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Items: 33

1.

Multivariate temporal modeling of crime with dynamic linear models.

Garton N, Niemi J.

PLoS One. 2019 Jul 3;14(7):e0218375. doi: 10.1371/journal.pone.0218375. eCollection 2019.

2.

Assessing the airborne survival of bacteria in populations of aerosol droplets with a novel technology.

Fernandez MO, Thomas RJ, Garton NJ, Hudson A, Haddrell A, Reid JP.

J R Soc Interface. 2019 Jan 31;16(150):20180779. doi: 10.1098/rsif.2018.0779.

PMID:
30958165
3.

Emergency physician utilization of transvaginal ultrasound after initiation of revised sterilization protocol.

O'Connor TP, Garton N, Jones C, Estephan M, Lu M, Adler D.

Am J Emerg Med. 2019 Apr;37(4):789-791. doi: 10.1016/j.ajem.2018.08.077. Epub 2018 Aug 30. No abstract available.

PMID:
30201239
4.

Formulation, stabilisation and encapsulation of bacteriophage for phage therapy.

Malik DJ, Sokolov IJ, Vinner GK, Mancuso F, Cinquerrui S, Vladisavljevic GT, Clokie MRJ, Garton NJ, Stapley AGF, Kirpichnikova A.

Adv Colloid Interface Sci. 2017 Nov;249:100-133. doi: 10.1016/j.cis.2017.05.014. Epub 2017 May 14. Review.

5.

Click chemistry enables preclinical evaluation of targeted epigenetic therapies.

Tyler DS, Vappiani J, Cañeque T, Lam EYN, Ward A, Gilan O, Chan YC, Hienzsch A, Rutkowska A, Werner T, Wagner AJ, Lugo D, Gregory R, Ramirez Molina C, Garton N, Wellaway CR, Jackson S, MacPherson L, Figueiredo M, Stolzenburg S, Bell CC, House C, Dawson SJ, Hawkins ED, Drewes G, Prinjha RK, Rodriguez R, Grandi P, Dawson MA.

Science. 2017 Jun 30;356(6345):1397-1401. doi: 10.1126/science.aal2066. Epub 2017 Jun 15.

6.

The role of hydrophobicity in tuberculosis evolution and pathogenicity.

Jankute M, Nataraj V, Lee OY, Wu HHT, Ridell M, Garton NJ, Barer MR, Minnikin DE, Bhatt A, Besra GS.

Sci Rep. 2017 May 2;7(1):1315. doi: 10.1038/s41598-017-01501-0.

7.

TST positivity in household contacts of tuberculosis patients: a case-contact study in Malawi.

Hector J, Anderson ST, Banda G, Kamdolozi M, Jefferys LF, Shani D, Garton NJ, Mwale A, Jobe A, Davies GR, Sloan DJ.

BMC Infect Dis. 2017 Apr 11;17(1):259. doi: 10.1186/s12879-017-2348-2.

8.

Association of slow recovery of Mycobacterium africanum-infected patients posttreatment with high content of Persister-Like bacilli in pretreatment sputum.

Tientcheu LD, Bell A, Secka O, Ayorinde A, Otu J, Garton NJ, Sutherland JS, Ota MO, Antonio M, Dockrell HM, Kampmann B, Barer MR.

Int J Mycobacteriol. 2016 Dec;5 Suppl 1:S99-S100. doi: 10.1016/j.ijmyco.2016.09.033. Epub 2016 Nov 11.

9.

Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors.

Garton NS, Barker MD, Davis RP, Douault C, Hooper-Greenhill E, Jones E, Lewis HD, Liddle J, Lugo D, McCleary S, Preston AGS, Ramirez-Molina C, Neu M, Shipley TJ, Somers DO, Watson RJ, Wilson DM.

Bioorg Med Chem Lett. 2016 Oct 1;26(19):4606-4612. doi: 10.1016/j.bmcl.2016.08.070. Epub 2016 Aug 23.

PMID:
27578246
10.

Functional interdependence of BRD4 and DOT1L in MLL leukemia.

Gilan O, Lam EY, Becher I, Lugo D, Cannizzaro E, Joberty G, Ward A, Wiese M, Fong CY, Ftouni S, Tyler D, Stanley K, MacPherson L, Weng CF, Chan YC, Ghisi M, Smil D, Carpenter C, Brown P, Garton N, Blewitt ME, Bannister AJ, Kouzarides T, Huntly BJ, Johnstone RW, Drewes G, Dawson SJ, Arrowsmith CH, Grandi P, Prinjha RK, Dawson MA.

