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The RNA-binding protein SART3 promotes miR-34a biogenesis and G1 cell cycle arrest in lung cancer cells.

Sherman EJ, Mitchell DC, Garner AL.

J Biol Chem. 2019 Nov 15;294(46):17188-17196. doi: 10.1074/jbc.AC119.010419. Epub 2019 Oct 16.


Pulsed electric field inactivation of microorganisms: from fundamental biophysics to synergistic treatments.

Garner AL.

Appl Microbiol Biotechnol. 2019 Oct;103(19):7917-7929. doi: 10.1007/s00253-019-10067-y. Epub 2019 Aug 7. Review.


A click chemistry assay to identify natural product ligands for pre-microRNAs.

Garner AL, Lorenz DA, Gallagher EE.

Methods Enzymol. 2019;623:85-99. doi: 10.1016/bs.mie.2019.04.020. Epub 2019 May 11.


CarD contributes to diverse gene expression outcomes throughout the genome of Mycobacterium tuberculosis.

Zhu DX, Garner AL, Galburt EA, Stallings CL.

Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13573-13581. doi: 10.1073/pnas.1900176116. Epub 2019 Jun 19.


The role of olefin geometry in the activity of hydrocarbon stapled peptides targeting eukaryotic translation initiation factor 4E (eIF4E).

Song JM, Gallagher EE, Menon A, Mishra LD, Garner AL.

Org Biomol Chem. 2019 Jul 14;17(26):6414-6419. doi: 10.1039/c9ob01041f. Epub 2019 Jun 19.


Nanosecond pulsed electric field induced proliferation and differentiation of osteoblasts and myoblasts.

Vadlamani RA, Nie Y, Detwiler DA, Dhanabal A, Kraft AM, Kuang S, Gavin TP, Garner AL.

J R Soc Interface. 2019 Jun 28;16(155):20190079. doi: 10.1098/rsif.2019.0079. Epub 2019 Jun 19.


Click Chemistry-Mediated Complementation Assay for RNA-Protein Interactions.

Sherman EJ, Lorenz DA, Garner AL.

ACS Comb Sci. 2019 Jul 8;21(7):522-527. doi: 10.1021/acscombsci.9b00071. Epub 2019 Jun 7.


Tetracyclines as Inhibitors of Pre-microRNA Maturation: A Disconnection between RNA Binding and Inhibition.

Garner AL, Lorenz DA, Sandoval J, Gallagher EE, Kerk SA, Kaur T, Menon A.

ACS Med Chem Lett. 2019 Apr 22;10(5):816-821. doi: 10.1021/acsmedchemlett.9b00091. eCollection 2019 May 9.


Chemoproteomic Profiling Uncovers CDK4-Mediated Phosphorylation of the Translational Suppressor 4E-BP1.

Mitchell DC, Menon A, Garner AL.

Cell Chem Biol. 2019 Jul 18;26(7):980-990.e8. doi: 10.1016/j.chembiol.2019.03.012. Epub 2019 May 2.


Consideration of Binding Kinetics in the Design of Stapled Peptide Mimics of the Disordered Proteins Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 and Eukaryotic Translation Initiation Factor 4G.

Gallagher EE, Song JM, Menon A, Mishra LD, Chmiel AF, Garner AL.

J Med Chem. 2019 May 23;62(10):4967-4978. doi: 10.1021/acs.jmedchem.9b00068. Epub 2019 May 9.


The Transition to Paschen's Law for Microscale Gas Breakdown at Subatmospheric Pressure.

Loveless AM, Meng G, Ying Q, Wu F, Wang K, Cheng Y, Garner AL.

Sci Rep. 2019 Apr 5;9(1):5669. doi: 10.1038/s41598-019-42111-2.


Using extracellular calcium concentration and electric pulse conditions to tune platelet-rich plasma growth factor release and clotting.

Garner AL, Frelinger AL 3rd, Gerrits AJ, Gremmel T, Forde EE, Carmichael SL, Michelson AD, Neculaes VB.

Med Hypotheses. 2019 Apr;125:100-105. doi: 10.1016/j.mehy.2019.02.036. Epub 2019 Feb 16.


Synthesis of 7-benzylguanosine cap-analogue conjugates for eIF4E targeted degradation.

Kaur T, Menon A, Garner AL.

Eur J Med Chem. 2019 Mar 15;166:339-350. doi: 10.1016/j.ejmech.2019.01.080. Epub 2019 Jan 31.


