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Items: 1 to 50 of 142

1.

Allergen Delivery Inhibitors: Characterisation of Potent and Selective Inhibitors of Der p 1 and Their Attenuation of Airway Responses to House Dust Mite Allergens.

Zhang J, Chen J, Zuo J, Newton GK, Stewart MR, Perrior TR, Garrod DR, Robinson C.

Int J Mol Sci. 2018 Oct 15;19(10). pii: E3166. doi: 10.3390/ijms19103166.

2.

Pathways of airway oxidant formation by house dust mite allergens and viral RNA converge through myosin motors, pannexons and Toll-like receptor 4.

Zhang J, Chen J, Mangat SC, Perera Baruhupolage C, Garrod DR, Robinson C.

Immun Inflamm Dis. 2018 Jun;6(2):276-296. doi: 10.1002/iid3.216. Epub 2018 Mar 15.

3.

Desmocollin 1 is abundantly expressed in atherosclerosis and impairs high-density lipoprotein biogenesis.

Choi HY, Ruel I, Malina A, Garrod DR, Oda MN, Pelletier J, Schwertani A, Genest J.

Eur Heart J. 2018 Apr 7;39(14):1194-1202. doi: 10.1093/eurheartj/ehx340.

PMID:
29106519
4.

Allergen-dependent oxidant formation requires purinoceptor activation of ADAM 10 and prothrombin.

Chen J, Zhang J, Tachie-Menson T, Shukla N, Garrod DR, Robinson C.

J Allergy Clin Immunol. 2017 Jun;139(6):2023-2026.e9. doi: 10.1016/j.jaci.2016.12.954. Epub 2017 Jan 19. No abstract available.

5.

Innate generation of thrombin and intracellular oxidants in airway epithelium by allergen Der p 1.

Zhang J, Chen J, Allen-Philbey K, Perera Baruhupolage C, Tachie-Menson T, Mangat SC, Garrod DR, Robinson C.

J Allergy Clin Immunol. 2016 Oct;138(4):1224-1227. doi: 10.1016/j.jaci.2016.05.006. Epub 2016 May 24. No abstract available.

6.

Controlled laser texturing of titanium results in reliable osteointegration.

Coathup MJ, Blunn GW, Mirhosseini N, Erskine K, Liu Z, Garrod DR, Li L.

J Orthop Res. 2017 Apr;35(4):820-828. doi: 10.1002/jor.23340. Epub 2016 Jun 28.

7.

The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma.

Newton GK, Perrior TR, Jenkins K, Major MR, Key RE, Stewart MR, Firth-Clark S, Lloyd SM, Zhang J, Francis-Newton NJ, Richardson JP, Chen J, Lai P, Garrod DR, Robinson C.

J Med Chem. 2014 Nov 26;57(22):9447-62. doi: 10.1021/jm501102h. Epub 2014 Nov 17.

8.

The assay that defines desmosome hyper-adhesion.

Garrod DR.

J Invest Dermatol. 2013 Feb;133(2):576-7. doi: 10.1038/jid.2012.275. Epub 2012 Aug 30. No abstract available.

9.

Desmosomal adhesiveness is developmentally regulated in the mouse embryo and modulated during trophectoderm migration.

Kimura TE, Merritt AJ, Lock FR, Eckert JJ, Fleming TP, Garrod DR.

Dev Biol. 2012 Sep 15;369(2):286-97. doi: 10.1016/j.ydbio.2012.06.025. Epub 2012 Jul 20.

10.

Direct evidence that PKCĪ± positively regulates wound re-epithelialization: correlation with changes in desmosomal adhesiveness.

Thomason HA, Cooper NH, Ansell DM, Chiu M, Merrit AJ, Hardman MJ, Garrod DR.

J Pathol. 2012 Jul;227(3):346-56. doi: 10.1002/path.4016. Epub 2012 May 8.

PMID:
22407785
11.

Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris.

Tsang SM, Brown L, Lin K, Liu L, Piper K, O'Toole EA, Grose R, Hart IR, Garrod DR, Fortune F, Wan H.

J Pathol. 2012 May;227(1):81-93. doi: 10.1002/path.3982. Epub 2012 Feb 17.

PMID:
22294297
12.

Future inhaled drugs by virtual innovation: allergen delivery inhibitors.

Robinson C, Zhang J, Garrod DR, Newton GK, Jenkins K, Perrior TR.

Future Med Chem. 2011 Oct;3(13):1567-70. doi: 10.4155/fmc.11.107. No abstract available.

13.

Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src.

Tsang SM, Liu L, Teh MT, Wheeler A, Grose R, Hart IR, Garrod DR, Fortune F, Wan H.

PLoS One. 2010 Dec 3;5(12):e14211. doi: 10.1371/journal.pone.0014211.

14.

Desmosomes: adhesive strength and signalling in health and disease.

Thomason HA, Scothern A, McHarg S, Garrod DR.

