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Items: 1 to 50 of 57

1.

SOX2, OCT3/4 and NANOG expression and cellular plasticity in rare human somatic cells requires CD73.

Pan D, Roy S, Gascard P, Zhao J, Chen-Tanyolac C, Tlsty TD.

Cell Signal. 2016 Dec;28(12):1923-1932. doi: 10.1016/j.cellsig.2016.09.008. Epub 2016 Oct 2.

2.

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy.

Gascard P, Tlsty TD.

Genes Dev. 2016 May 1;30(9):1002-19. doi: 10.1101/gad.279737.116. Review.

3.

Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization.

Kurup A, Ravindranath S, Tran T, Keating M, Gascard P, Valdevit L, Tlsty TD, Botvinick EL.

Sci Rep. 2015 Oct 16;5:15153. doi: 10.1038/srep15153.

4.

Towards aspirin-inspired self-immolating molecules which target the cyclooxygenases.

Drake CR, Estévez-Salmerón L, Gascard P, Shen Y, Tlsty TD, Jones EF.

Org Biomol Chem. 2015 Dec 7;13(45):11078-86. doi: 10.1039/c5ob01805f. Epub 2015 Sep 24.

5.

Integrative analysis of 111 reference human epigenomes.

Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis M.

Nature. 2015 Feb 19;518(7539):317-30. doi: 10.1038/nature14248.

6.

Intermediate DNA methylation is a conserved signature of genome regulation.

Elliott G, Hong C, Xing X, Zhou X, Li D, Coarfa C, Bell RJ, Maire CL, Ligon KL, Sigaroudinia M, Gascard P, Tlsty TD, Harris RA, Schalkwyk LC, Bilenky M, Mill J, Farnham PJ, Kellis M, Marra MA, Milosavljevic A, Hirst M, Stormo GD, Wang T, Costello JF.

Nat Commun. 2015 Feb 18;6:6363. doi: 10.1038/ncomms7363.

7.

Epigenetic and transcriptional determinants of the human breast.

Gascard P, Bilenky M, Sigaroudinia M, Zhao J, Li L, Carles A, Delaney A, Tam A, Kamoh B, Cho S, Griffith M, Chu A, Robertson G, Cheung D, Li I, Heravi-Moussavi A, Moksa M, Mingay M, Hussainkhel A, Davis B, Nagarajan RP, Hong C, Echipare L, O'Geen H, Hangauer MJ, Cheng JB, Neel D, Hu D, McManus MT, Moore R, Mungall A, Ma Y, Plettner P, Ziv E, Wang T, Farnham PJ, Jones SJ, Marra MA, Tlsty TD, Costello JF, Hirst M.

Nat Commun. 2015 Feb 18;6:6351. doi: 10.1038/ncomms7351.

8.

Regulatory network decoded from epigenomes of surface ectoderm-derived cell types.

Lowdon RF, Zhang B, Bilenky M, Mauro T, Li D, Gascard P, Sigaroudinia M, Farnham PJ, Bastian BC, Tlsty TD, Marra MA, Hirst M, Costello JF, Wang T, Cheng JB.

Nat Commun. 2014 Nov 25;5:5442. doi: 10.1038/ncomms6442.

9.

Phosphatidylinositol-4,5 bisphosphate (PIP(2)) inhibits apo-calmodulin binding to protein 4.1.

Nunomura W, Gascard P, Wakui H, Takakuwa Y.

Biochem Biophys Res Commun. 2014 Apr 4;446(2):434-40. doi: 10.1016/j.bbrc.2014.02.121. Epub 2014 Mar 6.

PMID:
24607279
10.

Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm.

Zhang B, Zhou Y, Lin N, Lowdon RF, Hong C, Nagarajan RP, Cheng JB, Li D, Stevens M, Lee HJ, Xing X, Zhou J, Sundaram V, Elliott G, Gu J, Shi T, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O'Geen H, Farnham PJ, Maire CL, Ligon KL, Madden PA, Tam A, Moore R, Hirst M, Marra MA, Zhang B, Costello JF, Wang T.

Genome Res. 2013 Sep;23(9):1522-40. doi: 10.1101/gr.156539.113. Epub 2013 Jun 26.

11.

DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape.

