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Items: 1 to 50 of 156

1.

Fluorescent Nitric Oxide Photodonors Based on BODIPY and Rhodamine Antennae.

Parisi C, Failla M, Fraix A, Rolando B, Gianquinto E, Spyrakis F, Gazzano E, Riganti C, Lazzarato L, Fruttero R, Gasco A, Sortino S.

Chemistry. 2019 Aug 22;25(47):11080-11084. doi: 10.1002/chem.201902062. Epub 2019 Jul 4.

PMID:
31074543
2.

Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive/doxorubicin-resistant osteosarcoma cells and xenografts.

Gazzano E, Buondonno I, Marengo A, Rolando B, Chegaev K, Kopecka J, Saponara S, Sorge M, Hattinger CM, Gasco A, Fruttero R, Brancaccio M, Serra M, Stella B, Fattal E, Arpicco S, Riganti C.

Cancer Lett. 2019 Aug 1;456:29-39. doi: 10.1016/j.canlet.2019.04.029. Epub 2019 Apr 29.

PMID:
31047947
3.

Correction to "Light-Regulated NO Release as a Novel Strategy To Overcome Doxorubicin Multidrug Resistance".

Chegaev K, Fraix A, Gazzano E, Abd-Ellatef GEF, Blangetti M, Rolando B, Conoci S, Riganti C, Fruttero R, Gasco A, Sortino S.

ACS Med Chem Lett. 2019 Feb 28;10(3):393. doi: 10.1021/acsmedchemlett.9b00048. eCollection 2019 Mar 14.

4.

A molecular hybrid producing simultaneously singlet oxygen and nitric oxide by single photon excitation with green light.

Parisi C, Failla M, Fraix A, Rescifina A, Rolando B, Lazzarato L, Cardile V, Graziano ACE, Fruttero R, Gasco A, Sortino S.

Bioorg Chem. 2019 Apr;85:18-22. doi: 10.1016/j.bioorg.2018.12.027. Epub 2018 Dec 20.

PMID:
30599409
5.

Endoplasmic reticulum-targeting doxorubicin: a new tool effective against doxorubicin-resistant osteosarcoma.

Buondonno I, Gazzano E, Tavanti E, Chegaev K, Kopecka J, Fanelli M, Rolando B, Fruttero R, Gasco A, Hattinger C, Serra M, Riganti C.

Cell Mol Life Sci. 2019 Feb;76(3):609-625. doi: 10.1007/s00018-018-2967-9. Epub 2018 Nov 14.

PMID:
30430199
6.

Tuning the Hydrophobicity of a Mitochondria-Targeted NO Photodonor.

Sodano F, Rolando B, Spyrakis F, Failla M, Lazzarato L, Gazzano E, Riganti C, Fruttero R, Gasco A, Sortino S.

ChemMedChem. 2018 Jun 20;13(12):1238-1245. doi: 10.1002/cmdc.201800088. Epub 2018 May 8.

PMID:
29633541
7.

Symptoms associated with reading from a smartphone in conditions of light and dark.

Antona B, Barrio AR, Gascó A, Pinar A, González-Pérez M, Puell MC.

Appl Ergon. 2018 Apr;68:12-17. doi: 10.1016/j.apergo.2017.10.014. Epub 2017 Nov 2.

PMID:
29409625
8.

Folate-targeted liposomal nitrooxy-doxorubicin: An effective tool against P-glycoprotein-positive and folate receptor-positive tumors.

Gazzano E, Rolando B, Chegaev K, Salaroglio IC, Kopecka J, Pedrini I, Saponara S, Sorge M, Buondonno I, Stella B, Marengo A, Valoti M, Brancaccio M, Fruttero R, Gasco A, Arpicco S, Riganti C.

J Control Release. 2018 Jan 28;270:37-52. doi: 10.1016/j.jconrel.2017.11.042. Epub 2017 Dec 2.

PMID:
29191785
9.

A Molecular Hybrid for Mitochondria-Targeted NO Photodelivery.

Sodano F, Gazzano E, Fraix A, Rolando B, Lazzarato L, Russo M, Blangetti M, Riganti C, Fruttero R, Gasco A, Sortino S.

ChemMedChem. 2018 Jan 8;13(1):87-96. doi: 10.1002/cmdc.201700608. Epub 2017 Nov 30.

PMID:
29110418
10.

Scale of human mobility in the southern Andes (Argentina and Chile): A new framework based on strontium isotopes.

Barberena R, Durán VA, Novellino P, Winocur D, Benítez A, Tessone A, Quiroga MN, Marsh EJ, Gasco A, Cortegoso V, Lucero G, Llano C, Knudson KJ.

