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Mapping levels of palliative care development in 198 countries: the situation in 2017.

Clark D, Baur N, Clelland D, Garralda E, López-Fidalgo J, Connor S, Centeno C.

J Pain Symptom Manage. 2019 Nov 21. pii: S0885-3924(19)30664-5. doi: 10.1016/j.jpainsymman.2019.11.009. [Epub ahead of print]


Capturing Hyperprogressive disease with immune checkpoint inhibitors using RECIST 1.1 criteria.

Matos I, Martin-Liberal J, Garcia-Ruiz A, Hierro C, Ochoa de Olza M, Viaplana C, Azaro A, Vieito M, Brana I, Mur G, Ros J, Mateos J, Villacampa G, Berché R, Oliveira M, Alsina M, Élez E, Oaknin A, Muñoz-Couselo E, Carles J, Felip E, Rodon J, Tabernero J, Dienstmann R, Perez-Lopez R, Garralda E.

Clin Cancer Res. 2019 Nov 22. pii: clincanres.2226.2019. doi: 10.1158/1078-0432.CCR-19-2226. [Epub ahead of print]


Recalibrating the 'world map' of palliative care development.

Baur N, Centeno C, Garralda E, Connor S, Clark D.

Version 2. Wellcome Open Res. 2019 Aug 16 [revised 2019 Jan 1];4:77. doi: 10.12688/wellcomeopenres.15109.2. eCollection 2019.


Early-drug development in the era of immuno-oncology: are we ready to face the challenges?

de Olza MO, Oliva M, Hierro C, Matos I, Martin-Liberal J, Garralda E.

Ann Oncol. 2019 Oct 1;30(10):1670. doi: 10.1093/annonc/mdz211. No abstract available.


LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy.

Pascual-García M, Bonfill-Teixidor E, Planas-Rigol E, Rubio-Perez C, Iurlaro R, Arias A, Cuartas I, Sala-Hojman A, Escudero L, Martínez-Ricarte F, Huber-Ruano I, Nuciforo P, Pedrosa L, Marques C, Braña I, Garralda E, Vieito M, Squatrito M, Pineda E, Graus F, Espejo C, Sahuquillo J, Tabernero J, Seoane J.

Nat Commun. 2019 Jun 11;10(1):2416. doi: 10.1038/s41467-019-10369-9.


Consensus Building on Health Indicators to Assess PC Global Development With an International Group of Experts.

Arias-Casais N, Garralda E, López-Fidalgo J, Rhee JY, Pons JJ, de Lima L, Centeno C.

J Pain Symptom Manage. 2019 Sep;58(3):445-453.e1. doi: 10.1016/j.jpainsymman.2019.04.024. Epub 2019 Jun 1.


Feasibility and Acceptability of Methods to Collect Follow-Up Information From Parents 12 Months After Their Child's Emergency Admission to Pediatric Intensive Care.

Pulham RA, Wray J, Feinstein Y, Brown K, Pierce C, Nadel S, Pathan N, Garralda E, Ramnarayan P.

Pediatr Crit Care Med. 2019 Apr;20(4):e199-e207. doi: 10.1097/PCC.0000000000001892.


New clinical trial designs in the era of precision medicine.

Garralda E, Dienstmann R, Piris-Giménez A, Braña I, Rodon J, Tabernero J.

Mol Oncol. 2019 Mar;13(3):549-557. doi: 10.1002/1878-0261.12465. Epub 2019 Feb 22. Review.


Agnostic-Histology Approval of New Drugs in Oncology: Are We Already There?

Hierro C, Matos I, Martin-Liberal J, Ochoa de Olza M, Garralda E.

Clin Cancer Res. 2019 Jun 1;25(11):3210-3219. doi: 10.1158/1078-0432.CCR-18-3694. Epub 2019 Jan 22. Review.


Global Palliative Care and Cross-National Comparison: How Is Palliative Care Development Assessed?

Arias N, Garralda E, De Lima L, Rhee JY, Centeno C.

J Palliat Med. 2019 May;22(5):580-590. doi: 10.1089/jpm.2018.0510. Epub 2019 Jan 7.


Innovations and changes in the ICD-11 classification of mental, behavioural and neurodevelopmental disorders.

Reed GM, First MB, Kogan CS, Hyman SE, Gureje O, Gaebel W, Maj M, Stein DJ, Maercker A, Tyrer P, Claudino A, Garralda E, Salvador-Carulla L, Ray R, Saunders JB, Dua T, Poznyak V, Medina-Mora ME, Pike KM, Ayuso-Mateos JL, Kanba S, Keeley JW, Khoury B, Krasnov VN, Kulygina M, Lovell AM, de Jesus Mari J, Maruta T, Matsumoto C, Rebello TJ, Roberts MC, Robles R, Sharan P, Zhao M, Jablensky A, Udomratn P, Rahimi-Movaghar A, Rydelius PA, Bährer-Kohler S, Watts AD, Saxena S.

