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Items: 44

1.

Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage.

Goulielmaki E, Ioannidou A, Tsekrekou M, Stratigi K, Poutakidou IK, Gkirtzimanaki K, Aivaliotis M, Evangelou K, Topalis P, Altmüller J, Gorgoulis VG, Chatzinikolaou G, Garinis GA.

Nat Commun. 2020 Jan 2;11(1):42. doi: 10.1038/s41467-019-13894-9.

2.

Nucleotide Excision Repair and Transcription-Associated Genome Instability.

Apostolou Z, Chatzinikolaou G, Stratigi K, Garinis GA.

Bioessays. 2019 Apr;41(4):e1800201. doi: 10.1002/bies.201800201. Review.

PMID:
30919497
3.

Nuclear DNA Damage and Ageing.

Agathangelou K, Apostolou Z, Garinis GA.

Subcell Biochem. 2018;90:309-322. doi: 10.1007/978-981-13-2835-0_10. Review.

PMID:
30779013
4.

Editorial: DNA damage & immunity.

Garinis GA, Schwer B, Schumacher B.

Mech Ageing Dev. 2017 Jul;165(Pt A):1-2. doi: 10.1016/j.mad.2017.04.006. Epub 2017 Apr 23. No abstract available.

5.

ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes.

Chatzinikolaou G, Apostolou Z, Aid-Pavlidis T, Ioannidou A, Karakasilioti I, Papadopoulos GL, Aivaliotis M, Tsekrekou M, Strouboulis J, Kosteas T, Garinis GA.

Nat Cell Biol. 2017 May;19(5):421-432. doi: 10.1038/ncb3499. Epub 2017 Apr 3.

PMID:
28368372
6.

DNA Damage: From Chronic Inflammation to Age-Related Deterioration.

Ioannidou A, Goulielmaki E, Garinis GA.

Front Genet. 2016 Oct 25;7:187. eCollection 2016. Review.

7.

DNA damage-induced inflammation and nuclear architecture.

Stratigi K, Chatzidoukaki O, Garinis GA.

Mech Ageing Dev. 2017 Jul;165(Pt A):17-26. doi: 10.1016/j.mad.2016.09.008. Epub 2016 Oct 1. Review.

PMID:
27702596
8.

Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging.

Visser WE, Bombardieri CR, Zevenbergen C, Barnhoorn S, Ottaviani A, van der Pluijm I, Brandt R, Kaptein E, van Heerebeek R, van Toor H, Garinis GA, Peeters RP, Medici M, van Ham W, Vermeij WP, de Waard MC, de Krijger RR, Boelen A, Kwakkel J, Kopchick JJ, List EO, Melis JP, Darras VM, Dollé ME, van der Horst GT, Hoeijmakers JH, Visser TJ.

PLoS One. 2016 Mar 8;11(3):e0149941. doi: 10.1371/journal.pone.0149941. eCollection 2016.

9.

Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function.

Oliverio M, Schmidt E, Mauer J, Baitzel C, Hansmeier N, Khani S, Konieczka S, Pradas-Juni M, Brodesser S, Van TM, Bartsch D, Brönneke HS, Heine M, Hilpert H, Tarcitano E, Garinis GA, Frommolt P, Heeren J, Mori MA, Brüning JC, Kornfeld JW.

Nat Cell Biol. 2016 Mar;18(3):328-36. doi: 10.1038/ncb3316. Epub 2016 Feb 22.

PMID:
26900752
10.

DNA damage and innate immunity: links and trade-offs.

Chatzinikolaou G, Karakasilioti I, Garinis GA.

Trends Immunol. 2014 Sep;35(9):429-35. doi: 10.1016/j.it.2014.06.003. Epub 2014 Jul 8. Review.

PMID:
25023467
11.

Tissue-specific aging: a tale of functional asymmetry.

Karakasilioti I, Garinis GA.

