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Amyotrophic lateral sclerosis: The complement and inflammatory hypothesis.

Kjældgaard AL, Pilely K, Olsen KS, Pedersen SW, Lauritsen AØ, Møller K, Garred P.

Mol Immunol. 2018 Jun 19. pii: S0161-5890(18)30196-2. doi: 10.1016/j.molimm.2018.06.007. [Epub ahead of print]


The Lectin Complement Pathway Is Involved in Protection Against Enteroaggregative Escherichia coli Infection.

Adler Sørensen C, Rosbjerg A, Hebbelstrup Jensen B, Krogfelt KA, Garred P.

Front Immunol. 2018 May 29;9:1153. doi: 10.3389/fimmu.2018.01153. eCollection 2018.


Omics-Based Approach Reveals Complement-Mediated Inflammation in Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS).

Blaabjerg M, Hemdrup AL, Drici L, Ruprecht K, Garred P, Höftberger R, Kristensen BW, Kondziella D, Sejbaek T, Hansen SW, Nielsen HH, Jensen P, Meyer M, Paul F, Lassmann H, Larsen MR, Illes Z.

Front Immunol. 2018 Apr 23;9:741. doi: 10.3389/fimmu.2018.00741. eCollection 2018.


Persistent Intracellular Staphylococcus aureus in Keratinocytes Lead to Activation of the Complement System with Subsequent Reduction in the Intracellular Bacterial Load.

Abu-Humaidan AH, Elvén M, Sonesson A, Garred P, Sørensen OE.

Front Immunol. 2018 Mar 1;9:396. doi: 10.3389/fimmu.2018.00396. eCollection 2018.


Mannose-binding lectin genotypes and outcome in end-stage renal disease: a prospective cohort study.

Adrian T, Hornum M, Eriksson F, Hansen JM, Pilely K, Garred P, Feldt-Rasmussen B.

Nephrol Dial Transplant. 2018 Mar 3. doi: 10.1093/ndt/gfy034. [Epub ahead of print]


Human brain trauma severity is associated with lectin complement pathway activation.

De Blasio D, Fumagalli S, Orsini F, Neglia L, Perego C, Ortolano F, Zanier ER, Picetti E, Locatelli M, Stocchetti N, Longhi L, Garred P, De Simoni MG.

J Cereb Blood Flow Metab. 2018 Jan 1:271678X18758881. doi: 10.1177/0271678X18758881. [Epub ahead of print]


Acute heart failure following myocardial infarction: complement activation correlates with the severity of heart failure in patients developing cardiogenic shock.

Orrem HL, Nilsson PH, Pischke SE, Grindheim G, Garred P, Seljeflot I, Husebye T, Aukrust P, Yndestad A, Andersen GØ, Barratt-Due A, Mollnes TE.

ESC Heart Fail. 2018 Jun;5(3):292-301. doi: 10.1002/ehf2.12266. Epub 2018 Feb 9.


Low Levels of Immunoglobulins and Mannose-Binding Lectin Are Not Associated With Etiology, Severity, or Outcome in Community-Acquired Pneumonia.

Siljan WW, Holter JC, Nymo SH, Husebye E, Ueland T, Skattum L, Bosnes V, Garred P, Frøland SS, Mollnes TE, Aukrust P, Heggelund L.

Open Forum Infect Dis. 2018 Jan 5;5(2):ofy002. doi: 10.1093/ofid/ofy002. eCollection 2018 Feb.


Preoperative methylprednisolone increases plasma Pentraxin 3 early after total knee arthroplasty: a randomized, double-blind, placebo-controlled trial.

Lindberg-Larsen V, Kehlet H, Pilely K, Bagger J, Rovsing ML, Garred P.

Clin Exp Immunol. 2018 Mar;191(3):356-362. doi: 10.1111/cei.13071. Epub 2017 Nov 9.


Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress.

Fanelli G, Gonzalez-Cordero A, Gardner PJ, Peng Q, Fernando M, Kloc M, Farrar CA, Naeem A, Garred P, Ali RR, Sacks SH.

Sci Rep. 2017 Nov 7;7(1):14625. doi: 10.1038/s41598-017-15212-z.


Prognostic value of lectin pathway molecules and complement proteins in ascitic fluid and blood in patients with liver cirrhosis.

Glargaard S, Boysen T, Pilely K, Garred P, Ytting H.

Scand J Gastroenterol. 2018 Jan;53(1):64-69. doi: 10.1080/00365521.2017.1386710. Epub 2017 Oct 6.


C-Reactive Protein Binds to Cholesterol Crystals and Co-Localizes with the Terminal Complement Complex in Human Atherosclerotic Plaques.

Pilely K, Fumagalli S, Rosbjerg A, Genster N, Skjoedt MO, Perego C, Ferrante AMR, De Simoni MG, Garred P.

