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Cystathionine γ-lyase deficiency enhances airway reactivity and viral-induced disease in mice exposed to side-stream tobacco smoke.

Ivanciuc T, Sbrana E, Casola A, Garofalo RP.

Pediatr Res. 2019 Jul;86(1):39-46. doi: 10.1038/s41390-019-0396-6. Epub 2019 Apr 15.


Proinflammatory Effects of Respiratory Syncytial Virus-Induced Epithelial HMGB1 on Human Innate Immune Cell Activation.

Rayavara K, Kurosky A, Stafford SJ, Garg NJ, Brasier AR, Garofalo RP, Hosakote YM.

J Immunol. 2018 Nov 1;201(9):2753-2766. doi: 10.4049/jimmunol.1800558. Epub 2018 Oct 1.


Exchange Proteins Directly Activated by cAMP and Their Roles in Respiratory Syncytial Virus Infection.

Choi EJ, Ren Y, Chen Y, Liu S, Wu W, Ren J, Wang P, Garofalo RP, Zhou J, Bao X.

J Virol. 2018 Oct 29;92(22). pii: e01200-18. doi: 10.1128/JVI.01200-18. Print 2018 Nov 15.


Lysines and Arginines play non-redundant roles in mediating chemokine-glycosaminoglycan interactions.

Joseph PRB, Sawant KV, Iwahara J, Garofalo RP, Desai UR, Rajarathnam K.

Sci Rep. 2018 Aug 16;8(1):12289. doi: 10.1038/s41598-018-30697-y.


Protective Role of Nuclear Factor Erythroid 2-Related Factor 2 Against Respiratory Syncytial Virus and Human Metapneumovirus Infections.

Ivanciuc T, Sbrana E, Casola A, Garofalo RP.

Front Immunol. 2018 Apr 23;9:854. doi: 10.3389/fimmu.2018.00854. eCollection 2018.


Central Role of the NF-κB Pathway in the Scgb1a1-Expressing Epithelium in Mediating Respiratory Syncytial Virus-Induced Airway Inflammation.

Tian B, Yang J, Zhao Y, Ivanciuc T, Sun H, Wakamiya M, Garofalo RP, Brasier AR.

J Virol. 2018 May 14;92(11). pii: e00441-18. doi: 10.1128/JVI.00441-18. Print 2018 Jun 1.


Respiratory syncytial virus induces NRF2 degradation through a promyelocytic leukemia protein - ring finger protein 4 dependent pathway.

Komaravelli N, Ansar M, Garofalo RP, Casola A.

Free Radic Biol Med. 2017 Dec;113:494-504. doi: 10.1016/j.freeradbiomed.2017.10.380. Epub 2017 Oct 28.


Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition.

Yang J, Tian B, Sun H, Garofalo RP, Brasier AR.

Nat Microbiol. 2017 Jun 5;2:17086. doi: 10.1038/nmicrobiol.2017.86.


Hydrogen Sulfide: A Novel Player in Airway Development, Pathophysiology of Respiratory Diseases, and Antiviral Defenses.

Bazhanov N, Ansar M, Ivanciuc T, Garofalo RP, Casola A.

Am J Respir Cell Mol Biol. 2017 Oct;57(4):403-410. doi: 10.1165/rcmb.2017-0114TR. Review.


The interdependencies of viral load, the innate immune response, and clinical outcome in children presenting to the emergency department with respiratory syncytial virus-associated bronchiolitis.

Piedra FA, Mei M, Avadhanula V, Mehta R, Aideyan L, Garofalo RP, Piedra PA.

PLoS One. 2017 Mar 7;12(3):e0172953. doi: 10.1371/journal.pone.0172953. eCollection 2017.


Systematic Analysis of Cell-Type Differences in the Epithelial Secretome Reveals Insights into the Pathogenesis of Respiratory Syncytial Virus-Induced Lower Respiratory Tract Infections.

Zhao Y, Jamaluddin M, Zhang Y, Sun H, Ivanciuc T, Garofalo RP, Brasier AR.

J Immunol. 2017 Apr 15;198(8):3345-3364. doi: 10.4049/jimmunol.1601291. Epub 2017 Mar 3.


Broad-Range Antiviral Activity of Hydrogen Sulfide Against Highly Pathogenic RNA Viruses.

Bazhanov N, Escaffre O, Freiberg AN, Garofalo RP, Casola A.

Sci Rep. 2017 Jan 20;7:41029. doi: 10.1038/srep41029.


BRD4 Couples NF-κB/RelA with Airway Inflammation and the IRF-RIG-I Amplification Loop in Respiratory Syncytial Virus Infection.