Aging (Albany NY). 2014 Jan;6(1):7-8. No abstract available.

12.

DNA damage triggers a chronic autoinflammatory response, leading to fat depletion in NER progeria.

Karakasilioti I, Kamileri I, Chatzinikolaou G, Kosteas T, Vergadi E, Robinson AR, Tsamardinos I, Rozgaja TA, Siakouli S, Tsatsanis C, Niedernhofer LJ, Garinis GA.

Cell Metab. 2013 Sep 3;18(3):403-15. doi: 10.1016/j.cmet.2013.08.011.

13.

Programmed death-1 shapes memory phenotype CD8 T cell subsets in a cell-intrinsic manner.

Charlton JJ, Chatzidakis I, Tsoukatou D, Boumpas DT, Garinis GA, Mamalaki C.

J Immunol. 2013 Jun 15;190(12):6104-14. doi: 10.4049/jimmunol.1201617. Epub 2013 May 17.

14.

Nucleotide excision repair: new tricks with old bricks.

Kamileri I, Karakasilioti I, Garinis GA.

Trends Genet. 2012 Nov;28(11):566-73. doi: 10.1016/j.tig.2012.06.004. Epub 2012 Jul 22. Review.

PMID:
22824526
15.

NF-κB inhibition delays DNA damage-induced senescence and aging in mice.

Tilstra JS, Robinson AR, Wang J, Gregg SQ, Clauson CL, Reay DP, Nasto LA, St Croix CM, Usas A, Vo N, Huard J, Clemens PR, Stolz DB, Guttridge DC, Watkins SC, Garinis GA, Wang Y, Niedernhofer LJ, Robbins PD.

J Clin Invest. 2012 Jul;122(7):2601-12. doi: 10.1172/JCI45785. Epub 2012 Jun 18.

16.

Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria.

Kamileri I, Karakasilioti I, Sideri A, Kosteas T, Tatarakis A, Talianidis I, Garinis GA.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000. doi: 10.1073/pnas.1114941109. Epub 2012 Feb 8.

17.

The role of metformin in the management of NAFLD.

Mazza A, Fruci B, Garinis GA, Giuliano S, Malaguarnera R, Belfiore A.

Exp Diabetes Res. 2012;2012:716404. doi: 10.1155/2012/716404. Epub 2011 Dec 12. Review.

18.

A mouse model of accelerated liver aging caused by a defect in DNA repair.

Gregg SQ, Gutiérrez V, Robinson AR, Woodell T, Nakao A, Ross MA, Michalopoulos GK, Rigatti L, Rothermel CE, Kamileri I, Garinis GA, Stolz DB, Niedernhofer LJ.

Hepatology. 2012 Feb;55(2):609-21. doi: 10.1002/hep.24713.

19.

Metformin versus dietary treatment in nonalcoholic hepatic steatosis: a randomized study.

Garinis GA, Fruci B, Mazza A, De Siena M, Abenavoli S, Gulletta E, Ventura V, Greco M, Abenavoli L, Belfiore A.

Int J Obes (Lond). 2010 Aug;34(8):1255-64. doi: 10.1038/ijo.2010.40. Epub 2010 Feb 23.

PMID:
20179669
20.

Transcription-blocking DNA damage in aging and longevity.

Garinis GA, Schumacher B.

Cell Cycle. 2009 Jul 15;8(14):2134-5. Epub 2009 Jul 20. No abstract available.

PMID:
19556874
21.

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity.

Garinis GA, Uittenboogaard LM, Stachelscheid H, Fousteri M, van Ijcken W, Breit TM, van Steeg H, Mullenders LH, van der Horst GT, Brüning JC, Niessen CM, Hoeijmakers JH, Schumacher B.

Nat Cell Biol. 2009 May;11(5):604-15. doi: 10.1038/ncb1866. Epub 2009 Apr 12.

22.

Sealing the gap between nuclear DNA damage and longevity.

