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Pancreatic cancer organoids recapitulate disease and allow personalized drug screening.

Driehuis E, van Hoeck A, Moore K, Kolders S, Francies HE, Gulersonmez MC, Stigter ECA, Burgering B, Geurts V, Gracanin A, Bounova G, Morsink FH, Vries R, Boj S, van Es J, Offerhaus GJA, Kranenburg O, Garnett MJ, Wessels L, Cuppen E, Brosens LAA, Clevers H.

Proc Natl Acad Sci U S A. 2019 Dec 9. pii: 201911273. doi: 10.1073/pnas.1911273116. [Epub ahead of print]


Poly (glycerol adipate) (PGA): From a functionalized nano-carrier to a polymeric-prodrug matrix to create amorphous solid dispersions.

Gordhan D, Swainson SME, Pearce AK, Styliari ID, Lovato T, Burley JC, Garnett MC, Taresco V.

J Pharm Sci. 2019 Dec 6. pii: S0022-3549(19)30809-3. doi: 10.1016/j.xphs.2019.12.004. [Epub ahead of print]


Tropical forest soil carbon stocks do not increase despite 15 years of doubled litter inputs.

Sayer EJ, Lopez-Sangil L, Crawford JA, Bréchet LM, Birkett AJ, Baxendale C, Castro B, Rodtassana C, Garnett MH, Weiss L, Schmidt MWI.

Sci Rep. 2019 Dec 2;9(1):18030. doi: 10.1038/s41598-019-54487-2.


Quantitative Proteome Landscape of the NCI-60 Cancer Cell Lines.

Guo T, Luna A, Rajapakse VN, Koh CC, Wu Z, Liu W, Sun Y, Gao H, Menden MP, Xu C, Calzone L, Martignetti L, Auwerx C, Buljan M, Banaei-Esfahani A, Ori A, Iskar M, Gillet L, Bi R, Zhang J, Zhang H, Yu C, Zhong Q, Varma S, Schmitt U, Qiu P, Zhang Q, Zhu Y, Wild PJ, Garnett MJ, Bork P, Beck M, Liu K, Saez-Rodriguez J, Elloumi F, Reinhold WC, Sander C, Pommier Y, Aebersold R.

iScience. 2019 Nov 22;21:664-680. doi: 10.1016/j.isci.2019.10.059. Epub 2019 Oct 31.


Is rat a good model for assessment of particulate-based taste-masked formulations?

Ali J, Chiang M, Bong Lee J, Voronin GO, Bennett J, Cram A, Kagan L, Garnett MC, Roberts CJ, Gershkovich P.

Eur J Pharm Biopharm. 2019 Nov 11. pii: S0939-6411(19)31292-5. doi: 10.1016/j.ejpb.2019.11.001. [Epub ahead of print]


Poly (glycerol adipate) (PGA), an Enzymatically Synthesized Functionalizable Polyester and Versatile Drug Delivery Carrier: A Literature Update.

Swainson SME, Styliari ID, Taresco V, Garnett MC.

Polymers (Basel). 2019 Sep 25;11(10). pii: E1561. doi: 10.3390/polym11101561. Review.


Correction: Modelling outcomes after paediatric brain injury with admission laboratory values: a machine-learning approach.

Kayhanian S, Young AMH, Mangla C, Jalloh I, Fernandes HM, Garnett MR, Hutchinson PJ, Agrawal S.

Pediatr Res. 2019 Nov;86(5):675. doi: 10.1038/s41390-019-0545-y.


How Payment for Research Participation Can Be Coercive.

Millum J, Garnett M.

Am J Bioeth. 2019 Sep;19(9):21-31. doi: 10.1080/15265161.2019.1630497.


C mobilisation in disturbed tropical peat swamps: old DOC can fuel the fluvial efflux of old carbon dioxide, but site recovery can occur.

Waldron S, Vihermaa L, Evers S, Garnett MH, Newton J, Henderson ACG.

Sci Rep. 2019 Aug 7;9(1):11429. doi: 10.1038/s41598-019-46534-9.


Hydrocephalus as the first presenting symptom of neurosarcoidosis in two patients: a diagnosis more forthcoming in the context of systemic disease.

McKeever A, Cox A, Garnett M, Cunniffe NG.