Tian B, Yang J, Zhao Y, Ivanciuc T, Sun H, Garofalo RP, Brasier AR.

J Virol. 2017 Feb 28;91(6). pii: e00007-17. doi: 10.1128/JVI.00007-17. Print 2017 Mar 15.


Hydrogen Sulfide Is an Antiviral and Antiinflammatory Endogenous Gasotransmitter in the Airways. Role in Respiratory Syncytial Virus Infection.

Ivanciuc T, Sbrana E, Ansar M, Bazhanov N, Szabo C, Casola A, Garofalo RP.

Am J Respir Cell Mol Biol. 2016 Nov;55(5):684-696.


Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions.

Sawant KV, Poluri KM, Dutta AK, Sepuru KM, Troshkina A, Garofalo RP, Rajarathnam K.

Sci Rep. 2016 Sep 14;6:33123. doi: 10.1038/srep33123.


Respiratory Syncytial Virus Infection Triggers Epithelial HMGB1 Release as a Damage-Associated Molecular Pattern Promoting a Monocytic Inflammatory Response.

Hosakote YM, Brasier AR, Casola A, Garofalo RP, Kurosky A.

J Virol. 2016 Oct 14;90(21):9618-9631. doi: 10.1128/JVI.01279-16. Print 2016 Nov 1.


Robust Cytokine and Chemokine Response in Nasopharyngeal Secretions: Association With Decreased Severity in Children With Physician Diagnosed Bronchiolitis.

Nicholson EG, Schlegel C, Garofalo RP, Mehta R, Scheffler M, Mei M, Piedra PA.

J Infect Dis. 2016 Aug 15;214(4):649-55. doi: 10.1093/infdis/jiw191. Epub 2016 May 18.


The calcium-sensing receptor as a mediator of inflammation.

Klein GL, Castro SM, Garofalo RP.

Semin Cell Dev Biol. 2016 Jan;49:52-6. doi: 10.1016/j.semcdb.2015.08.006. Epub 2015 Aug 21. Review.


Chemokine CXCL1-Mediated Neutrophil Trafficking in the Lung: Role of CXCR2 Activation.

Sawant KV, Xu R, Cox R, Hawkins H, Sbrana E, Kolli D, Garofalo RP, Rajarathnam K.

J Innate Immun. 2015;7(6):647-58. doi: 10.1159/000430914. Epub 2015 Jul 1.


Respiratory syncytial virus infection down-regulates antioxidant enzyme expression by triggering deacetylation-proteasomal degradation of Nrf2.

Komaravelli N, Tian B, Ivanciuc T, Mautemps N, Brasier AR, Garofalo RP, Casola A.

Free Radic Biol Med. 2015 Nov;88(Pt B):391-403. doi: 10.1016/j.freeradbiomed.2015.05.043. Epub 2015 Jun 11.


Mitochondrial antiviral-signalling protein plays an essential role in host immunity against human metapneumovirus.

Deng J, Chen Y, Liu G, Ren J, Go C, Ivanciuc T, Deepthi K, Casola A, Garofalo RP, Bao X.

J Gen Virol. 2015 Aug;96(8):2104-13. doi: 10.1099/vir.0.000178. Epub 2015 May 7.


Role of hydrogen sulfide in paramyxovirus infections.

Li H, Ma Y, Escaffre O, Ivanciuc T, Komaravelli N, Kelley JP, Coletta C, Szabo C, Rockx B, Garofalo RP, Casola A.

J Virol. 2015 May;89(10):5557-68. doi: 10.1128/JVI.00264-15. Epub 2015 Mar 4.


Ataxia telangiectasia mutated kinase mediates NF-κB serine 276 phosphorylation and interferon expression via the IRF7-RIG-I amplification loop in paramyxovirus infection.

Fang L, Choudhary S, Tian B, Boldogh I, Yang C, Ivanciuc T, Ma Y, Garofalo RP, Brasier AR.

J Virol. 2015 Mar;89(5):2628-42. doi: 10.1128/JVI.02458-14. Epub 2014 Dec 17.


Lactate dehydrogenase and caspase activity in nasopharyngeal secretions are predictors of bronchiolitis severity.

Mehta R, Scheffler M, Tapia L, Aideyan L, Patel KD, Jewell AM, Avadhanula V, Mei M, Garofalo RP, Piedra PA.

Influenza Other Respir Viruses. 2014 Nov;8(6):617-25. doi: 10.1111/irv.12276. Epub 2014 Aug 12.


Paramyxovirus infection regulates T cell responses by BDCA-1+ and BDCA-3+ myeloid dendritic cells.

Gupta MR, Kolli D, Molteni C, Casola A, Garofalo RP.

