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Items: 1 to 50 of 71


A randomized, proof-of-concept clinical trial on repurposing chlorcyclizine for the treatment of chronic hepatitis C.

Koh C, Dubey P, Han MAT, Walter PJ, Garraffo HM, Surana P, Southall NT, Borochov N, Uprichard SL, Cotler SJ, Etzion O, Heller T, Dahari H, Liang TJ.

Antiviral Res. 2019 Mar;163:149-155. doi: 10.1016/j.antiviral.2019.01.017. Epub 2019 Jan 31.


Gluconeogenesis and risk for fasting hyperglycemia in Black and White women.

Chung ST, Courville AB, Onuzuruike AU, Galvan-De La Cruz M, Mabundo LS, DuBose CW, Kasturi K, Cai H, Gharib AM, Walter PJ, Garraffo HM, Chacko S, Haymond MW, Sumner AE.

JCI Insight. 2018 Sep 20;3(18). pii: 121495. doi: 10.1172/jci.insight.121495. eCollection 2018 Sep 20.


Regulation of Human Adipose Tissue Activation, Gallbladder Size, and Bile Acid Metabolism by a β3-Adrenergic Receptor Agonist.

Baskin AS, Linderman JD, Brychta RJ, McGehee S, Anflick-Chames E, Cero C, Johnson JW, O'Mara AE, Fletcher LA, Leitner BP, Duckworth CJ, Huang S, Cai H, Garraffo HM, Millo CM, Dieckmann W, Tolstikov V, Chen EY, Gao F, Narain NR, Kiebish MA, Walter PJ, Herscovitch P, Chen KY, Cypess AM.

Diabetes. 2018 Oct;67(10):2113-2125. doi: 10.2337/db18-0462. Epub 2018 Jul 6.


Metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy.

Brown RJ, Valencia A, Startzell M, Cochran E, Walter PJ, Garraffo HM, Cai H, Gharib AM, Ouwerkerk R, Courville AB, Bernstein S, Brychta RJ, Chen KY, Walter M, Auh S, Gorden P.

J Clin Invest. 2018 Aug 1;128(8):3504-3516. doi: 10.1172/JCI95476. Epub 2018 Jul 16.


Pharmacokinetics of Sucralose and Acesulfame-Potassium in Breast Milk Following Ingestion of Diet Soda.

Rother KI, Sylvetsky AC, Walter PJ, Garraffo HM, Fields DA.

J Pediatr Gastroenterol Nutr. 2018 Mar;66(3):466-470. doi: 10.1097/MPG.0000000000001817.


Plasma concentrations of sucralose in children and adults.

Sylvetsky AC, Bauman V, Blau JE, Garraffo HM, Walter PJ, Rother KI.

Toxicol Environ Chem. 2017;99(3):535-542. doi: 10.1080/02772248.2016.1234754. Epub 2016 Oct 17.


Widespread sucralose exposure in a randomized clinical trial in healthy young adults.

Sylvetsky AC, Walter PJ, Garraffo HM, Robien K, Rother KI.

Am J Clin Nutr. 2017 Apr;105(4):820-823. doi: 10.3945/ajcn.116.144402. Epub 2017 Feb 22.


A role for muscarinic receptors in neutrophil extracellular trap formation and levamisole-induced autoimmunity.

Carmona-Rivera C, Purmalek MM, Moore E, Waldman M, Walter PJ, Garraffo HM, Phillips KA, Preston KL, Graf J, Kaplan MJ, Grayson PC.

JCI Insight. 2017 Feb 9;2(3):e89780. doi: 10.1172/jci.insight.89780.


Individual and Geographic Variation of Skin Alkaloids in Three Swamp-Forest Species of Madagascan Poison Frogs (Mantella).

Andriamaharavo NR, Garraffo HM, Spande TF, Giddings LA, Vieites DR, Vences M, Saporito RA.

J Chem Ecol. 2015 Sep;41(9):837-47. doi: 10.1007/s10886-015-0616-4. Epub 2015 Sep 2.


Nonnutritive Sweeteners in Breast Milk.

Sylvetsky AC, Gardner AL, Bauman V, Blau JE, Garraffo HM, Walter PJ, Rother KI.