Xie M, Hong C, Zhang B, Lowdon RF, Xing X, Li D, Zhou X, Lee HJ, Maire CL, Ligon KL, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O'Geen H, Farnham PJ, Madden PA, Mungall AJ, Tam A, Kamoh B, Cho S, Moore R, Hirst M, Marra MA, Costello JF, Wang T.

Nat Genet. 2013 Jul;45(7):836-41. doi: 10.1038/ng.2649. Epub 2013 May 26.

12.

Coordinate transcriptional and translational repression of p53 by TGF-β1 impairs the stress response.

López-Díaz FJ, Gascard P, Balakrishnan SK, Zhao J, Del Rincon SV, Spruck C, Tlsty TD, Emerson BM.

Mol Cell. 2013 May 23;50(4):552-64. doi: 10.1016/j.molcel.2013.04.029.

13.

A physical sciences network characterization of non-tumorigenic and metastatic cells.

Physical Sciences - Oncology Centers Network, Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH.

Sci Rep. 2013;3:1449. doi: 10.1038/srep01449.

14.

Rare somatic cells from human breast tissue exhibit extensive lineage plasticity.

Roy S, Gascard P, Dumont N, Zhao J, Pan D, Petrie S, Margeta M, Tlsty TD.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4598-603. doi: 10.1073/pnas.1218682110. Epub 2013 Mar 4.

15.

Characterization of cytoskeletal protein 4.1R interaction with NHE1 (Na(+)/H(+) exchanger isoform 1).

Nunomura W, Denker SP, Barber DL, Takakuwa Y, Gascard P.

Biochem J. 2012 Sep 15;446(3):427-35. doi: 10.1042/BJ20120535.

16.

The clonal and mutational evolution spectrum of primary triple-negative breast cancers.

Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y, Turashvili G, Ding J, Tse K, Haffari G, Bashashati A, Prentice LM, Khattra J, Burleigh A, Yap D, Bernard V, McPherson A, Shumansky K, Crisan A, Giuliany R, Heravi-Moussavi A, Rosner J, Lai D, Birol I, Varhol R, Tam A, Dhalla N, Zeng T, Ma K, Chan SK, Griffith M, Moradian A, Cheng SW, Morin GB, Watson P, Gelmon K, Chia S, Chin SF, Curtis C, Rueda OM, Pharoah PD, Damaraju S, Mackey J, Hoon K, Harkins T, Tadigotla V, Sigaroudinia M, Gascard P, Tlsty T, Costello JF, Meyer IM, Eaves CJ, Wasserman WW, Jones S, Huntsman D, Hirst M, Caldas C, Marra MA, Aparicio S.

Nature. 2012 Apr 4;486(7403):395-9. doi: 10.1038/nature10933.

17.

Isoforms of protein 4.1 are differentially distributed in heart muscle cells: relation of 4.1R and 4.1G to components of the Ca2+ homeostasis system.

Pinder JC, Taylor-Harris PM, Bennett PM, Carter E, Hayes NV, King MD, Holt MR, Maggs AM, Gascard P, Baines AJ.

Exp Cell Res. 2012 Aug 1;318(13):1467-79. doi: 10.1016/j.yexcr.2012.03.003. Epub 2012 Mar 10.

PMID:
22429617
18.

Insights into the Function of the Unstructured N-Terminal Domain of Proteins 4.1R and 4.1G in Erythropoiesis.

Nunomura W, Gascard P, Takakuwa Y.

Int J Cell Biol. 2011;2011:943272. doi: 10.1155/2011/943272. Epub 2011 Aug 28.

19.

Similarities and differences in the structure and function of 4.1G and 4.1R135, two protein 4.1 paralogues expressed in erythroid cells.

Nunomura W, Kinoshita K, Parra M, Gascard P, An X, Mohandas N, Takakuwa Y.

Biochem J. 2010 Dec 1;432(2):407-16. doi: 10.1042/BJ20100041.

20.

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition.

Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, Hu Z, Knight Z, Feiler HS, Gascard P, Parvin B, Spellman PT, Shokat KM, Wyrobek AJ, Bissell MJ, McCormick F, Kuo WL, Mills GB, Gray JW, Korn WM.

Cancer Res. 2009 Jan 15;69(2):565-72. doi: 10.1158/0008-5472.CAN-08-3389.

21.

Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition.

Andarawewa KL, Erickson AC, Chou WS, Costes SV, Gascard P, Mott JD, Bissell MJ, Barcellos-Hoff MH.

