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Items: 37

1.

Donor T-cell-derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract.

Gartlan KH, Koyama M, Lineburg KE, Chang K, Ensbey KS, Kuns RD, Henden AS, Samson LD, Clouston AD, Lopez AF, MacDonald KPA, Hill GR.

Blood Adv. 2019 Oct 8;3(19):2859-2865. doi: 10.1182/bloodadvances.2019000053.

2.

IL-6 dysregulation originates in dendritic cells and initiates graft-versus-host disease via classical signaling.

Wilkinson AN, Chang K, Kuns RD, Henden AS, Minnie SA, Ensbey KS, Clouston AD, Zhang P, Koyama M, Hidalgo J, Rose-John S, Varelias A, Vuckovic S, Gartlan KH, Hill GR.

Blood. 2019 Oct 2. pii: blood.2019000396. doi: 10.1182/blood.2019000396. [Epub ahead of print]

PMID:
31578204
3.

Inhibition of the Cytolytic Protein Perforin Prevents Rejection of Transplanted Bone Marrow Stem Cells in Vivo.

Spicer JA, Miller CK, O'Connor PD, Jose J, Giddens AC, Jaiswal JK, Jamieson SMF, Bull MR, Denny WA, Akhlaghi H, Trapani JA, Hill GR, Chang K, Gartlan KH.

J Med Chem. 2019 Sep 26. doi: 10.1021/acs.jmedchem.9b00881. [Epub ahead of print]

PMID:
31525966
4.

Imaging Flow Cytometry to Assess Antigen-Presenting-Cell Function.

Markey KA, Gartlan KH.

Curr Protoc Immunol. 2019 Jun;125(1):e72. doi: 10.1002/cpim.72. Epub 2019 Mar 6.

PMID:
30840360
5.

Expansion of IL-17A-secreting CD8+ mucosa-associated invariant T cells in peripheral blood following stem cell mobilization.

Varelias A, Gartlan KH, Wilkinson AN, Olver SD, Samson LD, Tey SK, MacDonald KPA, Hill GR.

Blood Adv. 2019 Mar 12;3(5):718-723. doi: 10.1182/bloodadvances.2018025601. No abstract available.

6.

Phase I Trial of Inducible Caspase 9 T Cells in Adult Stem Cell Transplant Demonstrates Massive Clonotypic Proliferative Potential and Long-term Persistence of Transgenic T Cells.

Zhang P, Raju J, Ullah MA, Au R, Varelias A, Gartlan KH, Olver SD, Samson LD, Sturgeon E, Zomerdijk N, Avery J, Gargett T, Brown MP, Coin LJ, Ganesamoorthy D, Hutchins C, Pratt GR, Kennedy GA, Morton AJ, Curley CI, Hill GR, Tey SK.

Clin Cancer Res. 2019 Mar 15;25(6):1749-1755. doi: 10.1158/1078-0432.CCR-18-3069. Epub 2019 Feb 14.

PMID:
30765390
7.

Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis.

Welz M, Eickhoff S, Abdullah Z, Trebicka J, Gartlan KH, Spicer JA, Demetris AJ, Akhlaghi H, Anton M, Manske K, Zehn D, Nieswandt B, Kurts C, Trapani JA, Knolle P, Wohlleber D, Kastenmüller W.

Nat Commun. 2018 Nov 15;9(1):4805. doi: 10.1038/s41467-018-07213-x.

8.

Bone marrow transplantation generates T cell-dependent control of myeloma in mice.

Vuckovic S, Minnie SA, Smith D, Gartlan KH, Watkins TS, Markey KA, Mukhopadhyay P, Guillerey C, Kuns RD, Locke KR, Pritchard AL, Johansson PA, Varelias A, Zhang P, Huntington ND, Waddell N, Chesi M, Miles JJ, Smyth MJ, Hill GR.

J Clin Invest. 2019 Jan 2;129(1):106-121. doi: 10.1172/JCI98888. Epub 2018 Nov 19.

9.

Myeloma escape after stem cell transplantation is a consequence of T-cell exhaustion and is prevented by TIGIT blockade.

Minnie SA, Kuns RD, Gartlan KH, Zhang P, Wilkinson AN, Samson L, Guillerey C, Engwerda C, MacDonald KPA, Smyth MJ, Markey KA, Vuckovic S, Hill GR.

Blood. 2018 Oct 18;132(16):1675-1688. doi: 10.1182/blood-2018-01-825240. Epub 2018 Aug 28.

PMID:
30154111
10.

Recipient mucosal-associated invariant T cells control GVHD within the colon.