Nat Struct Mol Biol. 2016 Jul;23(7):673-81. doi: 10.1038/nsmb.3249. Epub 2016 Jun 13.

PMID:
27294782
11.

Interrogating the Druggability of the 2-Oxoglutarate-Dependent Dioxygenase Target Class by Chemical Proteomics.

Joberty G, Boesche M, Brown JA, Eberhard D, Garton NS, Humphreys PG, Mathieson T, Muelbaier M, Ramsden NG, Reader V, Rueger A, Sheppard RJ, Westaway SM, Bantscheff M, Lee K, Wilson DM, Prinjha RK, Drewes G.

ACS Chem Biol. 2016 Jul 15;11(7):2002-10. doi: 10.1021/acschembio.6b00080. Epub 2016 May 19.

PMID:
27197014
12.

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.

Westaway SM, Preston AG, Barker MD, Brown F, Brown JA, Campbell M, Chung CW, Drewes G, Eagle R, Garton N, Gordon L, Haslam C, Hayhow TG, Humphreys PG, Joberty G, Katso R, Kruidenier L, Leveridge M, Pemberton M, Rioja I, Seal GA, Shipley T, Singh O, Suckling CJ, Taylor J, Thomas P, Wilson DM, Lee K, Prinjha RK.

J Med Chem. 2016 Feb 25;59(4):1370-87. doi: 10.1021/acs.jmedchem.5b01538. Epub 2016 Jan 15.

PMID:
26771203
13.

Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice.

Sullivan JM, Badimon A, Schaefer U, Ayata P, Gray J, Chung CW, von Schimmelmann M, Zhang F, Garton N, Smithers N, Lewis H, Tarakhovsky A, Prinjha RK, Schaefer A.

J Exp Med. 2015 Oct 19;212(11):1771-81. doi: 10.1084/jem.20151271. Epub 2015 Sep 21.

14.

Pharmacodynamic Modeling of Bacillary Elimination Rates and Detection of Bacterial Lipid Bodies in Sputum to Predict and Understand Outcomes in Treatment of Pulmonary Tuberculosis.

Sloan DJ, Mwandumba HC, Garton NJ, Khoo SH, Butterworth AE, Allain TJ, Heyderman RS, Corbett EL, Barer MR, Davies GR.

Clin Infect Dis. 2015 Jul 1;61(1):1-8. doi: 10.1093/cid/civ195. Epub 2015 Mar 16.

15.

Face mask sampling for the detection of Mycobacterium tuberculosis in expelled aerosols.

Williams CM, Cheah ES, Malkin J, Patel H, Otu J, Mlaga K, Sutherland JS, Antonio M, Perera N, Woltmann G, Haldar P, Garton NJ, Barer MR.

PLoS One. 2014 Aug 14;9(8):e104921. doi: 10.1371/journal.pone.0104921. eCollection 2014.

16.

Tuberculosis: feeding the enemy.

Garton NJ, O'Hare HM.

Chem Biol. 2013 Aug 22;20(8):971-2. doi: 10.1016/j.chembiol.2013.08.001.

17.

Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.

Liddle J, Atkinson FL, Barker MD, Carter PS, Curtis NR, Davis RP, Douault C, Dickson MC, Elwes D, Garton NS, Gray M, Hayhow TG, Hobbs CI, Jones E, Leach S, Leavens K, Lewis HD, McCleary S, Neu M, Patel VK, Preston AG, Ramirez-Molina C, Shipley TJ, Skone PA, Smithers N, Somers DO, Walker AL, Watson RJ, Weingarten GG.

Bioorg Med Chem Lett. 2011 Oct 15;21(20):6188-94. doi: 10.1016/j.bmcl.2011.07.082. Epub 2011 Aug 12.

PMID:
21903390
18.

Discovery of biaryl inhibitors of H+/K+ ATPase.

Garton N, Bailey N, Bamford M, Demont E, Farre-Gutierrez I, Hutley G, Bravi G, Pickering P.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):1049-54. doi: 10.1016/j.bmcl.2009.12.040. Epub 2009 Dec 21.

PMID:
20053560
19.

Evaluation of basic, heterocyclic ring systems as templates for use as potassium competitive acid blockers (pCABs).

