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Items: 1 to 50 of 100

1.

Strong and Sustained Antihypertensive Effect of Small Interfering RNA Targeting Liver Angiotensinogen.

Uijl E, Mirabito Colafella KM, Sun Y, Ren L, van Veghel R, Garrelds IM, de Vries R, Poglitsch M, Zlatev I, Kim JB, Hoorn EJ, Foster D, Danser AHJ.

Hypertension. 2019 Jun;73(6):1249-1257. doi: 10.1161/HYPERTENSIONAHA.119.12703.

PMID:
31030610
2.

The macula densa prorenin receptor is essential in renin release and blood pressure control.

Riquier-Brison ADM, Sipos A, Prókai Á, Vargas SL, Toma L, Meer EJ, Villanueva KG, Chen JCM, Gyarmati G, Yih C, Tang E, Nadim B, Pendekanti S, Garrelds IM, Nguyen G, Danser AHJ, Peti-Peterdi J.

Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F521-F534. doi: 10.1152/ajprenal.00029.2018. Epub 2018 Apr 18.

PMID:
29667908
3.

Neprilysin inhibition and endothelin-1 elevation: Focus on the kidney.

Roksnoer LCW, Uijl E, de Vries R, Garrelds IM, Jan Danser AH.

Eur J Pharmacol. 2018 Apr 5;824:128-132. doi: 10.1016/j.ejphar.2018.02.007. Epub 2018 Feb 9.

PMID:
29432709
4.

Trigeminovascular calcitonin gene-related peptide function in Cacna1a R192Q-mutated knock-in mice.

Chan KY, Labastida-Ramírez A, Ramírez-Rosas MB, Labruijere S, Garrelds IM, Danser AH, van den Maagdenberg AM, MaassenVanDenBrink A.

J Cereb Blood Flow Metab. 2019 Apr;39(4):718-729. doi: 10.1177/0271678X17725673. Epub 2017 Aug 9.

5.

Low Soluble Fms-Like Tyrosine Kinase-1, Endoglin, and Endothelin-1 Levels in Women With Confirmed or Suspected Preeclampsia Using Proton Pump Inhibitors.

Saleh L, Samantar R, Garrelds IM, van den Meiracker AH, Visser W, Danser AHJ.

Hypertension. 2017 Sep;70(3):594-600. doi: 10.1161/HYPERTENSIONAHA.117.09741. Epub 2017 Jul 17.

PMID:
28716993
6.

Brain Renin-Angiotensin System: Does It Exist?

van Thiel BS, Góes Martini A, Te Riet L, Severs D, Uijl E, Garrelds IM, Leijten FPJ, van der Pluijm I, Essers J, Qadri F, Alenina N, Bader M, Paulis L, Rajkovicova R, Domenig O, Poglitsch M, Danser AHJ.

Hypertension. 2017 Jun;69(6):1136-1144. doi: 10.1161/HYPERTENSIONAHA.116.08922. Epub 2017 Apr 10.

PMID:
28396529
7.

Do prorenin-synthesizing cells release active, 'open' prorenin?

Martini AG, Krop M, Saleh L, Garrelds IM, Danser AH.

J Hypertens. 2017 Feb;35(2):330-337. doi: 10.1097/HJH.0000000000001174.

PMID:
28005703
8.

Blood pressure-independent renoprotection in diabetic rats treated with AT1 receptor-neprilysin inhibition compared with AT1 receptor blockade alone.

Roksnoer LC, van Veghel R, van Groningen MC, de Vries R, Garrelds IM, Bhaggoe UM, van Gool JM, Friesema EC, Leijten FP, Hoorn EJ, Danser AH, Batenburg WW.

Clin Sci (Lond). 2016 Jul 1;130(14):1209-20. doi: 10.1042/CS20160197. Epub 2016 Apr 19.

PMID:
27129187
9.

Depression and markers of inflammation as predictors of all-cause mortality in heart failure.

Mommersteeg PMC, Schoemaker RG, Naudé PJW, Eisel ULM, Garrelds IM, Schalkwijk CG, Westerhuis BWJJM, Kop WJ, Denollet J.

Brain Behav Immun. 2016 Oct;57:144-150. doi: 10.1016/j.bbi.2016.03.012. Epub 2016 Mar 21.

PMID:
27013355
10.

Changes in Coronary Blood Flow After Acute Myocardial Infarction: Insights From a Patient Study and an Experimental Porcine Model.

de Waard GA, Hollander MR, Teunissen PF, Jansen MF, Eerenberg ES, Beek AM, Marques KM, van de Ven PM, Garrelds IM, Danser AH, Duncker DJ, van Royen N.