Varelias A, Bunting MD, Ormerod KL, Koyama M, Olver SD, Straube J, Kuns RD, Robb RJ, Henden AS, Cooper L, Lachner N, Gartlan KH, Lantz O, Kjer-Nielsen L, Mak JY, Fairlie DP, Clouston AD, McCluskey J, Rossjohn J, Lane SW, Hugenholtz P, Hill GR.

J Clin Invest. 2018 May 1;128(5):1919-1936. doi: 10.1172/JCI91646. Epub 2018 Apr 9.

11.

Granulocytes Are Unresponsive to IL-6 Due to an Absence of gp130.

Wilkinson AN, Gartlan KH, Kelly G, Samson LD, Olver SD, Avery J, Zomerdijk N, Tey SK, Lee JS, Vuckovic S, Hill GR.

J Immunol. 2018 May 15;200(10):3547-3555. doi: 10.4049/jimmunol.1701191. Epub 2018 Apr 6.

12.

Conventional dendritic cells are required for the cross-presentation of leukemia-specific antigen in a model of AML relapse post-BMT.

Markey KA, Gartlan KH, Kuns RD, Lane SW, Hill GR.

Bone Marrow Transplant. 2018 Jun;53(6):800-803. doi: 10.1038/s41409-018-0148-y. Epub 2018 Mar 13. No abstract available.

PMID:
29535380
13.

Flt-3L Expansion of Recipient CD8α+ Dendritic Cells Deletes Alloreactive Donor T Cells and Represents an Alternative to Posttransplant Cyclophosphamide for the Prevention of GVHD.

Markey KA, Kuns RD, Browne DJ, Gartlan KH, Robb RJ, Martins JP, Henden AS, Minnie SA, Cheong M, Koyama M, Smyth MJ, Steptoe RJ, Belz GT, Brocker T, Degli-Esposti MA, Lane SW, Hill GR.

Clin Cancer Res. 2018 Apr 1;24(7):1604-1616. doi: 10.1158/1078-0432.CCR-17-2148. Epub 2018 Jan 24.

14.

Development of a Multiplexed Microsphere PCR for Culture-Free Detection and Gram-Typing of Bacteria in Human Blood Samples.

Liang F, Browne DJ, Gray MJ, Gartlan KH, Smith DD, Barnard RT, Hill GR, Corrie SR, Markey KA.

ACS Infect Dis. 2018 May 11;4(5):837-844. doi: 10.1021/acsinfecdis.7b00277. Epub 2018 Jan 31.

PMID:
29350524
15.

Th17 plasticity and transition toward a pathogenic cytokine signature are regulated by cyclosporine after allogeneic SCT.

Gartlan KH, Varelias A, Koyama M, Robb RJ, Markey KA, Chang K, Wilkinson AN, Smith D, Ullah MA, Kuns RD, Raffelt NC, Olver SD, Lineburg KE, Teal BE, Cheong M, Teng MWL, Smyth MJ, Tey SK, MacDonald KPA, Hill GR.

Blood Adv. 2017 Jan 26;1(6):341-351. doi: 10.1182/bloodadvances.2016002980. eCollection 2017 Feb 14.

16.

A critical role for donor-derived IL-22 in cutaneous chronic GVHD.

Gartlan KH, Bommiasamy H, Paz K, Wilkinson AN, Owen M, Reichenbach DK, Banovic T, Wehner K, Buchanan F, Varelias A, Kuns RD, Chang K, Fedoriw Y, Shea T, Coghill J, Zaiken M, Plank MW, Foster PS, Clouston AD, Blazar BR, Serody JS, Hill GR.

Am J Transplant. 2018 Apr;18(4):810-820. doi: 10.1111/ajt.14513. Epub 2017 Oct 24.

17.

Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivo.

Khoury DS, Cromer D, Elliott T, Soon MSF, Thomas BS, James KR, Best SE, Aogo RA, Engel JA, Gartlan KH, Akter J, Sebina I, Haque A, Davenport MP.

Int J Parasitol. 2017 Dec;47(14):913-922. doi: 10.1016/j.ijpara.2017.05.009. Epub 2017 Aug 31.

PMID:
28864033
18.

Eomesodermin promotes the development of type 1 regulatory T (TR1) cells.

Zhang P, Lee JS, Gartlan KH, Schuster IS, Comerford I, Varelias A, Ullah MA, Vuckovic S, Koyama M, Kuns RD, Locke KR, Beckett KJ, Olver SD, Samson LD, Montes de Oca M, de Labastida Rivera F, Clouston AD, Belz GT, Blazar BR, MacDonald KP, McColl SR, Thomas R, Engwerda CR, Degli-Esposti MA, Kallies A, Tey SK, Hill GR.