Cancer Res. 2007 Sep 15;67(18):8662-70.

22.

Effect of complete protein 4.1R deficiency on ion transport properties of murine erythrocytes.

Rivera A, De Franceschi L, Peters LL, Gascard P, Mohandas N, Brugnara C.

Am J Physiol Cell Physiol. 2006 Nov;291(5):C880-6. Epub 2006 Jun 14.

23.

New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium.

Calinisan V, Gravem D, Chen RP, Brittin S, Mohandas N, Lecomte MC, Gascard P.

Front Biosci. 2006 May 1;11:1646-66. Review.

PMID:
16368544
24.

Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis.

De Franceschi L, Rivera A, Fleming MD, Honczarenko M, Peters LL, Gascard P, Mohandas N, Brugnara C.

Blood. 2005 Aug 15;106(4):1454-9. Epub 2005 Apr 26.

25.

Development of a targeted transgenesis strategy in highly differentiated cells: a powerful tool for functional genomic analysis.

Puttini S, Ouvrard-Pascaud A, Palais G, Beggah AT, Gascard P, Cohen-Tannoudji M, Babinet C, Blot-Chabaud M, Jaisser F.

J Biotechnol. 2005 Mar 16;116(2):145-51. Epub 2004 Dec 31.

PMID:
15664078
26.

Putative tumor suppressor protein 4.1B is differentially expressed in kidney and brain via alternative promoters and 5' alternative splicing.

Gascard P, Parra MK, Zhao Z, Calinisan VR, Nunomura W, Rivkees SA, Mohandas N, Conboy JG.

Biochim Biophys Acta. 2004 Oct 21;1680(2):71-82.

PMID:
15488987
27.

Differential domain evolution and complex RNA processing in a family of paralogous EPB41 (protein 4.1) genes facilitate expression of diverse tissue-specific isoforms.

Parra M, Gee S, Chan N, Ryaboy D, Dubchak I, Mohandas N, Gascard PD, Conboy JG.

Genomics. 2004 Oct;84(4):637-46.

PMID:
15475241
28.

Identification of a third Protein 4.1 tumor suppressor, Protein 4.1R, in meningioma pathogenesis.

Robb VA, Li W, Gascard P, Perry A, Mohandas N, Gutmann DH.

Neurobiol Dis. 2003 Aug;13(3):191-202.

PMID:
12901833
29.

Distinct distribution of specific members of protein 4.1 gene family in the mouse nephron.

Ramez M, Blot-Chabaud M, Cluzeaud F, Chanan S, Patterson M, Walensky LD, Marfatia S, Baines AJ, Chasis JA, Conboy JG, Mohandas N, Gascard P.

Kidney Int. 2003 Apr;63(4):1321-37.

30.

Nucleolar localization of RPS19 protein in normal cells and mislocalization due to mutations in the nucleolar localization signals in 2 Diamond-Blackfan anemia patients: potential insights into pathophysiology.

Da Costa L, Tchernia G, Gascard P, Lo A, Meerpohl J, Niemeyer C, Chasis JA, Fixler J, Mohandas N.

Blood. 2003 Jun 15;101(12):5039-45. Epub 2003 Feb 13.

31.

Cytoskeletal Proteins in Heart Muscle.

Pinder JC, Taylor-Harris PM, Hayes NV, Gascard PD, Maggs AM, Baines AJ.

Cell Mol Biol Lett. 2001;6(2):227. No abstract available.

PMID:
11544678
32.

Structural and functional characterization of protein 4.1R-phosphatidylserine interaction: potential role in 4.1R sorting within cells.

An XL, Takakuwa Y, Manno S, Han BG, Gascard P, Mohandas N.

J Biol Chem. 2001 Sep 21;276(38):35778-85. Epub 2001 Jun 22.

33.

What do mouse gene knockouts tell us about the structure and function of the red cell membrane?

Mohandas N, Gascard P.

Baillieres Best Pract Res Clin Haematol. 1999 Dec;12(4):605-20. Review. Erratum in: Baillieres Best Pract Res Clin Haematol. 2001 Dec;14(4):835.

PMID:
10895255
34.

New insights into functions of erythroid proteins in nonerythroid cells.

Gascard P, Mohandas N.

Curr Opin Hematol. 2000 Mar;7(2):123-9. Review.

PMID:
10698300
35.

Molecular and functional characterization of protein 4.1B, a novel member of the protein 4.1 family with high level, focal expression in brain.