JACC Cardiovasc Interv. 2016 Mar 28;9(6):602-13. doi: 10.1016/j.jcin.2016.01.001.

11.

On the Origin of Urinary Renin: A Translational Approach.

Roksnoer LC, Heijnen BF, Nakano D, Peti-Peterdi J, Walsh SB, Garrelds IM, van Gool JM, Zietse R, Struijker-Boudier HA, Hoorn EJ, Danser AH.

Hypertension. 2016 May;67(5):927-33. doi: 10.1161/HYPERTENSIONAHA.115.07012. Epub 2016 Feb 29.

12.

AT1-receptor blockade, but not renin inhibition, reduces aneurysm growth and cardiac failure in fibulin-4 mice.

Te Riet L, van Deel ED, van Thiel BS, Moltzer E, van Vliet N, Ridwan Y, van Veghel R, van Heijningen PM, Robertus JL, Garrelds IM, Vermeij M, van der Pluijm I, Danser AH, Essers J.

J Hypertens. 2016 Apr;34(4):654-65. doi: 10.1097/HJH.0000000000000845.

PMID:
26828783
13.

Signatures of miR-181a on the Renal Transcriptome and Blood Pressure.

Marques FZ, Romaine SP, Denniff M, Eales J, Dormer J, Garrelds IM, Wojnar L, Musialik K, Duda-Raszewska B, Kiszka B, Duda M, Morris BJ, Samani NJ, Danser AJ, Bogdanski P, Zukowska-Szczechowska E, Charchar FJ, Tomaszewski M.

Mol Med. 2015 Nov;21(1):739-748. doi: 10.2119/molmed.2015.00096. Epub 2015 Aug 24.

14.

Chymase: a multifunctional player in pulmonary hypertension associated with lung fibrosis.

Kosanovic D, Luitel H, Dahal BK, Cornitescu T, Janssen W, Danser AH, Garrelds IM, De Mey JG, Fazzi G, Schiffers P, Iglarz M, Fischli W, Ghofrani HA, Weissmann N, Grimminger F, Seeger W, Reiss I, Schermuly RT.

Eur Respir J. 2015 Oct;46(4):1084-94. doi: 10.1183/09031936.00018215. Epub 2015 Jun 25.

15.

Angiotensin II type 2 receptor- and acetylcholine-mediated relaxation: essential contribution of female sex hormones and chromosomes.

Pessôa BS, Slump DE, Ibrahimi K, Grefhorst A, van Veghel R, Garrelds IM, Roks AJ, Kushner SA, Danser AH, van Esch JH.

Hypertension. 2015 Aug;66(2):396-402. doi: 10.1161/HYPERTENSIONAHA.115.05303. Epub 2015 Jun 8.

PMID:
26056343
16.

Association studies suggest a key role for endothelin-1 in the pathogenesis of preeclampsia and the accompanying renin-angiotensin-aldosterone system suppression.

Verdonk K, Saleh L, Lankhorst S, Smilde JE, van Ingen MM, Garrelds IM, Friesema EC, Russcher H, van den Meiracker AH, Visser W, Danser AH.

Hypertension. 2015 Jun;65(6):1316-23. doi: 10.1161/HYPERTENSIONAHA.115.05267. Epub 2015 Apr 13.

PMID:
25870197
17.

Optimum AT1 receptor-neprilysin inhibition has superior cardioprotective effects compared with AT1 receptor blockade alone in hypertensive rats.

Roksnoer LC, van Veghel R, de Vries R, Garrelds IM, Bhaggoe UM, Friesema EC, Leijten FP, Poglitsch M, Domenig O, Clahsen-van Groningen MC, Hoorn EJ, Jan Danser AH, Batenburg WW.

Kidney Int. 2015 Jul;88(1):109-20. doi: 10.1038/ki.2015.107. Epub 2015 Apr 1.

PMID:
25830765
18.

Nitric oxide dysregulation in patients with heart failure: the association of depressive symptoms with L-arginine, asymmetric dimethylarginine, symmetric dimethylarginine, and isoprostane.

Mommersteeg PM, Schoemaker RG, Eisel UL, Garrelds IM, Schalkwijk CG, Kop WJ.

Psychosom Med. 2015 Apr;77(3):292-302. doi: 10.1097/PSY.0000000000000162.

PMID:
25790241
19.

Reduced trigeminovascular cyclicity in patients with menstrually related migraine.

