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Items: 22


Effective glucose metabolism maintains low intracellular glucose in airway epithelial cells after exposure to hyperglycemia.

Bearham J, Garnett JP, Schroeder V, Biggart MGS, Baines DL.

Am J Physiol Cell Physiol. 2019 Nov 1;317(5):C983-C992. doi: 10.1152/ajpcell.00193.2019. Epub 2019 Aug 21.


Real-Time, Semi-Automated Fluorescent Measurement of the Airway Surface Liquid pH of Primary Human Airway Epithelial Cells.

Saint-Criq V, Haq IJ, Gardner AI, Garnett JP, Ward C, Brodlie M, Gray MA.

J Vis Exp. 2019 Jun 13;(148). doi: 10.3791/59815.


Human lung fibroblast-to-myofibroblast transformation is not driven by an LDH5-dependent metabolic shift towards aerobic glycolysis.

Schruf E, Schroeder V, Kuttruff CA, Weigle S, Krell M, Benz M, Bretschneider T, Holweg A, Schuler M, Frick M, Nicklin P, Garnett JP, Sobotta MC.

Respir Res. 2019 May 9;20(1):87. doi: 10.1186/s12931-019-1058-2.


Metformin attenuates the effect of Staphylococcus aureus on airway tight junctions by increasing PKCζ-mediated phosphorylation of occludin.

Kalsi KK, Garnett JP, Patkee W, Weekes A, Dockrell ME, Baker EH, Baines DL.

J Cell Mol Med. 2019 Jan;23(1):317-327. doi: 10.1111/jcmm.13929. Epub 2018 Nov 18.


Differential Effect of LPS on Glucose, Lactate and Inflammatory Markers in the Lungs of Normal and Diabetic Mice.

Holmberg CN, Åstrand A, Wingren C, Garnett JP, Mayer G, Taylor JD, Baker EH, Baines DL.

J Pulm Respir Med. 2017 May 11;2017(1). pii: PROA-101.


Excess Mucin Impairs Subglottic Epithelial Host Defense in Mechanically Ventilated Patients.

Powell J, Garnett JP, Mather MW, Cooles FAH, Nelson A, Verdon B, Scott J, Jiwa K, Ruchaud-Sparagano MH, Cummings SP, Perry JD, Wright SE, Wilson JA, Pearson J, Ward C, Simpson AJ.

Am J Respir Crit Care Med. 2018 Aug 1;198(3):340-349. doi: 10.1164/rccm.201709-1819OC.


Dapagliflozin-lowered blood glucose reduces respiratory Pseudomonas aeruginosa infection in diabetic mice.

Åstrand A, Wingren C, Benjamin A, Tregoning JS, Garnett JP, Groves H, Gill S, Orogo-Wenn M, Lundqvist AJ, Walters D, Smith DM, Taylor JD, Baker EH, Baines DL.

Br J Pharmacol. 2017 May;174(9):836-847. doi: 10.1111/bph.13741. Epub 2017 Mar 9.


Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H+ secretion.

Garnett JP, Kalsi KK, Sobotta M, Bearham J, Carr G, Powell J, Brodlie M, Ward C, Tarran R, Baines DL.

Sci Rep. 2016 Nov 29;6:37955. doi: 10.1038/srep37955.


Hydrogen sulfide as a regulator of respiratory epithelial sodium transport: the role of sodium-potassium ATPase. Focus on "Hydrogen sulfide contributes to hypoxic inhibition of airway transepithelial sodium absorption".

Garnett JP, Leiter JC.

Am J Physiol Regul Integr Comp Physiol. 2016 Sep 1;311(3):R564-5. doi: 10.1152/ajpregu.00327.2016. Epub 2016 Aug 3. No abstract available.


Increased airway glucose increases airway bacterial load in hyperglycaemia.

Gill SK, Hui K, Farne H, Garnett JP, Baines DL, Moore LS, Holmes AH, Filloux A, Tregoning JS.

Sci Rep. 2016 Jun 8;6:27636. doi: 10.1038/srep27636.


Metformin prevents the effects of Pseudomonas aeruginosa on airway epithelial tight junctions and restricts hyperglycaemia-induced bacterial growth.