BMJ Case Rep. 2019 Aug 4;12(8). pii: e229903. doi: 10.1136/bcr-2019-229903.


Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer.

Lazzari L, Corti G, Picco G, Isella C, Montone M, Arcella P, Durinikova E, Zanella ER, Novara L, Barbosa F, Cassingena A, Cancelliere C, Medico E, Sartore-Bianchi A, Siena S, Garnett MJ, Bertotti A, Trusolino L, Di Nicolantonio F, Linnebacher M, Bardelli A, Arena S.

Clin Cancer Res. 2019 Oct 15;25(20):6243-6259. doi: 10.1158/1078-0432.CCR-18-3440. Epub 2019 Aug 2.


Value of computerized shunt infusion study in assessment of pediatric hydrocephalus shunt function-a two center cross-sectional study.

Dias SF, Lalou AD, Spang R, Haas-Lude K, Garnett M, Fernandez H, Czosnyka M, Schuhmann MU, Czosnyka Z.

Childs Nerv Syst. 2019 Aug 1. doi: 10.1007/s00381-019-04264-3. [Epub ahead of print]


Modelling outcomes after paediatric brain injury with admission laboratory values: a machine-learning approach.

Kayhanian S, Young AMH, Mangla C, Jalloh I, Fernandes HM, Garnett MR, Hutchinson PJ, Agrawal S.

Pediatr Res. 2019 Nov;86(5):641-645. doi: 10.1038/s41390-019-0510-9. Epub 2019 Jul 26. Erratum in: Pediatr Res. 2019 Aug 28;:.


Cerebrospinal fluid dynamics in pediatric pseudotumor cerebri syndrome.

Lalou AD, McTaggart JS, Czosnyka ZH, Garnett MR, Krishnakumar D, Czosnyka M.

Childs Nerv Syst. 2019 Jul 19. doi: 10.1007/s00381-019-04263-4. [Epub ahead of print]


Exploring the enzymatic degradation of poly(glycerol adipate).

Swainson SME, Taresco V, Pearce AK, Clapp LH, Ager B, McAllister M, Bosquillon C, Garnett MC.

Eur J Pharm Biopharm. 2019 Sep;142:377-386. doi: 10.1016/j.ejpb.2019.07.015. Epub 2019 Jul 15.


Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen.

Menden MP, Wang D, Mason MJ, Szalai B, Bulusu KC, Guan Y, Yu T, Kang J, Jeon M, Wolfinger R, Nguyen T, Zaslavskiy M; AstraZeneca-Sanger Drug Combination DREAM Consortium, Jang IS, Ghazoui Z, Ahsen ME, Vogel R, Neto EC, Norman T, Tang EKY, Garnett MJ, Veroli GYD, Fawell S, Stolovitzky G, Guinney J, Dry JR, Saez-Rodriguez J.

Nat Commun. 2019 Jun 17;10(1):2674. doi: 10.1038/s41467-019-09799-2.


Economic instability and household chaos relate to cortisol for children in poverty.

Brown ED, Anderson KE, Garnett ML, Hill EM.

J Fam Psychol. 2019 Sep;33(6):629-639. doi: 10.1037/fam0000545. Epub 2019 Jun 6.


Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia.

Nii T, Prabhu VV, Ruvolo V, Madhukar N, Zhao R, Mu H, Heese L, Nishida Y, Kojima K, Garnett MJ, McDermott U, Benes CH, Charter N, Deacon S, Elemento O, Allen JE, Oster W, Stogniew M, Ishizawa J, Andreeff M.

Leukemia. 2019 Dec;33(12):2805-2816. doi: 10.1038/s41375-019-0491-z. Epub 2019 May 24.


Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening.

Picco G, Chen ED, Alonso LG, Behan FM, Gonçalves E, Bignell G, Matchan A, Fu B, Banerjee R, Anderson E, Butler A, Benes CH, McDermott U, Dow D, Iorio F, Stronach E, Yang F, Yusa K, Saez-Rodriguez J, Garnett MJ.

Nat Commun. 2019 May 16;10(1):2198. doi: 10.1038/s41467-019-09940-1.


Current forest carbon fixation fuels stream CO2 emissions.