Ibrahimi K, van Oosterhout WP, van Dorp W, Danser AH, Garrelds IM, Kushner SA, Lesaffre EM, Terwindt GM, Ferrari MD, van den Meiracker AH, MaassenVanDenBrink A.

Neurology. 2015 Jan 13;84(2):125-31. doi: 10.1212/WNL.0000000000001142. Epub 2014 Dec 10.

PMID:
25503623
20.

A human capsaicin model to quantitatively assess salivary CGRP secretion.

van Oosterhout WP, Schoonman GG, Garrelds IM, Danser AH, Chan KY, Terwindt GM, Ferrari MD, MaassenVanDenBrink A.

Cephalalgia. 2015 Jul;35(8):675-82. doi: 10.1177/0333102414553824. Epub 2014 Nov 3.

PMID:
25366550
21.

Methodologic issues in the measurement of urinary renin.

Roksnoer LC, Verdonk K, Garrelds IM, van Gool JM, Zietse R, Hoorn EJ, Danser AH.

Clin J Am Soc Nephrol. 2014 Jul;9(7):1163-7. doi: 10.2215/CJN.12661213. Epub 2014 Apr 17.

22.

Deterioration of kidney function by the (pro)renin receptor blocker handle region peptide in aliskiren-treated diabetic transgenic (mRen2)27 rats.

te Riet L, van den Heuvel M, Peutz-Kootstra CJ, van Esch JH, van Veghel R, Garrelds IM, Musterd-Bhaggoe U, Bouhuizen AM, Leijten FP, Danser AH, Batenburg WW.

Am J Physiol Renal Physiol. 2014 May 15;306(10):F1179-89. doi: 10.1152/ajprenal.00010.2014. Epub 2014 Apr 2.

23.

Renin inhibitor VTP-27999 differs from aliskiren: focus on their intracellular accumulation and the (pro)renin receptor.

Lu X, Krop M, Batenburg WW, Musterd-Bhaggoe UM, Garrelds IM, Danser AH.

J Hypertens. 2014 Jun;32(6):1255-63. doi: 10.1097/HJH.0000000000000167.

PMID:
24637873
24.

Methylation of migraine-related genes in different tissues of the rat.

Labruijere S, Stolk L, Verbiest M, de Vries R, Garrelds IM, Eilers PH, Danser AH, Uitterlinden AG, MaassenVanDenBrink A.

PLoS One. 2014 Mar 7;9(3):e87616. doi: 10.1371/journal.pone.0087616. eCollection 2014.

25.

Multiple ascending dose study with the new renin inhibitor VTP-27999: nephrocentric consequences of too much renin inhibition.

Balcarek J, Sevá Pessôa B, Bryson C, Azizi M, Ménard J, Garrelds IM, McGeehan G, Reeves RA, Griffith SG, Danser AH, Gregg R.

Hypertension. 2014 May;63(5):942-50. doi: 10.1161/HYPERTENSIONAHA.113.02893. Epub 2014 Jan 27.

PMID:
24470465
26.

Cranioselectivity of sumatriptan revisited: pronounced contractions to sumatriptan in small human isolated coronary artery.

Chan KY, Labruijere S, Ramírez Rosas MB, de Vries R, Garrelds IM, Danser AH, Villalón CM, van den Bogaerdt A, Dirven C, MaassenVanDenBrink A.

CNS Drugs. 2014 Mar;28(3):273-8. doi: 10.1007/s40263-013-0136-0.

PMID:
24430784
27.

Stabilization of hypoxia inducible factor-1α ameliorates acute renal neurogenic hypertension.

Koeners MP, Vink EE, Kuijper A, Gadellaa N, Rosenberger C, Mathia S, van den Meiracker AH, Garrelds IM, Blankestijn PJ, Joles JA.

J Hypertens. 2014 Mar;32(3):587-97. doi: 10.1097/HJH.0000000000000060.

PMID:
24309492
28.

Genetic variation and gender determine bradykinin type 1 receptor responses in human tissue: implications for the ACE-inhibitor-induced effects in patients with coronary artery disease.

Wu H, Roks AJ, Leijten FP, Garrelds IM, Musterd-Bhaggoe UM, van den Bogaerdt AJ, de Maat MP, Simoons ML, Danser AH, Oeseburg H.

Clin Sci (Lond). 2014 Mar;126(6):441-9. doi: 10.1042/CS20130204.

PMID:
24117346
29.

Urinary renin and angiotensinogen in type 2 diabetes: added value beyond urinary albumin?

Persson F, Lu X, Rossing P, Garrelds IM, Danser AH, Parving HH.

