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Items: 40

1.

Targeting pancreatic islet PTP1B improves islet graft revascularization and transplant outcomes.

Figueiredo H, Figueroa ALC, Garcia A, Fernandez-Ruiz R, Broca C, Wojtusciszyn A, Malpique R, Gasa R, Gomis R.

Sci Transl Med. 2019 Jun 19;11(497). pii: eaar6294. doi: 10.1126/scitranslmed.aar6294.

PMID:
31217339
2.

Modulation of the endocrine transcriptional program by targeting histone modifiers of the H3K27me3 mark.

Fontcuberta-PiSunyer M, Cervantes S, Miquel E, Mora-Castilla S, Laurent LC, Raya A, Gomis R, Gasa R.

Biochim Biophys Acta Gene Regul Mech. 2018 May;1861(5):473-480. doi: 10.1016/j.bbagrm.2018.03.003. Epub 2018 Mar 9.

3.

Stress-Induced MicroRNA-708 Impairs β-Cell Function and Growth.

Rodríguez-Comas J, Moreno-Asso A, Moreno-Vedia J, Martín M, Castaño C, Marzà-Florensa A, Bofill-De Ros X, Mir-Coll J, Montané J, Fillat C, Gasa R, Novials A, Servitja JM.

Diabetes. 2017 Dec;66(12):3029-3040. doi: 10.2337/db16-1569. Epub 2017 Oct 2.

4.

Late-stage differentiation of embryonic pancreatic β-cells requires Jarid2.

Cervantes S, Fontcuberta-PiSunyer M, Servitja JM, Fernandez-Ruiz R, García A, Sanchez L, Lee YS, Gomis R, Gasa R.

Sci Rep. 2017 Sep 14;7(1):11643. doi: 10.1038/s41598-017-11691-2.

5.

Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.

Ramírez S, Gómez-Valadés AG, Schneeberger M, Varela L, Haddad-Tóvolli R, Altirriba J, Noguera E, Drougard A, Flores-Martínez Á, Imbernón M, Chivite I, Pozo M, Vidal-Itriago A, Garcia A, Cervantes S, Gasa R, Nogueiras R, Gama-Pérez P, Garcia-Roves PM, Cano DA, Knauf C, Servitja JM, Horvath TL, Gomis R, Zorzano A, Claret M.

Cell Metab. 2017 Jun 6;25(6):1390-1399.e6. doi: 10.1016/j.cmet.2017.05.010.

6.

Preservation of cell-survival mechanisms by the presenilin-1 K239N mutation may cause its milder clinical phenotype.

Sarroca S, Molina-Martínez P, Aresté C, Etzrodt M, García de Frutos P, Gasa R, Antonell A, Molinuevo JL, Sánchez-Valle R, Saura CA, Lladó A, Sanfeliu C.

Neurobiol Aging. 2016 Oct;46:169-79. doi: 10.1016/j.neurobiolaging.2016.07.002. Epub 2016 Jul 15.

PMID:
27498054
7.

Genetic models rule out a major role of beta cell glycogen in the control of glucose homeostasis.

Mir-Coll J, Duran J, Slebe F, García-Rocha M, Gomis R, Gasa R, Guinovart JJ.

Diabetologia. 2016 May;59(5):1012-20. doi: 10.1007/s00125-016-3871-1. Epub 2016 Jan 29.

PMID:
26825527
8.

Wnt9a deficiency discloses a repressive role of Tcf7l2 on endocrine differentiation in the embryonic pancreas.

Pujadas G, Cervantes S, Tutusaus A, Ejarque M, Sanchez L, García A, Esteban Y, Fargas L, Alsina B, Hartmann C, Gomis R, Gasa R.

Sci Rep. 2016 Jan 14;6:19223. doi: 10.1038/srep19223.

9.

Generation of a Conditional Allele of the Transcription Factor Atonal Homolog 8 (Atoh8).

Ejarque M, Mir-Coll J, Gomis R, German MS, Lynn FC, Gasa R.

PLoS One. 2016 Jan 11;11(1):e0146273. doi: 10.1371/journal.pone.0146273. eCollection 2016.

10.

Targeting type 2 diabetes: lessons from a knockout model of insulin receptor substrate 2.

Oliveira JM, Rebuffat SA, Gasa R, Gomis R.

Can J Physiol Pharmacol. 2014 Aug;92(8):613-20. doi: 10.1139/cjpp-2014-0114. Epub 2014 Jun 3. Review.

PMID:
24977713
11.

Integrative analysis reveals novel pathways mediating the interaction between adipose tissue and pancreatic islets in obesity in rats.