Campeau A, Bishop K, Amvrosiadi N, Billett MF, Garnett MH, Laudon H, Öquist MG, Wallin MB.

Nat Commun. 2019 Apr 23;10(1):1876. doi: 10.1038/s41467-019-09922-3.


Using Rural⁻Urban Continuum Codes (RUCCS) to Examine Alcohol-Related Motor Vehicle Crash Injury and Enforcement in New York State.

Pressley JC, Hines LM, Bauer MJ, Oh SA, Kuhl JR, Liu C, Cheng B, Garnett MF.

Int J Environ Res Public Health. 2019 Apr 15;16(8). pii: E1346. doi: 10.3390/ijerph16081346.


Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ.

Nature. 2019 Apr;568(7753):511-516. doi: 10.1038/s41586-019-1103-9. Epub 2019 Apr 10.


Penetration and Uptake of Nanoparticles in 3D Tumor Spheroids.

Tchoryk A, Taresco V, Argent RH, Ashford M, Gellert PR, Stolnik S, Grabowska A, Garnett MC.

Bioconjug Chem. 2019 May 15;30(5):1371-1384. doi: 10.1021/acs.bioconjchem.9b00136. Epub 2019 Apr 12.


Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis.

Petljak M, Alexandrov LB, Brammeld JS, Price S, Wedge DC, Grossmann S, Dawson KJ, Ju YS, Iorio F, Tubio JMC, Koh CC, Georgakopoulos-Soares I, Rodríguez-Martín B, Otlu B, O'Meara S, Butler AP, Menzies A, Bhosle SG, Raine K, Jones DR, Teague JW, Beal K, Latimer C, O'Neill L, Zamora J, Anderson E, Patel N, Maddison M, Ng BL, Graham J, Garnett MJ, McDermott U, Nik-Zainal S, Campbell PJ, Stratton MR.

Cell. 2019 Mar 7;176(6):1282-1294.e20. doi: 10.1016/j.cell.2019.02.012.


Thresholds for identifying pathological intracranial pressure in paediatric traumatic brain injury.

Kayhanian S, Young AMH, Ewen RL, Piper RJ, Guilfoyle MR, Donnelly J, Fernandes HM, Garnett M, Smielewski P, Czosnyka M, Agrawal S, Hutchinson PJ.

Sci Rep. 2019 Mar 5;9(1):3537. doi: 10.1038/s41598-019-39848-1.


Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects.

Gonçalves E, Behan FM, Louzada S, Arnol D, Stronach EA, Yang F, Yusa K, Stegle O, Iorio F, Garnett MJ.

Genome Biol. 2019 Feb 5;20(1):27. doi: 10.1186/s13059-019-1637-z.


JACKS: joint analysis of CRISPR/Cas9 knockout screens.

Allen F, Behan F, Khodak A, Iorio F, Yusa K, Garnett M, Parts L.

Genome Res. 2019 Mar;29(3):464-471. doi: 10.1101/gr.238923.118. Epub 2019 Jan 23.


Ventriculo-peritoneal shunting is a safe and effective treatment for idiopathic intracranial hypertension.

Bjornson A, Tapply I, Nabbanja E, Lalou AD, Czosnyka M, Czosnyka Z, Muthusamy B, Garnett M.

Br J Neurosurg. 2019 Feb;33(1):62-70. doi: 10.1080/02688697.2018.1538478. Epub 2019 Jan 17.


CellMinerCDB for Integrative Cross-Database Genomics and Pharmacogenomics Analyses of Cancer Cell Lines.

Rajapakse VN, Luna A, Yamade M, Loman L, Varma S, Sunshine M, Iorio F, Sousa FG, Elloumi F, Aladjem MI, Thomas A, Sander C, Kohn KW, Benes CH, Garnett M, Reinhold WC, Pommier Y.

iScience. 2018 Dec 21;10:247-264. doi: 10.1016/j.isci.2018.11.029. Epub 2018 Dec 12.


Application of biorelevant saliva-based dissolution for optimisation of orally disintegrating formulations of felodipine.

Ali J, Zgair A, Hameed GS, Garnett MC, Roberts CJ, Burley JC, Gershkovich P.