Biochem J. 2010 Aug 1;429(3):419-33. doi: 10.1042/BJ20100567. Review.

PMID:
20626351
15.

Pervanadate stabilizes desmosomes.

Garrod DR, Fisher C, Smith A, Nie Z.

Cell Adh Migr. 2008 Jul-Sep;2(3):161-6. Epub 2008 Jul 3.

16.

Comparative enzymology of native and recombinant house dust mite allergen Der p 1.

Zhang J, Saint-Remy JM, Garrod DR, Robinson C.

Allergy. 2009 Mar;64(3):469-77. doi: 10.1111/j.1398-9995.2008.01852.x. Epub 2009 Jan 27.

PMID:
19175594
17.

Pollen proteolytic enzymes degrade tight junctions.

Runswick S, Mitchell T, Davies P, Robinson C, Garrod DR.

Respirology. 2007 Nov;12(6):834-42.

PMID:
17986111
18.

Interactions between mature Der p 1 and its free prodomain indicate membership of a new family of C1 peptidases.

Zhang J, Hamilton JM, Garrod DR, Robinson C.

Allergy. 2007 Nov;62(11):1302-9.

PMID:
17919146
19.

Desmoplakin Is Essential for Epidermal Sheet Formation.

Hopkins G, Kimura TE, Garrod DR.

J Invest Dermatol. 2007 Jan;127 Suppl 3:E12. doi: 10.1038/sj.skinbio.6250005. No abstract available.

PMID:
26879536
20.

Milestones in Investigative Dermatology: The Desmosome.

Kowalczyk AP, Rubenstein DS, Garrod DR, Green KJ, Stanley JR.

J Invest Dermatol. 2007 Jan;127 Suppl 3:E1. doi: 10.1038/sj.skinbio.6250007. No abstract available.

PMID:
26879533
21.

Desmoplakin is essential for epidermal sheet formation.

Hopkins G, Kimura TE, Garrod DR.

J Invest Dermatol. 2007 Jan 30;127(E1):E12. doi: 10.1038/sj.skinbio.6250005. No abstract available.

22.

Calcium-independent desmosomes of keratinocytes are hyper-adhesive.

Kimura TE, Merritt AJ, Garrod DR.

J Invest Dermatol. 2007 Apr;127(4):775-81. Epub 2006 Dec 28.

23.

A 4 kb fragment of the desmocollin 3 promoter directs reporter gene expression to parakeratotic epidermis and primary hair follicles.

Merritt AJ, Zhu K, Garrod DR, Chidgey MA.

J Invest Dermatol. 2007 Jan;127(1):245-7. Epub 2006 Jul 13. No abstract available.

24.

Hyper-adhesion in desmosomes: its regulation in wound healing and possible relationship to cadherin crystal structure.

Garrod DR, Berika MY, Bardsley WF, Holmes D, Tabernero L.

J Cell Sci. 2005 Dec 15;118(Pt 24):5743-54. Epub 2005 Nov 22.

25.

Interferon-gamma selectively increases epithelial permeability to large molecules by activating different populations of paracellular pores.

Watson CJ, Hoare CJ, Garrod DR, Carlson GL, Warhurst G.

J Cell Sci. 2005 Nov 15;118(Pt 22):5221-30. Epub 2005 Oct 25.

26.

Desmosomal cadherin misexpression alters beta-catenin stability and epidermal differentiation.

Hardman MJ, Liu K, Avilion AA, Merritt A, Brennan K, Garrod DR, Byrne C.

Mol Cell Biol. 2005 Feb;25(3):969-78.

27.

Protein kinase C alpha expression in normal breast, ductal carcinoma in situ and invasive ductal carcinoma.

Ainsworth PD, Winstanley JH, Pearson JM, Bishop HM, Garrod DR.

Eur J Cancer. 2004 Oct;40(15):2269-73.

PMID:
15454252
28.

Intercellular junctions in normal epidermis.

Garrod DR.

Exp Dermatol. 2004 Oct;13(10):652-3. No abstract available.

PMID:
15447727
30.

Mast cells disrupt epithelial barrier function during enteric nematode infection.

McDermott JR, Bartram RE, Knight PA, Miller HR, Garrod DR, Grencis RK.

Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7761-6. Epub 2003 Jun 9.

31.

Altered expression of desmosomal components in high-grade squamous intraepithelial lesions of the cervix.

Alazawi WO, Morris LS, Stanley MA, Garrod DR, Coleman N.

Virchows Arch. 2003 Jul;443(1):51-6. Epub 2003 May 21.

PMID:
12759751
32.

Peptidase allergen Der p 1 initiates apoptosis of epithelial cells independently of tight junction proteolysis.

Baker SF, Yin Y, Runswick SK, Stewart GA, Thompson PJ, Garrod DR, Robinson C.

Mol Membr Biol. 2003 Jan-Mar;20(1):71-81.