Malpique R, Figueiredo H, Esteban Y, Rebuffat SA, Hanzu FA, Vinaixa M, Yanes O, Correig X, Barceló-Batllori S, Gasa R, Kalko SG, Gomis R.

Diabetologia. 2014 Jun;57(6):1219-31. doi: 10.1007/s00125-014-3205-0. Epub 2014 Mar 15.

PMID:
24633677
12.

Tungstate promotes β-cell survival in Irs2-/- mice.

Oliveira JM, Rebuffat SA, Gasa R, Burks DJ, Garcia A, Kalko SG, Zafra D, Guinovart JJ, Gomis R.

Am J Physiol Endocrinol Metab. 2014 Jan 1;306(1):E36-47. doi: 10.1152/ajpendo.00409.2013. Epub 2013 Nov 19.

13.

Characterization of the transcriptional activity of the basic helix-loop-helix (bHLH) transcription factor Atoh8.

Ejarque M, Altirriba J, Gomis R, Gasa R.

Biochim Biophys Acta. 2013 Nov;1829(11):1175-83. doi: 10.1016/j.bbagrm.2013.08.003. Epub 2013 Aug 9.

PMID:
23938248
14.

The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development.

Rawnsley DR, Xiao J, Lee JS, Liu X, Mericko-Ishizuka P, Kumar V, He J, Basu A, Lu M, Lynn FC, Pack M, Gasa R, Kahn ML.

J Biol Chem. 2013 Aug 23;288(34):24429-40. doi: 10.1074/jbc.M113.463083. Epub 2013 Jul 8.

15.

Neurogenin3 cooperates with Foxa2 to autoactivate its own expression.

Ejarque M, Cervantes S, Pujadas G, Tutusaus A, Sanchez L, Gasa R.

J Biol Chem. 2013 Apr 26;288(17):11705-17. doi: 10.1074/jbc.M112.388173. Epub 2013 Mar 7.

16.

The role of Raf-1 kinase inhibitor protein in the regulation of pancreatic beta cell proliferation in mice.

Pardo FN, Altirriba J, Pradas-Juni M, García A, Ahlgren U, Barberà A, Slebe JC, Yáñez AJ, Gomis R, Gasa R.

Diabetologia. 2012 Dec;55(12):3331-40. doi: 10.1007/s00125-012-2696-9. Epub 2012 Aug 29.

PMID:
22926403
17.

Expression of TMEM16A and SLC4A4 in human pancreatic islets.

Hanzu FA, Gasa R, Bulur N, Lybaert P, Gomis R, Malaisse WJ, Beauwens R, Sener A.

Cell Physiol Biochem. 2012;29(1-2):61-4. doi: 10.1159/000337587. Epub 2012 Mar 1.

18.

Convergence of the insulin and serotonin programs in the pancreatic β-cell.

Ohta Y, Kosaka Y, Kishimoto N, Wang J, Smith SB, Honig G, Kim H, Gasa RM, Neubauer N, Liou A, Tecott LH, Deneris ES, German MS.

Diabetes. 2011 Dec;60(12):3208-16. doi: 10.2337/db10-1192. Epub 2011 Oct 19.

19.

Sequence and epigenetic determinants in the regulation of the Math6 gene by Neurogenin3.

Pujadas G, Felipe F, Ejarque M, Sanchez L, Cervantes S, Lynn FC, Gomis R, Gasa R.

Differentiation. 2011 Sep;82(2):66-76. doi: 10.1016/j.diff.2011.05.006. Epub 2011 Jun 14.

PMID:
21676531
20.

Sodium tungstate regulates food intake and body weight through activation of the hypothalamic leptin pathway.

Amigó-Correig M, Barceló-Batllori S, Piquer S, Soty M, Pujadas G, Gasa R, Bortolozzi A, Carmona MC, Gomis R.

Diabetes Obes Metab. 2011 Mar;13(3):235-42. doi: 10.1111/j.1463-1326.2010.01339.x.

PMID:
21205112
21.

The role of transmembrane protein 27 (TMEM27) in islet physiology and its potential use as a beta cell mass biomarker.

Altirriba J, Gasa R, Casas S, Ramírez-Bajo MJ, Ros S, Gutierrez-Dalmau A, Ruiz de Villa MC, Barbera A, Gomis R.

Diabetologia. 2010 Jul;53(7):1406-14. doi: 10.1007/s00125-010-1728-6. Epub 2010 Apr 13.

PMID:
20386877
22.

Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network.

Lynn FC, Sanchez L, Gomis R, German MS, Gasa R.