PLoS One. 2014 Jun 11;9(6):e99227. doi: 10.1371/journal.pone.0099227. eCollection 2014.


Alveolar macrophages contribute to the pathogenesis of human metapneumovirus infection while protecting against respiratory syncytial virus infection.

Kolli D, Gupta MR, Sbrana E, Velayutham TS, Chao H, Casola A, Garofalo RP.

Am J Respir Cell Mol Biol. 2014 Oct;51(4):502-15. doi: 10.1165/rcmb.2013-0414OC.


Critical role of TLR4 in human metapneumovirus mediated innate immune responses and disease pathogenesis.

Velayutham TS, Kolli D, Ivanciuc T, Garofalo RP, Casola A.

PLoS One. 2013 Oct 29;8(10):e78849. doi: 10.1371/journal.pone.0078849. eCollection 2013.


Proline substitution of dimer interface β-strand residues as a strategy for the design of functional monomeric proteins.

Joseph PR, Poluri KM, Gangavarapu P, Rajagopalan L, Raghuwanshi S, Richardson RM, Garofalo RP, Rajarathnam K.

Biophys J. 2013 Sep 17;105(6):1491-501. doi: 10.1016/j.bpj.2013.08.008.


Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation.

Joseph PR, Sawant KV, Isley A, Pedroza M, Garofalo RP, Richardson RM, Rajarathnam K.

Biochem J. 2013 Dec 1;456(2):241-51. doi: 10.1042/BJ20130148.


MyD88 controls human metapneumovirus-induced pulmonary immune responses and disease pathogenesis.

Ren J, Kolli D, Deng J, Fang R, Gong B, Xue M, Casola A, Garofalo RP, Wang T, Bao X.

Virus Res. 2013 Sep;176(1-2):241-50. doi: 10.1016/j.virusres.2013.06.014. Epub 2013 Jul 8. Erratum in: Virus Res. 2013 Nov 6;177(2):226. Garafalo, Roberto P [corrected to Garofalo, Roberto P].


Differential response of BDCA-1+ and BDCA-3+ myeloid dendritic cells to respiratory syncytial virus infection.

Gupta MR, Kolli D, Garofalo RP.

Respir Res. 2013 Jul 5;14:71. doi: 10.1186/1465-9921-14-71.


Pancreatitis activates pancreatic apelin-APJ axis in mice.

Han S, Englander EW, Gomez GA, Aronson JF, Rastellini C, Garofalo RP, Kolli D, Quertermous T, Kundu R, Greeley GH Jr.

Am J Physiol Gastrointest Liver Physiol. 2013 Jul 15;305(2):G139-50. doi: 10.1152/ajpgi.00370.2012. Epub 2013 May 16.


Human metapneumovirus glycoprotein G disrupts mitochondrial signaling in airway epithelial cells.

Bao X, Kolli D, Ren J, Liu T, Garofalo RP, Casola A.

PLoS One. 2013 Apr 23;8(4):e62568. doi: 10.1371/journal.pone.0062568. Print 2013.


CDK9-dependent transcriptional elongation in the innate interferon-stimulated gene response to respiratory syncytial virus infection in airway epithelial cells.

Tian B, Zhao Y, Kalita M, Edeh CB, Paessler S, Casola A, Teng MN, Garofalo RP, Brasier AR.

J Virol. 2013 Jun;87(12):7075-92. doi: 10.1128/JVI.03399-12. Epub 2013 Apr 17.


Antioxidant mimetics modulate oxidative stress and cellular signaling in airway epithelial cells infected with respiratory syncytial virus.

Hosakote YM, Komaravelli N, Mautemps N, Liu T, Garofalo RP, Casola A.

Am J Physiol Lung Cell Mol Physiol. 2012 Dec 1;303(11):L991-1000. doi: 10.1152/ajplung.00192.2012. Epub 2012 Sep 28.


Respiratory syncytial virus infection: mechanisms of redox control and novel therapeutic opportunities.

Garofalo RP, Kolli D, Casola A.

Antioxid Redox Signal. 2013 Jan 10;18(2):186-217. doi: 10.1089/ars.2011.4307. Epub 2012 Sep 7. Review.


The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment.

Gangavarapu P, Rajagopalan L, Kolli D, Guerrero-Plata A, Garofalo RP, Rajarathnam K.

J Leukoc Biol. 2012 Feb;91(2):259-65. doi: 10.1189/jlb.0511239. Epub 2011 Dec 2.


Human metapneumovirus inhibits IFN-β signaling by downregulating Jak1 and Tyk2 cellular levels.

Ren J, Kolli D, Liu T, Xu R, Garofalo RP, Casola A, Bao X.