World Psychiatry. 2019 Feb;18(1):3-19. doi: 10.1002/wps.20611.


A Phase I Dose-Escalation Study of Veliparib Combined with Carboplatin and Etoposide in Patients with Extensive-Stage Small Cell Lung Cancer and Other Solid Tumors.

Atrafi F, Groen HJM, Byers LA, Garralda E, Lolkema MP, Sangha RS, Viteri S, Chae YK, Camidge DR, Gabrail NY, Hu B, Tian T, Nuthalapati S, Hoening E, He L, Komarnitsky P, Calles A.

Clin Cancer Res. 2019 Jan 15;25(2):496-505. doi: 10.1158/1078-0432.CCR-18-2014. Epub 2018 Oct 16.


Palliative care teaching shapes medical undergraduate students' professional development: a scoping review.

Noguera A, Robledano R, Garralda E.

Curr Opin Support Palliat Care. 2018 Dec;12(4):495-503. doi: 10.1097/SPC.0000000000000402.


Gender-related challenges facing oncologists: the results of the ESMO Women for Oncology Committee survey.

Banerjee S, Dafni U, Allen T, Arnold D, Curigliano G M.D, Garralda E, Garassino MC, Haanen J, Hofstädter-Thalmann E, Robert C, Sessa C, Tsourti Z, Zygoura P, Peters S.

ESMO Open. 2018 Sep 21;3(6):e000422. doi: 10.1136/esmoopen-2018-000422. eCollection 2018.


Report on the status of women occupying leadership roles in oncology.

Hofstädter-Thalmann E, Dafni U, Allen T, Arnold D, Banerjee S, Curigliano G M.D, Garralda E, Garassino MC, Haanen J, Robert C, Sessa C, Tsourti Z, Zygoura P, Peters S.

ESMO Open. 2018 Sep 21;3(6):e000423. doi: 10.1136/esmoopen-2018-000423. eCollection 2018.


Documento de Posición Oficial sobre la Promoción Global de Cuidados Paliativos: Recomendaciones del Grupo Internacional Asesor PAL-LIFE de la Academia Pontificia de la Vida, Ciudad del Vaticano.

Centeno C, Sitte T, de Lima L, Alsirafy S, Bruera E, Callaway M, Foley K, Luyirika E, Mosoiu D, Pettus K, Puchalski C, Rajagopal MR, Yong J, Garralda E, Rhee JY, Comoretto N.

J Palliat Med. 2018 Oct;21(10):1398-1407. doi: 10.1089/jpm.2018.0387. Epub 2018 Sep 26.


White Paper for Global Palliative Care Advocacy: Recommendations from a PAL-LIFE Expert Advisory Group of the Pontifical Academy for Life, Vatican City.

Centeno C, Sitte T, de Lima L, Alsirafy S, Bruera E, Callaway M, Foley K, Luyirika E, Mosoiu D, Pettus K, Puchalski C, Rajagopal MR, Yong J, Garralda E, Rhee JY, Comoretto N.

J Palliat Med. 2018 Oct;21(10):1389-1397. doi: 10.1089/jpm.2018.0248. Epub 2018 Sep 26.


How Do Experienced Professors Teach Palliative Medicine in European Universities? A Cross-Case Analysis of Eight Undergraduate Educational Programs.

Noguera A, Bolognesi D, Garralda E, Beccaro M, Kotlinska-Lemieszek A, Furst CJ, Ellershaw J, Elsner F, Csikos A, Filbet M, Biasco G, Centeno C.

J Palliat Med. 2018 Nov;21(11):1621-1626. doi: 10.1089/jpm.2018.0071. Epub 2018 Jul 9.


Dynamic Angiogenic Switch as Predictor of Response to Chemotherapy-Bevacizumab in Patients With Metastatic Colorectal Cancer.

Cubillo A, Álvarez-Gallego R, Muñoz M, Pond G, Perea S, Sánchez G, Martin M, Rodríguez-Pascual J, Garralda E, Vega E, de Vicente E, Quijano Y, Muñoz C, Ugidos L, Toledo RA, Hidalgo M.

Am J Clin Oncol. 2019 Jan;42(1):56-59. doi: 10.1097/COC.0000000000000474.


