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Endogenous IL-33 Deficiency Exacerbates Liver Injury and Increases Hepatic Influx of Neutrophils in Acute Murine Viral Hepatitis.

Carrière V, Arshad MI, Le Seyec J, Lefevre B, Farooq M, Jan A, Manuel C, Touami-Bernard L, Lucas-Clerc C, Genet V, Gascan H, Girard JP, Chalmel F, Lamontagne L, Piquet-Pellorce C, Samson M.

Mediators Inflamm. 2017;2017:1359064. doi: 10.1155/2017/1359064. Epub 2017 May 4.


Oncostatin M induces IL-33 expression in liver endothelial cells in mice and expands ST2+CD4+ lymphocytes.

Arshad MI, Guihard P, Danger Y, Noel G, Le Seyec J, Boutet MA, Richards CD, L'Helgoualc'h A, Genet V, Lucas-Clerc C, Gascan H, Blanchard F, Piquet-Pellorce C, Samson M.

Am J Physiol Gastrointest Liver Physiol. 2015 Oct 1;309(7):G542-53. doi: 10.1152/ajpgi.00398.2014. Epub 2015 Aug 6.


Interleukin-27 and IFNγ regulate the expression of CXCL9, CXCL10, and CXCL11 in hepatitis.

Basset L, Chevalier S, Danger Y, Arshad MI, Piquet-Pellorce C, Gascan H, Samson M.

J Mol Med (Berl). 2015 Dec;93(12):1355-67. doi: 10.1007/s00109-015-1319-6. Epub 2015 Jul 23.


Expression of HLA-G by mast cells is associated with hepatitis C virus-induced liver fibrosis.

Amiot L, Vu N, Rauch M, L'Helgoualc'h A, Chalmel F, Gascan H, Turlin B, Guyader D, Samson M.

J Hepatol. 2014 Feb;60(2):245-52. doi: 10.1016/j.jhep.2013.09.006. Epub 2013 Sep 12.


Invariant NKT cells drive hepatic cytokinic microenvironment favoring efficient granuloma formation and early control of Leishmania donovani infection.

Robert-Gangneux F, Drogoul AS, Rostan O, Piquet-Pellorce C, Cayon J, Lisbonne M, Herbelin A, Gascan H, Guiguen C, Samson M, Gangneux JP.

PLoS One. 2012;7(3):e33413. doi: 10.1371/journal.pone.0033413. Epub 2012 Mar 22.


Induction of osteogenesis in mesenchymal stem cells by activated monocytes/macrophages depends on oncostatin M signaling.

Guihard P, Danger Y, Brounais B, David E, Brion R, Delecrin J, Richards CD, Chevalier S, Rédini F, Heymann D, Gascan H, Blanchard F.

Stem Cells. 2012 Apr;30(4):762-72. doi: 10.1002/stem.1040.


IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variants.

Rousseau F, Basset L, Froger J, Dinguirard N, Chevalier S, Gascan H.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19420-5. doi: 10.1073/pnas.1005793107. Epub 2010 Oct 25.


Definition and characterization of an inhibitor for interleukin-31.

Venereau E, Diveu C, Grimaud L, Ravon E, Froger J, Preisser L, Danger Y, Maillasson M, Garrigue-Antar L, Jacques Y, Chevalier S, Gascan H.

J Biol Chem. 2010 May 14;285(20):14955-63. doi: 10.1074/jbc.M109.049163. Epub 2010 Mar 24.


Molecular dissection of human interleukin-31-mediated signal transduction through site-directed mutagenesis.

Le Saux S, Rousseau F, Barbier F, Ravon E, Grimaud L, Danger Y, Froger J, Chevalier S, Gascan H.

J Biol Chem. 2010 Jan 29;285(5):3470-7. doi: 10.1074/jbc.M109.049189. Epub 2009 Nov 17.


Interleukin-33 overexpression is associated with liver fibrosis in mice and humans.

Marvie P, Lisbonne M, L'helgoualc'h A, Rauch M, Turlin B, Preisser L, Bourd-Boittin K, Théret N, Gascan H, Piquet-Pellorce C, Samson M.