A Conditionally Fluorescent Peptide Reporter of Secondary Structure Modulation.

Johnson OT, Kaur T, Garner AL.

Chembiochem. 2019 Jan 2;20(1):40-45. doi: 10.1002/cbic.201800377. Epub 2018 Oct 17.


Synergistic bacterial inactivation by combining antibiotics with nanosecond electric pulses.

Vadlamani A, Detwiler DA, Dhanabal A, Garner AL.

Appl Microbiol Biotechnol. 2018 Sep;102(17):7589-7596. doi: 10.1007/s00253-018-9215-y. Epub 2018 Jul 17.


Fabrication and characterization of implantable flushable electrodes for electric field-mediated drug delivery in a brain tissue-mimic agarose gel.

Parupudi T, Rahimi R, Ammirati M, Sundararajan R, Garner AL, Ziaie B.

Electrophoresis. 2018 Sep;39(17):2262-2269. doi: 10.1002/elps.201800161. Epub 2018 Jul 17.


Expansion of cat-ELCCA for the Discovery of Small Molecule Inhibitors of the Pre-let-7-Lin28 RNA-Protein Interaction.

Lorenz DA, Kaur T, Kerk SA, Gallagher EE, Sandoval J, Garner AL.

ACS Med Chem Lett. 2018 May 16;9(6):517-521. doi: 10.1021/acsmedchemlett.8b00126. eCollection 2018 Jun 14.


cat-ELCCA: catalyzing drug discovery through click chemistry.

Garner AL.

Chem Commun (Camb). 2018 Jun 19;54(50):6531-6539. doi: 10.1039/c8cc02332h.


Domains within RbpA Serve Specific Functional Roles That Regulate the Expression of Distinct Mycobacterial Gene Subsets.

Prusa J, Jensen D, Santiago-Collazo G, Pope SS, Garner AL, Miller JJ, Ruiz Manzano A, Galburt EA, Stallings CL.

J Bacteriol. 2018 Jun 11;200(13). pii: e00690-17. doi: 10.1128/JB.00690-17. Print 2018 Jul 1.


High-Throughput Chemical Probing of Full-Length Protein-Protein Interactions.

Song JM, Menon A, Mitchell DC, Johnson OT, Garner AL.

ACS Comb Sci. 2017 Dec 11;19(12):763-769. doi: 10.1021/acscombsci.7b00128. Epub 2017 Nov 14.


Design, characterization and experimental validation of a compact, flexible pulsed power architecture for ex vivo platelet activation.

Garner AL, Caiafa A, Jiang Y, Klopman S, Morton C, Torres AS, Loveless AM, Neculaes VB.

PLoS One. 2017 Jul 26;12(7):e0181214. doi: 10.1371/journal.pone.0181214. eCollection 2017.


Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.

Wlodarska M, Luo C, Kolde R, d'Hennezel E, Annand JW, Heim CE, Krastel P, Schmitt EK, Omar AS, Creasey EA, Garner AL, Mohammadi S, O'Connell DJ, Abubucker S, Arthur TD, Franzosa EA, Huttenhower C, Murphy LO, Haiser HJ, Vlamakis H, Porter JA, Xavier RJ.

Cell Host Microbe. 2017 Jul 12;22(1):25-37.e6. doi: 10.1016/j.chom.2017.06.007.


Development and Implementation of an HTS-Compatible Assay for the Discovery of Selective Small-Molecule Ligands for Pre-microRNAs.

Lorenz DA, Vander Roest S, Larsen MJ, Garner AL.

SLAS Discov. 2018 Jan;23(1):47-54. doi: 10.1177/2472555217717944. Epub 2017 Jul 7.


Effects of Increasing the Affinity of CarD for RNA Polymerase on Mycobacterium tuberculosis Growth, rRNA Transcription, and Virulence.

Garner AL, Rammohan J, Huynh JP, Onder LM, Chen J, Bae B, Jensen D, Weiss LA, Manzano AR, Darst SA, Campbell EA, Nickels BE, Galburt EA, Stallings CL.

J Bacteriol. 2017 Jan 30;199(4). pii: e00698-16. doi: 10.1128/JB.00698-16. Print 2017 Feb 15.


Modification of Pulsed Electric Field Conditions Results in Distinct Activation Profiles of Platelet-Rich Plasma.

