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Probing the Robustness of Inhibitors of Tuberculosis Aminoglycoside Resistance Enzyme Eis by Mutagenesis.

Green KD, Punetha A, Hou C, Garneau-Tsodikova S, Tsodikov OV.

ACS Infect Dis. 2019 Aug 21. doi: 10.1021/acsinfecdis.9b00228. [Epub ahead of print]


Novel zafirlukast derivatives exhibit selective antibacterial activity against Porphyromonas gingivalis.

Thamban Chandrika N, Fosso MY, Alimova Y, May A, Gonzalez OA, Garneau-Tsodikova S.

Medchemcomm. 2019 Jun 10;10(6):926-933. doi: 10.1039/c9md00074g. eCollection 2019 Jun 1.


Publisher Correction: Unusual substrate and halide versatility of phenolic halogenase PltM.

Mori S, Pang AH, Chandrika NT, Garneau-Tsodikova S, Tsodikov OV.

Nat Commun. 2019 Apr 30;10(1):2053. doi: 10.1038/s41467-019-09731-8.


Unusual substrate and halide versatility of phenolic halogenase PltM.

Mori S, Pang AH, Thamban Chandrika N, Garneau-Tsodikova S, Tsodikov OV.

Nat Commun. 2019 Mar 19;10(1):1255. doi: 10.1038/s41467-019-09215-9. Erratum in: Nat Commun. 2019 Apr 30;10(1):2053.


Investigating the promiscuity of the chloramphenicol nitroreductase from Haemophilus influenzae towards the reduction of 4-nitrobenzene derivatives.

Green KD, Fosso MY, Mayhoub AS, Garneau-Tsodikova S.

Bioorg Med Chem Lett. 2019 May 1;29(9):1127-1132. doi: 10.1016/j.bmcl.2019.02.025. Epub 2019 Feb 21.


Probing the limits of interrupted adenylation domains by engineering a trifunctional enzyme capable of adenylation, N-, and S-methylation.

Lundy TA, Mori S, Garneau-Tsodikova S.

Org Biomol Chem. 2019 Jan 31;17(5):1169-1175. doi: 10.1039/c8ob02996b.


N,N'-diaryl-bishydrazones in a biphenyl platform: Broad spectrum antifungal agents.

Thamban Chandrika N, Dennis EK, Shrestha SK, Ngo HX, Green KD, Kwiatkowski S, Deaciuc AG, Dwoskin LP, Watt DS, Garneau-Tsodikova S.

Eur J Med Chem. 2019 Feb 15;164:273-281. doi: 10.1016/j.ejmech.2018.12.042. Epub 2018 Dec 18.


Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors.

Green KD, Fosso MY, Garneau-Tsodikova S.

Molecules. 2018 Dec 8;23(12). pii: E3252. doi: 10.3390/molecules23123252.


Synthesis, antimicrobial activity, attenuation of aminoglycoside resistance in MRSA, and ribosomal A-site binding of pyrene-neomycin conjugates.

Story S, Skriba MJ, Maiti K, Nihar Ranjan, Degtyareva NN, Green KD, Khodaverdian V, Oyelere AK, Garneau-Tsodikova S, Arya DP.

Eur J Med Chem. 2019 Feb 1;163:381-393. doi: 10.1016/j.ejmech.2018.11.022. Epub 2018 Nov 14.


Synergistic combinations of azoles and antihistamines against Candida species in vitro.

Dennis EK, Garneau-Tsodikova S.

Med Mycol. 2018 Oct 8. doi: 10.1093/mmy/myy088. [Epub ahead of print]


Making figures: are you taking the best approach to maximize visibility?

Mori S, Garneau-Tsodikova S.

Medchemcomm. 2018 Aug 8;9(9):1399-1403. doi: 10.1039/c8md90036a. eCollection 2018 Sep 1. Review.


Interfering With DNA Decondensation as a Strategy Against Mycobacteria.

Scutigliani EM, Scholl ER, Grootemaat AE, Khanal S, Kochan JA, Krawczyk PM, Reits EA, Garzan A, Ngo HX, Green KD, Garneau-Tsodikova S, Ruijter JM, van Veen HA, van der Wel NN.

Front Microbiol. 2018 Sep 5;9:2034. doi: 10.3389/fmicb.2018.02034. eCollection 2018.


Nucleoside triphosphate cosubstrates control the substrate profile and efficiency of aminoglycoside 3'-O-phosphotransferase type IIa.