Schumacher B, Hoeijmakers JH, Garinis GA.

Mol Cell Endocrinol. 2009 Feb 5;299(1):112-7. doi: 10.1016/j.mce.2008.10.031. Epub 2008 Nov 5. Review. Erratum in: Mol Cell Endocrinol. 2009 May 6;303(1-2):107.

PMID:
19027821
23.

DNA damage and ageing: new-age ideas for an age-old problem.

Garinis GA, van der Horst GT, Vijg J, Hoeijmakers JH.

Nat Cell Biol. 2008 Nov;10(11):1241-7. doi: 10.1038/ncb1108-1241. Review.

24.

Delayed and accelerated aging share common longevity assurance mechanisms.

Schumacher B, van der Pluijm I, Moorhouse MJ, Kosteas T, Robinson AR, Suh Y, Breit TM, van Steeg H, Niedernhofer LJ, van Ijcken W, Bartke A, Spindler SR, Hoeijmakers JH, van der Horst GT, Garinis GA.

PLoS Genet. 2008 Aug 15;4(8):e1000161. doi: 10.1371/journal.pgen.1000161.

25.

Nucleotide excision repair deficiencies and the somatotropic axis in aging.

Garinis GA.

Hormones (Athens). 2008 Jan-Mar;7(1):9-16. Review.

26.

Age to survive: DNA damage and aging.

Schumacher B, Garinis GA, Hoeijmakers JH.

Trends Genet. 2008 Feb;24(2):77-85. doi: 10.1016/j.tig.2007.11.004. Epub 2008 Jan 14. Review.

PMID:
18192065
27.

"The molecular basis of aging": the Boehringer Ingelheim Fonds 95th International Titisee Conference.

Garinis GA, Patil CK, Schumacher B.

Mech Ageing Dev. 2007 Jul-Aug;128(7-8):469-75. Epub 2007 Jun 20.

PMID:
17643476
28.

Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome.

van der Pluijm I, Garinis GA, Brandt RM, Gorgels TG, Wijnhoven SW, Diderich KE, de Wit J, Mitchell JR, van Oostrom C, Beems R, Niedernhofer LJ, Velasco S, Friedberg EC, Tanaka K, van Steeg H, Hoeijmakers JH, van der Horst GT.

PLoS Biol. 2007 Jan;5(1):e2. Erratum in: PLoS Biol. 2008 Nov;6(11):e304.

29.

Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice.

Hanada K, Vermeij M, Garinis GA, de Waard MC, Kunen MG, Myers L, Maas A, Duncker DJ, Meijers C, Dietz HC, Kanaar R, Essers J.

Circ Res. 2007 Mar 16;100(5):738-46. Epub 2007 Feb 9.

PMID:
17293478
30.

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis.

Niedernhofer LJ, Garinis GA, Raams A, Lalai AS, Robinson AR, Appeldoorn E, Odijk H, Oostendorp R, Ahmad A, van Leeuwen W, Theil AF, Vermeulen W, van der Horst GT, Meinecke P, Kleijer WJ, Vijg J, Jaspers NG, Hoeijmakers JH.

Nature. 2006 Dec 21;444(7122):1038-43.

PMID:
17183314
31.

Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles.

Kurek D, Garinis GA, van Doorninck JH, van der Wees J, Grosveld FG.

Development. 2007 Jan;134(2):261-72. Epub 2006 Dec 6.

32.

Retinal degeneration and ionizing radiation hypersensitivity in a mouse model for Cockayne syndrome.

Gorgels TG, van der Pluijm I, Brandt RM, Garinis GA, van Steeg H, van den Aardweg G, Jansen GH, Ruijter JM, Bergen AA, van Norren D, Hoeijmakers JH, van der Horst GT.

Mol Cell Biol. 2007 Feb;27(4):1433-41. Epub 2006 Dec 4.

33.