Patkee WR, Carr G, Baker EH, Baines DL, Garnett JP.

J Cell Mol Med. 2016 Apr;20(4):758-64. doi: 10.1111/jcmm.12784. Epub 2016 Feb 2.


Airway surface liquid homeostasis in cystic fibrosis: pathophysiology and therapeutic targets.

Haq IJ, Gray MA, Garnett JP, Ward C, Brodlie M.

Thorax. 2016 Mar;71(3):284-7. doi: 10.1136/thoraxjnl-2015-207588. Epub 2015 Dec 30. Review.


Hypercapnia modulates cAMP signalling and cystic fibrosis transmembrane conductance regulator-dependent anion and fluid secretion in airway epithelia.

Turner MJ, Saint-Criq V, Patel W, Ibrahim SH, Verdon B, Ward C, Garnett JP, Tarran R, Cann MJ, Gray MA.

J Physiol. 2016 Mar 15;594(6):1643-61. doi: 10.1113/JP271309. Epub 2015 Dec 20.


A novel fluorescent sensor protein for detecting changes in airway surface liquid glucose concentration.

Helassa N, Garnett JP, Farrant M, Khan F, Pickup JC, Hahn KM, MacNevin CJ, Tarran R, Baines DL.

Biochem J. 2014 Dec 1;464(2):213-20. doi: 10.1042/BJ20141041.


Fructose transport-deficient Staphylococcus aureus reveals important role of epithelial glucose transporters in limiting sugar-driven bacterial growth in airway surface liquid.

Garnett JP, Braun D, McCarthy AJ, Farrant MR, Baker EH, Lindsay JA, Baines DL.

Cell Mol Life Sci. 2014 Dec;71(23):4665-73. doi: 10.1007/s00018-014-1635-y. Epub 2014 May 9.


Elevated paracellular glucose flux across cystic fibrosis airway epithelial monolayers is an important factor for Pseudomonas aeruginosa growth.

Garnett JP, Gray MA, Tarran R, Brodlie M, Ward C, Baker EH, Baines DL.

PLoS One. 2013 Oct 4;8(10):e76283. doi: 10.1371/journal.pone.0076283. eCollection 2013.


Controversies surrounding the role of CFTR in airway bicarbonate secretion.

Garnett JP, Turner MJ.

J Physiol. 2013 May 1;591(9):2241-2. doi: 10.1113/jphysiol.2013.251199. No abstract available.


Metformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucose.

Garnett JP, Baker EH, Naik S, Lindsay JA, Knight GM, Gill S, Tregoning JS, Baines DL.

Thorax. 2013 Sep;68(9):835-45. doi: 10.1136/thoraxjnl-2012-203178. Epub 2013 May 24.


Protein phosphatase 1 coordinates CFTR-dependent airway epithelial HCO3- secretion by reciprocal regulation of apical and basolateral membrane Cl(-)-HCO3- exchangers.

Garnett JP, Hickman E, Tunkamnerdthai O, Cuthbert AW, Gray MA.

Br J Pharmacol. 2013 Apr;168(8):1946-60. doi: 10.1111/bph.12085.


Sweet talk: insights into the nature and importance of glucose transport in lung epithelium.

Garnett JP, Baker EH, Baines DL.

Eur Respir J. 2012 Nov;40(5):1269-76. doi: 10.1183/09031936.00052612. Epub 2012 Aug 9. Review.


Proinflammatory mediators disrupt glucose homeostasis in airway surface liquid.

Garnett JP, Nguyen TT, Moffatt JD, Pelham ER, Kalsi KK, Baker EH, Baines DL.

J Immunol. 2012 Jul 1;189(1):373-80. doi: 10.4049/jimmunol.1200718. Epub 2012 May 23.


Novel role for pendrin in orchestrating bicarbonate secretion in cystic fibrosis transmembrane conductance regulator (CFTR)-expressing airway serous cells.

Garnett JP, Hickman E, Burrows R, Hegyi P, Tiszlavicz L, Cuthbert AW, Fong P, Gray MA.

J Biol Chem. 2011 Nov 25;286(47):41069-82. doi: 10.1074/jbc.M111.266734. Epub 2011 Sep 13.

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