Holbrook SYL, Gentry MS, Tsodikov OV, Garneau-Tsodikova S.

Medchemcomm. 2018 Jul 16;9(8):1332-1339. doi: 10.1039/c8md00234g. eCollection 2018 Aug 1.


Using MbtH-Like Proteins to Alter the Substrate Profile of a Nonribosomal Peptide Adenylation Enzyme.

Mori S, Green KD, Choi R, Buchko GW, Fried MG, Garneau-Tsodikova S.

Chembiochem. 2018 Oct 18;19(20):2186-2194. doi: 10.1002/cbic.201800240. Epub 2018 Oct 4.


What are the drugs of the future?

Ngo HX, Garneau-Tsodikova S.

Medchemcomm. 2018 Apr 23;9(5):757-758. doi: 10.1039/c8md90019a. eCollection 2018 May 1. Review.


What is medicinal chemistry? - Demystifying a rapidly evolving discipline!

Holbrook SYL, Garneau-Tsodikova S.

Medchemcomm. 2017 Aug 16;8(9):1739-1741. doi: 10.1039/c7md90030a. eCollection 2017 Sep 1. Review.


Derivatives of Ribosome-Inhibiting Antibiotic Chloramphenicol Inhibit the Biosynthesis of Bacterial Cell Wall.

Louzoun Zada S, Green KD, Shrestha SK, Herzog IM, Garneau-Tsodikova S, Fridman M.

ACS Infect Dis. 2018 Jul 13;4(7):1121-1129. doi: 10.1021/acsinfecdis.8b00078. Epub 2018 May 1.


Differential Effects of Linkers on the Activity of Amphiphilic Tobramycin Antifungals.

Fosso MY, Shrestha SK, Thamban Chandrika N, Dennis EK, Green KD, Garneau-Tsodikova S.

Molecules. 2018 Apr 13;23(4). pii: E899. doi: 10.3390/molecules23040899.


Potent 1,2,4-Triazino[5,6 b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis.

Ngo HX, Green KD, Gajadeera CS, Willby MJ, Holbrook SYL, Hou C, Garzan A, Mayhoub AS, Posey JE, Tsodikov OV, Garneau-Tsodikova S.

ACS Infect Dis. 2018 Jun 8;4(6):1030-1040. doi: 10.1021/acsinfecdis.8b00074. Epub 2018 Mar 30.


Structural basis for backbone N-methylation by an interrupted adenylation domain.

Mori S, Pang AH, Lundy TA, Garzan A, Tsodikov OV, Garneau-Tsodikova S.

Nat Chem Biol. 2018 May;14(5):428-430. doi: 10.1038/s41589-018-0014-7. Epub 2018 Mar 19.


Engineering Bifunctional Enzymes Capable of Adenylating and Selectively Methylating the Side Chain or Core of Amino Acids.

Lundy TA, Mori S, Garneau-Tsodikova S.

ACS Synth Biol. 2018 Feb 16;7(2):399-404. doi: 10.1021/acssynbio.7b00426. Epub 2018 Feb 2.


Acetylation by Eis and Deacetylation by Rv1151c of Mycobacterium tuberculosis HupB: Biochemical and Structural Insight.

Green KD, Biswas T, Pang AH, Willby MJ, Reed MS, Stuchlik O, Pohl J, Posey JE, Tsodikov OV, Garneau-Tsodikova S.

Biochemistry. 2018 Feb 6;57(5):781-790. doi: 10.1021/acs.biochem.7b01089. Epub 2018 Jan 18.


Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities.

Thamban Chandrika N, Garneau-Tsodikova S.

Chem Soc Rev. 2018 Feb 19;47(4):1189-1249. doi: 10.1039/c7cs00407a. Review.


Novel fluconazole derivatives with promising antifungal activity.

Thamban Chandrika N, Shrestha SK, Ngo HX, Howard KC, Garneau-Tsodikova S.

Bioorg Med Chem. 2018 Feb 1;26(3):573-580. doi: 10.1016/j.bmc.2017.12.018. Epub 2017 Dec 17.


Evaluation of Aminoglycoside and Carbapenem Resistance in a Collection of Drug-Resistant Pseudomonas aeruginosa Clinical Isolates.

Holbrook SYL, Garneau-Tsodikova S.