J Cell Mol Med. 2010 Jun;14(6B):1726-39. doi: 10.1111/j.1582-4934.2009.00801.x. Epub 2009 Jun 5.


Prokineticin 1 induces CCL4, CXCL1 and CXCL8 in human monocytes but not in macrophages and dendritic cells.

Monnier J, Quillien V, Piquet-Pellorce C, Leberre C, Preisser L, Gascan H, Samson M.

Eur Cytokine Netw. 2008 Dec;19(4):166-75. doi: 10.1684/ecn.2008.0138.


Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain.

Rousseau F, Chevalier S, Guillet C, Ravon E, Diveu C, Froger J, Barbier F, Grimaud L, Gascan H.

J Biol Chem. 2008 Oct 31;283(44):30341-50. doi: 10.1074/jbc.M803239200. Epub 2008 Aug 26.


Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes.

Pène J, Chevalier S, Preisser L, Vénéreau E, Guilleux MH, Ghannam S, Molès JP, Danger Y, Ravon E, Lesaux S, Yssel H, Gascan H.

J Immunol. 2008 Jun 1;180(11):7423-30.


Neonatal and adult microglia cross-present exogenous antigens.

Beauvillain C, Donnou S, Jarry U, Scotet M, Gascan H, Delneste Y, Guermonprez P, Jeannin P, Couez D.

Glia. 2008 Jan 1;56(1):69-77.


Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells.

Duluc D, Delneste Y, Tan F, Moles MP, Grimaud L, Lenoir J, Preisser L, Anegon I, Catala L, Ifrah N, Descamps P, Gamelin E, Gascan H, Hebbar M, Jeannin P.

Blood. 2007 Dec 15;110(13):4319-30. Epub 2007 Sep 11.


Neutrophils efficiently cross-prime naive T cells in vivo.

Beauvillain C, Delneste Y, Scotet M, Peres A, Gascan H, Guermonprez P, Barnaba V, Jeannin P.

Blood. 2007 Oct 15;110(8):2965-73. Epub 2007 Jun 11.


The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps.

Jaillon S, Peri G, Delneste Y, Frémaux I, Doni A, Moalli F, Garlanda C, Romani L, Gascan H, Bellocchio S, Bozza S, Cassatella MA, Jeannin P, Mantovani A.

J Exp Med. 2007 Apr 16;204(4):793-804. Epub 2007 Mar 26.


Oncostatin M secreted by skin infiltrating T lymphocytes is a potent keratinocyte activator involved in skin inflammation.

Boniface K, Diveu C, Morel F, Pedretti N, Froger J, Ravon E, Garcia M, Venereau E, Preisser L, Guignouard E, Guillet G, Dagregorio G, Pène J, Moles JP, Yssel H, Chevalier S, Bernard FX, Gascan H, Lecron JC.

J Immunol. 2007 Apr 1;178(7):4615-22.


Comparative effects of five bisphosphonates on apoptosis of macrophage cells in vitro.

Moreau MF, Guillet C, Massin P, Chevalier S, Gascan H, Baslé MF, Chappard D.

Biochem Pharmacol. 2007 Mar 1;73(5):718-23. Epub 2006 Nov 3.


Molecular and functional characterization of a soluble form of oncostatin M/interleukin-31 shared receptor.

Diveu C, Venereau E, Froger J, Ravon E, Grimaud L, Rousseau F, Chevalier S, Gascan H.

J Biol Chem. 2006 Dec 1;281(48):36673-82. Epub 2006 Oct 6.


Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient.

Rousseau F, Gauchat JF, McLeod JG, Chevalier S, Guillet C, Guilhot F, Cognet I, Froger J, Hahn AF, Knappskog PM, Gascan H, Boman H.

Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10068-73. Epub 2006 Jun 16.


Target-dependent specification of the neurotransmitter phenotype: cholinergic differentiation of sympathetic neurons is mediated in vivo by gp 130 signaling.

