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Items: 50


The extent of Ssa1/Ssa2 Hsp70 chaperone involvement in nuclear protein quality control degradation varies with the substrate.

Jones RD, Enam C, Ibarra R, Borror HR, Mostoller KE, Fredrickson EK, Lin J, Chuang E, March Z, Shorter J, Ravid T, Kleiger G, Gardner RG.

Mol Biol Cell. 2020 Feb 1;31(3):221-233. doi: 10.1091/mbc.E18-02-0121. Epub 2019 Dec 11.


Osmolyte accumulation regulates the SUMOylation and inclusion dynamics of the prionogenic Cyc8-Tup1 transcription corepressor.

Nadel CM, Mackie TD, Gardner RG.

PLoS Genet. 2019 Apr 22;15(4):e1008115. doi: 10.1371/journal.pgen.1008115. eCollection 2019 Apr.


Integrated Proteogenomic Approach for Identifying Degradation Motifs in Eukaryotic Cells.

Geffen Y, Appleboim A, Gardner RG, Ravid T.

Methods Mol Biol. 2018;1844:121-136. doi: 10.1007/978-1-4939-8706-1_9.


From Precise Slicing to General SHREDding: The Ubiquitin Ligase Ubr1 Roqs as a Multipurpose Protein Terminator.

Gardner RG, Ravid T.

Mol Cell. 2018 Jun 21;70(6):989-990. doi: 10.1016/j.molcel.2018.06.006.


Protein Quality Control Degradation in the Nucleus.

Enam C, Geffen Y, Ravid T, Gardner RG.

Annu Rev Biochem. 2018 Jun 20;87:725-749. doi: 10.1146/annurev-biochem-062917-012730. Review.


Sex-dependent behavioral impairments in the HdhQ350/+ mouse line.

Cao JK, Detloff PJ, Gardner RG, Stella N.

Behav Brain Res. 2018 Jan 30;337:34-45. doi: 10.1016/j.bbr.2017.09.026. Epub 2017 Sep 18.


Employees on the rebound: Extending the careers literature to include boomerang employment.

Swider BW, Liu JT, Harris TB, Gardner RG.

J Appl Psychol. 2017 Jun;102(6):890-909. doi: 10.1037/apl0000200. Epub 2017 Mar 9.


Structure of the Shroom-Rho Kinase Complex Reveals a Binding Interface with Monomeric Shroom That Regulates Cell Morphology and Stimulates Kinase Activity.

Zalewski JK, Mo JH, Heber S, Heroux A, Gardner RG, Hildebrand JD, VanDemark AP.

J Biol Chem. 2016 Dec 2;291(49):25364-25374. Epub 2016 Oct 10.


Mapping the Landscape of a Eukaryotic Degronome.

Geffen Y, Appleboim A, Gardner RG, Friedman N, Sadeh R, Ravid T.

Mol Cell. 2016 Sep 15;63(6):1055-65. doi: 10.1016/j.molcel.2016.08.005. Epub 2016 Sep 8.


Rewiring MAP kinases in Saccharomyces cerevisiae to regulate novel targets through ubiquitination.

Groves B, Khakhar A, Nadel CM, Gardner RG, Seelig G.

Elife. 2016 Aug 15;5. pii: e15200. doi: 10.7554/eLife.15200.


The San1 Ubiquitin Ligase Functions Preferentially with Ubiquitin-conjugating Enzyme Ubc1 during Protein Quality Control.

Ibarra R, Sandoval D, Fredrickson EK, Gardner RG, Kleiger G.

J Biol Chem. 2016 Sep 2;291(36):18778-90. doi: 10.1074/jbc.M116.737619. Epub 2016 Jul 12.


Protein quality control in the nucleus.

Jones RD, Gardner RG.

Curr Opin Cell Biol. 2016 Jun;40:81-89. doi: 10.1016/ Epub 2016 Mar 22. Review.


Dynamic Sumoylation of a Conserved Transcription Corepressor Prevents Persistent Inclusion Formation during Hyperosmotic Stress.

Oeser ML, Amen T, Nadel CM, Bradley AI, Reed BJ, Jones RD, Gopalan J, Kaganovich D, Gardner RG.

PLoS Genet. 2016 Jan 22;12(1):e1005809. doi: 10.1371/journal.pgen.1005809. eCollection 2016 Jan.


Digging for Buried Amino Acids Unearths New Protein Quality Control Treasure.

Jones RD, Gardner RG.

Structure. 2015 Jul 7;23(7):1151-2. doi: 10.1016/j.str.2015.06.008.


A Conserved Deubiquitinating Enzyme Uses Intrinsically Disordered Regions to Scaffold Multiple Protein Interaction Sites.