J Hypertens. 2013 Aug;31(8):1646-52. doi: 10.1097/HJH.0b013e328362217c.

PMID:
23743807
30.

Analysis of the vascular responses in a murine model of polycystic ovary syndrome.

Labruijere S, van Houten EL, de Vries R, Musterd-Bagghoe UM, Garrelds IM, Kramer P, Danser AH, Villalón CM, Visser JA, Van Den Brink AM.

J Endocrinol. 2013;218(2):205-13.

PMID:
23734045
31.

(Pro)renin receptor is required for prorenin-dependent and -independent regulation of vacuolar H⁺-ATPase activity in MDCK.C11 collecting duct cells.

Lu X, Garrelds IM, Wagner CA, Danser AH, Meima ME.

Am J Physiol Renal Physiol. 2013 Aug 1;305(3):F417-25. doi: 10.1152/ajprenal.00037.2013. Epub 2013 May 22.

32.

Cardiac remodeling during and after renin-angiotensin system stimulation in Cyp1a1-Ren2 transgenic rats.

Heijnen BF, Pelkmans LP, Danser AH, Garrelds IM, Mullins JJ, De Mey JG, Struijker-Boudier HA, Janssen BJ.

J Renin Angiotensin Aldosterone Syst. 2014 Mar;15(1):69-81. doi: 10.1177/1470320313480537. Epub 2013 Mar 5.

PMID:
23462119
33.

Elevated sensitivity to cardiac ischemia in proteinuric rats is independent of adverse cardiac remodeling.

Szymanski MK, Hillege HL, Danser AH, Garrelds IM, Schoemaker RG.

J Hypertens. 2013 May;31(5):966-74. doi: 10.1097/HJH.0b013e32835f7482.

PMID:
23449019
34.

The (pro)renin receptor blocker handle region peptide upregulates endothelium-derived contractile factors in aliskiren-treated diabetic transgenic (mREN2)27 rats.

Batenburg WW, van den Heuvel M, van Esch JH, van Veghel R, Garrelds IM, Leijten F, Danser AH.

J Hypertens. 2013 Feb;31(2):292-302. doi: 10.1097/HJH.0b013e32835c1789.

PMID:
23303354
35.

AT1 antagonism and renin inhibition in mice: pivotal role of targeting angiotensin II in chronic kidney disease.

Fraune C, Lange S, Krebs C, Hölzel A, Baucke J, Divac N, Schwedhelm E, Streichert T, Velden J, Garrelds IM, Danser AH, Frenay AR, van Goor H, Jankowski V, Stahl R, Nguyen G, Wenzel UO.

Am J Physiol Renal Physiol. 2012 Oct;303(7):F1037-48. doi: 10.1152/ajprenal.00672.2011. Epub 2012 Jul 11.

36.

Red wine extract protects against oxidative-stress-induced endothelial senescence.

Botden IP, Oeseburg H, Durik M, Leijten FP, Van Vark-Van Der Zee LC, Musterd-Bhaggoe UM, Garrelds IM, Seynhaeve AL, Langendonk JG, Sijbrands EJ, Danser AH, Roks AJ.

Clin Sci (Lond). 2012 Oct;123(8):499-507. doi: 10.1042/CS20110679.

PMID:
22563892
37.

Urinary renin, but not angiotensinogen or aldosterone, reflects the renal renin-angiotensin-aldosterone system activity and the efficacy of renin-angiotensin-aldosterone system blockade in the kidney.

van den Heuvel M, Batenburg WW, Jainandunsing S, Garrelds IM, van Gool JM, Feelders RA, van den Meiracker AH, Danser AH.

J Hypertens. 2011 Nov;29(11):2147-55. doi: 10.1097/HJH.0b013e32834bbcbf.

PMID:
21941204
38.

Handle region peptide counteracts the beneficial effects of the Renin inhibitor aliskiren in spontaneously hypertensive rats.

van Esch JH, van Veghel R, Garrelds IM, Leijten F, Bouhuizen AM, Danser AH.

Hypertension. 2011 Apr;57(4):852-8. doi: 10.1161/HYPERTENSIONAHA.110.169060. Epub 2011 Feb 14.

PMID:
21321303
39.

Beneficial cardiac effects of the renin inhibitor aliskiren in spontaneously hypertensive rats.

van Esch JH, Moltzer E, van Veghel R, Garrelds IM, Leijten F, Bouhuizen AM, Danser AH.

J Hypertens. 2010 Oct;28(10):2145-55. doi: 10.1097/HJH.0b013e32833d01ae.

PMID:
20625318
40.

