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Items: 1 to 50 of 130

1.

Shining light on the alphaproteobacterial general stress response: Comment on: Fiebig et al., Mol Microbiol, 2019.

Dikiy I, Gardner KH.

Mol Microbiol. 2019 Aug;112(2):438-441. doi: 10.1111/mmi.14311. Epub 2019 Jun 5.

PMID:
31120626
2.

Insights into histidine kinase activation mechanisms from the monomeric blue light sensor EL346.

Dikiy I, Edupuganti UR, Abzalimov RR, Borbat PP, Srivastava M, Freed JH, Gardner KH.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4963-4972. doi: 10.1073/pnas.1813586116. Epub 2019 Feb 26.

3.

Isotopic Labeling of Eukaryotic Membrane Proteins for NMR Studies of Interactions and Dynamics.

Dikiy I, Clark LD, Gardner KH, Rosenbaum DM.

Methods Enzymol. 2019;614:37-65. doi: 10.1016/bs.mie.2018.08.030. Epub 2018 Dec 18.

PMID:
30611431
4.

On the use of Pichia pastoris for isotopic labeling of human GPCRs for NMR studies.

Clark L, Dikiy I, Rosenbaum DM, Gardner KH.

J Biomol NMR. 2018 Aug;71(4):203-211. doi: 10.1007/s10858-018-0204-3. Epub 2018 Aug 18. Review.

PMID:
30121871
5.

Directly light-regulated binding of RGS-LOV photoreceptors to anionic membrane phospholipids.

Glantz ST, Berlew EE, Jaber Z, Schuster BS, Gardner KH, Chow BY.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7720-E7727. doi: 10.1073/pnas.1802832115. Epub 2018 Jul 31.

6.

Blue-Light Receptors for Optogenetics.

Losi A, Gardner KH, Möglich A.

Chem Rev. 2018 Nov 14;118(21):10659-10709. doi: 10.1021/acs.chemrev.8b00163. Epub 2018 Jul 9. Review.

PMID:
29984995
7.

Influences of water quality and climate on the water-energy nexus: A spatial comparison of two water systems.

Stang S, Wang H, Gardner KH, Mo W.

J Environ Manage. 2018 Jul 15;218:613-621. doi: 10.1016/j.jenvman.2018.04.095. Epub 2018 Apr 30.

PMID:
29715670
8.

Optimization of Field and Laboratory Sample Processing for Characterization of Metallic Residues at Military Training Ranges.

Clausen JL, Georgian T, Gardner KH, Douglas TA.

Bull Environ Contam Toxicol. 2018 May;100(5):603-608. doi: 10.1007/s00128-018-2311-y. Epub 2018 Mar 12.

PMID:
29532132
9.

Inadequacy of Conventional Grab Sampling for Remediation Decision-Making for Metal Contamination at Small-Arms Ranges.

Clausen JL, Georgian T, Gardner KH, Douglas TA.

Bull Environ Contam Toxicol. 2018 Jan;100(1):147-154. doi: 10.1007/s00128-017-2255-7. Epub 2018 Jan 3.

PMID:
29299633
10.

Applying Incremental Sampling Methodology to Soils Containing Heterogeneously Distributed Metallic Residues to Improve Risk Analysis.

Clausen JL, Georgian T, Gardner KH, Douglas TA.

Bull Environ Contam Toxicol. 2018 Jan;100(1):155-161. doi: 10.1007/s00128-017-2252-x. Epub 2017 Dec 21.

PMID:
29270645
11.

Ligand modulation of sidechain dynamics in a wild-type human GPCR.

Clark LD, Dikiy I, Chapman K, Rödström KE, Aramini J, LeVine MV, Khelashvili G, Rasmussen SG, Gardner KH, Rosenbaum DM.

Elife. 2017 Oct 6;6. pii: e28505. doi: 10.7554/eLife.28505.

12.

TAEL: a zebrafish-optimized optogenetic gene expression system with fine spatial and temporal control.

Reade A, Motta-Mena LB, Gardner KH, Stainier DY, Weiner OD, Woo S.

Development. 2017 Jan 15;144(2):345-355. doi: 10.1242/dev.139238. Epub 2016 Dec 19.

13.

Targeting renal cell carcinoma with a HIF-2 antagonist.