Front Immunol. 2017 Aug 29;8:1040. doi: 10.3389/fimmu.2017.01040. eCollection 2017.


Associations of Plasma Nitrite, L-Arginine and Asymmetric Dimethylarginine With Morbidity and Mortality in Patients With Necrotizing Soft Tissue Infections.

Hansen MB, Rasmussen LS, Garred P, Pilely K, Wahl AM, Perner A, Madsen MB, Hedegaard ER, Simonsen U, Hyldegaard O.

Shock. 2018 Jun;49(6):667-674. doi: 10.1097/SHK.0000000000000975.


Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation.

Bakke SS, Aune MH, Niyonzima N, Pilely K, Ryan L, Skjelland M, Garred P, Aukrust P, Halvorsen B, Latz E, Damås JK, Mollnes TE, Espevik T.

J Immunol. 2017 Oct 15;199(8):2910-2920. doi: 10.4049/jimmunol.1700302. Epub 2017 Aug 30.


Tuberculosis-Related Diabetes: Is It Reversible after Complete Treatment?

Aftab H, Christensen DL, Ambreen A, Jamil M, Garred P, Petersen JH, Nielsen SD, Bygbjerg IC.

Am J Trop Med Hyg. 2017 Oct;97(4):1099-1102. doi: 10.4269/ajtmh.16-0816. Epub 2017 Aug 18.


Ficolins do not alter host immune responses to lipopolysaccharide-induced inflammation in vivo.

Genster N, Østrup O, Schjalm C, Eirik Mollnes T, Cowland JB, Garred P.

Sci Rep. 2017 Jun 20;7(1):3852. doi: 10.1038/s41598-017-04121-w.


Evasion Mechanisms Used by Pathogens to Escape the Lectin Complement Pathway.

Rosbjerg A, Genster N, Pilely K, Garred P.

Front Microbiol. 2017 May 12;8:868. doi: 10.3389/fmicb.2017.00868. eCollection 2017. Review.


Complement factors C4 and C3 are down regulated in response to short term overfeeding in healthy young men.

Foghmar C, Brøns C, Pilely K, Vaag A, Garred P.

Sci Rep. 2017 Apr 27;7(1):1235. doi: 10.1038/s41598-017-01382-3.


An overview of the synergy and crosstalk between pentraxins and collectins/ficolins: their functional relevance in complement activation.

Ma YJ, Lee BL, Garred P.

Exp Mol Med. 2017 Apr 21;49(4):e320. doi: 10.1038/emm.2017.51. Review.


Inflammatory biomarkers and cancer: CRP and suPAR as markers of incident cancer in patients with serious nonspecific symptoms and signs of cancer.

Rasmussen LJH, Schultz M, Gaardsting A, Ladelund S, Garred P, Iversen K, Eugen-Olsen J, Helms M, David KP, Kjaer A, Lebech AM, Kronborg G.

Int J Cancer. 2017 Jul 1;141(1):191-199. doi: 10.1002/ijc.30732. Epub 2017 Apr 24.


Lectin Pathway of Complement Activation Is Associated with Vulnerability of Atherosclerotic Plaques.

Fumagalli S, Perego C, Zangari R, De Blasio D, Oggioni M, De Nigris F, Snider F, Garred P, Ferrante AM, De Simoni MG.

Front Immunol. 2017 Mar 16;8:288. doi: 10.3389/fimmu.2017.00288. eCollection 2017.


Comparative study of HbA1c and fasting plasma glucose vs the oral glucose tolerance test for diagnosis of diabetes in people with tuberculosis.

Aftab H, Ambreen A, Jamil M, Garred P, Petersen JH, Nielsen SD, Bygbjerg IC, Christensen DL.

Diabet Med. 2017 Jun;34(6):800-803. doi: 10.1111/dme.13354. Epub 2017 Apr 11.


Lectin pathway effector enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in absence of C4 and/or C2.

Yaseen S, Demopulos G, Dudler T, Yabuki M, Wood CL, Cummings WJ, Tjoelker LW, Fujita T, Sacks S, Garred P, Andrew P, Sim RB, Lachmann PJ, Wallis R, Lynch N, Schwaeble WJ.

FASEB J. 2017 May;31(5):2210-2219. doi: 10.1096/fj.201601306R. Epub 2017 Feb 10.


Association between cytokine response, the LRINEC score and outcome in patients with necrotising soft tissue infection: a multicentre, prospective study.

Hansen MB, Rasmussen LS, Svensson M, Chakrakodi B, Bruun T, Madsen MB, Perner A, Garred P, Hyldegaard O, Norrby-Teglund A; INFECT study group.

Sci Rep. 2017 Feb 8;7:42179. doi: 10.1038/srep42179.


High prevalence of diabetes and anthropometric heterogeneity among tuberculosis patients in Pakistan.