PLoS One. 2008 Jun 18;3(6):e2430. doi: 10.1371/journal.pone.0002430.

23.

Induction of pancreatic islet cell differentiation by the neurogenin-neuroD cascade.

Gasa R, Mrejen C, Lynn FC, Skewes-Cox P, Sanchez L, Yang KY, Lin CH, Gomis R, German MS.

Differentiation. 2008 Apr;76(4):381-91. Epub 2007 Oct 9.

PMID:
17924961
24.

Transcriptional control of pancreatic endocrine cell development.

Gasa R.

Drug News Perspect. 2005 Nov;18(9):567-76. Review.

PMID:
16421630
25.

Proendocrine genes coordinate the pancreatic islet differentiation program in vitro.

Gasa R, Mrejen C, Leachman N, Otten M, Barnes M, Wang J, Chakrabarti S, Mirmira R, German M.

Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13245-50. Epub 2004 Aug 30.

26.

Inflammatory mechanisms in diabetes: lessons from the beta-cell.

Hohmeier HE, Tran VV, Chen G, Gasa R, Newgard CB.

Int J Obes Relat Metab Disord. 2003 Dec;27 Suppl 3:S12-6. Review.

PMID:
14704737
27.

Neurogenin3 and hepatic nuclear factor 1 cooperate in activating pancreatic expression of Pax4.

Smith SB, Gasa R, Watada H, Wang J, Griffen SC, German MS.

J Biol Chem. 2003 Oct 3;278(40):38254-9. Epub 2003 Jul 1.

28.

Reversal of diet-induced glucose intolerance by hepatic expression of a variant glycogen-targeting subunit of protein phosphatase-1.

Gasa R, Clark C, Yang R, DePaoli-Roach AA, Newgard CB.

J Biol Chem. 2002 Jan 11;277(2):1524-30. Epub 2001 Nov 13.

29.

Glycogen-targeting subunits and glucokinase differentially affect pathways of glycogen metabolism and their regulation in hepatocytes.

Yang R, Cao L, Gasa R, Brady MJ, Sherry AD, Newgard CB.

J Biol Chem. 2002 Jan 11;277(2):1514-23. Epub 2001 Oct 12.

31.

Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity.

Chen G, Hohmeier HE, Gasa R, Tran VV, Newgard CB.

Diabetes. 2000 Apr;49(4):562-70.

PMID:
10871193
32.

Distinctive regulatory and metabolic properties of glycogen-targeting subunits of protein phosphatase-1 (PTG, GL, GM/RGl) expressed in hepatocytes.

Gasa R, Jensen PB, Berman HK, Brady MJ, DePaoli-Roach AA, Newgard CB.

J Biol Chem. 2000 Aug 25;275(34):26396-403.

33.

The role of glucose and its metabolism in the regulation of glucokinase expression in isolated human pancreatic islets.

Gasa R, Fabregat ME, Gomis R.

Biochem Biophys Res Commun. 2000 Feb 16;268(2):491-5.

PMID:
10679232
35.

Effect of high glucose concentration on proinsulin biosynthesis and conversion by human islets.

Usac EF, Nadal B, Gasa R, Fernandez-Alvarez J, Gomis R.

Biochem Biophys Res Commun. 1998 Jul 9;248(1):186-9.

PMID:
9675108
36.

Autoantibodies against mitochondrial glycerophosphate dehydrogenase in patients with IDDM.

Fabregat ME, Gasa R, Rodriguez C, Novials A, Gallart T, Malaisse WJ, Gomis R.

Diabetes Res Clin Pract. 1997 Nov;38(2):115-21.

PMID:
9483375
37.

Glucose regulation of islet amyloid polypeptide gene expression in rat pancreatic islets.

Gasa R, Gomis R, Casamitjana R, Rivera F, Novials A.

Am J Physiol. 1997 Apr;272(4 Pt 1):E543-9.

PMID:
9142872
38.

Signals related to glucose metabolism regulate islet amyloid polypeptide (IAPP) gene expression in human pancreatic islets.

Gasa R, Gomis R, Casamitjana R, Novials A.

Regul Pept. 1997 Jan 29;68(2):99-104.

PMID:
9110380
39.

IAPP and insulin regulation in human pancreatic islets.

Novials A, Gasa R, Fernandez-Alvarez J, Gomis R.

Adv Exp Med Biol. 1997;426:363-9. No abstract available.

PMID:
9544295
40.

Apparent starvation-induced repression of pancreatic islet glucokinase.

Gasa R, Sener A, Malaisse WJ, Gomis R.

Biochem Mol Med. 1995 Dec;56(2):99-103.

PMID:
8825071

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