Frelinger AL 3rd, Gerrits AJ, Garner AL, Torres AS, Caiafa A, Morton CA, Berny-Lang MA, Carmichael SL, Neculaes VB, Michelson AD.

PLoS One. 2016 Aug 24;11(8):e0160933. doi: 10.1371/journal.pone.0160933. eCollection 2016.


Cooperative stabilization of Mycobacterium tuberculosis rrnAP3 promoter open complexes by RbpA and CarD.

Rammohan J, Ruiz Manzano A, Garner AL, Prusa J, Stallings CL, Galburt EA.

Nucleic Acids Res. 2016 Sep 6;44(15):7304-13. doi: 10.1093/nar/gkw577. Epub 2016 Jun 24.


A click chemistry-based microRNA maturation assay optimized for high-throughput screening.

Lorenz DA, Garner AL.

Chem Commun (Camb). 2016 Jul 7;52(53):8267-70. doi: 10.1039/c6cc02894b. Epub 2016 Jun 10.


Mycobacterium tuberculosis Transcription Machinery: Ready To Respond to Host Attacks.

Flentie K, Garner AL, Stallings CL.

J Bacteriol. 2016 Apr 14;198(9):1360-73. doi: 10.1128/JB.00935-15. Print 2016 May. Review.


MINCR is not a MYC-induced lncRNA.

Hart JR, Weinberg MS, Morris KV, Roberts TC, Janda KD, Garner AL, Vogt PK.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E496-7. doi: 10.1073/pnas.1519903113. Epub 2016 Jan 25. No abstract available.


Plasma membrane temperature gradients and multiple cell permeabilization induced by low peak power density femtosecond lasers.

Garner AL, Neculaes VB, Deminsky M, Dylov DV, Joo C, Loghin ER, Yazdanfar S, Conway KR.

Biochem Biophys Rep. 2015 Dec 2;5:168-174. doi: 10.1016/j.bbrep.2015.11.019. eCollection 2016 Mar.


CarD stabilizes mycobacterial open complexes via a two-tiered kinetic mechanism.

Rammohan J, Ruiz Manzano A, Garner AL, Stallings CL, Galburt EA.

Nucleic Acids Res. 2015 Mar 31;43(6):3272-85. doi: 10.1093/nar/gkv078. Epub 2015 Feb 19.


High-throughput platform assay technology for the discovery of pre-microrna-selective small molecule probes.

Lorenz DA, Song JM, Garner AL.

Bioconjug Chem. 2015 Jan 21;26(1):19-23. doi: 10.1021/bc500544v. Epub 2014 Dec 17.


Platelet activation using electric pulse stimulation: growth factor profile and clinical implications.

Torres AS, Caiafa A, Garner AL, Klopman S, LaPlante N, Morton C, Conway K, Michelson AD, Frelinger AL 3rd, Neculaes VB.

J Trauma Acute Care Surg. 2014 Sep;77(3 Suppl 2):S94-S100. doi: 10.1097/TA.0000000000000322.


Inhibitor of MYC identified in a Kröhnke pyridine library.

Hart JR, Garner AL, Yu J, Ito Y, Sun M, Ueno L, Rhee JK, Baksh MM, Stefan E, Hartl M, Bister K, Vogt PK, Janda KD.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12556-61. doi: 10.1073/pnas.1319488111. Epub 2014 Aug 11.


Should we screen heterosexuals for extra-genital chlamydial and gonococcal infections?

Garner AL, Schembri G, Cullen T, Lee V.

Int J STD AIDS. 2015 Jun;26(7):462-6. doi: 10.1177/0956462414543120. Epub 2014 Jul 10.


CarD integrates three functional modules to promote efficient transcription, antibiotic tolerance, and pathogenesis in mycobacteria.

Garner AL, Weiss LA, Manzano AR, Galburt EA, Stallings CL.

Mol Microbiol. 2014 Aug;93(4):682-97. doi: 10.1111/mmi.12681. Epub 2014 Jul 16.


Structure and function of CarD, an essential mycobacterial transcription factor.

Srivastava DB, Leon K, Osmundson J, Garner AL, Weiss LA, Westblade LF, Glickman MS, Landick R, Darst SA, Stallings CL, Campbell EA.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12619-24. doi: 10.1073/pnas.1308270110. Epub 2013 Jul 15.


Development of a high-throughput screen and its use in the discovery of Streptococcus pneumoniae immunoglobulin A1 protease inhibitors.