Int J Pharm. 2019 Jan 30;555:228-236. doi: 10.1016/j.ijpharm.2018.11.051. Epub 2018 Nov 19.


Corrigendum: High-throughput RNAi screen for essential genes and drug synergistic combinations in colorectal cancer.

Williams SP, Barthorpe AS, Lightfoot H, Garnett MJ, McDermott U.

Sci Data. 2018 Oct 9;5:180215. doi: 10.1038/sdata.2018.215.


Cell Model Passports-a hub for clinical, genetic and functional datasets of preclinical cancer models.

van der Meer D, Barthorpe S, Yang W, Lightfoot H, Hall C, Gilbert J, Francies HE, Garnett MJ.

Nucleic Acids Res. 2019 Jan 8;47(D1):D923-D929. doi: 10.1093/nar/gky872.


Implementation of the Stopping Elderly Accidents, Deaths, and Injuries Initiative in Primary Care: An Outcome Evaluation.

Johnston YA, Bergen G, Bauer M, Parker EM, Wentworth L, McFadden M, Reome C, Garnett M.

Gerontologist. 2019 Nov 16;59(6):1182-1191. doi: 10.1093/geront/gny101.


NOTCH1 Represses MCL-1 Levels in GSI-resistant T-ALL, Making them Susceptible to ABT-263.

Dastur A, Choi A, Costa C, Yin X, Williams A, McClanaghan J, Greenberg M, Roderick J, Patel NU, Boisvert J, McDermott U, Garnett MJ, Almenara J, Grant S, Rizzo K, Engelman JA, Kelliher M, Faber AC, Benes CH.

Clin Cancer Res. 2019 Jan 1;25(1):312-324. doi: 10.1158/1078-0432.CCR-18-0867. Epub 2018 Sep 17.


In Silico Screening for Solid Dispersions: The Trouble with Solubility Parameters and χFH.

Turpin ER, Taresco V, Al-Hachami WA, Booth J, Treacher K, Tomasi S, Alexander C, Burley J, Laughton CA, Garnett MC.

Mol Pharm. 2018 Oct 1;15(10):4654-4667. doi: 10.1021/acs.molpharmaceut.8b00637. Epub 2018 Sep 4.


The germline genetic component of drug sensitivity in cancer cell lines.

Menden MP, Casale FP, Stephan J, Bignell GR, Iorio F, McDermott U, Garnett MJ, Saez-Rodriguez J, Stegle O.

Nat Commun. 2018 Aug 23;9(1):3385. doi: 10.1038/s41467-018-05811-3.


Isotopic evidence of biotrophy and unusual nitrogen nutrition in soil-dwelling Hygrophoraceae.

Halbwachs H, Easton GL, Bol R, Hobbie EA, Garnett MH, Peršoh D, Dixon L, Ostle N, Karasch P, Griffith GW.

Environ Microbiol. 2018 Oct;20(10):3573-3588. doi: 10.1111/1462-2920.14327.


Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting.

Iorio F, Behan FM, Gonçalves E, Bhosle SG, Chen E, Shepherd R, Beaver C, Ansari R, Pooley R, Wilkinson P, Harper S, Butler AP, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ.

BMC Genomics. 2018 Aug 13;19(1):604. doi: 10.1186/s12864-018-4989-y.


Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics.

Li X, Francies HE, Secrier M, Perner J, Miremadi A, Galeano-Dalmau N, Barendt WJ, Letchford L, Leyden GM, Goffin EK, Barthorpe A, Lightfoot H, Chen E, Gilbert J, Noorani A, Devonshire G, Bower L, Grantham A, MacRae S, Grehan N, Wedge DC, Fitzgerald RC, Garnett MJ.

Nat Commun. 2018 Jul 30;9(1):2983. doi: 10.1038/s41467-018-05190-9.


Erratum to: Drug Sensitivity Assays of Human Cancer Organoid Cultures.

Francies HE, Barthorpe A, McLaren-Douglas A, Barendt WJ, Garnett MJ.

Methods Mol Biol. 2019;1576:353. doi: 10.1007/7651_2018_138.


Enhanced nanoparticle uptake into virus infected cells: Could nanoparticles be useful in antiviral therapy?

Abo-Zeid Y, Urbanowicz RA, Thomson BJ, Irving WL, Tarr AW, Garnett MC.