Am J Phys Anthropol. 2017 Oct;164(2):305-320. doi: 10.1002/ajpa.23270. Epub 2017 Jun 20.

PMID:
28631376
11.

A Nonmetal-Containing Nitric Oxide Donor Activated with Single-Photon Green Light.

Blangetti M, Fraix A, Lazzarato L, Marini E, Rolando B, Sodano F, Fruttero R, Gasco A, Sortino S.

Chemistry. 2017 Jul 6;23(38):9026-9029. doi: 10.1002/chem.201701889. Epub 2017 Jun 9.

PMID:
28543638
12.

Light-Regulated NO Release as a Novel Strategy To Overcome Doxorubicin Multidrug Resistance.

Chegaev K, Fraix A, Gazzano E, Abd-Ellatef GE, Blangetti M, Rolando B, Conoci S, Riganti C, Fruttero R, Gasco A, Sortino S.

ACS Med Chem Lett. 2017 Jan 30;8(3):361-365. doi: 10.1021/acsmedchemlett.7b00016. eCollection 2017 Mar 9. Erratum in: ACS Med Chem Lett. 2019 Feb 28;10(3):393.

13.

New furoxan derivatives for the treatment of ocular hypertension.

Blangetti M, Rolando B, Chegaev K, Guglielmo S, Lazzarato L, Durante M, Masini E, Almirante N, Bastia E, Impagnatiello F, Fruttero R, Gasco A.

Bioorg Med Chem Lett. 2017 Feb 1;27(3):479-483. doi: 10.1016/j.bmcl.2016.12.041. Epub 2016 Dec 18.

14.

Synergistic roles of climate warming and human occupation in Patagonian megafaunal extinctions during the Last Deglaciation.

Metcalf JL, Turney C, Barnett R, Martin F, Bray SC, Vilstrup JT, Orlando L, Salas-Gismondi R, Loponte D, Medina M, De Nigris M, Civalero T, Fernández PM, Gasco A, Duran V, Seymour KL, Otaola C, Gil A, Paunero R, Prevosti FJ, Bradshaw CJ, Wheeler JC, Borrero L, Austin JJ, Cooper A.

Sci Adv. 2016 Jun 17;2(6):e1501682. doi: 10.1126/sciadv.1501682. eCollection 2016 Jun.

15.

Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4'-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein.

Guglielmo S, Lazzarato L, Contino M, Perrone MG, Chegaev K, Carrieri A, Fruttero R, Colabufo NA, Gasco A.

J Med Chem. 2016 Jul 28;59(14):6729-38. doi: 10.1021/acs.jmedchem.6b00252. Epub 2016 Jul 7.

PMID:
27336199
16.

H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance.

Chegaev K, Rolando B, Cortese D, Gazzano E, Buondonno I, Lazzarato L, Fanelli M, Hattinger CM, Serra M, Riganti C, Fruttero R, Ghigo D, Gasco A.

J Med Chem. 2016 May 26;59(10):4881-9. doi: 10.1021/acs.jmedchem.6b00184. Epub 2016 May 5.

17.

Light-Tunable Generation of Singlet Oxygen and Nitric Oxide with a Bichromophoric Molecular Hybrid: a Bimodal Approach to Killing Cancer Cells.

Fraix A, Blangetti M, Guglielmo S, Lazzarato L, Marino N, Cardile V, Graziano AC, Manet I, Fruttero R, Gasco A, Sortino S.

ChemMedChem. 2016 Jun 20;11(12):1371-9. doi: 10.1002/cmdc.201500396. Epub 2015 Nov 5.

PMID:
26537319
18.

NO-Donor Dihydroartemisinin Derivatives as Multitarget Agents for the Treatment of Cerebral Malaria.

Bertinaria M, Orjuela-Sanchez P, Marini E, Guglielmo S, Hofer A, Martins YC, Zanini GM, Frangos JA, Gasco A, Fruttero R, Carvalho LJ.

J Med Chem. 2015 Oct 8;58(19):7895-9. doi: 10.1021/acs.jmedchem.5b01036. Epub 2015 Sep 24.

19.

NO-donor thiacarbocyanines as multifunctional agents for Alzheimer's disease.

Chegaev K, Federico A, Marini E, Rolando B, Fruttero R, Morbin M, Rossi G, Fugnanesi V, Bastone A, Salmona M, Badiola NB, Gasparini L, Cocco S, Ripoli C, Grassi C, Gasco A.