Stanke M, Duong CV, Pape M, Geissen M, Burbach G, Deller T, Gascan H, Otto C, Parlato R, Schütz G, Rohrer H.

Development. 2006 Jan;133(1):141-50. Epub 2005 Nov 30. Erratum in: Development. 2006 Jan;133(2):383. Otto, Christiane [added].


Direct stimulation of human T cells via TLR5 and TLR7/8: flagellin and R-848 up-regulate proliferation and IFN-gamma production by memory CD4+ T cells.

Caron G, Duluc D, Frémaux I, Jeannin P, David C, Gascan H, Delneste Y.

J Immunol. 2005 Aug 1;175(3):1551-7.


Cardiotrophin-like cytokine labelling using Bir A biotin ligase: a sensitive tool to study receptor expression by immune and non-immune cells.

Cognet I, Guilhot F, Gabriac M, Chevalier S, Chouikh Y, Herman-Bert A, Guay-Giroux A, Corneau S, Magistrelli G, Elson GC, Gascan H, Gauchat JF.

J Immunol Methods. 2005 Jun;301(1-2):53-65. Epub 2005 Apr 26.


Rapid protein kinase C-dependent reduction of rat skeletal muscle voltage-gated sodium channels by ciliary neurotrophic factor.

Talon S, Giroux-Metges MA, Pennec JP, Guillet C, Gascan H, Gioux M.

J Physiol. 2005 Jun 15;565(Pt 3):827-41. Epub 2005 Apr 14.


clc is co-expressed with clf or cntfr in developing mouse muscles.

de Bovis B, Derouet D, Gauchat JF, Elson G, Gascan H, Delapeyrière O.

Cell Commun Signal. 2005 Jan 31;3(1):1.


Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling.

Diveu C, Lak-Hal AH, Froger J, Ravon E, Grimaud L, Barbier F, Hermann J, Gascan H, Chevalier S.

Eur Cytokine Netw. 2004 Oct-Dec;15(4):291-302.


Expression of biologically active mouse ciliary neutrophic factor (CNTF) and soluble CNTFRalpha in Escherichia coli and characterization of their functional specificities.

Cognet I, Guilhot F, Chevalier S, Guay-Giroux A, Bert A, Elson GC, Gascan H, Gauchat JF.

Eur Cytokine Netw. 2004 Jul-Sep;15(3):255-62.


Two different contact sites are recruited by cardiotrophin-like cytokine (CLC) to generate the CLC/CLF and CLC/sCNTFRalpha composite cytokines.

Perret D, Guillet C, Elson G, Froger J, Plun-Favreau H, Rousseau F, Chabbert M, Gauchat JF, Gascan H.

J Biol Chem. 2004 Oct 15;279(42):43961-70. Epub 2004 Jul 22.


Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor.

Derouet D, Rousseau F, Alfonsi F, Froger J, Hermann J, Barbier F, Perret D, Diveu C, Guillet C, Preisser L, Dumont A, Barbado M, Morel A, deLapeyrière O, Gascan H, Chevalier S.

Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4827-32. Epub 2004 Mar 29.


GPL, a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor.

Diveu C, Lelièvre E, Perret D, Lak-Hal AH, Froger J, Guillet C, Chevalier S, Rousseau F, Wesa A, Preisser L, Chabbert M, Gauchat JF, Galy A, Gascan H, Morel A.

J Biol Chem. 2003 Dec 12;278(50):49850-9. Epub 2003 Sep 22.


Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling.

Weber AN, Tauszig-Delamasure S, Hoffmann JA, Lelièvre E, Gascan H, Ray KP, Morse MA, Imler JL, Gay NJ.

Nat Immunol. 2003 Aug;4(8):794-800. Epub 2003 Jul 20.


Leukemia inhibitory factor (LIF), cardiotrophin-1, and oncostatin M share structural binding determinants in the immunoglobulin-like domain of LIF receptor.

Plun-Favreau H, Perret D, Diveu C, Froger J, Chevalier S, Lelièvre E, Gascan H, Chabbert M.

J Biol Chem. 2003 Jul 18;278(29):27169-79. Epub 2003 Apr 21.