J Toxicol Environ Health A. 2015;78(16):1029-32. doi: 10.1080/15287394.2015.1053646. Epub 2015 Aug 12.


Molecular mechanisms of hypoxic responses via unique roles of Ras1, Cdc24 and Ptp3 in a human fungal pathogen Cryptococcus neoformans.

Chang YC, Khanal Lamichhane A, Garraffo HM, Walter PJ, Leerkes M, Kwon-Chung KJ.

PLoS Genet. 2014 Apr 24;10(4):e1004292. doi: 10.1371/journal.pgen.1004292. eCollection 2014 Apr.


Alkaloids from single skins of the Argentinian toad Melanophryniscus rubriventris (ANURA, BUFONIDAE): An unexpected variability in alkaloid profiles and a profusion of new structures.

Garraffo HM, Andriamaharavo NR, Vaira M, Quiroga MF, Heit C, Spande TF.

Springerplus. 2012 Nov 23;1(1):51. doi: 10.1186/2193-1801-1-51. Print 2012 Dec.


Histrionicotoxin alkaloids finally detected in an ant.

Jones TH, Adams RM, Spande TF, Garraffo HM, Kaneko T, Schultz TR.

J Nat Prod. 2012 Nov 26;75(11):1930-6. doi: 10.1021/np300485v. Epub 2012 Oct 22.


Involvement of PDK1, PKC and TOR signalling pathways in basal fluconazole tolerance in Cryptococcus neoformans.

Lee H, Khanal Lamichhane A, Garraffo HM, Kwon-Chung KJ, Chang YC.

Mol Microbiol. 2012 Apr;84(1):130-46. doi: 10.1111/j.1365-2958.2012.08016.x. Epub 2012 Mar 15.


Identification of a Cryptococcus neoformans cytochrome P450 lanosterol 14α-demethylase (Erg11) residue critical for differential susceptibility between fluconazole/voriconazole and itraconazole/posaconazole.

Sionov E, Chang YC, Garraffo HM, Dolan MA, Ghannoum MA, Kwon-Chung KJ.

Antimicrob Agents Chemother. 2012 Mar;56(3):1162-9. doi: 10.1128/AAC.05502-11. Epub 2011 Dec 12.


Alkaloids in the mite Scheloribates laevigatus: further alkaloids common to oribatid mites and poison frogs.

Saporito RA, Norton RA, Andriamaharavo NR, Garraffo HM, Spande TF.

J Chem Ecol. 2011 Feb;37(2):213-8. doi: 10.1007/s10886-011-9914-7. Epub 2011 Feb 12.


Phantasmidine: an epibatidine congener from the ecuadorian poison frog Epipedobates anthonyi.

Fitch RW, Spande TF, Garraffo HM, Yeh HJ, Daly JW.

J Nat Prod. 2010 Mar 26;73(3):331-7. doi: 10.1021/np900727e.


Roughing it: a mantellid poison frog shows greater alkaloid diversity in some disturbed habitats.

Andriamaharavo NR, Garraffo HM, Saporito RA, Daly JW, Razafindrabe CR, Andriantsiferana M, Spande TF.

J Nat Prod. 2010 Mar 26;73(3):322-30. doi: 10.1021/np900721r.


Caste-specific tyramides from Myrmicine ants.

Jones TH, Garraffo HM, Spande TF, Andriamaharavo NR, Gorman JS, Snyder AJ, Jeter AW, Torres JA, Snelling RR, Daly JW.

J Nat Prod. 2010 Mar 26;73(3):313-6. doi: 10.1021/np900697s.


Sex-related differences in alkaloid chemical defenses of the dendrobatid frog Oophaga pumilio from Cayo Nancy, Bocas del Toro, Panama.

Saporito RA, Donnelly MA, Madden AA, Garraffo HM, Spande TF.

J Nat Prod. 2010 Mar 26;73(3):317-21. doi: 10.1021/np900702d.


Efficient enantio- and diastereodivergent synthesis of poison-frog alkaloids 251O and trans-223B.

Toyooka N, Zhou D, Nemoto H, Tezuka Y, Kadota S, Andriamaharavo NR, Garraffo HM, Spande TF, Daly JW.

J Org Chem. 2009 Sep 4;74(17):6784-91. doi: 10.1021/jo901100m.