Characterization of the calcitonin gene-related peptide receptor antagonist telcagepant (MK-0974) in human isolated coronary arteries.

Chan KY, Edvinsson L, Eftekhari S, Kimblad PO, Kane SA, Lynch J, Hargreaves RJ, de Vries R, Garrelds IM, van den Bogaerdt AJ, Danser AH, Maassenvandenbrink A.

J Pharmacol Exp Ther. 2010 Sep 1;334(3):746-52. doi: 10.1124/jpet.110.165993. Epub 2010 Jun 23.

PMID:
20573757
41.

Mast cell degranulation mediates bronchoconstriction via serotonin and not via renin release.

Krop M, Ozünal ZG, Chai W, de Vries R, Fekkes D, Bouhuizen AM, Garrelds IM, Danser AH.

Eur J Pharmacol. 2010 Aug 25;640(1-3):185-9. doi: 10.1016/j.ejphar.2010.04.058. Epub 2010 May 10.

PMID:
20462506
42.

Steroidogenesis vs. steroid uptake in the heart: do corticosteroids mediate effects via cardiac mineralocorticoid receptors?

Chai W, Hofland J, Jansen PM, Garrelds IM, de Vries R, van den Bogaerdt AJ, Feelders RA, de Jong FH, Danser AH.

J Hypertens. 2010 May;28(5):1044-53. doi: 10.1097/HJH.0b013e328335c381.

PMID:
20179635
43.

Cardiac Renin levels are not influenced by the amount of resident mast cells.

Krop M, van Veghel R, Garrelds IM, de Bruin RJ, van Gool JM, van den Meiracker AH, Thio M, van Daele PL, Danser AH.

Hypertension. 2009 Aug;54(2):315-21. doi: 10.1161/HYPERTENSIONAHA.109.133892. Epub 2009 Jun 29.

PMID:
19564544
44.

The impact of left ventricular assist device-induced left ventricular unloading on the myocardial renin-angiotensin-aldosterone system: therapeutic consequences?

Klotz S, Burkhoff D, Garrelds IM, Boomsma F, Danser AH.

Eur Heart J. 2009 Apr;30(7):805-12. doi: 10.1093/eurheartj/ehp012. Epub 2009 Feb 17.

PMID:
19223317
45.

Aliskiren accumulates in Renin secretory granules and binds plasma prorenin.

Krop M, Garrelds IM, de Bruin RJ, van Gool JM, Fisher ND, Hollenberg NK, Jan Danser AH.

Hypertension. 2008 Dec;52(6):1076-83. doi: 10.1161/HYPERTENSIONAHA.108.123042. Epub 2008 Nov 3.

PMID:
18981317
46.

Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors.

Gembardt F, Heringer-Walther S, van Esch JH, Sterner-Kock A, van Veghel R, Le TH, Garrelds IM, Coffman TM, Danser AH, Schultheiss HP, Walther T.

FASEB J. 2008 Aug;22(8):3068-77. doi: 10.1096/fj.08-108316. Epub 2008 May 22.

PMID:
18497303
47.

A twofold genetic increase of ACE expression has no effect on the development of spontaneous hypertension.

Nassar I, Schulz A, Bernardy C, Garrelds IM, Plehm R, Huber M, Danser AH, Kreutz R.

Am J Hypertens. 2008 Feb;21(2):200-5. doi: 10.1038/ajh.2007.38. Epub 2008 Jan 3.

PMID:
18174884
48.

Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor.

Batenburg WW, Krop M, Garrelds IM, de Vries R, de Bruin RJ, Burcklé CA, Müller DN, Bader M, Nguyen G, Danser AH.

J Hypertens. 2007 Dec;25(12):2441-53.

PMID:
17984666
49.

Antihypertensive therapy upregulates renin and (pro)renin receptor in the clipped kidney of Goldblatt hypertensive rats.

Krebs C, Hamming I, Sadaghiani S, Steinmetz OM, Meyer-Schwesinger C, Fehr S, Stahl RA, Garrelds IM, Danser AH, van Goor H, Contrepas A, Nguyen G, Wenzel U.

Kidney Int. 2007 Sep;72(6):725-30. Epub 2007 Jun 27.

50.

Vasoactive peptides upregulate mRNA expression and secretion of vascular endothelial growth factor in human airway smooth muscle cells.

Alagappan VK, Willems-Widyastuti A, Seynhaeve AL, Garrelds IM, ten Hagen TL, Saxena PR, Sharma HS.

Cell Biochem Biophys. 2007;47(1):109-18.

PMID:
17406064

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