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Items: 1 to 50 of 187

1.

Allergen Delivery Inhibitors: Characterisation of Potent and Selective Inhibitors of Der p 1 and Their Attenuation of Airway Responses to House Dust Mite Allergens.

Zhang J, Chen J, Zuo J, Newton GK, Stewart MR, Perrior TR, Garrod DR, Robinson C.

Int J Mol Sci. 2018 Oct 15;19(10). pii: E3166. doi: 10.3390/ijms19103166.

2.

Pathways of airway oxidant formation by house dust mite allergens and viral RNA converge through myosin motors, pannexons and Toll-like receptor 4.

Zhang J, Chen J, Mangat SC, Perera Baruhupolage C, Garrod DR, Robinson C.

Immun Inflamm Dis. 2018 Jun;6(2):276-296. doi: 10.1002/iid3.216. Epub 2018 Mar 15.

3.

Desmocollin 1 is abundantly expressed in atherosclerosis and impairs high-density lipoprotein biogenesis.

Choi HY, Ruel I, Malina A, Garrod DR, Oda MN, Pelletier J, Schwertani A, Genest J.

Eur Heart J. 2018 Apr 7;39(14):1194-1202. doi: 10.1093/eurheartj/ehx340.

PMID:
29106519
4.

Allergen-dependent oxidant formation requires purinoceptor activation of ADAM 10 and prothrombin.

Chen J, Zhang J, Tachie-Menson T, Shukla N, Garrod DR, Robinson C.

J Allergy Clin Immunol. 2017 Jun;139(6):2023-2026.e9. doi: 10.1016/j.jaci.2016.12.954. Epub 2017 Jan 19. No abstract available.

5.

Innate generation of thrombin and intracellular oxidants in airway epithelium by allergen Der p 1.

Zhang J, Chen J, Allen-Philbey K, Perera Baruhupolage C, Tachie-Menson T, Mangat SC, Garrod DR, Robinson C.

J Allergy Clin Immunol. 2016 Oct;138(4):1224-1227. doi: 10.1016/j.jaci.2016.05.006. Epub 2016 May 24. No abstract available.

6.

Controlled laser texturing of titanium results in reliable osteointegration.

Coathup MJ, Blunn GW, Mirhosseini N, Erskine K, Liu Z, Garrod DR, Li L.

J Orthop Res. 2017 Apr;35(4):820-828. doi: 10.1002/jor.23340. Epub 2016 Jun 28.

7.

Cadherin flexibility provides a key difference between desmosomes and adherens junctions.

Tariq H, Bella J, Jowitt TA, Holmes DF, Rouhi M, Nie Z, Baldock C, Garrod D, Tabernero L.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5395-400. doi: 10.1073/pnas.1420508112. Epub 2015 Apr 8.

8.

The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma.

Newton GK, Perrior TR, Jenkins K, Major MR, Key RE, Stewart MR, Firth-Clark S, Lloyd SM, Zhang J, Francis-Newton NJ, Richardson JP, Chen J, Lai P, Garrod DR, Robinson C.

J Med Chem. 2014 Nov 26;57(22):9447-62. doi: 10.1021/jm501102h. Epub 2014 Nov 17.

9.

Down-regulation of desmosomes in cultured cells: the roles of PKC, microtubules and lysosomal/proteasomal degradation.

McHarg S, Hopkins G, Lim L, Garrod D.

PLoS One. 2014 Oct 7;9(10):e108570. doi: 10.1371/journal.pone.0108570. eCollection 2014.

10.

A novel Nrf2-miR-29-desmocollin-2 axis regulates desmosome function in keratinocytes.

Kurinna S, Schäfer M, Ostano P, Karouzakis E, Chiorino G, Bloch W, Bachmann A, Gay S, Garrod D, Lefort K, Dotto GP, Beer HD, Werner S.

Nat Commun. 2014 Oct 6;5:5099. doi: 10.1038/ncomms6099.

PMID:
25283360
11.

Hyper-adhesion: a unique property of desmosomes.