N-methyldecahydroquinolines: an unexpected class of alkaloids from Amazonian poison frogs (Dendrobatidae).

Daly JW, Ware N, Saporito RA, Spande TF, Garraffo HM.

J Nat Prod. 2009 Jun;72(6):1110-4. doi: 10.1021/np900094v.


Heteroresistance to fluconazole in Cryptococcus neoformans is intrinsic and associated with virulence.

Sionov E, Chang YC, Garraffo HM, Kwon-Chung KJ.

Antimicrob Agents Chemother. 2009 Jul;53(7):2804-15. doi: 10.1128/AAC.00295-09. Epub 2009 May 4.


Epiquinamide: a poison that wasn't from a frog that was.

Fitch RW, Sturgeon GD, Patel SR, Spande TF, Garraffo HM, Daly JW, Blaauw RH.

J Nat Prod. 2009 Feb 27;72(2):243-7. doi: 10.1021/np8005452.


Indolizidine 239Q and quinolizidine 275I. Major alkaloids in two Argentinian bufonid toads (Melanophryniscus).

Daly JW, Garraffo HM, Spande TF, Yeh HJ, Peltzer PM, Cacivio PM, Baldo JD, Faivovich J.

Toxicon. 2008 Dec 15;52(8):858-70. doi: 10.1016/j.toxicon.2008.08.016. Epub 2008 Sep 20.


John William Daly, 1933-2008.

Garraffo HM.

Cell Mol Neurobiol. 2009 Jun;29(4):439-40. doi: 10.1007/s10571-008-9280-3. Epub 2008 Apr 11. No abstract available.


Facile synthesis of two diastereomeric indolizidines corresponding to the postulated structure of alkaloid 5,9E-259B from a Bufonid toad (Melanophryniscus).

Nelson A, Garraffo HM, Spande TF, Daly JW, Stevenson PJ.

Beilstein J Org Chem. 2008 Jan 21;4:6. doi: 10.1186/1860-5397-4-6.


Individual and geographic variation of skin alkaloids in three species of Madagascan poison frogs (Mantella).

Daly JW, Garraffo HM, Spande TF, Giddings LA, Saporito RA, Vieites DR, Vences M.

J Chem Ecol. 2008 Feb;34(2):252-79. doi: 10.1007/s10886-007-9396-9. Epub 2008 Jan 15.


Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptors.

Toyooka N, Kobayashi S, Zhou D, Tsuneki H, Wada T, Sakai H, Nemoto H, Sasaoka T, Garraffo HM, Spande TF, Daly JW.

Bioorg Med Chem Lett. 2007 Nov 1;17(21):5872-5. Epub 2007 Aug 26.


Oribatid mites as a major dietary source for alkaloids in poison frogs.

Saporito RA, Donnelly MA, Norton RA, Garraffo HM, Spande TF, Daly JW.

Proc Natl Acad Sci U S A. 2007 May 22;104(21):8885-90. Epub 2007 May 14. Erratum in: Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17586.


Alkaloids in bufonid toads (melanophryniscus): temporal and geographic determinants for two argentinian species.

Daly JW, Wilham JM, Spande TF, Garraffo HM, Gil RR, Silva GL, Vaira M.

J Chem Ecol. 2007 Apr;33(4):871-87. Epub 2007 Feb 28.


Venom chemistry of the ant Myrmicaria melanogaster from Brunei.

Jones TH, Voegtle HL, Miras HM, Weatherford RG, Spande TF, Garraffo HM, Daly JW, Davidson DW, Snelling RR.

J Nat Prod. 2007 Feb;70(2):160-8. Epub 2007 Jan 23.


Flexible synthesis of poison-frog alkaloids of the 5,8-disubstituted indolizidine-class. II: Synthesis of (-)-209B, (-)-231C, (-)-233D, (-)-235B", (-)-221I, and an epimer of 193E and pharmacological effects at neuronal nicotinic acetylcholine receptors.

Kobayashi S, Toyooka N, Zhou D, Tsuneki H, Wada T, Sasaoka T, Sakai H, Nemoto H, Garraffo HM, Spande TF, Daly JW.

Beilstein J Org Chem. 2007;3:30. doi: 10.1186/1860-5397-3-30. Epub 2007 Sep 28.


