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Items: 23


Structural Basis of CD160:HVEM Recognition.

Liu W, Garrett SC, Fedorov EV, Ramagopal UA, Garforth SJ, Bonanno JB, Almo SC.

Structure. 2019 Aug 6;27(8):1286-1295.e4. doi: 10.1016/j.str.2019.05.010. Epub 2019 Jun 20.


Publisher Correction: A naturally occurring antiviral ribonucleotide encoded by the human genome.

Gizzi AS, Grove TL, Arnold JJ, Jose J, Jangra RK, Garforth SJ, Du Q, Cahill SM, Dulyaninova NG, Love JD, Chandran K, Bresnick AR, Cameron CE, Almo SC.

Nature. 2018 Oct;562(7725):E3. doi: 10.1038/s41586-018-0355-0.


A naturally occurring antiviral ribonucleotide encoded by the human genome.

Gizzi AS, Grove TL, Arnold JJ, Jose J, Jangra RK, Garforth SJ, Du Q, Cahill SM, Dulyaninova NG, Love JD, Chandran K, Bresnick AR, Cameron CE, Almo SC.

Nature. 2018 Jun;558(7711):610-614. doi: 10.1038/s41586-018-0238-4. Epub 2018 Jun 20. Erratum in: Nature. 2018 Oct;562(7725):E3.


Identification of Mycobacterial Ribosomal Proteins as Targets for CD4+ T Cells That Enhance Protective Immunity in Tuberculosis.

Kennedy SC, Johnson AJ, Bharrhan S, Lindestam Arlehamn CS, Xu J, Garforth SJ, Chan J, Jacobs WR Jr, Sette A, Almo SC, Porcelli SA.

Infect Immun. 2018 Aug 22;86(9). pii: e00009-18. doi: 10.1128/IAI.00009-18. Print 2018 Sep.


A Herpes Simplex Virus (HSV)-2 Single-Cycle Candidate Vaccine Deleted in Glycoprotein D Protects Male Mice From Lethal Skin Challenge With Clinical Isolates of HSV-1 and HSV-2.

Burn C, Ramsey N, Garforth SJ, Almo S, Jacobs WR Jr, Herold BC.

J Infect Dis. 2018 Feb 14;217(5):754-758. doi: 10.1093/infdis/jix628.


Panoramic view of a superfamily of phosphatases through substrate profiling.

Huang H, Pandya C, Liu C, Al-Obaidi NF, Wang M, Zheng L, Toews Keating S, Aono M, Love JD, Evans B, Seidel RD, Hillerich BS, Garforth SJ, Almo SC, Mariano PS, Dunaway-Mariano D, Allen KN, Farelli JD.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E1974-83. doi: 10.1073/pnas.1423570112. Epub 2015 Apr 6.


The lysine 65 residue in HIV-1 reverse transcriptase function and in nucleoside analog drug resistance.

Garforth SJ, Lwatula C, Prasad VR.

Viruses. 2014 Oct 23;6(10):4080-94. doi: 10.3390/v6104080. Review.


Overexpression of MERTK receptor tyrosine kinase in epithelial cancer cells drives efferocytosis in a gain-of-function capacity.

Nguyen KQ, Tsou WI, Calarese DA, Kimani SG, Singh S, Hsieh S, Liu Y, Lu B, Wu Y, Garforth SJ, Almo SC, Kotenko SV, Birge RB.

J Biol Chem. 2014 Sep 12;289(37):25737-49. doi: 10.1074/jbc.M114.570838. Epub 2014 Jul 29.


Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation.

Tsou WI, Nguyen KQ, Calarese DA, Garforth SJ, Antes AL, Smirnov SV, Almo SC, Birge RB, Kotenko SV.

J Biol Chem. 2014 Sep 12;289(37):25750-63. doi: 10.1074/jbc.M114.569020. Epub 2014 Jul 29.


Protein production from the structural genomics perspective: achievements and future needs.

Almo SC, Garforth SJ, Hillerich BS, Love JD, Seidel RD, Burley SK.

Curr Opin Struct Biol. 2013 Jun;23(3):335-44. doi: 10.1016/ Epub 2013 May 1. Review.


Lys66 residue as a determinant of high mismatch extension and misinsertion rates of HIV-1 reverse transcriptase.

Lwatula C, Garforth SJ, Prasad VR.

FEBS J. 2012 Nov;279(21):4010-24. doi: 10.1111/j.1742-4658.2012.08807.x. Epub 2012 Sep 27.


Pre-steady state kinetic analysis of cyclobutyl derivatives of 2'-deoxyadenosine 5'-triphosphate as inhibitors of HIV-1 reverse transcriptase.

Kim J, Wang L, Li Y, Becnel KD, Frey KM, Garforth SJ, Prasad VR, Schinazi RF, Liotta DC, Anderson KS.

Bioorg Med Chem Lett. 2012 Jun 15;22(12):4064-7. doi: 10.1016/j.bmcl.2012.04.078. Epub 2012 Apr 24.


K65R and K65A substitutions in HIV-1 reverse transcriptase enhance polymerase fidelity by decreasing both dNTP misinsertion and mispaired primer extension efficiencies.

Garforth SJ, Domaoal RA, Lwatula C, Landau MJ, Meyer AJ, Anderson KS, Prasad VR.

J Mol Biol. 2010 Aug 6;401(1):33-44. doi: 10.1016/j.jmb.2010.06.001. Epub 2010 Jun 9.


An anaerobic-type alpha-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis.

Baughn AD, Garforth SJ, Vilch├Ęze C, Jacobs WR Jr.

PLoS Pathog. 2009 Nov;5(11):e1000662. doi: 10.1371/journal.ppat.1000662. Epub 2009 Nov 20.


Utilization of a deoxynucleoside diphosphate substrate by HIV reverse transcriptase.

Garforth SJ, Parniak MA, Prasad VR.

PLoS One. 2008 Apr 30;3(4):e2074. doi: 10.1371/journal.pone.0002074.


Probing the active site steric flexibility of HIV-1 reverse transcriptase: different constraints for DNA- versus RNA-templated synthesis.

Silverman AP, Garforth SJ, Prasad VR, Kool ET.

Biochemistry. 2008 Apr 22;47(16):4800-7. doi: 10.1021/bi702427y. Epub 2008 Mar 27.


The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis.

Glover RT, Kriakov J, Garforth SJ, Baughn AD, Jacobs WR Jr.

J Bacteriol. 2007 Aug;189(15):5495-503. Epub 2007 May 25.


A single cleavage assay for T5 5'-->3' exonuclease: determination of the catalytic parameters forwild-type and mutant proteins.

Pickering TJ, Garforth SJ, Thorpe SJ, Sayers JR, Grasby JA.

Nucleic Acids Res. 1999 Feb 1;27(3):730-5.


Structure-specific DNA binding by bacteriophage T5 5'-->3' exonuclease.

Garforth SJ, Sayers JR.

Nucleic Acids Res. 1997 Oct 1;25(19):3801-7.

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