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Items: 14

1.

Single and multiple ascending-dose study of glucagon-receptor antagonist RN909 in type 2 diabetes: a phase 1, randomized, double-blind, placebo-controlled trial.

Gumbiner B, Esteves B, Dell V, Joh T, Garzone PD, Forgie A, Udata C.

Endocrine. 2018 Nov;62(2):371-380. doi: 10.1007/s12020-018-1597-1. Epub 2018 Sep 10.

PMID:
30203123
2.

The effects of single- and multiple-dose administration of bococizumab (RN316/PF-04950615), a humanized IgG2Δa monoclonal antibody binding proprotein convertase subtilisin/kexin type 9, in hypercholesterolemic subjects treated with and without atorvastatin: Results from four phase I studies.

Gumbiner B, Joh T, Liang H, Wan H, Levisetti M, Vana AM, Shelton DL, Forgues P, Billotte S, Pons J, Baum CM, Garzone PD.

Cardiovasc Ther. 2018 Feb;36(1). doi: 10.1111/1755-5922.12309. Epub 2017 Nov 23.

PMID:
29078037
3.

Effects of 12 weeks of treatment with intravenously administered bococizumab, a humanized monoclonal antibody blocking proprotein convertase subtilisin/kexin type 9, in hypercholesterolemic subjects on high-dose statin.

Fazio S, Robertson DG, Joh T, Wan H, Riel T, Forgues P, Baum CM, Garzone PD, Gumbiner B.

Cardiovasc Ther. 2018 Feb;36(1). doi: 10.1111/1755-5922.12308. Epub 2017 Nov 25.

PMID:
29057618
4.

Effects of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibition with Bococizumab on Lipoprotein Particles in Hypercholesterolemic Subjects.

Wan H, Gumbiner B, Joh T, Riel T, Udata C, Forgues P, Garzone PD.

Clin Ther. 2017 Nov;39(11):2243-2259.e5. doi: 10.1016/j.clinthera.2017.09.009. Epub 2017 Oct 14.

PMID:
29037448
5.

A Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for Bococizumab, a Humanized Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9, and Its Application in Early Clinical Development.

Udata C, Garzone PD, Gumbiner B, Joh T, Liang H, Liao KH, Williams JH, Meng X.

J Clin Pharmacol. 2017 Jul;57(7):855-864. doi: 10.1002/jcph.867. Epub 2017 Feb 9.

PMID:
28181260
6.

A Phase I Randomized Study of a Specifically Engineered, pH-Sensitive PCSK9 Inhibitor RN317 (PF-05335810) in Hypercholesterolemic Subjects on Statin Therapy.

Levisetti M, Joh T, Wan H, Liang H, Forgues P, Gumbiner B, Garzone PD.

Clin Transl Sci. 2017 Jan;10(1):3-11. doi: 10.1111/cts.12430. Epub 2016 Nov 17.

7.

In search of physiologically based distribution volume estimates for macromolecules.

Garzone PD, Atkinson AJ Jr.

Clin Pharmacol Ther. 2012 Oct;92(4):419-21. doi: 10.1038/clpt.2012.156. Review.

PMID:
22992670
8.

Enhancement of the efficacy of an antagonist of an extracellular receptor by attachment to the surface of a biocompatible carrier.

Wartchow CA, Alters SE, Garzone PD, Li L, Choi S, DeChene NE, Doede T, Huang L, Pease JS, Shen Z, Knox SJ, Cleland JL.

Pharm Res. 2004 Oct;21(10):1880-5.

PMID:
15553236
9.

Phase I evaluation of intravenous recombinant human interleukin 12 in patients with advanced malignancies.

Atkins MB, Robertson MJ, Gordon M, Lotze MT, DeCoste M, DuBois JS, Ritz J, Sandler AB, Edington HD, Garzone PD, Mier JW, Canning CM, Battiato L, Tahara H, Sherman ML.

Clin Cancer Res. 1997 Mar;3(3):409-17.

10.

Recombinant human factor IX: replacement therapy, prophylaxis, and pharmacokinetics in canine hemophilia B.

Brinkhous KM, Sigman JL, Read MS, Stewart PF, McCarthy KP, Timony GA, Leppanen SD, Rup BJ, Keith JC Jr, Garzone PD, Schaub RG.

Blood. 1996 Oct 1;88(7):2603-10.

PMID:
8839853
11.

Comparison of the spectrum of cognitive effects of alprazolam and adinazolam after single doses in healthy subjects.

Fleishaker JC, Garzone PD, Chambers JH, Sirocco K, Weingartner H.

Psychopharmacology (Berl). 1995 Jul;120(2):169-76.

PMID:
7480549
12.

Pain perception and serum beta-endorphin in trauma patients.

Bernstein L, Garzone PD, Rudy T, Kramer B, Stiff D, Peitzman A.

Psychosomatics. 1995 May-Jun;36(3):276-84.

PMID:
7638315
13.

Alzheimer's disease and other dementias.

Garzone PD.

J Pract Nurs. 1992 Sep;42(3):52-61. No abstract available.

PMID:
1432748
14.

Pharmacokinetics of the newer benzodiazepines.

Garzone PD, Kroboth PD.

Clin Pharmacokinet. 1989 Jun;16(6):337-64. Review.

PMID:
2567646

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