Geographic and seasonal variation in alkaloid-based chemical defenses of Dendrobates pumilio from Bocas del Toro, Panama.

Saporito RA, Donnelly MA, Garraffo HM, Spande TF, Daly JW.

J Chem Ecol. 2006 Apr;32(4):795-814. Epub 2006 May 5.


Alkaloids of anuran skin: antimicrobial function?

Macfoy C, Danosus D, Sandit R, Jones TH, Garraffo HM, Spande TF, Daly JW.

Z Naturforsch C. 2005 Nov-Dec;60(11-12):932-7.


A revised structure for alkaloid 235C isolated from skin extracts of mantellid (Mantella) frogs of Madagascar.

Andriamaharavo NR, Andriantsiferana M, Stevenson PA, O'mahony G, Yeh HJ, Kaneko T, Garraffo HM, Spande TF, Daly JW.

J Nat Prod. 2005 Dec;68(12):1743-8.


Alkaloids from amphibian skin: a tabulation of over eight-hundred compounds.

Daly JW, Spande TF, Garraffo HM.

J Nat Prod. 2005 Oct;68(10):1556-75. Review.


Biologically active substances from amphibians: preliminary studies on anurans from twenty-one genera of Thailand.

Daly JW, Noimai N, Kongkathip B, Kongkathip N, Wilham JM, Garraffo HM, Kaneko T, Spande TF, Nimit Y, Nabhitabhata J, Chan-Ard T.

Toxicon. 2004 Dec 15;44(8):805-15.


Formicine ants: An arthropod source for the pumiliotoxin alkaloids of dendrobatid poison frogs.

Saporito RA, Garraffo HM, Donnelly MA, Edwards AL, Longino JT, Daly JW.

Proc Natl Acad Sci U S A. 2004 May 25;101(21):8045-50. Epub 2004 May 5.


A siphonotid millipede (Rhinotus) as the source of spiropyrrolizidine oximes of dendrobatid frogs.

Saporito RA, Donnelly MA, Hoffman RL, Garraffo HM, Daly JW.

J Chem Ecol. 2003 Dec;29(12):2781-6.


Evidence for an enantioselective pumiliotoxin 7-hydroxylase in dendrobatid poison frogs of the genus Dendrobates.

Daly JW, Garraffo HM, Spande TF, Clark VC, Ma J, Ziffer H, Cover JF Jr.

Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11092-7. Epub 2003 Sep 5.


Bioactive alkaloids of frog skin: combinatorial bioprospecting reveals that pumiliotoxins have an arthropod source.

Daly JW, Kaneko T, Wilham J, Garraffo HM, Spande TF, Espinosa A, Donnelly MA.

Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):13996-4001. Epub 2002 Oct 14.


Synthesis of alkaloid 223A and a structural revision.

Toyooka N, Fukutome A, Nemoto H, Daly JW, Spande TF, Garraffo HM, Kaneko T.

Org Lett. 2002 May 16;4(10):1715-7.


Ammonia chemical ionization tandem mass spectrometry in structural determination of alkaloids. II. Tetraponerines from pseudomyrmecine ants.

Garraffo HM, Spande TF, Jain P, Kaneko T, Jones TH, Blum MS, Ali TM, Snelling RR, Isbell LA, Robertson HG, Daly JW.

Rapid Commun Mass Spectrom. 2001;15(16):1409-15.


Structure of alkaloid 275A, a novel 1-azabicyclo[5.3.0]decane from a dendrobatid frog, Dendrobates lehmanni: synthesis of the tetrahydrodiastereomers.

Garraffo HM, Jain P, Spande TF, Daly JW, Jones TH, Smith LJ, Zottig VE.

J Nat Prod. 2001 Apr;64(4):421-7.


Alkaloids from frog skin: the discovery of epibatidine and the potential for developing novel non-opioid analgesics.

Daly JW, Garraffo HM, Spande TF, Decker MW, Sullivan JP, Williams M.

Nat Prod Rep. 2000 Apr;17(2):131-5. Review. No abstract available.


3-methyl-4-phenylpyrrole from the ants Anochetus kempfi and Anochetus mayri.

Jones TH, Flournoy RC, Torres JA, Snelling RR, Spande TF, Garraffo HM.

J Nat Prod. 1999 Sep;62(9):1343-5.


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