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Items: 26

1.

Small-molecule allosteric inhibitors of BAX.

Garner TP, Amgalan D, Reyna DE, Li S, Kitsis RN, Gavathiotis E.

Nat Chem Biol. 2019 Apr;15(4):322-330. doi: 10.1038/s41589-018-0223-0. Epub 2019 Feb 4.

2.

BCL-2 Protein Family Interaction Analysis by Nuclear Magnetic Resonance Spectroscopy.

Garner TP, Gavathiotis E.

Methods Mol Biol. 2019;1877:217-231. doi: 10.1007/978-1-4939-8861-7_15.

3.

Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia.

Reyna DE, Garner TP, Lopez A, Kopp F, Choudhary GS, Sridharan A, Narayanagari SR, Mitchell K, Dong B, Bartholdy BA, Walensky LD, Verma A, Steidl U, Gavathiotis E.

Cancer Cell. 2017 Oct 9;32(4):490-505.e10. doi: 10.1016/j.ccell.2017.09.001.

4.

Progress in targeting the BCL-2 family of proteins.

Garner TP, Lopez A, Reyna DE, Spitz AZ, Gavathiotis E.

Curr Opin Chem Biol. 2017 Aug;39:133-142. doi: 10.1016/j.cbpa.2017.06.014. Epub 2017 Aug 17. Review.

5.

An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.

Garner TP, Reyna DE, Priyadarshi A, Chen HC, Li S, Wu Y, Ganesan YT, Malashkevich VN, Cheng EH, Gavathiotis E.

Mol Cell. 2016 Oct 20;64(2):431. doi: 10.1016/j.molcel.2016.10.005. No abstract available.

6.

An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.

Garner TP, Reyna DE, Priyadarshi A, Chen HC, Li S, Wu Y, Ganesan YT, Malashkevich VN, Cheng EH, Gavathiotis E.

Mol Cell. 2016 Aug 4;63(3):485-97. doi: 10.1016/j.molcel.2016.06.010. Epub 2016 Jul 14. Erratum in: Mol Cell. 2016 Oct 20;64(2):431.

7.

Mass spectrometry insights into a tandem ubiquitin-binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin.

Scott D, Garner TP, Long J, Strachan J, Mistry SC, Bottrill AR, Tooth DJ, Searle MS, Oldham NJ, Layfield R.

Proteomics. 2016 Jul;16(14):1961-9. doi: 10.1002/pmic.201600067.

PMID:
27037516
8.

A Kazal-Type Serine Protease Inhibitor from the Defense Gland Secretion of the Subterranean Termite Coptotermes formosanus Shiraki.

Negulescu H, Guo Y, Garner TP, Goodwin OY, Henderson G, Laine RA, Macnaughtan MA.

PLoS One. 2015 May 15;10(5):e0125376. doi: 10.1371/journal.pone.0125376. eCollection 2015.

9.

Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.

Barclay LA, Wales TE, Garner TP, Wachter F, Lee S, Guerra RM, Stewart ML, Braun CR, Bird GH, Gavathiotis E, Engen JR, Walensky LD.

Mol Cell. 2015 Mar 5;57(5):873-886. doi: 10.1016/j.molcel.2015.01.014. Epub 2015 Feb 12.

10.

Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors.

Li R, Cheng C, Balasis ME, Liu Y, Garner TP, Daniel KG, Li J, Qin Y, Gavathiotis E, Sebti SM.

Eur J Med Chem. 2015 Jan 27;90:315-331. doi: 10.1016/j.ejmech.2014.11.035. Epub 2014 Nov 20.

11.

Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim.

Cheng C, Liu Y, Balasis ME, Garner TP, Li J, Simmons NL, Berndt N, Song H, Pan L, Qin Y, Nicolaou KC, Gavathiotis E, Sebti SM, Li R.

Mar Drugs. 2014 Jul 29;12(8):4311-25. doi: 10.3390/md12084311.

12.

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts.

Iachettini S, Stevens MF, Frigerio M, Hummersone MG, Hutchinson I, Garner TP, Searle MS, Wilson DW, Munde M, Nanjunda R, D'Angelo C, Zizza P, Rizzo A, Cingolani C, De Cicco F, Porru M, D'Incalci M, Leonetti C, Biroccio A, Salvati E.

J Exp Clin Cancer Res. 2013 Sep 19;32:68. doi: 10.1186/1756-9966-32-68.

13.

Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives.

Anguiano J, Garner TP, Mahalingam M, Das BC, Gavathiotis E, Cuervo AM.

Nat Chem Biol. 2013 Jun;9(6):374-82. doi: 10.1038/nchembio.1230. Epub 2013 Apr 14. Erratum in: Nat Chem Biol. 2013 Nov;9(11):746.