Garrod D, Tabernero L.

Cell Commun Adhes. 2014 Oct;21(5):249-56. doi: 10.3109/15419061.2014.930133. Epub 2014 Jun 30. Review.

PMID:
24978153
12.

Desmosomal adhesion in vivo.

Berika M, Garrod D.

Cell Commun Adhes. 2014 Feb;21(1):65-75. doi: 10.3109/15419061.2013.876018. Review.

PMID:
24460202
13.

The assay that defines desmosome hyper-adhesion.

Garrod DR.

J Invest Dermatol. 2013 Feb;133(2):576-7. doi: 10.1038/jid.2012.275. Epub 2012 Aug 30. No abstract available.

14.

Desmosomal adhesiveness is developmentally regulated in the mouse embryo and modulated during trophectoderm migration.

Kimura TE, Merritt AJ, Lock FR, Eckert JJ, Fleming TP, Garrod DR.

Dev Biol. 2012 Sep 15;369(2):286-97. doi: 10.1016/j.ydbio.2012.06.025. Epub 2012 Jul 20.

15.

Talkback: a strategic approach to working with maternity service users.

Garrod D.

Pract Midwife. 2012 Apr;15(4):18-20.

PMID:
22662535
16.

Direct evidence that PKCα positively regulates wound re-epithelialization: correlation with changes in desmosomal adhesiveness.

Thomason HA, Cooper NH, Ansell DM, Chiu M, Merrit AJ, Hardman MJ, Garrod DR.

J Pathol. 2012 Jul;227(3):346-56. doi: 10.1002/path.4016. Epub 2012 May 8.

PMID:
22407785
17.

Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris.

Tsang SM, Brown L, Lin K, Liu L, Piper K, O'Toole EA, Grose R, Hart IR, Garrod DR, Fortune F, Wan H.

J Pathol. 2012 May;227(1):81-93. doi: 10.1002/path.3982. Epub 2012 Feb 17.

PMID:
22294297
18.

Desmosomal cadherins in zebrafish epiboly and gastrulation.

Goonesinghe A, Luan XM, Hurlstone A, Garrod D.

BMC Dev Biol. 2012 Jan 11;12:1. doi: 10.1186/1471-213X-12-1. Erratum in: BMC Dev Biol. 2014;14:13.

19.

An adult passive transfer mouse model to study desmoglein 3 signaling in pemphigus vulgaris.

Schulze K, Galichet A, Sayar BS, Scothern A, Howald D, Zymann H, Siffert M, Zenhäusern D, Bolli R, Koch PJ, Garrod D, Suter MM, Müller EJ.

J Invest Dermatol. 2012 Feb;132(2):346-55. doi: 10.1038/jid.2011.299. Epub 2011 Sep 29.

20.

Future inhaled drugs by virtual innovation: allergen delivery inhibitors.

Robinson C, Zhang J, Garrod DR, Newton GK, Jenkins K, Perrior TR.

Future Med Chem. 2011 Oct;3(13):1567-70. doi: 10.4155/fmc.11.107. No abstract available.

21.

Stroma regulates increased epithelial lateral cell adhesion in 3D culture: a role for actin/cadherin dynamics.

Chambers KF, Pearson JF, Aziz N, O'Toole P, Garrod D, Lang SH.

PLoS One. 2011 Apr 18;6(4):e18796. doi: 10.1371/journal.pone.0018796.

22.

Saving Mothers' Lives: Reviewing maternal deaths to make motherhood safer: 2006-2008. The Eighth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom.

Cantwell R, Clutton-Brock T, Cooper G, Dawson A, Drife J, Garrod D, Harper A, Hulbert D, Lucas S, McClure J, Millward-Sadler H, Neilson J, Nelson-Piercy C, Norman J, O'Herlihy C, Oates M, Shakespeare J, de Swiet M, Williamson C, Beale V, Knight M, Lennox C, Miller A, Parmar D, Rogers J, Springett A.

