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Items: 42


In vivo liposomal delivery of PPAR╬▒/╬│ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects.

Osinski V, Bauknight DK, Dasa SSK, Harms MJ, Kroon T, Marshall MA, Garmey JC, Nguyen AT, Hartman J, Upadhye A, Srikakulapu P, Zhou A, O'Mahony G, Klibanov AL, Kelly KA, Boucher J, McNamara CA.

Theranostics. 2020 Jan 1;10(2):585-601. doi: 10.7150/thno.36572. eCollection 2020.


Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked to Human Coronary Atherosclerosis.

Upadhye A, Srikakulapu P, Gonen A, Hendrikx S, Perry HM, Nguyen A, McSkimming C, Marshall MA, Garmey JC, Taylor AM, Bender TP, Tsimikas S, Holodick NE, Rothstein TL, Witztum JL, McNamara CA.

Circ Res. 2019 Oct 25;125(10):e55-e70. doi: 10.1161/CIRCRESAHA.119.315786. Epub 2019 Sep 24.


Age increases MCP-1 level in association with bariatric surgery operating time and metabolic risk severity.

Malin SK, Kaplan JL, Meng L, Garmey JC, Kirby JL, Taylor AM, Hallowell PT, McNamara CA.

Obes Sci Pract. 2017 Apr 26;3(2):193-200. doi: 10.1002/osp4.105. eCollection 2017 Jun.


Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance.

Harmon DB, Srikakulapu P, Kaplan JL, Oldham SN, McSkimming C, Garmey JC, Perry HM, Kirby JL, Prohaska TA, Gonen A, Hallowell P, Schirmer B, Tsimikas S, Taylor AM, Witztum JL, McNamara CA.

Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):682-91. doi: 10.1161/ATVBAHA.116.307166. Epub 2016 Feb 11.


Adipocyte progenitor cells initiate monocyte chemoattractant protein-1-mediated macrophage accumulation in visceral adipose tissue.

Kaplan JL, Marshall MA, C McSkimming C, Harmon DB, Garmey JC, Oldham SN, Hallowell P, McNamara CA.

Mol Metab. 2015 Aug 12;4(11):779-94. doi: 10.1016/j.molmet.2015.07.010. eCollection 2015 Nov.


Loss of Id3 increases VCAM-1 expression, macrophage accumulation, and atherogenesis in Ldlr-/- mice.

Lipinski MJ, Campbell KA, Duong SQ, Welch TJ, Garmey JC, Doran AC, Skaflen MD, Oldham SN, Kelly KA, McNamara CA.

Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2855-61. doi: 10.1161/ATVBAHA.112.300352. Epub 2012 Oct 4.


B-cell aortic homing and atheroprotection depend on Id3.

Doran AC, Lipinski MJ, Oldham SN, Garmey JC, Campbell KA, Skaflen MD, Cutchins A, Lee DJ, Glover DK, Kelly KA, Galkina EV, Ley K, Witztum JL, Tsimikas S, Bender TP, McNamara CA.

Circ Res. 2012 Jan 6;110(1):e1-12. doi: 10.1161/CIRCRESAHA.111.256438. Epub 2011 Oct 27.


Increased 12/15-lipoxygenase enhances cell growth, fibronectin deposition, and neointimal formation in response to carotid injury.

Deliri H, Meller N, Kadakkal A, Malhotra R, Brewster J, Doran AC, Pei H, Oldham SN, Skaflen MD, Garmey JC, McNamara CA.

Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):110-6. doi: 10.1161/ATVBAHA.110.212068. Epub 2010 Oct 14.


Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling.

Ogihara T, Chuang JC, Vestermark GL, Garmey JC, Ketchum RJ, Huang X, Brayman KL, Thorner MO, Repa JJ, Mirmira RG, Evans-Molina C.

J Biol Chem. 2010 Feb 19;285(8):5392-404. doi: 10.1074/jbc.M109.064659. Epub 2009 Dec 11.


Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure.

Evans-Molina C, Robbins RD, Kono T, Tersey SA, Vestermark GL, Nunemaker CS, Garmey JC, Deering TG, Keller SR, Maier B, Mirmira RG.