Astroglial expression of the P-glycoprotein is controlled by intracellular CNTF.

Monville C, Fages C, Feyens AM, D'Hondt V, Guillet C, Vernallis A, Gascan H, Peschanski M.

BMC Cell Biol. 2002 Jul 31;3:20.


Secretion of IL-6, IL-11 and LIF by human cardiomyocytes in primary culture.

Ancey C, Corbi P, Froger J, Delwail A, Wijdenes J, Gascan H, Potreau D, Lecron JC.

Cytokine. 2002 May 21;18(4):199-205.


Functionally active fusion protein of the novel composite cytokine CLC/soluble CNTF receptor.

Guillet C, Lelièvre E, Plun-Favreau H, Froger J, Chabbert M, Hermann J, Benoit de Coignac A, Bonnefoy JY, Gascan H, Gauchat JF, Elson G.

Eur J Biochem. 2002 Apr;269(7):1932-41.


Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression.

Radtke S, Hermanns HM, Haan C, Schmitz-Van De Leur H, Gascan H, Heinrich PC, Behrmann I.

J Biol Chem. 2002 Mar 29;277(13):11297-305. Epub 2002 Jan 10.


Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.

Giraud S, Bienvenu F, Avril S, Gascan H, Heery DM, Coqueret O.

J Biol Chem. 2002 Mar 8;277(10):8004-11. Epub 2001 Dec 31.


Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component.

Lelièvre E, Plun-Favreau H, Chevalier S, Froger J, Guillet C, Elson GC, Gauchat JF, Gascan H.

J Biol Chem. 2001 Jun 22;276(25):22476-84. Epub 2001 Apr 6.


The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine.

Plun-Favreau H, Elson G, Chabbert M, Froger J, deLapeyrière O, Lelièvre E, Guillet C, Hermann J, Gauchat JF, Gascan H, Chevalier S.

EMBO J. 2001 Apr 2;20(7):1692-703.


Cyclin D1 represses STAT3 activation through a Cdk4-independent mechanism.

Bienvenu F, Gascan H, Coqueret O.

J Biol Chem. 2001 May 18;276(20):16840-7. Epub 2001 Feb 20.


Activation of the Jak/Stat signal transduction pathway in GH-treated rat osteoblast-like cells in culture.

Gerland K, Bataillé-Simoneau N, Baslé M, Fourcin M, Gascan H, Mercier L.

Mol Cell Endocrinol. 2000 Oct 25;168(1-2):1-9.


CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex.

Elson GC, Lelièvre E, Guillet C, Chevalier S, Plun-Favreau H, Froger J, Suard I, de Coignac AB, Delneste Y, Bonnefoy JY, Gauchat JF, Gascan H.

Nat Neurosci. 2000 Sep;3(9):867-72.


Ciliary neurotrophic factor prevents unweighting-induced functional changes in rat soleus muscle.

Fraysse B, Guillet C, Huchet-Cadiou C, Camerino DC, Gascan H, Léoty C.

J Appl Physiol (1985). 2000 May;88(5):1623-30.


Identification of a gp130 cytokine receptor critical site involved in oncostatin M response.

Olivier C, Auguste P, Chabbert M, Lelièvre E, Chevalier S, Gascan H.

J Biol Chem. 2000 Feb 25;275(8):5648-56.


Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.

Kallen KJ, Grötzinger J, Lelièvre E, Vollmer P, Aasland D, Renné C, Müllberg J, Myer zum Büschenfelde KH, Gascan H, Rose-John S.

J Biol Chem. 1999 Apr 23;274(17):11859-67.


Ciliary neurotrophic factor is a regulator of muscular strength in aging.

Guillet C, Auguste P, Mayo W, Kreher P, Gascan H.

J Neurosci. 1999 Feb 15;19(4):1257-62.


Changes in CNTF receptor alpha expression in rat skeletal muscle during the recovery period after hindlimb suspension.

Guillet C, Huchet-Cadiou C, Gascan H, Léoty C.

Acta Physiol Scand. 1998 Jul;163(3):273-8.


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