Aftab H, Ambreen A, Jamil M, Garred P, Petersen JH, Nielsen SD, Bygbjerg IC, Christensen DL.

Trop Med Int Health. 2017 Apr;22(4):465-473. doi: 10.1111/tmi.12842. Epub 2017 Feb 23.


Association of ficolin-3 with abdominal aortic aneurysm presence and progression.

Fernandez-García CE, Burillo E, Lindholt JS, Martinez-Lopez D, Pilely K, Mazzeo C, Michel JB, Egido J, Garred P, Blanco-Colio LM, Martin-Ventura JL.

J Thromb Haemost. 2017 Mar;15(3):575-585. doi: 10.1111/jth.13608. Epub 2017 Feb 15.


Plasma ficolin levels and risk of nephritis in Danish patients with systemic lupus erythematosus.

Tanha N, Pilely K, Faurschou M, Garred P, Jacobsen S.

Clin Rheumatol. 2017 Feb;36(2):335-341. doi: 10.1007/s10067-016-3508-2. Epub 2016 Dec 15.


Complementary Roles of the Classical and Lectin Complement Pathways in the Defense against Aspergillus fumigatus.

Rosbjerg A, Genster N, Pilely K, Skjoedt MO, Stahl GL, Garred P.

Front Immunol. 2016 Nov 3;7:473. eCollection 2016.


Ficolins Promote Fungal Clearance in vivo and Modulate the Inflammatory Cytokine Response in Host Defense against Aspergillus fumigatus.

Genster N, Præstekjær Cramer E, Rosbjerg A, Pilely K, Cowland JB, Garred P.

J Innate Immun. 2016;8(6):579-588. Epub 2016 Jul 29.


A journey through the lectin pathway of complement-MBL and beyond.

Garred P, Genster N, Pilely K, Bayarri-Olmos R, Rosbjerg A, Ma YJ, Skjoedt MO.

Immunol Rev. 2016 Nov;274(1):74-97. doi: 10.1111/imr.12468. Review.


Dangerous liaisons: complement, coagulation, and kallikrein/kinin cross-talk act as a linchpin in the events leading to thromboinflammation.

Ekdahl KN, Teramura Y, Hamad OA, Asif S, Duehrkop C, Fromell K, Gustafson E, Hong J, Kozarcanin H, Magnusson PU, Huber-Lang M, Garred P, Nilsson B.

Immunol Rev. 2016 Nov;274(1):245-269. doi: 10.1111/imr.12471. Review.


Complement activation by cholesterol crystals triggers a subsequent cytokine response.

Niyonzima N, Halvorsen B, Sporsheim B, Garred P, Aukrust P, Mollnes TE, Espevik T.

Mol Immunol. 2017 Apr;84:43-50. doi: 10.1016/j.molimm.2016.09.019. Epub 2016 Sep 28. Review.


YKL-40 in allogeneic hematopoietic cell transplantation after AML and myelodysplastic syndrome.

Kornblit B, Wang T, Lee SJ, Spellman SR, Zhu X, Fleischhauer K, Müller C, Verneris MR, Müller K, Johansen JS, Vindelov L, Garred P.

Bone Marrow Transplant. 2016 Dec;51(12):1556-1560. doi: 10.1038/bmt.2016.192. Epub 2016 Jul 18.


The Lectin Complement Pathway in Patients with Necrotizing Soft Tissue Infection.

Hansen MB, Rasmussen LS, Pilely K, Hellemann D, Hein E, Madsen MB, Hyldegaard O, Garred P.

J Innate Immun. 2016;8(5):507-16. doi: 10.1159/000447327. Epub 2016 Jun 30.


Association of Low Ficolin-Lectin Pathway Parameters with Cardiac Syndrome X.

Horváth Z, Csuka D, Vargova K, Leé S, Varga L, Garred P, Préda I, Zsámboki ET, Prohászka Z, Kiss RG.

Scand J Immunol. 2016 Sep;84(3):174-81. doi: 10.1111/sji.12454.


Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis.

Pilely K, Rosbjerg A, Genster N, Gal P, Pál G, Halvorsen B, Holm S, Aukrust P, Bakke SS, Sporsheim B, Nervik I, Niyonzima N, Bartels ED, Stahl GL, Mollnes TE, Espevik T, Garred P.

J Immunol. 2016 Jun 15;196(12):5064-74. doi: 10.4049/jimmunol.1502595. Epub 2016 May 16.


Pentraxin-3 as a marker of disease severity and risk of death in patients with necrotizing soft tissue infections: a nationwide, prospective, observational study.

Hansen MB, Rasmussen LS, Garred P, Bidstrup D, Madsen MB, Hyldegaard O.

Crit Care. 2016 Feb 15;20:40. doi: 10.1186/s13054-016-1210-z.