Mol Cell Biol. 2009 Apr;29(8):2053-67. doi: 10.1128/MCB.01179-08. Epub 2009 Feb 23.


12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet.

Nunemaker CS, Chen M, Pei H, Kimble SD, Keller SR, Carter JD, Yang Z, Smith KM, Wu R, Bevard MH, Garmey JC, Nadler JL.

Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1065-75. doi: 10.1152/ajpendo.90371.2008. Epub 2008 Sep 9.


Research resource: nuclear hormone receptor expression in the endocrine pancreas.

Chuang JC, Cha JY, Garmey JC, Mirmira RG, Repa JJ.

Mol Endocrinol. 2008 Oct;22(10):2353-63. doi: 10.1210/me.2007-0568. Epub 2008 Jul 31.


Pdx1 and BETA2/NeuroD1 participate in a transcriptional complex that mediates short-range DNA looping at the insulin gene.

Babu DA, Chakrabarti SK, Garmey JC, Mirmira RG.

J Biol Chem. 2008 Mar 28;283(13):8164-72. doi: 10.1074/jbc.M800336200. Epub 2008 Feb 4.


Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes.

McDuffie M, Maybee NA, Keller SR, Stevens BK, Garmey JC, Morris MA, Kropf E, Rival C, Ma K, Carter JD, Tersey SA, Nunemaker CS, Nadler JL.

Diabetes. 2008 Jan;57(1):199-208. Epub 2007 Oct 16.


Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets.

Evans-Molina C, Garmey JC, Ketchum R, Brayman KL, Deng S, Mirmira RG.

Diabetes. 2007 Mar;56(3):827-35.


Role of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1.

Francis J, Babu DA, Deering TG, Chakrabarti SK, Garmey JC, Evans-Molina C, Taylor DG, Mirmira RG.

Mol Endocrinol. 2006 Dec;20(12):3133-45. Epub 2006 Aug 10.


Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes.

Yang Z, Chen M, Carter JD, Nunemaker CS, Garmey JC, Kimble SD, Nadler JL.

Biochem Biophys Res Commun. 2006 Jun 9;344(3):1017-22. Epub 2006 Apr 5.


Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription.

Francis J, Chakrabarti SK, Garmey JC, Mirmira RG.

J Biol Chem. 2005 Oct 28;280(43):36244-53. Epub 2005 Sep 1.


Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.

Iype T, Francis J, Garmey JC, Schisler JC, Nesher R, Weir GC, Becker TC, Newgard CB, Griffen SC, Mirmira RG.

J Biol Chem. 2005 Apr 29;280(17):16798-807. Epub 2005 Mar 2.


Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells.

Chakrabarti SK, Francis J, Ziesmann SM, Garmey JC, Mirmira RG.

J Biol Chem. 2003 Jun 27;278(26):23617-23. Epub 2003 Apr 23.


Expression of parathyroid hormone-related peptide (PTH-rp) and its receptorin the porcine ovary: regulation by transforming growth factor-beta and possible paracrine effects of granulosa cell PTH-rp secretion on theca cells.

Garmey JC, Schnorr JA, Bruns ME, Bruns DE, Seaner RM, Ferguson II JE, Luking Jayes FC, Aguirre C, Veldhuis JD.

Biol Reprod. 2000 Feb;62(2):334-9.


Mechanisms underlying endothelin's inhibition of FSH-stimulated progesterone production by ovarian granulosa cells.

Flores JA, Garmey JC, Lahav M, Veldhuis JD.

Mol Cell Endocrinol. 1999 Oct 25;156(1-2):169-78.


Coordinate developmental expression of genes regulating sterol economy and cholesterol side-chain cleavage in the porcine ovary.

LaVoie HA, Benoit AM, Garmey JC, Dailey RA, Wright DJ, Veldhuis JD.

Biol Reprod. 1997 Aug;57(2):402-7.


Sites of inhibition of steroidogenesis by activation of protein kinase-C in swine ovarian (granulosa) cells.

Flores JA, Garmey JC, Nestler JE, Veldhuis JD.

Endocrinology. 1993 May;132(5):1983-90.


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