Microb Drug Resist. 2018 Sep;24(7):1020-1030. doi: 10.1089/mdr.2017.0101. Epub 2017 Dec 20.


Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents.

Thamban Chandrika N, Shrestha SK, Ngo HX, Tsodikov OV, Howard KC, Garneau-Tsodikova S.

J Med Chem. 2018 Jan 11;61(1):158-173. doi: 10.1021/acs.jmedchem.7b01138. Epub 2017 Dec 19.


New Application of Neomycin B-Bisbenzimidazole Hybrids as Antifungal Agents.

Thamban Chandrika N, Shrestha SK, Ranjan N, Sharma A, Arya DP, Garneau-Tsodikova S.

ACS Infect Dis. 2018 Feb 9;4(2):196-207. doi: 10.1021/acsinfecdis.7b00254. Epub 2017 Dec 11.


Deciphering Nature's Intricate Way of N,S-Dimethylating l-Cysteine: Sequential Action of Two Bifunctional Adenylation Domains.

Mori S, Garzan A, Tsodikov OV, Garneau-Tsodikova S.

Biochemistry. 2017 Nov 21;56(46):6087-6097. doi: 10.1021/acs.biochem.7b00980. Epub 2017 Nov 7.


Repurposing antipsychotic drugs into antifungal agents: Synergistic combinations of azoles and bromperidol derivatives in the treatment of various fungal infections.

Holbrook SYL, Garzan A, Dennis EK, Shrestha SK, Garneau-Tsodikova S.

Eur J Med Chem. 2017 Oct 20;139:12-21. doi: 10.1016/j.ejmech.2017.07.030. Epub 2017 Jul 19.


Activation and Loading of the Starter Unit during Thiocoraline Biosynthesis.

Mori S, Shrestha SK, Fernández J, Álvarez San Millán M, Garzan A, Al-Mestarihi AH, Lombó F, Garneau-Tsodikova S.

Biochemistry. 2017 Aug 29;56(34):4457-4467. doi: 10.1021/acs.biochem.7b00661. Epub 2017 Aug 17.


Zinc transporters YbtX and ZnuABC are required for the virulence of Yersinia pestis in bubonic and pneumonic plague in mice.

Bobrov AG, Kirillina O, Fosso MY, Fetherston JD, Miller MC, VanCleave TT, Burlison JA, Arnold WK, Lawrenz MB, Garneau-Tsodikova S, Perry RD.

Metallomics. 2017 Jun 21;9(6):757-772. doi: 10.1039/c7mt00126f.


Novel alkylated azoles as potent antifungals.

Shrestha SK, Garzan A, Garneau-Tsodikova S.

Eur J Med Chem. 2017 Jun 16;133:309-318. doi: 10.1016/j.ejmech.2017.03.075. Epub 2017 Mar 31.


Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis Inhibitors.

Garzan A, Willby MJ, Ngo HX, Gajadeera CS, Green KD, Holbrook SY, Hou C, Posey JE, Tsodikov OV, Garneau-Tsodikova S.

ACS Infect Dis. 2017 Apr 14;3(4):302-309. doi: 10.1021/acsinfecdis.6b00193. Epub 2017 Feb 17.


Antimicrobial Activity, AME Resistance, and A-Site Binding Studies of Anthraquinone-Neomycin Conjugates.

Degtyareva NN, Gong C, Story S, Levinson NS, Oyelere AK, Green KD, Garneau-Tsodikova S, Arya DP.

ACS Infect Dis. 2017 Mar 10;3(3):206-215. doi: 10.1021/acsinfecdis.6b00176. Epub 2017 Feb 17.


Discovery and Optimization of Two Eis Inhibitor Families as Kanamycin Adjuvants against Drug-Resistant M. tuberculosis.

Garzan A, Willby MJ, Green KD, Tsodikov OV, Posey JE, Garneau-Tsodikova S.

ACS Med Chem Lett. 2016 Sep 15;7(12):1219-1221. eCollection 2016 Dec 8.


Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis.

Garzan A, Willby MJ, Green KD, Gajadeera CS, Hou C, Tsodikov OV, Posey JE, Garneau-Tsodikova S.

J Med Chem. 2016 Dec 8;59(23):10619-10628. Epub 2016 Nov 22.


In Vitro Assays to Identify Antibiotics Targeting DNA Metabolism.

Pang AH, Garneau-Tsodikova S, Tsodikov OV.