BJOG. 2011 Mar;118 Suppl 1:1-203. doi: 10.1111/j.1471-0528.2010.02847.x. Erratum in: BJOG. 2015 Apr;122(5):e1. Erratum in: BJOG. 2015 Apr;122(5):e1.

23.

Tight junction proteins and the epidermis.

O'Neill CA, Garrod D.

Exp Dermatol. 2011 Feb;20(2):88-91. doi: 10.1111/j.1600-0625.2010.01206.x.

PMID:
21255086
24.

Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src.

Tsang SM, Liu L, Teh MT, Wheeler A, Grose R, Hart IR, Garrod DR, Fortune F, Wan H.

PLoS One. 2010 Dec 3;5(12):e14211. doi: 10.1371/journal.pone.0014211.

25.

Membrane-impermeable cross-linking provides evidence for homophilic, isoform-specific binding of desmosomal cadherins in epithelial cells.

Nie Z, Merritt A, Rouhi-Parkouhi M, Tabernero L, Garrod D.

J Biol Chem. 2011 Jan 21;286(3):2143-54. doi: 10.1074/jbc.M110.192245. Epub 2010 Nov 22.

26.

Desmosomes in vivo.

Garrod D.

Dermatol Res Pract. 2010;2010:212439. doi: 10.1155/2010/212439. Epub 2010 Jun 24.

27.

Desmosomes: adhesive strength and signalling in health and disease.

Thomason HA, Scothern A, McHarg S, Garrod DR.

Biochem J. 2010 Aug 1;429(3):419-33. doi: 10.1042/BJ20100567. Review.

PMID:
20626351
28.

Tissue section AFM: In situ ultrastructural imaging of native biomolecules.

Graham HK, Hodson NW, Hoyland JA, Millward-Sadler SJ, Garrod D, Scothern A, Griffiths CE, Watson RE, Cox TR, Erler JT, Trafford AW, Sherratt MJ.

Matrix Biol. 2010 May;29(4):254-60. doi: 10.1016/j.matbio.2010.01.008. Epub 2010 Feb 6.

29.

Pervanadate stabilizes desmosomes.

Garrod DR, Fisher C, Smith A, Nie Z.

Cell Adh Migr. 2008 Jul-Sep;2(3):161-6. Epub 2008 Jul 3.

30.

Comparative enzymology of native and recombinant house dust mite allergen Der p 1.

Zhang J, Saint-Remy JM, Garrod DR, Robinson C.

Allergy. 2009 Mar;64(3):469-77. doi: 10.1111/j.1398-9995.2008.01852.x. Epub 2009 Jan 27.

PMID:
19175594
31.

A qualitative study of mild to moderate psychological distress during pregnancy.

Furber CM, Garrod D, Maloney E, Lovell K, McGowan L.

Int J Nurs Stud. 2009 May;46(5):669-77. doi: 10.1016/j.ijnurstu.2008.12.003. Epub 2009 Jan 15.

PMID:
19150062
32.

EphB2 and EphB3 forward signalling are required for palate development.

Risley M, Garrod D, Henkemeyer M, McLean W.

Mech Dev. 2009 Mar-Apr;126(3-4):230-9. doi: 10.1016/j.mod.2008.10.009. Epub 2008 Nov 6.

33.

The cell adhesion molecule nectin-1 is critical for normal enamel formation in mice.

Barron MJ, Brookes SJ, Draper CE, Garrod D, Kirkham J, Shore RC, Dixon MJ.

Hum Mol Genet. 2008 Nov 15;17(22):3509-20. doi: 10.1093/hmg/ddn243. Epub 2008 Aug 14.

34.

Visualization of desmosomes in the electron microscope.

Scothern A, Garrod D.

Methods Cell Biol. 2008;88:347-66. doi: 10.1016/S0091-679X(08)00418-4. Review.

PMID:
18617042
35.

Hyper-adhesion: a new concept in cell-cell adhesion.

Garrod D, Kimura TE.

Biochem Soc Trans. 2008 Apr;36(Pt 2):195-201. doi: 10.1042/BST0360195. Review.