Alveolar recruitment of ficolin-3 in response to acute pulmonary inflammation in humans.

Plovsing RR, Berg RM, Munthe-Fog L, Konge L, Iversen M, Møller K, Garred P.

Immunobiology. 2016 May;221(5):690-7. doi: 10.1016/j.imbio.2015.11.015. Epub 2016 Feb 1.


Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke.

Zangari R, Zanier ER, Torgano G, Bersano A, Beretta S, Beghi E, Casolla B, Checcarelli N, Lanfranconi S, Maino A, Mandelli C, Micieli G, Orzi F, Picetti E, Silvestrini M, Stocchetti N, Zecca B, Garred P, De Simoni MG; LEPAS group.

J Neuroinflammation. 2016 Jan 20;13:16. doi: 10.1186/s12974-016-0481-2.


The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation.

Kozarcanin H, Lood C, Munthe-Fog L, Sandholm K, Hamad OA, Bengtsson AA, Skjoedt MO, Huber-Lang M, Garred P, Ekdahl KN, Nilsson B.

J Thromb Haemost. 2016 Mar;14(3):531-45. doi: 10.1111/jth.13208. Epub 2016 Feb 15.


The Levels of the Lectin Pathway Serine Protease MASP-1 and Its Complex Formation with C1 Inhibitor Are Linked to the Severity of Hereditary Angioedema.

Hansen CB, Csuka D, Munthe-Fog L, Varga L, Farkas H, Hansen KM, Koch C, Skjødt K, Garred P, Skjoedt MO.

J Immunol. 2015 Oct 15;195(8):3596-604. doi: 10.4049/jimmunol.1402838. Epub 2015 Sep 14.


HIV-1 Disease Progression and Survival in an Adult Population in Zimbabwe: Is There an Effect of the Mannose Binding Lectin Deficiency?

Zinyama-Gutsire RB, Chasela C, Kallestrup P, Rusakaniko S, Christiansen M, Ngara B, Gomo E, Ullum H, Erikstrup C, Madsen HO, Stray-Pedersen B, Garred P, Mduluza T.

OMICS. 2015 Sep;19(9):542-52. doi: 10.1089/omi.2015.0047.


The Lectin Pathway of Complement and Biocompatibility.

Hein E, Garred P.

Adv Exp Med Biol. 2015;865:77-92. doi: 10.1007/978-3-319-18603-0_5. Review.


Soluble Collectin-12 (CL-12) Is a Pattern Recognition Molecule Initiating Complement Activation via the Alternative Pathway.

Ma YJ, Hein E, Munthe-Fog L, Skjoedt MO, Bayarri-Olmos R, Romani L, Garred P.

J Immunol. 2015 Oct 1;195(7):3365-73. doi: 10.4049/jimmunol.1500493. Epub 2015 Aug 19.


Genetically engineered fusion of MAP-1 and factor H domains 1-5 generates a potent dual upstream inhibitor of both the lectin and alternative complement pathways.

Nordmaj MA, Munthe-Fog L, Hein E, Skjoedt MO, Garred P.

FASEB J. 2015 Dec;29(12):4945-55. doi: 10.1096/fj.15-277103. Epub 2015 Aug 10.


A Metalloproteinase Mirolysin of Tannerella forsythia Inhibits All Pathways of the Complement System.

Jusko M, Potempa J, Mizgalska D, Bielecka E, Ksiazek M, Riesbeck K, Garred P, Eick S, Blom AM.

J Immunol. 2015 Sep 1;195(5):2231-40. doi: 10.4049/jimmunol.1402892. Epub 2015 Jul 24.


Systemic and Ocular Long Pentraxin 3 in Patients with Age-Related Macular Degeneration.

Juel HB, Faber C, Munthe-Fog L, Bastrup-Birk S, Reese-Petersen AL, Falk MK, Singh A, Sørensen TL, Garred P, Nissen MH.

PLoS One. 2015 Jul 15;10(7):e0132800. doi: 10.1371/journal.pone.0132800. eCollection 2015.


The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis.

Hovland A, Jonasson L, Garred P, Yndestad A, Aukrust P, Lappegård KT, Espevik T, Mollnes TE.

Atherosclerosis. 2015 Aug;241(2):480-94. doi: 10.1016/j.atherosclerosis.2015.05.038. Epub 2015 Jun 5. Review.


Studies of the binding of ficolin-2 and ficolin-3 from the complement lectin pathway to Leptospira biflexa, Pasteurella pneumotropica and Diarrheagenic Escherichia coli.

Sahagún-Ruiz A, Breda LC, Valencia MM, Elias WP, Munthe-Fog L, Garred P, Barbosa AS, Isaac L.

Immunobiology. 2015 Oct;220(10):1177-85. doi: 10.1016/j.imbio.2015.06.001. Epub 2015 Jun 4.


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