Sci Immunol. 2017 Apr 7;2(10). pii: eaah7152. doi: 10.1126/sciimmunol.aah7152.

19.

Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome.

Varelias A, Ormerod KL, Bunting MD, Koyama M, Gartlan KH, Kuns RD, Lachner N, Locke KR, Lim CY, Henden AS, Zhang P, Clouston AD, Hasnain SZ, McGuckin MA, Blazar BR, MacDonald KP, Hugenholtz P, Hill GR.

Blood. 2017 Apr 13;129(15):2172-2185. doi: 10.1182/blood-2016-08-732628. Epub 2017 Jan 30.

20.

Sterile inflammation induced by Carbopol elicits robust adaptive immune responses in the absence of pathogen-associated molecular patterns.

Gartlan KH, Krashias G, Wegmann F, Hillson WR, Scherer EM, Greenberg PD, Eisenbarth SC, Moghaddam AE, Sattentau QJ.

Vaccine. 2016 Apr 27;34(19):2188-96. doi: 10.1016/j.vaccine.2016.03.025. Epub 2016 Mar 19.

21.

Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects.

Gartlan KH, Markey KA, Varelias A, Bunting MD, Koyama M, Kuns RD, Raffelt NC, Olver SD, Lineburg KE, Cheong M, Teal BE, Lor M, Comerford I, Teng MW, Smyth MJ, McCluskey J, Rossjohn J, Stockinger B, Boyle GM, Lane SW, Clouston AD, McColl SR, MacDonald KP, Hill GR.

Blood. 2015 Sep 24;126(13):1609-20. doi: 10.1182/blood-2015-01-622662. Epub 2015 Jul 23.

PMID:
26206951
22.

Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease.

Koyama M, Cheong M, Markey KA, Gartlan KH, Kuns RD, Locke KR, Lineburg KE, Teal BE, Leveque-El Mouttie L, Bunting MD, Vuckovic S, Zhang P, Teng MW, Varelias A, Tey SK, Wockner LF, Engwerda CR, Smyth MJ, Belz GT, McColl SR, MacDonald KP, Hill GR.

J Exp Med. 2015 Jul 27;212(8):1303-21. doi: 10.1084/jem.20150329. Epub 2015 Jul 13.

23.

The Carbomer-Lecithin Adjuvant Adjuplex Has Potent Immunoactivating Properties and Elicits Protective Adaptive Immunity against Influenza Virus Challenge in Mice.

Wegmann F, Moghaddam AE, Schiffner T, Gartlan KH, Powell TJ, Russell RA, Baart M, Carrow EW, Sattentau QJ.

Clin Vaccine Immunol. 2015 Sep;22(9):1004-12. doi: 10.1128/CVI.00736-14. Epub 2015 Jul 1.

24.

Imaging the immunological synapse between dendritic cells and T cells.

Markey KA, Gartlan KH, Kuns RD, MacDonald KP, Hill GR.

J Immunol Methods. 2015 Aug;423:40-4. doi: 10.1016/j.jim.2015.04.029. Epub 2015 May 9.

PMID:
25967948
25.

Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation.

Varelias A, Gartlan KH, Kreijveld E, Olver SD, Lor M, Kuns RD, Lineburg KE, Teal BE, Raffelt NC, Cheong M, Alexander KA, Koyama M, Markey KA, Sturgeon E, Leach J, Reddy P, Kennedy GA, Yanik GA, Blazar BR, Tey SK, Clouston AD, MacDonald KP, Cooke KR, Hill GR.

Blood. 2015 Apr 9;125(15):2435-44. doi: 10.1182/blood-2014-07-590232. Epub 2015 Feb 11.

26.

Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial.

Kennedy GA, Varelias A, Vuckovic S, Le Texier L, Gartlan KH, Zhang P, Thomas G, Anderson L, Boyle G, Cloonan N, Leach J, Sturgeon E, Avery J, Olver SD, Lor M, Misra AK, Hutchins C, Morton AJ, Durrant ST, Subramoniapillai E, Butler JP, Curley CI, MacDonald KPA, Tey SK, Hill GR.

Lancet Oncol. 2014 Dec;15(13):1451-1459. doi: 10.1016/S1470-2045(14)71017-4. Epub 2014 Nov 14.

PMID:
25456364
27.

Dry roasting enhances peanut-induced allergic sensitization across mucosal and cutaneous routes in mice.