Extended longevity mechanisms in short-lived progeroid mice: identification of a preservative stress response associated with successful aging.

van de Ven M, Andressoo JO, Holcomb VB, Hasty P, Suh Y, van Steeg H, Garinis GA, Hoeijmakers JH, Mitchell JR.

Mech Ageing Dev. 2007 Jan;128(1):58-63. Epub 2006 Nov 28. Review.

34.

Differential role of basal keratinocytes in UV-induced immunosuppression and skin cancer.

Jans J, Garinis GA, Schul W, van Oudenaren A, Moorhouse M, Smid M, Sert YG, van der Velde A, Rijksen Y, de Gruijl FR, van der Spek PJ, Yasui A, Hoeijmakers JH, Leenen PJ, van der Horst GT.

Mol Cell Biol. 2006 Nov;26(22):8515-26. Epub 2006 Sep 11.

35.

Photolyases: capturing the light to battle skin cancer.

Garinis GA, Jans J, van der Horst GT.

Future Oncol. 2006 Apr;2(2):191-9. Review.

PMID:
16563088
36.

Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks.

Garinis GA, Mitchell JR, Moorhouse MJ, Hanada K, de Waard H, Vandeputte D, Jans J, Brand K, Smid M, van der Spek PJ, Hoeijmakers JH, Kanaar R, van der Horst GT.

EMBO J. 2005 Nov 16;24(22):3952-62. Epub 2005 Oct 27.

37.

Elevated serum levels of the apoptosis related molecules TNF-alpha, Fas/Apo-1 and Bcl-2 in oral lichen planus.

Sklavounou-Andrikopoulou A, Chrysomali E, Iakovou M, Garinis GA, Karameris A.

J Oral Pathol Med. 2004 Aug;33(7):386-90.

PMID:
15250829
38.
39.

High frequency of concomitant nm23-H1 and E-cadherin transcriptional inactivation in primary non-inheriting colorectal carcinomas.

Garinis GA, Manolis EN, Spanakis NE, Patrinos GP, Peros G, Menounos PG.

J Mol Med (Berl). 2003 Apr;81(4):256-63. Epub 2003 Apr 2.

PMID:
12684753
40.

Transcriptional impairment of beta-catenin/E-cadherin complex is not associated with beta-catenin mutations in colorectal carcinomas.

Garinis GA, Spanakis NE, Menounos PG, Manolis EN, Peros G.

Br J Cancer. 2003 Jan 27;88(2):206-9.

41.

Hypermethylation-associated transcriptional silencing of E-cadherin in primary sporadic colorectal carcinomas.

Garinis GA, Menounos PG, Spanakis NE, Papadopoulos K, Karavitis G, Parassi I, Christeli E, Patrinos GP, Manolis EN, Peros G.

J Pathol. 2002 Dec;198(4):442-9.

PMID:
12434413
42.

DNA hypermethylation: when tumour suppressor genes go silent.

Garinis GA, Patrinos GP, Spanakis NE, Menounos PG.

Hum Genet. 2002 Aug;111(2):115-27. Epub 2002 Jul 16. Review.

PMID:
12189484
43.

Cytokine serum levels in patients with chronic HCV infection.

Spanakis NE, Garinis GA, Alexopoulos EC, Patrinos GP, Menounos PG, Sklavounou A, Manolis EN, Gorgoulis VG, Valis D.

J Clin Lab Anal. 2002;16(1):40-6.

44.

Association of allelic loss at the FHIT locus and p53 alterations with tumour kinetics and chromosomal instability in non-small cell lung carcinomas (NSCLCs).

Garinis GA, Gorgoulis VG, Mariatos G, Zacharatos P, Kotsinas A, Liloglou T, Foukas P, Kanavaros P, Kastrinakis NG, Vassilakopoulos T, Vogiatzi T, Field JK, Kittas C.

J Pathol. 2001 Jan;193(1):55-65.

PMID:
11169516

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