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Items: 19


Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.

Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveillé K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavallée VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G, Roux PP, Lemieux S, Tyers M, Thibault P, Hébert J, Marinier A, Sauvageau G.

Cancer Cell. 2019 Jul 8;36(1):84-99.e8. doi: 10.1016/j.ccell.2019.06.003.


Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition.

Moison C, Lavallée VP, Thiollier C, Lehnertz B, Boivin I, Mayotte N, Gareau Y, Fréchette M, Blouin-Chagnon V, Corneau S, Lavallée S, Lemieux S, Marinier A, Hébert J, Sauvageau G.

Blood Adv. 2019 Feb 26;3(4):552-563. doi: 10.1182/bloodadvances.2018028480.


Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.

Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp DJ, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW, Sauvageau G.

Science. 2014 Sep 19;345(6203):1509-12. doi: 10.1126/science.1256337.


Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series.

Lachance N, Gareau Y, Guiral S, Huang Z, Isabel E, Leclerc JP, Léger S, Martins E, Nadeau C, Oballa RM, Ouellet SG, Powell DA, Ramtohul YK, Tranmer GK, Trinh T, Wang H, Zhang L.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):980-4. doi: 10.1016/j.bmcl.2011.12.002. Epub 2011 Dec 8.


Synthesis and SAR of pyrimidine-based, non-nucleotide P2Y14 receptor antagonists.

Guay D, Beaulieu C, Belley M, Crane SN, DeLuca J, Gareau Y, Hamel M, Henault M, Hyjazie H, Kargman S, Chan CC, Xu L, Gordon R, Li L, Mamane Y, Morin N, Mancini J, Thérien M, Tranmer G, Truong VL, Wang Z, Black WC.

Bioorg Med Chem Lett. 2011 May 15;21(10):2832-5. doi: 10.1016/j.bmcl.2011.03.084. Epub 2011 Mar 30.


The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14.

Gauthier JY, Belley M, Deschênes D, Fournier JF, Gagné S, Gareau Y, Hamel M, Hénault M, Hyjazie H, Kargman S, Lavallée G, Levesque JF, Li L, Mamane Y, Mancini J, Morin N, Mulrooney E, Robichaud J, Thérien M, Tranmer G, Wang Z, Wu J, Black WC.

Bioorg Med Chem Lett. 2011 May 15;21(10):2836-9. doi: 10.1016/j.bmcl.2011.03.081. Epub 2011 Mar 31.


The discovery of setileuton, a potent and selective 5-lipoxygenase inhibitor.

Ducharme Y, Blouin M, Brideau C, Châteauneuf A, Gareau Y, Grimm EL, Juteau H, Laliberté S, MacKay B, Massé F, Ouellet M, Salem M, Styhler A, Friesen RW.

ACS Med Chem Lett. 2010 Apr 13;1(4):170-4. doi: 10.1021/ml100029k. eCollection 2010 Jul 8.


Comparison between two classes of selective EP(3) antagonists and their biological activities.

Belley M, Chan CC, Gareau Y, Gallant M, Juteau H, Houde K, Lachance N, Labelle M, Sawyer N, Tremblay N, Lamontagne S, Carrière MC, Denis D, Greig GM, Slipetz D, Gordon R, Chauret N, Li C, Zamboni RJ, Metters KM.

Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. Epub 2006 Aug 22.


Preparation of 2,5,7-trithiabicyclo[2.2.1]heptane from 1,2-bis-triisopropylsilanylsulfanyl alkenes.

Gareau Y, Juteau H, Tsou NN, Ball RG.

Org Lett. 2006 Jan 5;8(1):59-61.


Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.

Riendeau D, Aspiotis R, Ethier D, Gareau Y, Grimm EL, Guay J, Guiral S, Juteau H, Mancini JA, Méthot N, Rubin J, Friesen RW.

Bioorg Med Chem Lett. 2005 Jul 15;15(14):3352-5.


Structure-activity relationship of biaryl acylsulfonamide analogues on the human EP(3) prostanoid receptor.

Gallant M, Carrière MC, Chateauneuf A, Denis D, Gareau Y, Godbout C, Greig G, Juteau H, Lachance N, Lacombe P, Lamontagne S, Metters KM, Rochette C, Ruel R, Slipetz D, Sawyer N, Tremblay N, Labelle M.

Bioorg Med Chem Lett. 2002 Sep 16;12(18):2583-6.


Structure-activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptor.

Juteau H, Gareau Y, Labelle M, Sturino CF, Sawyer N, Tremblay N, Lamontagne S, Carrière MC, Denis D, Metters KM.

Bioorg Med Chem. 2001 Aug;9(8):1977-84.


Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptide.

Roy S, Bayly CI, Gareau Y, Houtzager VM, Kargman S, Keen SL, Rowland K, Seiden IM, Thornberry NA, Nicholson DW.

Proc Natl Acad Sci U S A. 2001 May 22;98(11):6132-7. Epub 2001 May 15.


Structure-activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry.

Juteau H, Gareau Y, Labelle M, Lamontagne S, Tremblay N, Carrière MC, Sawyer N, Denis D, Metters KM.

Bioorg Med Chem Lett. 2001 Mar 12;11(5):747-9.


The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs.

Abramovitz M, Adam M, Boie Y, Carrière M, Denis D, Godbout C, Lamontagne S, Rochette C, Sawyer N, Tremblay NM, Belley M, Gallant M, Dufresne C, Gareau Y, Ruel R, Juteau H, Labelle M, Ouimet N, Metters KM.

Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93.


The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis.

Rotonda J, Nicholson DW, Fazil KM, Gallant M, Gareau Y, Labelle M, Peterson EP, Rasper DM, Ruel R, Vaillancourt JP, Thornberry NA, Becker JW.

Nat Struct Biol. 1996 Jul;3(7):619-25.


Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase.

Slipetz DM, O'Neill GP, Favreau L, Dufresne C, Gallant M, Gareau Y, Guay D, Labelle M, Metters KM.

Mol Pharmacol. 1995 Aug;48(2):352-61.


Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis.

Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, et al.

Nature. 1995 Jul 6;376(6535):37-43.


Characterization of specific binding sites for cysteinyl leukotrienes in sheep lung.

Metters KM, Gareau Y, Lord A, Rochette C, Sawyer N.

J Pharmacol Exp Ther. 1994 Jul;270(1):399-406.


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