Bioorg Med Chem. 2015 Aug 1;23(15):4688-98. doi: 10.1016/j.bmc.2015.05.050. Epub 2015 Jun 3.

20.

Variation in photosynthetic performance and hydraulic architecture across European beech (Fagus sylvatica L.) populations supports the case for local adaptation to water stress.

Aranda I, Cano FJ, Gascó A, Cochard H, Nardini A, Mancha JA, López R, Sánchez-Gómez D.

Tree Physiol. 2015 Jan;35(1):34-46. doi: 10.1093/treephys/tpu101. Epub 2014 Dec 22.

PMID:
25536961
21.

The application of advanced oxidation technologies to the treatment of effluents from the pulp and paper industry: a review.

Hermosilla D, Merayo N, Gascó A, Blanco Á.

Environ Sci Pollut Res Int. 2015 Jan;22(1):168-91. doi: 10.1007/s11356-014-3516-1. Epub 2014 Sep 5. Review.

PMID:
25185495
22.

Furazan and furoxan sulfonamides are strong α-carbonic anhydrase inhibitors and potential antiglaucoma agents.

Chegaev K, Lazzarato L, Tamboli Y, Boschi D, Blangetti M, Scozzafava A, Carta F, Masini E, Fruttero R, Supuran CT, Gasco A.

Bioorg Med Chem. 2014 Aug 1;22(15):3913-21. doi: 10.1016/j.bmc.2014.06.016. Epub 2014 Jun 17.

PMID:
25022971
23.

New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni.

Guglielmo S, Cortese D, Vottero F, Rolando B, Kommer VP, Williams DL, Fruttero R, Gasco A.

Eur J Med Chem. 2014 Sep 12;84:135-45. doi: 10.1016/j.ejmech.2014.07.007. Epub 2014 Jul 3.

24.

Synthesis and Biological Evaluation of the First Example of NO-Donor Histone Deacetylase Inhibitor.

Borretto E, Lazzarato L, Spallotta F, Cencioni C, D'Alessandra Y, Gaetano C, Fruttero R, Gasco A.

ACS Med Chem Lett. 2013 Sep 4;4(10):994-9. doi: 10.1021/ml400289e. eCollection 2013 Oct 10.

25.

Nondisruptive p53 mutations are associated with shorter survival in patients with advanced non-small cell lung cancer.

Molina-Vila MA, Bertran-Alamillo J, Gascó A, Mayo-de-las-Casas C, Sánchez-Ronco M, Pujantell-Pastor L, Bonanno L, Favaretto AG, Cardona AF, Vergnenègre A, Majem M, Massuti B, Morán T, Carcereny E, Viteri S, Rosell R.

Clin Cancer Res. 2014 Sep 1;20(17):4647-59. doi: 10.1158/1078-0432.CCR-13-2391. Epub 2014 Apr 2.

26.

6-Cyclohexylmethoxy-5-(cyano-NNO-azoxy)pyrimidine-4-amine: a new scaffold endowed with potent CDK2 inhibitory activity.

Boschi D, Tosco P, Chandra N, Chaurasia S, Fruttero R, Griffin R, Wang LZ, Gasco A.

Eur J Med Chem. 2013 Oct;68:333-8. doi: 10.1016/j.ejmech.2013.07.031. Epub 2013 Aug 11.

PMID:
23994326
27.

Doxorubicin-antioxidant co-drugs.

Chegaev K, Riganti C, Rolando B, Lazzarato L, Gazzano E, Guglielmo S, Ghigo D, Fruttero R, Gasco A.

Bioorg Med Chem Lett. 2013 Oct 1;23(19):5307-10. doi: 10.1016/j.bmcl.2013.07.070. Epub 2013 Aug 8.

28.

Water-soluble nitric-oxide-releasing acetylsalicylic acid (ASA) prodrugs.

Rolando B, Lazzarato L, Donnola M, Marini E, Joseph S, Morini G, Pozzoli C, Fruttero R, Gasco A.

ChemMedChem. 2013 Jul;8(7):1199-209. doi: 10.1002/cmdc.201300105. Epub 2013 Jun 10.

PMID:
23754790
29.

Adaptive resistance to targeted therapies in cancer.

Rosell R, Karachaliou N, Morales-Espinosa D, Costa C, Molina MA, Sansano I, Gasco A, Viteri S, Massuti B, Wei J, González Cao M, Martínez Bueno A.

Transl Lung Cancer Res. 2013 Jun;2(3):152-9. doi: 10.3978/j.issn.2218-6751.2012.12.08. Review.

30.

CK-coated magnetic-based beads as a tool to isolate circulating tumor cells (CTCs) in human tumors.