Methods Mol Biol. 2017;1520:175-200. doi: 10.1007/978-1-4939-6634-9_11.


Bis(N-amidinohydrazones) and N-(amidino)-N'-aryl-bishydrazones: New classes of antibacterial/antifungal agents.

Shrestha SK, Kril LM, Green KD, Kwiatkowski S, Sviripa VM, Nickell JR, Dwoskin LP, Watt DS, Garneau-Tsodikova S.

Bioorg Med Chem. 2017 Jan 1;25(1):58-66. doi: 10.1016/j.bmc.2016.10.009. Epub 2016 Oct 10.


A complex game of hide and seek: the search for new antifungals.

Ngo HX, Garneau-Tsodikova S, Green KD.

Medchemcomm. 2016 Jul 1;7(7):1285-1306. Epub 2016 May 17.


Discovery of Allosteric and Selective Inhibitors of Inorganic Pyrophosphatase from Mycobacterium tuberculosis.

Pang AH, Garzan A, Larsen MJ, McQuade TJ, Garneau-Tsodikova S, Tsodikov OV.

ACS Chem Biol. 2016 Nov 18;11(11):3084-3092. Epub 2016 Sep 26.


Expanding Aminoglycoside Resistance Enzyme Regiospecificity by Mutation and Truncation.

Holbrook SY, Garneau-Tsodikova S.

Biochemistry. 2016 Oct 11;55(40):5726-5737. Epub 2016 Sep 26.


High throughput LSPR and SERS analysis of aminoglycoside antibiotics.

McKeating KS, Couture M, Dinel MP, Garneau-Tsodikova S, Masson JF.

Analyst. 2016 Aug 15;141(17):5120-6. doi: 10.1039/c6an00540c.


Flipping the Switch "On" for Aminoglycoside-Resistance Enzymes: The Mechanism Is Finally Revealed!

Ngo HX, Garneau-Tsodikova S.

Structure. 2016 Jul 6;24(7):1011-3. doi: 10.1016/j.str.2016.06.006.


Identification of Ebsulfur Analogues with Broad-Spectrum Antifungal Activity.

Ngo HX, Shrestha SK, Garneau-Tsodikova S.

ChemMedChem. 2016 Jul 19;11(14):1507-16. doi: 10.1002/cmdc.201600236. Epub 2016 Jun 23.


Ask the experts: how to curb antibiotic resistance and plug the antibiotics gap?

Piddock L, Garneau-Tsodikova S, Garner C.

Future Med Chem. 2016 Jun;8(10):1027-32. doi: 10.4155/fmc-2014-0032. Epub 2016 Jun 21. Review. No abstract available.


Synthesis and investigation of novel benzimidazole derivatives as antifungal agents.

Chandrika NT, Shrestha SK, Ngo HX, Garneau-Tsodikova S.

Bioorg Med Chem. 2016 Aug 15;24(16):3680-6. doi: 10.1016/j.bmc.2016.06.010. Epub 2016 Jun 4.


Expanding Substrate Promiscuity by Engineering a Novel Adenylating-Methylating NRPS Bifunctional Enzyme.

Shrestha SK, Garneau-Tsodikova S.

Chembiochem. 2016 Jul 15;17(14):1328-32. doi: 10.1002/cbic.201600234. Epub 2016 Jun 3.


Concise Synthesis of Spergualin-Inspired Molecules With Broad-Spectrum Antibiotic Activity.

Assimon VA, Shao H, Garneau-Tsodikova S, Gestwicki JE.

Medchemcomm. 2015 May 1;6(5):912-918. Epub 2015 Mar 30.


Development of ebsulfur analogues as potent antibacterials against methicillin-resistant Staphylococcus aureus.

Ngo HX, Shrestha SK, Green KD, Garneau-Tsodikova S.

Bioorg Med Chem. 2016 Dec 15;24(24):6298-6306. doi: 10.1016/j.bmc.2016.03.060. Epub 2016 Mar 31.


A biocatalytic approach to capuramycin analogues by exploiting a substrate permissive N-transacylase CapW.

Liu X, Jin Y, Cai W, Green KD, Goswami A, Garneau-Tsodikova S, Nonaka K, Baba S, Funabashi M, Yang Z, Van Lanen SG.

Org Biomol Chem. 2016 Apr 28;14(16):3956-62. doi: 10.1039/c6ob00381h. Epub 2016 Apr 6.

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