PLoS One. 2011;6(9):e24496. doi: 10.1371/journal.pone.0024496. Epub 2011 Sep 19.


RelA Ser276 phosphorylation-coupled Lys310 acetylation controls transcriptional elongation of inflammatory cytokines in respiratory syncytial virus infection.

Brasier AR, Tian B, Jamaluddin M, Kalita MK, Garofalo RP, Lu M.

J Virol. 2011 Nov;85(22):11752-69. doi: 10.1128/JVI.05360-11. Epub 2011 Sep 7.


TAK1 regulates NF-ΚB and AP-1 activation in airway epithelial cells following RSV infection.

Dey N, Liu T, Garofalo RP, Casola A.

Virology. 2011 Sep 30;418(2):93-101. doi: 10.1016/j.virol.2011.07.007. Epub 2011 Aug 10.


Human metapneumovirus glycoprotein G inhibits TLR4-dependent signaling in monocyte-derived dendritic cells.

Kolli D, Bao X, Liu T, Hong C, Wang T, Garofalo RP, Casola A.

J Immunol. 2011 Jul 1;187(1):47-54. doi: 10.4049/jimmunol.1002589. Epub 2011 Jun 1.


A novel mechanism for the inhibition of interferon regulatory factor-3-dependent gene expression by human respiratory syncytial virus NS1 protein.

Ren J, Liu T, Pang L, Li K, Garofalo RP, Casola A, Bao X.

J Gen Virol. 2011 Sep;92(Pt 9):2153-9. doi: 10.1099/vir.0.032987-0. Epub 2011 Jun 1.


Viral-mediated inhibition of antioxidant enzymes contributes to the pathogenesis of severe respiratory syncytial virus bronchiolitis.

Hosakote YM, Jantzi PD, Esham DL, Spratt H, Kurosky A, Casola A, Garofalo RP.

Am J Respir Crit Care Med. 2011 Jun 1;183(11):1550-60. doi: 10.1164/rccm.201010-1755OC. Epub 2011 Mar 4.


IKKε modulates RSV-induced NF-κB-dependent gene transcription.

Bao X, Indukuri H, Liu T, Liao SL, Tian B, Brasier AR, Garofalo RP, Casola A.

Virology. 2010 Dec 20;408(2):224-31. doi: 10.1016/j.virol.2010.09.016. Epub 2010 Oct 18.


Monomeric and dimeric CXCL8 are both essential for in vivo neutrophil recruitment.

Das ST, Rajagopalan L, Guerrero-Plata A, Sai J, Richmond A, Garofalo RP, Rajarathnam K.

PLoS One. 2010 Jul 26;5(7):e11754. doi: 10.1371/journal.pone.0011754.


Probing the role of CXC motif in chemokine CXCL8 for high affinity binding and activation of CXCR1 and CXCR2 receptors.

Joseph PR, Sarmiento JM, Mishra AK, Das ST, Garofalo RP, Navarro J, Rajarathnam K.

J Biol Chem. 2010 Sep 17;285(38):29262-9. doi: 10.1074/jbc.M110.146555. Epub 2010 Jul 14.


Role of peroxiredoxin 1 and peroxiredoxin 4 in protection of respiratory syncytial virus-induced cysteinyl oxidation of nuclear cytoskeletal proteins.

Jamaluddin M, Wiktorowicz JE, Soman KV, Boldogh I, Forbus JD, Spratt H, Garofalo RP, Brasier AR.

J Virol. 2010 Sep;84(18):9533-45. doi: 10.1128/JVI.01005-10. Epub 2010 Jul 7.


LDH concentration in nasal-wash fluid as a biochemical predictor of bronchiolitis severity.

Laham FR, Trott AA, Bennett BL, Kozinetz CA, Jewell AM, Garofalo RP, Piedra PA.

Pediatrics. 2010 Feb;125(2):e225-33. doi: 10.1542/peds.2009-0411. Epub 2010 Jan 25.


Expression of an IKKgamma splice variant determines IRF3 and canonical NF-kappaB pathway utilization in ssRNA virus infection.

Liu P, Lu M, Tian B, Li K, Garofalo RP, Prusak D, Wood TG, Brasier AR.

PLoS One. 2009 Nov 26;4(11):e8079. doi: 10.1371/journal.pone.0008079.


Respiratory syncytial virus infection induces a reactive oxygen species-MSK1-phospho-Ser-276 RelA pathway required for cytokine expression.

Jamaluddin M, Tian B, Boldogh I, Garofalo RP, Brasier AR.

J Virol. 2009 Oct;83(20):10605-15. doi: 10.1128/JVI.01090-09. Epub 2009 Aug 12.

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