PMID:
18363561
36.

Public health: why the debate?

Garrod D, Byrom S.

RCM Midwives. 2007 Nov-Dec;10(10):470-3. Review. No abstract available.

PMID:
18041320
37.

Pollen proteolytic enzymes degrade tight junctions.

Runswick S, Mitchell T, Davies P, Robinson C, Garrod DR.

Respirology. 2007 Nov;12(6):834-42.

PMID:
17986111
38.

Interactions between mature Der p 1 and its free prodomain indicate membership of a new family of C1 peptidases.

Zhang J, Hamilton JM, Garrod DR, Robinson C.

Allergy. 2007 Nov;62(11):1302-9.

PMID:
17919146
39.

Desmosome structure, composition and function.

Garrod D, Chidgey M.

Biochim Biophys Acta. 2008 Mar;1778(3):572-87. Epub 2007 Aug 9. Review.

40.

Normality in perspective.

Garrod D.

RCM Midwives. 2007 Jun;10(6):296. No abstract available.

PMID:
17596088
41.

Desmoplakin Is Essential for Epidermal Sheet Formation.

Hopkins G, Kimura TE, Garrod DR.

J Invest Dermatol. 2007 Jan;127 Suppl 3:E12. doi: 10.1038/sj.skinbio.6250005. No abstract available.

PMID:
26879536
42.

Milestones in Investigative Dermatology: The Desmosome.

Kowalczyk AP, Rubenstein DS, Garrod DR, Green KJ, Stanley JR.

J Invest Dermatol. 2007 Jan;127 Suppl 3:E1. doi: 10.1038/sj.skinbio.6250007. No abstract available.

PMID:
26879533
43.

Desmoplakin is essential for epidermal sheet formation.

Hopkins G, Kimura TE, Garrod DR.

J Invest Dermatol. 2007 Jan 30;127(E1):E12. doi: 10.1038/sj.skinbio.6250005. No abstract available.

44.

Calcium-independent desmosomes of keratinocytes are hyper-adhesive.

Kimura TE, Merritt AJ, Garrod DR.

J Invest Dermatol. 2007 Apr;127(4):775-81. Epub 2006 Dec 28.

45.

A 4 kb fragment of the desmocollin 3 promoter directs reporter gene expression to parakeratotic epidermis and primary hair follicles.

Merritt AJ, Zhu K, Garrod DR, Chidgey MA.

J Invest Dermatol. 2007 Jan;127(1):245-7. Epub 2006 Jul 13. No abstract available.

46.

Hyper-adhesion in desmosomes: its regulation in wound healing and possible relationship to cadherin crystal structure.

Garrod DR, Berika MY, Bardsley WF, Holmes D, Tabernero L.

J Cell Sci. 2005 Dec 15;118(Pt 24):5743-54. Epub 2005 Nov 22.

47.

Interferon-gamma selectively increases epithelial permeability to large molecules by activating different populations of paracellular pores.

Watson CJ, Hoare CJ, Garrod DR, Carlson GL, Warhurst G.

J Cell Sci. 2005 Nov 15;118(Pt 22):5221-30. Epub 2005 Oct 25.

48.

A cross-cultural investigation into the relationships between personality traits and work values.

Furnham A, Petrides KV, Tsaousis I, Pappas K, Garrod D.

J Psychol. 2005 Jan;139(1):5-32.

PMID:
15751827
49.

Desmosomal cadherin misexpression alters beta-catenin stability and epidermal differentiation.

Hardman MJ, Liu K, Avilion AA, Merritt A, Brennan K, Garrod DR, Byrne C.

Mol Cell Biol. 2005 Feb;25(3):969-78.

50.

Protein kinase C alpha expression in normal breast, ductal carcinoma in situ and invasive ductal carcinoma.

Ainsworth PD, Winstanley JH, Pearson JM, Bishop HM, Garrod DR.

Eur J Cancer. 2004 Oct;40(15):2269-73.

PMID:
15454252

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