Reed BJ, Locke MN, Gardner RG.

J Biol Chem. 2015 Aug 14;290(33):20601-12. doi: 10.1074/jbc.M115.650952. Epub 2015 Jul 6.


Misery loves company: team dissonance and the influence of supervisor-focused interpersonal justice climate on team cohesiveness.

Stoverink AC, Umphress EE, Gardner RG, Miner KN.

J Appl Psychol. 2014 Nov;99(6):1059-73. doi: 10.1037/a0037915. Epub 2014 Sep 22.


Systemic sarcoidosis and red dye granulomatous tattoo inflammation after influenza vaccination: a case report and review of literature.

Psaltis NM, Gardner RG, Denton WJ.

Ocul Immunol Inflamm. 2014 Aug;22(4):314-21. doi: 10.3109/09273948.2014.891041. Epub 2014 Mar 21. Review. No abstract available.


The requirement for Cdc48/p97 in nuclear protein quality control degradation depends on the substrate and correlates with substrate insolubility.

Gallagher PS, Clowes Candadai SV, Gardner RG.

J Cell Sci. 2014 May 1;127(Pt 9):1980-91. doi: 10.1242/jcs.141838. Epub 2014 Feb 25.


Cellular maintenance of nuclear protein homeostasis.

Gallagher PS, Oeser ML, Abraham AC, Kaganovich D, Gardner RG.

Cell Mol Life Sci. 2014 May;71(10):1865-79. doi: 10.1007/s00018-013-1530-y. Epub 2013 Dec 5. Review.


Physical and genetic associations of the Irc20 ubiquitin ligase with Cdc48 and SUMO.

Richardson A, Gardner RG, Prelich G.

PLoS One. 2013 Oct 14;8(10):e76424. doi: 10.1371/journal.pone.0076424. eCollection 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/72c05c58-2c2b-4d3b-a9b4-20a46dba9c05.


The recruitment of the Saccharomyces cerevisiae Paf1 complex to active genes requires a domain of Rtf1 that directly interacts with the Spt4-Spt5 complex.

Mayekar MK, Gardner RG, Arndt KM.

Mol Cell Biol. 2013 Aug;33(16):3259-73. doi: 10.1128/MCB.00270-13. Epub 2013 Jun 17.


Means of self-preservation: how an intrinsically disordered ubiquitin-protein ligase averts self-destruction.

Fredrickson EK, Clowes Candadai SV, Tam CH, Gardner RG.

Mol Biol Cell. 2013 Apr;24(7):1041-52. doi: 10.1091/mbc.E12-11-0811. Epub 2013 Jan 30.


Substrate recognition in nuclear protein quality control degradation is governed by exposed hydrophobicity that correlates with aggregation and insolubility.

Fredrickson EK, Gallagher PS, Clowes Candadai SV, Gardner RG.

J Biol Chem. 2013 Mar 1;288(9):6130-9. doi: 10.1074/jbc.M112.406710. Epub 2013 Jan 18.


First Report of Potato spindle tuber viroid Naturally Infecting Greenhouse Tomatoes in North Carolina.

Ling KS, Li R, Panthee DR, Gardner RG.

Plant Dis. 2013 Jan;97(1):148. doi: 10.1094/PDIS-07-12-0679-PDN.


High-density SNP genotyping of tomato (Solanum lycopersicum L.) reveals patterns of genetic variation due to breeding.

Sim SC, Van Deynze A, Stoffel K, Douches DS, Zarka D, Ganal MW, Chetelat RT, Hutton SF, Scott JW, Gardner RG, Panthee DR, Mutschler M, Myers JR, Francis DM.

PLoS One. 2012;7(9):e45520. doi: 10.1371/journal.pone.0045520. Epub 2012 Sep 20.


A conserved deubiquitinating enzyme controls cell growth by regulating RNA polymerase I stability.

Richardson LA, Reed BJ, Charette JM, Freed EF, Fredrickson EK, Locke MN, Baserga SJ, Gardner RG.

Cell Rep. 2012 Aug 30;2(2):372-85. doi: 10.1016/j.celrep.2012.07.009. Epub 2012 Aug 16.


Cdc73 subunit of Paf1 complex contains C-terminal Ras-like domain that promotes association of Paf1 complex with chromatin.

Amrich CG, Davis CP, Rogal WP, Shirra MK, Heroux A, Gardner RG, Arndt KM, VanDemark AP.

J Biol Chem. 2012 Mar 30;287(14):10863-75. doi: 10.1074/jbc.M111.325647. Epub 2012 Feb 8.


Selective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradation.

Fredrickson EK, Gardner RG.