Parra M, Gascard P, Walensky LD, Gimm JA, Blackshaw S, Chan N, Takakuwa Y, Berger T, Lee G, Chasis JA, Snyder SH, Mohandas N, Conboy JG.

J Biol Chem. 2000 Feb 4;275(5):3247-55.

36.

Deciphering the nuclear import pathway for the cytoskeletal red cell protein 4.1R.

Gascard P, Nunomura W, Lee G, Walensky LD, Krauss SW, Takakuwa Y, Chasis JA, Mohandas N, Conboy JG.

Mol Biol Cell. 1999 Jun;10(6):1783-98.

38.

Characterization of multiple isoforms of protein 4.1R expressed during erythroid terminal differentiation.

Gascard P, Lee G, Coulombel L, Auffray I, Lum M, Parra M, Conboy JG, Mohandas N, Chasis JA.

Blood. 1998 Dec 1;92(11):4404-14.

39.

Neurobehavioral deficits in mice lacking the erythrocyte membrane cytoskeletal protein 4.1.

Walensky LD, Shi ZT, Blackshaw S, DeVries AC, Demas GE, Gascard P, Nelson RJ, Conboy JG, Rubin EM, Snyder SH, Mohandas N.

Curr Biol. 1998 Nov 19;8(23):1269-72.

40.

The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane.

Chishti AH, Kim AC, Marfatia SM, Lutchman M, Hanspal M, Jindal H, Liu SC, Low PS, Rouleau GA, Mohandas N, Chasis JA, Conboy JG, Gascard P, Takakuwa Y, Huang SC, Benz EJ Jr, Bretscher A, Fehon RG, Gusella JF, Ramesh V, Solomon F, Marchesi VT, Tsukita S, Tsukita S, Hoover KB, et al.

Trends Biochem Sci. 1998 Aug;23(8):281-2. Review. No abstract available.

PMID:
9757824
41.

Cloning and characterization of 4.1G (EPB41L2), a new member of the skeletal protein 4.1 (EPB41) gene family.

Parra M, Gascard P, Walensky LD, Snyder SH, Mohandas N, Conboy JG.

Genomics. 1998 Apr 15;49(2):298-306.

PMID:
9598318
42.

The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1.

Walensky LD, Gascard P, Fields ME, Blackshaw S, Conboy JG, Mohandas N, Snyder SH.

J Cell Biol. 1998 Apr 6;141(1):143-53.

43.

Structural protein 4.1 in the nucleus of human cells: dynamic rearrangements during cell division.

Krauss SW, Larabell CA, Lockett S, Gascard P, Penman S, Mohandas N, Chasis JA.

J Cell Biol. 1997 Apr 21;137(2):275-89.

44.

Specific loss of protein kinase activities in senescent erythrocytes.

Jindal HK, Ai Z, Gascard P, Horton C, Cohen CM.

Blood. 1996 Aug 15;88(4):1479-87.

46.

Cellular distribution of polyphosphoinositides in rat hepatocytes.

Tran D, Gascard P, Berthon B, Fukami K, Takenawa T, Giraud F, Claret M.

Cell Signal. 1993 Sep;5(5):565-81.

PMID:
8312134
47.

Characterization of structural and functional phosphoinositide domains in human erythrocyte membranes.

Gascard P, Sauvage M, Sulpice JC, Giraud F.

Biochemistry. 1993 Jun 15;32(23):5941-8.

PMID:
8389583
48.

Trans-bilayer distribution of phosphatidylinositol 4,5-bisphosphate and its role in the changes of lipid asymmetry in the human erythrocyte membrane.

Gascard P, Sulpice JC, Tran D, Sauvage M, Claret M, Zachowski A, Devaux PF, Giraud F.

Biochem Soc Trans. 1993 May;21(2):253-7. Review. No abstract available.

PMID:
8395420
49.

The role of inositol phospholipids in the association of band 4.1 with the human erythrocyte membrane.

Gascard P, Pawelczyk T, Lowenstein JM, Cohen CM.

Eur J Biochem. 1993 Feb 1;211(3):671-81.

50.

Regulation and post-translational modification of erythrocyte membrane and membrane-skeletal proteins.

Cohen CM, Gascard P.

Semin Hematol. 1992 Oct;29(4):244-92. Review. No abstract available.

PMID:
1336625

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