Moghaddam AE, Hillson WR, Noti M, Gartlan KH, Johnson S, Thomas B, Artis D, Sattentau QJ.

J Allergy Clin Immunol. 2014 Dec;134(6):1453-1456. doi: 10.1016/j.jaci.2014.07.032. Epub 2014 Sep 22. No abstract available.

28.

Polyethyleneimine is a potent systemic adjuvant for glycoprotein antigens.

Sheppard NC, Brinckmann SA, Gartlan KH, Puthia M, Svanborg C, Krashias G, Eisenbarth SC, Flavell RA, Sattentau QJ, Wegmann F.

Int Immunol. 2014 Oct;26(10):531-8. doi: 10.1093/intimm/dxu055. Epub 2014 May 20.

PMID:
24844701
29.

Cross-dressing by donor dendritic cells after allogeneic bone marrow transplantation contributes to formation of the immunological synapse and maximizes responses to indirectly presented antigen.

Markey KA, Koyama M, Gartlan KH, Leveque L, Kuns RD, Lineburg KE, Teal BE, MacDonald KP, Hill GR.

J Immunol. 2014 Jun 1;192(11):5426-33. doi: 10.4049/jimmunol.1302490. Epub 2014 Apr 30.

30.

Tetraspanin CD37 contributes to the initiation of cellular immunity by promoting dendritic cell migration.

Gartlan KH, Wee JL, Demaria MC, Nastovska R, Chang TM, Jones EL, Apostolopoulos V, Pietersz GA, Hickey MJ, van Spriel AB, Wright MD.

Eur J Immunol. 2013 May;43(5):1208-19. doi: 10.1002/eji.201242730. Epub 2013 Mar 25.

31.

The tetraspanin CD37 orchestrates the α(4)β(1) integrin-Akt signaling axis and supports long-lived plasma cell survival.

van Spriel AB, de Keijzer S, van der Schaaf A, Gartlan KH, Sofi M, Light A, Linssen PC, Boezeman JB, Zuidscherwoude M, Reinieren-Beeren I, Cambi A, Mackay F, Tarlinton DM, Figdor CG, Wright MD.

Sci Signal. 2012 Nov 13;5(250):ra82. doi: 10.1126/scisignal.2003113.

PMID:
23150881
32.

Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens.

Wegmann F, Gartlan KH, Harandi AM, Brinckmann SA, Coccia M, Hillson WR, Kok WL, Cole S, Ho LP, Lambe T, Puthia M, Svanborg C, Scherer EM, Krashias G, Williams A, Blattman JN, Greenberg PD, Flavell RA, Moghaddam AE, Sheppard NC, Sattentau QJ.

Nat Biotechnol. 2012 Sep;30(9):883-8.

33.

Reactive carbonyls are a major Th2-inducing damage-associated molecular pattern generated by oxidative stress.

Moghaddam AE, Gartlan KH, Kong L, Sattentau QJ.

J Immunol. 2011 Aug 15;187(4):1626-33. doi: 10.4049/jimmunol.1003906. Epub 2011 Jul 8.

34.

A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity.

Gartlan KH, Belz GT, Tarrant JM, Minigo G, Katsara M, Sheng KC, Sofi M, van Spriel AB, Apostolopoulos V, Plebanski M, Robb L, Wright MD.

J Immunol. 2010 Sep 15;185(6):3158-66. doi: 10.4049/jimmunol.0902867. Epub 2010 Aug 13.

35.

The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity.

van Spriel AB, Sofi M, Gartlan KH, van der Schaaf A, Verschueren I, Torensma R, Raymakers RA, Loveland BE, Netea MG, Adema GJ, Wright MD, Figdor CG.

PLoS Pathog. 2009 Mar;5(3):e1000338. doi: 10.1371/journal.ppat.1000338. Epub 2009 Mar 13.

36.

Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC.

Sheng KC, van Spriel AB, Gartlan KH, Sofi M, Apostolopoulos V, Ashman L, Wright MD.

Eur J Immunol. 2009 Jan;39(1):50-5. doi: 10.1002/eji.200838798.

37.

Signal regulatory protein molecules are differentially expressed by CD8- dendritic cells.

Lahoud MH, Proietto AI, Gartlan KH, Kitsoulis S, Curtis J, Wettenhall J, Sofi M, Daunt C, O'keeffe M, Caminschi I, Satterley K, Rizzitelli A, Schnorrer P, Hinohara A, Yamaguchi Y, Wu L, Smyth G, Handman E, Shortman K, Wright MD.

J Immunol. 2006 Jul 1;177(1):372-82.

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