14.

Structural insights into specificity and diversity in mechanisms of ubiquitin recognition by ubiquitin-binding domains.

Searle MS, Garner TP, Strachan J, Long J, Adlington J, Cavey JR, Shaw B, Layfield R.

Biochem Soc Trans. 2012 Apr;40(2):404-8. doi: 10.1042/BST20110729. Review.

PMID:
22435820
15.

Insights into the molecular composition of endogenous unanchored polyubiquitin chains.

Strachan J, Roach L, Sokratous K, Tooth D, Long J, Garner TP, Searle MS, Oldham NJ, Layfield R.

J Proteome Res. 2012 Mar 2;11(3):1969-80. doi: 10.1021/pr201167n. Epub 2012 Feb 14.

PMID:
22268864
16.

Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase.

Takeuchi H, Fernández-Valdivia RC, Caswell DS, Nita-Lazar A, Rana NA, Garner TP, Weldeghiorghis TK, Macnaughtan MA, Jafar-Nejad H, Haltiwanger RS.

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16600-5. doi: 10.1073/pnas.1109696108. Epub 2011 Sep 26.

17.

Independent interactions of ubiquitin-binding domains in a ubiquitin-mediated ternary complex.

Garner TP, Strachan J, Shedden EC, Long JE, Cavey JR, Shaw B, Layfield R, Searle MS.

Biochemistry. 2011 Oct 25;50(42):9076-87. doi: 10.1021/bi201137e. Epub 2011 Sep 29.

PMID:
21923101
18.

Impact of p62/SQSTM1 UBA domain mutations linked to Paget's disease of bone on ubiquitin recognition.

Garner TP, Long J, Layfield R, Searle MS.

Biochemistry. 2011 May 31;50(21):4665-74. doi: 10.1021/bi200079n. Epub 2011 May 9.

PMID:
21517082
19.

Telomestatin: formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes.

Linder J, Garner TP, Williams HE, Searle MS, Moody CJ.

J Am Chem Soc. 2011 Feb 2;133(4):1044-51. doi: 10.1021/ja109158k. Epub 2010 Dec 16.

PMID:
21162526
20.

Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1).

Derecka K, Balkwill GD, Garner TP, Hodgman C, Flint AP, Searle MS.

Biochemistry. 2010 Sep 7;49(35):7625-33. doi: 10.1021/bi100804f.

PMID:
20715834
21.

Mutant p62/SQSTM1 UBA domains linked to Paget's disease of bone differ in their abilities to function as stabilization signals.

Heinen C, Garner TP, Long J, Böttcher C, Ralston SH, Cavey JR, Searle MS, Layfield R, Dantuma NP.

FEBS Lett. 2010 Apr 16;584(8):1585-90. doi: 10.1016/j.febslet.2010.03.018. Epub 2010 Mar 15.

22.

Dimerisation of the UBA domain of p62 inhibits ubiquitin binding and regulates NF-kappaB signalling.

Long J, Garner TP, Pandya MJ, Craven CJ, Chen P, Shaw B, Williamson MP, Layfield R, Searle MS.

J Mol Biol. 2010 Feb 12;396(1):178-94. doi: 10.1016/j.jmb.2009.11.032. Epub 2009 Nov 17.

PMID:
19931284
23.

Repression of translation of human estrogen receptor alpha by G-quadruplex formation.

Balkwill GD, Derecka K, Garner TP, Hodgman C, Flint AP, Searle MS.

Biochemistry. 2009 Dec 8;48(48):11487-95. doi: 10.1021/bi901420k.

PMID:
19860473
24.

Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures.

Garner TP, Williams HE, Gluszyk KI, Roe S, Oldham NJ, Stevens MF, Moses JE, Searle MS.

Org Biomol Chem. 2009 Oct 21;7(20):4194-200. doi: 10.1039/b910505k. Epub 2009 Aug 14.

PMID:
19795057
25.

Folding of single-stranded DNA quadruplexes containing an autonomously stable mini-hairpin loop.

Balkwill GD, Garner TP, Searle MS.

Mol Biosyst. 2009 May;5(5):542-7. doi: 10.1039/b900540d. Epub 2009 Mar 27.

PMID:
19381368
26.

Folding topology of a bimolecular DNA quadruplex containing a stable mini-hairpin motif within the diagonal loop.

Balkwill GD, Garner TP, Williams HE, Searle MS.

J Mol Biol. 2009 Feb 6;385(5):1600-15. doi: 10.1016/j.jmb.2008.11.050. Epub 2008 Dec 3.

PMID:
19070621

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