Early-drug development in the era of immuno-oncology: are we ready to face the challenges?

Ochoa de Olza M, Oliva M, Hierro C, Matos I, Martin-Liberal J, Garralda E.

Ann Oncol. 2018 Aug 1;29(8):1727-1740. doi: 10.1093/annonc/mdy225.


An Analysis of Palliative Care Development in Africa: A Ranking Based on Region-Specific Macroindicators.

Rhee JY, Garralda E, Namisango E, Luyirika E, de Lima L, Powell RA, López-Fidalgo J, Centeno C.

J Pain Symptom Manage. 2018 Aug;56(2):230-238. doi: 10.1016/j.jpainsymman.2018.05.005. Epub 2018 May 22.


Precision Targeted Therapy with BLU-667 for RET-Driven Cancers.

Subbiah V, Gainor JF, Rahal R, Brubaker JD, Kim JL, Maynard M, Hu W, Cao Q, Sheets MP, Wilson D, Wilson KJ, DiPietro L, Fleming P, Palmer M, Hu MI, Wirth L, Brose MS, Ou SI, Taylor M, Garralda E, Miller S, Wolf B, Lengauer C, Guzi T, Evans EK.

Cancer Discov. 2018 Jul;8(7):836-849. doi: 10.1158/2159-8290.CD-18-0338. Epub 2018 Apr 15.


Exome Sequencing of Plasma DNA Portrays the Mutation Landscape of Colorectal Cancer and Discovers Mutated VEGFR2 Receptors as Modulators of Antiangiogenic Therapies.

Toledo RA, Garralda E, Mitsi M, Pons T, Monsech J, Vega E, Otero Á, Albarran MI, Baños N, Durán Y, Bonilla V, Sarno F, Camacho-Artacho M, Sanchez-Perez T, Perea S, Álvarez R, De Martino A, Lietha D, Blanco-Aparicio C, Cubillo A, Domínguez O, Martínez-Torrecuadrada JL, Hidalgo M.

Clin Cancer Res. 2018 Aug 1;24(15):3550-3559. doi: 10.1158/1078-0432.CCR-18-0103. Epub 2018 Mar 27.


Factors Affecting Palliative Care Development in Africa: In-Country Experts' Perceptions in Seven Countries.

Rhee JY, Garralda E, Namisango E, Luyirika E, de Lima L, Powell RA, Robinson CA, Centeno C.

J Pain Symptom Manage. 2018 May;55(5):1313-1320.e2. doi: 10.1016/j.jpainsymman.2018.01.009. Epub 2018 Feb 2.


First-in-Human Phase I Study of Single-agent Vanucizumab, A First-in-Class Bispecific Anti-Angiopoietin-2/Anti-VEGF-A Antibody, in Adult Patients with Advanced Solid Tumors.

Hidalgo M, Martinez-Garcia M, Le Tourneau C, Massard C, Garralda E, Boni V, Taus A, Albanell J, Sablin MP, Alt M, Bahleda R, Varga A, Boetsch C, Franjkovic I, Heil F, Lahr A, Lechner K, Morel A, Nayak T, Rossomanno S, Smart K, Stubenrauch K, Krieter O.

Clin Cancer Res. 2018 Apr 1;24(7):1536-1545. doi: 10.1158/1078-0432.CCR-17-1588. Epub 2017 Dec 7.


Developing Macroindicators of Palliative Care Development in Africa: A Process with In-Country and International Experts.

Rhee JY, Garralda E, Namisango E, Luyirika E, de Lima L, Powell RA, Centeno C.

J Palliat Med. 2018 Mar;21(3):342-353. doi: 10.1089/jpm.2017.0207. Epub 2017 Oct 13.


What does the media say about palliative care? A descriptive study of news coverage in written media in Spain.

Carrasco JM, García M, Navas A, Olza I, Gómez-Baceiredo B, Pujol F, Garralda E, Centeno C.

PLoS One. 2017 Oct 2;12(10):e0184806. doi: 10.1371/journal.pone.0184806. eCollection 2017.


Palliative care in Africa: a scoping review from 2005-16.

Rhee JY, Garralda E, Torrado C, Blanco S, Ayala I, Namisango E, Luyirika E, de Lima L, Powell RA, Centeno C.

Lancet Oncol. 2017 Sep;18(9):e522-e531. doi: 10.1016/S1470-2045(17)30420-5. Review.


Publications on Palliative Care Development Can Be Used as an Indicator of Palliative Care Development in Africa.

Rhee JY, Garralda E, Torrado C, Blanco S, Ayala I, Namisango E, Luyirika E, de Lima L, Powell RA, López-Fidalgo J, Centeno C.