Semin Cell Dev Biol. 2012 Jul;23(5):530-7. doi: 10.1016/j.semcdb.2011.12.006. Epub 2012 Jan 8. Review.


How a disordered ubiquitin ligase maintains order in nuclear protein homeostasis.

Rosenbaum JC, Gardner RG.

Nucleus. 2011 Jul-Aug;2(4):264-70. doi: 10.4161/nucl.2.4.16118. Epub 2011 Jul 1. Review.


The five-factor model of personality traits and organizational citizenship behaviors: a meta-analysis.

Chiaburu DS, Oh IS, Berry CM, Li N, Gardner RG.

J Appl Psychol. 2011 Nov;96(6):1140-66. doi: 10.1037/a0024004. Epub 2011 Jun 20.


Exposed hydrophobicity is a key determinant of nuclear quality control degradation.

Fredrickson EK, Rosenbaum JC, Locke MN, Milac TI, Gardner RG.

Mol Biol Cell. 2011 Jul 1;22(13):2384-95. doi: 10.1091/mbc.E11-03-0256. Epub 2011 May 5.


A yeast model for polyalanine-expansion aggregation and toxicity.

Konopka CA, Locke MN, Gallagher PS, Pham N, Hart MP, Walker CJ, Gitler AD, Gardner RG.

Mol Biol Cell. 2011 Jun 15;22(12):1971-84. doi: 10.1091/mbc.E11-01-0037. Epub 2011 Apr 20.


Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates.

Rosenbaum JC, Fredrickson EK, Oeser ML, Garrett-Engele CM, Locke MN, Richardson LA, Nelson ZW, Hetrick ED, Milac TI, Gottschling DE, Gardner RG.

Mol Cell. 2011 Jan 7;41(1):93-106. doi: 10.1016/j.molcel.2010.12.004.


Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome.

Lyssand JS, Whiting JL, Lee KS, Kastl R, Wacker JL, Bruchas MR, Miyatake M, Langeberg LK, Chavkin C, Scott JD, Gardner RG, Adams ME, Hague C.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21854-9. doi: 10.1073/pnas.1010819107. Epub 2010 Nov 29.


Alpha-arrestins Aly1 and Aly2 regulate intracellular trafficking in response to nutrient signaling.

O'Donnell AF, Apffel A, Gardner RG, Cyert MS.

Mol Biol Cell. 2010 Oct 15;21(20):3552-66. doi: 10.1091/mbc.E10-07-0636. Epub 2010 Aug 25.


Cotrafficking of SV2 and synaptotagmin at the synapse.

Yao J, Nowack A, Kensel-Hammes P, Gardner RG, Bajjalieh SM.

J Neurosci. 2010 Apr 21;30(16):5569-78. doi: 10.1523/JNEUROSCI.4781-09.2010.


Degradation-mediated protein quality control in the nucleus.

Gardner RG, Nelson ZW, Gottschling DE.

Cell. 2005 Mar 25;120(6):803-15.


An oxysterol-derived positive signal for 3-hydroxy- 3-methylglutaryl-CoA reductase degradation in yeast.

Gardner RG, Shan H, Matsuda SP, Hampton RY.

J Biol Chem. 2001 Mar 23;276(12):8681-94. Epub 2000 Dec 27.


Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

Bays NW, Gardner RG, Seelig LP, Joazeiro CA, Hampton RY.

Nat Cell Biol. 2001 Jan;3(1):24-9.


Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p.

Gardner RG, Swarbrick GM, Bays NW, Cronin SR, Wilhovsky S, Seelig L, Kim C, Hampton RY.

J Cell Biol. 2000 Oct 2;151(1):69-82.


A putative role for the tomato genes DUMPY and CURL-3 in brassinosteroid biosynthesis and response.

Koka CV, Cerny RE, Gardner RG, Noguchi T, Fujioka S, Takatsuto S, Yoshida S, Clouse SD.

Plant Physiol. 2000 Jan;122(1):85-98.


A 'distributed degron' allows regulated entry into the ER degradation pathway.

Gardner RG, Hampton RY.

EMBO J. 1999 Nov 1;18(21):5994-6004.


A Prevotella ruminicola B(1)4 operon encoding extracellular polysaccharide hydrolases.

Gardner RG, Wells JE, Fields MW, Wilson DB, Russell JB.

Curr Microbiol. 1997 Nov;35(5):274-7.


The effect of carbohydrates on the expression of the Prevotella ruminicola 1,4-beta-D-endoglucanase.

Gardner RG, Wells JE, Russell JB, Wilson DB.

FEMS Microbiol Lett. 1995 Jan 15;125(2-3):305-10.


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