Mayo C, Ortega FG, Giménez-Capitán A, Molina-Vila MA, Serrano MJ, Viteri S, Costa C, Gascó A, Bertran-Alamillo J, Karachaliou N, Lorente JA, Tarón M, Rosell R.

Transl Lung Cancer Res. 2013 Apr;2(2):65-71. doi: 10.3978/j.issn.2218-6751.2013.02.06.

31.

BRCA1, LMO4, and CtIP mRNA expression in erlotinib-treated non-small-cell lung cancer patients with EGFR mutations.

Karachaliou N, Costa C, Gimenez-Capitan A, Molina-Vila MA, Bertran-Alamillo J, Mayo C, Massuti B, Majem M, Carcereny E, Moran T, Sanchez JJ, Viteri S, Gasco A, Wannesson L, Souglakos J, Jimeno J, Rosell R; Spanish Lung Cancer Group.

J Thorac Oncol. 2013 Mar;8(3):295-300. doi: 10.1097/JTO.0b013e31827db621.

32.

Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents.

Montanaro G, Bertinaria M, Rolando B, Fruttero R, Lucas CD, Dorward DA, Rossi AG, Megson IL, Gasco A.

Bioorg Med Chem. 2013 Apr 1;21(7):2107-16. doi: 10.1016/j.bmc.2013.01.009. Epub 2013 Jan 16.

33.

Designing multitarget anti-inflammatory agents: chemical modulation of the lumiracoxib structure toward dual thromboxane antagonists-COX-2 inhibitors.

Bertinaria M, Shaikh MA, Buccellati C, Cena C, Rolando B, Lazzarato L, Fruttero R, Gasco A, Hoxha M, Capra V, Sala A, Rovati GE.

ChemMedChem. 2012 Sep;7(9):1647-60. doi: 10.1002/cmdc.201200272. Epub 2012 Aug 2. Erratum in: ChemMedChem. 2012 Dec;7(12):2054.

34.

Carnosine analogues containing NO-donor substructures: synthesis, physico-chemical characterization and preliminary pharmacological profile.

Bertinaria M, Rolando B, Giorgis M, Montanaro G, Marini E, Collino M, Benetti E, Daniele PG, Fruttero R, Gasco A.

Eur J Med Chem. 2012 Aug;54:103-12. doi: 10.1016/j.ejmech.2012.04.032. Epub 2012 May 2.

35.

Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues.

Tamboli Y, Lazzarato L, Marini E, Guglielmo S, Novelli M, Beffy P, Masiello P, Fruttero R, Gasco A.

Bioorg Med Chem Lett. 2012 Jun 1;22(11):3810-5. doi: 10.1016/j.bmcl.2012.03.103. Epub 2012 Apr 11.

PMID:
22565215
36.

New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold.

Lolli ML, Giorgis M, Tosco P, Foti A, Fruttero R, Gasco A.

Eur J Med Chem. 2012 Mar;49:102-9. doi: 10.1016/j.ejmech.2011.12.038. Epub 2012 Jan 3.

37.

Synthesis physicochemical profile and PAMPA study of new NO-donor edaravone co-drugs.

Rolando B, Filieri A, Chegaev K, Lazzarato L, Giorgis M, De Nardi C, Fruttero R, Martel S, Carrupt PA, Gasco A.

Bioorg Med Chem. 2012 Jan 15;20(2):841-50. doi: 10.1016/j.bmc.2011.11.065. Epub 2011 Dec 8.

38.

mRNA expression levels and genetic status of genes involved in the EGFR and NF-κB pathways in metastatic non-small-cell lung cancer patients.

Santarpia M, Magri I, Sanchez-Ronco M, Costa C, Molina-Vila MA, Gimenez-Capitan A, Bertran-Alamillo J, Mayo C, Benlloch S, Viteri S, Gasco A, Mederos N, Carcereny E, Taron M, Rosell R.

J Transl Med. 2011 Sep 27;9:163. doi: 10.1186/1479-5876-9-163.

39.

Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells.

Molon B, Ugel S, Del Pozzo F, Soldani C, Zilio S, Avella D, De Palma A, Mauri P, Monegal A, Rescigno M, Savino B, Colombo P, Jonjic N, Pecanic S, Lazzarato L, Fruttero R, Gasco A, Bronte V, Viola A.

J Exp Med. 2011 Sep 26;208(10):1949-62. doi: 10.1084/jem.20101956. Epub 2011 Sep 19.

40.

Searching for new NO-donor aspirin-like molecules: Furoxanylacyl derivatives of salicylic acid and related furazans.