PMID:
12745920
33.

Desmosomal cadherins.

Garrod DR, Merritt AJ, Nie Z.

Curr Opin Cell Biol. 2002 Oct;14(5):537-45. Review.

PMID:
12231347
34.

Calcium induces differentiation of primary human salivary acinar cells.

Hiraki A, Shirasuna K, Ikari T, Shinohara M, Garrod DR.

J Cell Physiol. 2002 Oct;193(1):55-63.

PMID:
12209880
35.

Suprabasal desmoglein 3 expression in the epidermis of transgenic mice results in hyperproliferation and abnormal differentiation.

Merritt AJ, Berika MY, Zhai W, Kirk SE, Ji B, Hardman MJ, Garrod DR.

Mol Cell Biol. 2002 Aug;22(16):5846-58.

36.

Desmosomal adhesion: structural basis, molecular mechanism and regulation (Review).

Garrod DR, Merritt AJ, Nie Z.

Mol Membr Biol. 2002 Apr-Jun;19(2):81-94. Review.

PMID:
12126234
37.

Desmosomal adhesion regulates epithelial morphogenesis and cell positioning.

Runswick SK, O'Hare MJ, Jones L, Streuli CH, Garrod DR.

Nat Cell Biol. 2001 Sep;3(9):823-30.

PMID:
11533662
38.

The transmembrane protein occludin of epithelial tight junctions is a functional target for serine peptidases from faecal pellets of Dermatophagoides pteronyssinus.

Wan H, Winton HL, Soeller C, Taylor GW, Gruenert DC, Thompson PJ, Cannell MB, Stewart GA, Garrod DR, Robinson C.

Clin Exp Allergy. 2001 Feb;31(2):279-94.

PMID:
11251630
39.

Peptidase allergens, occludin and claudins. Do their interactions facilitate the development of hypersensitivity reactions at mucosal surfaces?

Robinson C, Baker SF, Garrod DR.

Clin Exp Allergy. 2001 Feb;31(2):186-92. Review. No abstract available.

PMID:
11251620
40.

Desmosomes are reduced in the mouse uterine luminal epithelium during the preimplantation period of pregnancy: a mechanism for facilitation of implantation.

Illingworth IM, Kiszka I, Bagley S, Ireland GW, Garrod DR, Kimber SJ.

Biol Reprod. 2000 Dec;63(6):1764-73.

PMID:
11090447
41.

Parenteral administration of an activating monoclonal antibody to the alpha1beta1 integrin in dogs.

Bank I, Hardan I, Lokshin E, Nas D, Miron S, Ohad D, Spong S, Garrod DR.

Immunobiology. 2000 Sep;202(3):239-53.

PMID:
11045660
42.

Tight junction properties of the immortalized human bronchial epithelial cell lines Calu-3 and 16HBE14o-.

Wan H, Winton HL, Soeller C, Stewart GA, Thompson PJ, Gruenert DC, Cannell MB, Garrod DR, Robinson C.

Eur Respir J. 2000 Jun;15(6):1058-68.

43.

Changes in intercellular junctions during apoptosis precede nuclear condensation or phosphatidylserine exposure on the cell surface.

Corfe BM, Dive C, Garrod DR.

Cell Death Differ. 2000 Feb;7(2):234-5. No abstract available.

44.

Quantitative structural and biochemical analyses of tight junction dynamics following exposure of epithelial cells to house dust mite allergen Der p 1.

Wan H, Winton HL, Soeller C, Gruenert DC, Thompson PJ, Cannell MB, Stewart GA, Garrod DR, Robinson C.

Clin Exp Allergy. 2000 May;30(5):685-98.

PMID:
10792361
45.

Expression of a single pair of desmosomal glycoproteins renders the corneal epithelium unique amongst stratified epithelia.

Messent AJ, Blissett MJ, Smith GL, North AJ, Magee A, Foreman D, Garrod DR, Boulton M.

Invest Ophthalmol Vis Sci. 2000 Jan;41(1):8-15.

PMID:
10634593
46.

Molecular map of the desmosomal plaque.

North AJ, Bardsley WG, Hyam J, Bornslaeger EA, Cordingley HC, Trinnaman B, Hatzfeld M, Green KJ, Magee AI, Garrod DR.

J Cell Sci. 1999 Dec;112 ( Pt 23):4325-36.

47.
48.

Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions.

Wan H, Winton HL, Soeller C, Tovey ER, Gruenert DC, Thompson PJ, Stewart GA, Taylor GW, Garrod DR, Cannell MB, Robinson C.

J Clin Invest. 1999 Jul;104(1):123-33.

50.

All-trans retinoic acid compromises desmosome expression in human epidermis.

Humphries JD, Parry EJ, Watson RE, Garrod DR, Griffiths CE.

Br J Dermatol. 1998 Oct;139(4):577-84.

PMID:
9892899

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