NR, Zal T, Yachi PP, Hoerter JA.

Curr Top Microbiol Immunol. 2010;340:171-89. doi: 10.1007/978-3-642-03858-7_9. Review.

46.

Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry.

Fu G, Gascoigne NR.

J Immunol Methods. 2009 Oct 31;350(1-2):194-9. doi: 10.1016/j.jim.2009.07.009. Epub 2009 Jul 30.

47.

Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling.

Fu G, Vallée S, Rybakin V, McGuire MV, Ampudia J, Brockmeyer C, Salek M, Fallen PR, Hoerter JA, Munshi A, Huang YH, Hu J, Fox HS, Sauer K, Acuto O, Gascoigne NR.

Nat Immunol. 2009 Aug;10(8):848-56. doi: 10.1038/ni.1766. Epub 2009 Jul 13.

48.

Visualizing intermolecular interactions in T cells.

Gascoigne NR, Ampudia J, Clamme JP, Fu G, Lotz C, Mallaun M, Niederberger N, Palmer E, Rybakin V, Yachi PP, Zal T.

Curr Top Microbiol Immunol. 2009;334:31-46. doi: 10.1007/978-3-540-93864-4_2. Review.

49.

Spatiotemporal patterning during T cell activation is highly diverse.

Singleton KL, Roybal KT, Sun Y, Fu G, Gascoigne NR, van Oers NS, Wülfing C.

Sci Signal. 2009 Apr 7;2(65):ra15. doi: 10.1126/scisignal.2000199.

50.

Do T cells need endogenous peptides for activation?

Gascoigne NR.

Nat Rev Immunol. 2008 Nov;8(11):895-900. doi: 10.1038/nri2431. Review.

PMID:
18846098

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