J Palliat Med. 2017 Dec;20(12):1372-1377. doi: 10.1089/jpm.2017.0168. Epub 2017 Jun 29. Review.


Pharmacokinetic/Pharmacodynamic Modeling for Drug Development in Oncology.

Garralda E, Dienstmann R, Tabernero J.

Am Soc Clin Oncol Educ Book. 2017;37:210-215. doi: 10.14694/EDBK_180460. Review.


The Palliative Care Challenge: Analysis of Barriers and Opportunities to Integrate Palliative Care in Europe in the View of National Associations.

Centeno C, Garralda E, Carrasco JM, den Herder-van der Eerden M, Aldridge M, Stevenson D, Meier DE, Hasselaar J.

J Palliat Med. 2017 Nov;20(11):1195-1204. doi: 10.1089/jpm.2017.0039. Epub 2017 May 16.


Clinical validation of prospective liquid biopsy monitoring in patients with wild-type RAS metastatic colorectal cancer treated with FOLFIRI-cetuximab.

Toledo RA, Cubillo A, Vega E, Garralda E, Alvarez R, de la Varga LU, Pascual JR, Sánchez G, Sarno F, Prieto SH, Perea S, Lopéz-Casas PP, López-Ríos F, Hidalgo M.

Oncotarget. 2017 May 23;8(21):35289-35300. doi: 10.18632/oncotarget.13311.


Integrated palliative care in Europe: a qualitative systematic literature review of empirically-tested models in cancer and chronic disease.

Siouta N, Van Beek K, van der Eerden ME, Preston N, Hasselaar JG, Hughes S, Garralda E, Centeno C, Csikos A, Groot M, Radbruch L, Payne S, Menten J.

BMC Palliat Care. 2016 Jul 8;15:56. doi: 10.1186/s12904-016-0130-7. Review.


Ranking of Palliative Care Development in the Countries of the European Union.

Woitha K, Garralda E, Martin-Moreno JM, Clark D, Centeno C.

J Pain Symptom Manage. 2016 Sep;52(3):370-7. doi: 10.1016/j.jpainsymman.2016.03.008. Epub 2016 Jun 7.


Integrated palliative care in the Spanish context: a systematic review of the literature.

Garralda E, Hasselaar J, Carrasco JM, Van Beek K, Siouta N, Csikos A, Menten J, Centeno C.

BMC Palliat Care. 2016 May 13;15:49. doi: 10.1186/s12904-016-0120-9. Review.


To what degree is palliative care integrated in guidelines and pathways for adult cancer patients in Europe: a systematic literature review.

Van Beek K, Siouta N, Preston N, Hasselaar J, Hughes S, Payne S, Radbruch L, Centeno C, Csikos A, Garralda E, van der Eerden M, Hodiamont F, Radvanyi I, Menten J.

BMC Palliat Care. 2016 Mar 3;15:26. doi: 10.1186/s12904-016-0100-0. Review.


Towards integration of palliative care in patients with chronic heart failure and chronic obstructive pulmonary disease: a systematic literature review of European guidelines and pathways.

Siouta N, van Beek K, Preston N, Hasselaar J, Hughes S, Payne S, Garralda E, Centeno C, van der Eerden M, Groot M, Hodiamont F, Radbruch L, Busa C, Csikos A, Menten J.

BMC Palliat Care. 2016 Feb 13;15:18. doi: 10.1186/s12904-016-0089-4. Review.


Policy on palliative care in the WHO European region: an overview of progress since the Council of Europe's (2003) recommendation 24.

Woitha K, Carrasco JM, Clark D, Lynch T, Garralda E, Martin-Moreno JM, Centeno C.

Eur J Public Health. 2016 Apr;26(2):230-5. doi: 10.1093/eurpub/ckv201. Epub 2015 Nov 6. Review.


Education, implementation, and policy barriers to greater integration of palliative care: A literature review.

Aldridge MD, Hasselaar J, Garralda E, van der Eerden M, Stevenson D, McKendrick K, Centeno C, Meier DE.

Palliat Med. 2016 Mar;30(3):224-39. doi: 10.1177/0269216315606645. Epub 2015 Sep 24. Review.


Coverage and development of specialist palliative care services across the World Health Organization European Region (2005-2012): Results from a European Association for Palliative Care Task Force survey of 53 Countries.

Centeno C, Lynch T, Garralda E, Carrasco JM, Guillen-Grima F, Clark D.

Palliat Med. 2016 Apr;30(4):351-62. doi: 10.1177/0269216315598671. Epub 2015 Jul 31.


