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Items: 5


Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.

Maurer T, Garrenton LS, Oh A, Pitts K, Anderson DJ, Skelton NJ, Fauber BP, Pan B, Malek S, Stokoe D, Ludlam MJ, Bowman KK, Wu J, Giannetti AM, Starovasnik MA, Mellman I, Jackson PK, Rudolph J, Wang W, Fang G.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5299-304. doi: 10.1073/pnas.1116510109. Epub 2012 Mar 19.


Pheromone-induced anisotropy in yeast plasma membrane phosphatidylinositol-4,5-bisphosphate distribution is required for MAPK signaling.

Garrenton LS, Stefan CJ, McMurray MA, Emr SD, Thorner J.

Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11805-10. doi: 10.1073/pnas.1005817107. Epub 2010 Jun 14.


Nucleus-specific and cell cycle-regulated degradation of mitogen-activated protein kinase scaffold protein Ste5 contributes to the control of signaling competence.

Garrenton LS, Braunwarth A, Irniger S, Hurt E, K├╝nzler M, Thorner J.

Mol Cell Biol. 2009 Jan;29(2):582-601. doi: 10.1128/MCB.01019-08. Epub 2008 Nov 10.


Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain.

Garrenton LS, Young SL, Thorner J.

Genes Dev. 2006 Jul 15;20(14):1946-58.


Jekyll and Hyde in the microbial world.

Truckses DM, Garrenton LS, Thorner J.

Science. 2004 Nov 26;306(5701):1509-11.


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