Panchal T, Bailey N, Bamford M, Demont E, Elliott R, Farre-Gutierrez I, Garton N, Hayhow T, Hutley G, Naylor A.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6813-7. doi: 10.1016/j.bmcl.2009.07.002. Epub 2009 Jul 4.

PMID:
19846298
20.

Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs).

Bailey N, Bamford MJ, Brissy D, Brookfield J, Demont E, Elliott R, Garton N, Farre-Gutierrez I, Hayhow T, Hutley G, Naylor A, Panchal TA, Seow HX, Spalding D, Takle AK.

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3602-6. doi: 10.1016/j.bmcl.2009.04.127. Epub 2009 May 3.

PMID:
19467868
21.

Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum.

Garton NJ, Waddell SJ, Sherratt AL, Lee SM, Smith RJ, Senner C, Hinds J, Rajakumar K, Adegbola RA, Besra GS, Butcher PD, Barer MR.

PLoS Med. 2008 Apr 1;5(4):e75. doi: 10.1371/journal.pmed.0050075.

22.
23.

A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversion.

Newton SM, Smith RJ, Wilkinson KA, Nicol MP, Garton NJ, Staples KJ, Stewart GR, Wain JR, Martineau AR, Fandrich S, Smallie T, Foxwell B, Al-Obaidi A, Shafi J, Rajakumar K, Kampmann B, Andrew PW, Ziegler-Heitbrock L, Barer MR, Wilkinson RJ.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15594-8. Epub 2006 Oct 6. Erratum in: Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):685.

24.

Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists.

Witherington J, Blaney EL, Bordas V, Elliott RL, Gaiba A, Garton N, Green PM, Naylor A, Smith DG, Spalding DJ, Takle AK, Ward RW.

Bioorg Med Chem Lett. 2006 Nov 1;16(21):5538-41. Epub 2006 Aug 22.

PMID:
16931004
25.

A novel strategy for the identification of genomic islands by comparative analysis of the contents and contexts of tRNA sites in closely related bacteria.

Ou HY, Chen LL, Lonnen J, Chaudhuri RR, Thani AB, Smith R, Garton NJ, Hinton J, Pallen M, Barer MR, Rajakumar K.

Nucleic Acids Res. 2006 Jan 9;34(1):e3.

26.

Identification of a lipoarabinomannan-like lipoglycan in the actinomycete Gordonia bronchialis.

Garton NJ, Sutcliffe IC.

Arch Microbiol. 2006 Feb;184(6):425-7. Epub 2005 Dec 1.

PMID:
16320036
27.

Characterization of a truncated lipoarabinomannan from the Actinomycete Turicella otitidis.

Gilleron M, Garton NJ, Nigou J, Brando T, Puzo G, Sutcliffe IC.

J Bacteriol. 2005 Feb;187(3):854-61.

28.

6-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

Witherington J, Bordas V, Gaiba A, Garton NS, Naylor A, Rawlings AD, Slingsby BP, Smith DG, Takle AK, Ward RW.

Bioorg Med Chem Lett. 2003 Sep 15;13(18):3055-7.

PMID:
12941332
29.

The cell wall of the pathogenic bacterium Rhodococcus equi contains two channel-forming proteins with different properties.

Riess FG, Elflein M, Benk M, Schiffler B, Benz R, Garton N, Sutcliffe I.

J Bacteriol. 2003 May;185(9):2952-60.

30.

Intracellular lipophilic inclusions of mycobacteria in vitro and in sputum.

Garton NJ, Christensen H, Minnikin DE, Adegbola RA, Barer MR.

Microbiology. 2002 Oct;148(Pt 10):2951-8.

PMID:
12368428
31.

A novel lipoarabinomannan from the equine pathogen Rhodococcus equi. Structure and effect on macrophage cytokine production.

Garton NJ, Gilleron M, Brando T, Dan HH, Giguère S, Puzo G, Prescott JF, Sutcliffe IC.

J Biol Chem. 2002 Aug 30;277(35):31722-33. Epub 2002 Jun 18.

32.

Fluorescence and Brightfield Cytology of Live M. tuberculosis Cells.

Cooney RP, Garton NJ, Barer MR.

Methods Mol Med. 2001;54:125-43. doi: 10.1385/1-59259-147-7:125.

PMID:
21341073
33.

Lipid domains of mycobacteria studied with fluorescent molecular probes.

Christensen H, Garton NJ, Horobin RW, Minnikin DE, Barer MR.

Mol Microbiol. 1999 Mar;31(5):1561-72.

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