Palliative Care Medical Education in European Universities: A Descriptive Study and Numerical Scoring System Proposal for Assessing Educational Development.

Carrasco JM, Lynch TJ, Garralda E, Woitha K, Elsner F, Filbet M, Ellershaw JE, Clark D, Centeno C.

J Pain Symptom Manage. 2015 Oct;50(4):516-23.e2. doi: 10.1016/j.jpainsymman.2015.04.019. Epub 2015 May 27.


Comprehensive assessment of the disputed RET Y791F variant shows no association with medullary thyroid carcinoma susceptibility.

Toledo RA, Hatakana R, Lourenço DM Jr, Lindsey SC, Camacho CP, Almeida M, Lima JV Jr, Sekiya T, Garralda E, Naslavsky MS, Yamamoto GL, Lazar M, Meirelles O, Sobreira TJ, Lebrao ML, Duarte YA, Blangero J, Zatz M, Cerutti JM, Maciel RM, Toledo SP.

Endocr Relat Cancer. 2015 Feb;22(1):65-76. doi: 10.1530/ERC-14-0491. Epub 2014 Nov 25.


Integrated next-generation sequencing and avatar mouse models for personalized cancer treatment.

Garralda E, Paz K, López-Casas PP, Jones S, Katz A, Kann LM, López-Rios F, Sarno F, Al-Shahrour F, Vasquez D, Bruckheimer E, Angiuoli SV, Calles A, Diaz LA, Velculescu VE, Valencia A, Sidransky D, Hidalgo M.

Clin Cancer Res. 2014 May 1;20(9):2476-84. doi: 10.1158/1078-0432.CCR-13-3047. Epub 2014 Mar 14.


Level of HER2 gene amplification predicts response and overall survival in HER2-positive advanced gastric cancer treated with trastuzumab.

Gomez-Martin C, Plaza JC, Pazo-Cid R, Salud A, Pons F, Fonseca P, Leon A, Alsina M, Visa L, Rivera F, Galan MC, Del Valle E, Vilardell F, Iglesias M, Fernandez S, Landolfi S, Cuatrecasas M, Mayorga M, Jose Paulés M, Sanz-Moncasi P, Montagut C, Garralda E, Rojo F, Hidalgo M, Lopez-Rios F.

J Clin Oncol. 2013 Dec 10;31(35):4445-52. doi: 10.1200/JCO.2013.48.9070. Epub 2013 Oct 14.


Incidence and 12-month outcome of non-transient childhood conversion disorder in the U.K. and Ireland.

Ani C, Reading R, Lynn R, Forlee S, Garralda E.

Br J Psychiatry. 2013 Jun;202:413-8. doi: 10.1192/bjp.bp.112.116707. Epub 2013 Apr 25.


A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C.

Sangro B, Gomez-Martin C, de la Mata M, Iñarrairaegui M, Garralda E, Barrera P, Riezu-Boj JI, Larrea E, Alfaro C, Sarobe P, Lasarte JJ, Pérez-Gracia JL, Melero I, Prieto J.

J Hepatol. 2013 Jul;59(1):81-8. doi: 10.1016/j.jhep.2013.02.022. Epub 2013 Mar 4.


HER2/neu testing for anti-HER2-based therapies in patients with unresectable and/or metastatic gastric cancer.

Gómez-Martin C, Garralda E, Echarri MJ, Ballesteros A, Arcediano A, Rodríguez-Peralto JL, Hidalgo M, López-Ríos F.

J Clin Pathol. 2012 Aug;65(8):751-7. doi: 10.1136/jclinpath-2012-200774. Epub 2012 May 8.


Efficacy and safety of sorafenib in combination with mammalian target of rapamycin inhibitors for recurrent hepatocellular carcinoma after liver transplantation.

Gomez-Martin C, Bustamante J, Castroagudin JF, Salcedo M, Garralda E, Testillano M, Herrero I, Matilla A, Sangro B.

Liver Transpl. 2012 Jan;18(1):45-52. doi: 10.1002/lt.22434.


Child involvement in the paediatric consultation: a qualitative study of children and carers' views.

Taylor S, Haase-Casanovas S, Weaver T, Kidd J, Garralda EM.

Child Care Health Dev. 2010 Sep;36(5):678-85. doi: 10.1111/j.1365-2214.2010.01076.x. Epub 2010 Mar 9.


Depression in adolescents. Collaboration to overcome barriers in primary care.

Kramer T, Iliffe S, Miller L, Gledhill J, Garralda E.

BMJ. 2010 Feb 16;340:c908. doi: 10.1136/bmj.c908. No abstract available.


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