Lazzarato L, Cena C, Rolando B, Marini E, Lolli ML, Guglielmo S, Guaita E, Morini G, Coruzzi G, Fruttero R, Gasco A.

Bioorg Med Chem. 2011 Oct 1;19(19):5852-60. doi: 10.1016/j.bmc.2011.08.018. Epub 2011 Aug 16.

PMID:
21906954
41.

Nitric oxide donor doxorubicins accumulate into Doxorubicin-resistant human colon cancer cells inducing cytotoxicity.

Chegaev K, Riganti C, Lazzarato L, Rolando B, Guglielmo S, Campia I, Fruttero R, Bosia A, Gasco A.

ACS Med Chem Lett. 2011 Apr 4;2(7):494-7. doi: 10.1021/ml100302t. eCollection 2011 Jul 14.

42.

New nitric oxide or hydrogen sulfide releasing aspirins.

Lazzarato L, Chegaev K, Marini E, Rolando B, Borretto E, Guglielmo S, Joseph S, Di Stilo A, Fruttero R, Gasco A.

J Med Chem. 2011 Aug 11;54(15):5478-84. doi: 10.1021/jm2004514. Epub 2011 Jul 6.

43.

Amodiaquine analogues containing NO-donor substructures: synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria.

Bertinaria M, Guglielmo S, Rolando B, Giorgis M, Aragno C, Fruttero R, Gasco A, Parapini S, Taramelli D, Martins YC, Carvalho LJ.

Eur J Med Chem. 2011 May;46(5):1757-67. doi: 10.1016/j.ejmech.2011.02.029. Epub 2011 Feb 22.

PMID:
21396743
44.

Nitrooxyacyl derivatives of salicylic acid: aspirin-like molecules that covalently inactivate cyclooxygenase-1.

Cena C, Tosco P, Marini E, Lazzarato L, Piccinini M, Ramondetti C, Lupino E, Fruttero R, Gasco A.

ChemMedChem. 2011 Mar 7;6(3):523-30. doi: 10.1002/cmdc.201000397. Epub 2011 Jan 5.

PMID:
21360823
45.

Synthesis, physicochemical characterization, and biological activities of new carnosine derivatives stable in human serum as potential neuroprotective agents.

Bertinaria M, Rolando B, Giorgis M, Montanaro G, Guglielmo S, Buonsanti MF, Carabelli V, Gavello D, Daniele PG, Fruttero R, Gasco A.

J Med Chem. 2011 Jan 27;54(2):611-21. doi: 10.1021/jm101394n. Epub 2010 Dec 23.

PMID:
21182325
46.

1,2,5-Oxadiazole analogues of leflunomide and related compounds.

Giorgis M, Lolli ML, Rolando B, Rao A, Tosco P, Chaurasia S, Marabello D, Fruttero R, Gasco A.

Eur J Med Chem. 2011 Jan;46(1):383-92. doi: 10.1016/j.ejmech.2010.10.029. Epub 2010 Nov 3.

PMID:
21109332
47.

Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and P-glycoprotein.

Fruttero R, Crosetti M, Chegaev K, Guglielmo S, Gasco A, Berardi F, Niso M, Perrone R, Panaro MA, Colabufo NA.

J Med Chem. 2010 Aug 12;53(15):5467-75. doi: 10.1021/jm100066y.

48.

Multitarget drugs: synthesis and preliminary pharmacological characterization of zileuton analogues endowed with Dual 5-LO inhibitor and NO-dependent activities.

Boschi D, Giorgis M, Cena C, Talniya NC, Di Stilo A, Morini G, Coruzzi G, Guaita E, Fruttero R, Gasco A.

ChemMedChem. 2010 Sep 3;5(9):1444-9. doi: 10.1002/cmdc.201000198. No abstract available.

49.

(Nitrooxyacyloxy)methyl esters of aspirin as novel nitric oxide releasing aspirins.

Lazzarato L, Donnola M, Rolando B, Chegaev K, Marini E, Cena C, Di Stilo A, Fruttero R, Biondi S, Ongini E, Gasco A.

J Med Chem. 2009 Aug 27;52(16):5058-68. doi: 10.1021/jm900587h.

PMID:
20560642
50.

Nitrooxymethyl-substituted analogues of rofecoxib: synthesis and pharmacological characterization.

Boschi D, Cena C, Di Stilo A, Rolando B, Manzini P, Fruttero R, Gasco A.

Chem Biodivers. 2010 May;7(5):1173-82. doi: 10.1002/cbdv.200900421.

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