Int J Pharm. 2018 Aug 25;547(1-2):572-581. doi: 10.1016/j.ijpharm.2018.06.027. Epub 2018 Jun 13.


Itraconazole targets cell cycle heterogeneity in colorectal cancer.

Buczacki SJA, Popova S, Biggs E, Koukorava C, Buzzelli J, Vermeulen L, Hazelwood L, Francies H, Garnett MJ, Winton DJ.

J Exp Med. 2018 Jul 2;215(7):1891-1912. doi: 10.1084/jem.20171385. Epub 2018 May 31.


Discrete taxa of saprotrophic fungi respire different ages of carbon from Antarctic soils.

Newsham KK, Garnett MH, Robinson CH, Cox F.

Sci Rep. 2018 May 18;8(1):7866. doi: 10.1038/s41598-018-25877-9.


Rux largely restores lungs in Iraq PM-exposed mice, Up-regulating regulatory T-cells (Tregs).

Lin D, Li J, Razi R, Qamar N, Levine L, Zimmerman T, Hamidi SA, Schmidt M, Golightly MG, Rueb T, Harrington A, Garnett M, Antonawich F, McClain S, Miller E, Cox C, Huang PH, Szema AM.

Exp Lung Res. 2018 Apr;44(3):153-166. doi: 10.1080/01902148.2018.1459957. Epub 2018 May 8.


The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils.

Stammnitz MR, Coorens THH, Gori KC, Hayes D, Fu B, Wang J, Martin-Herranz DE, Alexandrov LB, Baez-Ortega A, Barthorpe S, Beck A, Giordano F, Knowles GW, Kwon YM, Hall G, Price S, Pye RJ, Tubio JMC, Siddle HVT, Sohal SS, Woods GM, McDermott U, Yang F, Garnett MJ, Ning Z, Murchison EP.

Cancer Cell. 2018 Apr 9;33(4):607-619.e15. doi: 10.1016/j.ccell.2018.03.013.


Synthesis and properties of a biodegradable polymer-drug conjugate: Methotrexate-poly(glycerol adipate).

Suksiriworapong J, Taresco V, Ivanov DP, Styliari ID, Sakchaisri K, Junyaprasert VB, Garnett MC.

Colloids Surf B Biointerfaces. 2018 Jul 1;167:115-125. doi: 10.1016/j.colsurfb.2018.03.048. Epub 2018 Mar 28.


Vascular plant-mediated controls on atmospheric carbon assimilation and peat carbon decomposition under climate change.

Gavazov K, Albrecht R, Buttler A, Dorrepaal E, Garnett MH, Gogo S, Hagedorn F, Mills RTE, Robroek BJM, Bragazza L.

Glob Chang Biol. 2018 Sep;24(9):3911-3921. doi: 10.1111/gcb.14140. Epub 2018 Apr 17.


Cerebral autoregulation, cerebrospinal fluid outflow resistance, and outcome following cerebrospinal fluid diversion in normal pressure hydrocephalus.

Lalou AD, Czosnyka M, Donnelly J, Pickard JD; FMedSci, Nabbanja E, Keong NC, Garnett M, Czosnyka ZH.

J Neurosurg. 2018 Mar 16;130(1):154-162. doi: 10.3171/2017.7.JNS17216.


Water Solubility Enhancement of Pyrazolo[3,4-d]pyrimidine Derivatives via Miniaturized Polymer-Drug Microarrays.

Sanna M, Sicilia G, Alazzo A, Singh N, Musumeci F, Schenone S, Spriggs KA, Burley JC, Garnett MC, Taresco V, Alexander C.

ACS Med Chem Lett. 2018 Jan 29;9(3):193-197. doi: 10.1021/acsmedchemlett.7b00456. eCollection 2018 Mar 8.


Radiological Correlates of Raised Intracranial Pressure in Children: A Review.

Kayhanian S, Young AMH, Piper RJ, Donnelly J, Scoffings D, Garnett MR, Fernandes HM, Smielewski P, Czosnyka M, Hutchinson PJ, Agrawal S.

Front Pediatr. 2018 Feb 23;6:32. doi: 10.3389/fped.2018.00032. eCollection 2018. Review.

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