Garner AL, Fullagar JL, Day JA, Cohen SM, Janda KD.

J Am Chem Soc. 2013 Jul 10;135(27):10014-7. doi: 10.1021/ja404180x. Epub 2013 Jun 28.


Facilitating cytokine-mediated cancer cell death by proteobacterial N-acylhomoserine lactones.

Kravchenko V, Garner AL, Mathison J, Seit-Nebi A, Yu J, Gileva IP, Ulevitch R, Janda KD.

ACS Chem Biol. 2013;8(6):1117-20. doi: 10.1021/cb4000184. Epub 2013 Mar 21.


Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: tropolones as inhibitors of P. aeruginosa elastase.

Fullagar JL, Garner AL, Struss AK, Day JA, Martin DP, Yu J, Cai X, Janda KD, Cohen SM.

Chem Commun (Camb). 2013 Apr 21;49(31):3197-9. doi: 10.1039/c3cc41191e. Epub 2013 Mar 12.


Immunomodulation and the quorum sensing molecule 3-oxo-C12-homoserine lactone: the importance of chemical scaffolding for probe development.

Garner AL, Yu J, Struss AK, Kaufmann GF, Kravchenko VV, Janda KD.

Chem Commun (Camb). 2013 Feb 21;49(15):1515-7. doi: 10.1039/c3cc38851d.


3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB.

Garner AL, Struss AK, Fullagar JL, Agrawal A, Moreno AY, Cohen SM, Janda KD.

ACS Med Chem Lett. 2012 Aug 9;3(8):668-672. Epub 2012 Jun 19.


Stereochemical insignificance discovered in Acinetobacter baumannii quorum sensing.

Garner AL, Kim SK, Zhu J, Struss AK, Watkins R, Feske BD, Kaufmann GF, Janda KD.

PLoS One. 2012;7(5):e37102. doi: 10.1371/journal.pone.0037102. Epub 2012 May 22. Retraction in: PLoS One. 2013;8(5). doi: 10.1371/annotation/1345f9b0-016e-4123-9e72-6ccc4fa17ba2. PLoS One. 2013;8(4). doi: 10.1371/annotation/8f2ddf91-3499-4627-9a91-449b78465f9d.


Nonthermal atmospheric plasma rapidly disinfects multidrug-resistant microbes by inducing cell surface damage.

Kvam E, Davis B, Mondello F, Garner AL.

Antimicrob Agents Chemother. 2012 Apr;56(4):2028-36. doi: 10.1128/AAC.05642-11. Epub 2012 Jan 9.


Targeting the Wolbachia cell division protein FtsZ as a new approach for antifilarial therapy.

Li Z, Garner AL, Gloeckner C, Janda KD, Carlow CK.

PLoS Negl Trop Dis. 2011 Nov;5(11):e1411. doi: 10.1371/journal.pntd.0001411. Epub 2011 Nov 29.


A multivalent probe for AI-2 quorum-sensing receptors.

Garner AL, Park J, Zakhari JS, Lowery CA, Struss AK, Sawada D, Kaufmann GF, Janda KD.

J Am Chem Soc. 2011 Oct 12;133(40):15934-7. doi: 10.1021/ja207556d. Epub 2011 Sep 15.


The Use of 3,5,4'-Tri-O-acetylresveratrol as a Potential Pro-drug for Resveratrol Protects Mice from γ-Irradiation-Induced Death.

Koide K, Osman S, Garner AL, Song F, Dixon T, Greenberger JS, Epperly MW.

ACS Med Chem Lett. 2011 Jan 25;2(4):270-274.


A small molecule antagonist of ghrelin O-acyltransferase (GOAT).

Garner AL, Janda KD.

Chem Commun (Camb). 2011 Jul 14;47(26):7512-4. doi: 10.1039/c1cc11817j. Epub 2011 May 19.


Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus.

Garner AL, Gloeckner C, Tricoche N, Zakhari JS, Samje M, Cho-Ngwa F, Lustigman S, Janda KD.

J Med Chem. 2011 Jun 9;54(11):3963-72. doi: 10.1021/jm200364n. Epub 2011 May 12.


Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network.

Uckun FM, Qazi S, Ozer Z, Garner AL, Pitt J, Ma H, Janda KD.

Br J Haematol. 2011 Jun;153(6):741-52. doi: 10.1111/j.1365-2141.2011.08671.x. Epub 2011 Apr 25.


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