Chen W, Hill H, Christie A, Kim MS, Holloman E, Pavia-Jimenez A, Homayoun F, Ma Y, Patel N, Yell P, Hao G, Yousuf Q, Joyce A, Pedrosa I, Geiger H, Zhang H, Chang J, Gardner KH, Bruick RK, Reeves C, Hwang TH, Courtney K, Frenkel E, Sun X, Zojwalla N, Wong T, Rizzi JP, Wallace EM, Josey JA, Xie Y, Xie XJ, Kapur P, McKay RM, Brugarolas J.

Nature. 2016 Nov 3;539(7627):112-117. doi: 10.1038/nature19796. Epub 2016 Sep 5.

14.

Computational Repacking of HIF-2α Cavity Replaces Water-Based Stabilized Core.

Corrêa F, Key J, Kuhlman B, Gardner KH.

Structure. 2016 Nov 1;24(11):1918-1927. doi: 10.1016/j.str.2016.08.014. Epub 2016 Sep 22.

15.

Basis of Mutual Domain Inhibition in a Bacterial Response Regulator.

Corrêa F, Gardner KH.

Cell Chem Biol. 2016 Aug 18;23(8):945-954. doi: 10.1016/j.chembiol.2016.07.010. Epub 2016 Aug 11.

16.

Functional and topological diversity of LOV domain photoreceptors.

Glantz ST, Carpenter EJ, Melkonian M, Gardner KH, Boyden ES, Wong GK, Chow BY.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1442-51. doi: 10.1073/pnas.1509428113. Epub 2016 Feb 29.

17.

Erratum to: Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris.

Clark L, Zahm JA, Ali R, Kukula M, Bian L, Patrie SM, Gardner KH, Rosen MK, Rosenbaum DM.

J Biomol NMR. 2016 Mar;64(3):267. doi: 10.1007/s10858-016-0016-2. No abstract available.

18.

Superficial liposarcoma: A retrospective review of 13 cases.

Winchester DS, Gardner KH, Lehman JS, Otley CC.

J Am Acad Dermatol. 2016 Feb;74(2):391-3. doi: 10.1016/j.jaad.2015.08.019. No abstract available.

PMID:
26775787
19.

On the acquisition and analysis of microscale thermophoresis data.

Scheuermann TH, Padrick SB, Gardner KH, Brautigam CA.

Anal Biochem. 2016 Mar 1;496:79-93. doi: 10.1016/j.ab.2015.12.013. Epub 2015 Dec 29.

20.

Upstaging From Melanoma in Situ to Invasive Melanoma on the Head and Neck After Complete Surgical Resection.

Gardner KH, Hill DE, Wright AC, Brewer JD, Arpey CJ, Otley CC, Roenigk RK, Baum CL.

Dermatol Surg. 2015 Oct;41(10):1122-5. doi: 10.1097/DSS.0000000000000466.

PMID:
26356849
21.

Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2.

Scheuermann TH, Stroud D, Sleet CE, Bayeh L, Shokri C, Wang H, Caldwell CG, Longgood J, MacMillan JB, Bruick RK, Gardner KH, Tambar UK.

J Med Chem. 2015 Aug 13;58(15):5930-41. doi: 10.1021/acs.jmedchem.5b00529. Epub 2015 Jul 30.

PMID:
26226049
22.

Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris.

Clark L, Zahm JA, Ali R, Kukula M, Bian L, Patrie SM, Gardner KH, Rosen MK, Rosenbaum DM.

J Biomol NMR. 2015 Jul;62(3):239-45. doi: 10.1007/s10858-015-9939-2. Epub 2015 May 30. Erratum in: J Biomol NMR. 2016 Mar;64(3):267.

23.

Ligand-induced folding of a two-component signaling receiver domain.

Ocasio VJ, Corrêa F, Gardner KH.

Biochemistry. 2015 Feb 17;54(6):1353-63. doi: 10.1021/bi501143b. Epub 2015 Feb 6.

24.

Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization.

Guo Y, Scheuermann TH, Partch CL, Tomchick DR, Gardner KH.

J Biol Chem. 2015 Mar 20;290(12):7707-21. doi: 10.1074/jbc.M114.632786. Epub 2015 Jan 27.

25.

Full-length structure of a monomeric histidine kinase reveals basis for sensory regulation.

Rivera-Cancel G, Ko WH, Tomchick DR, Correa F, Gardner KH.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17839-44. doi: 10.1073/pnas.1413983111. Epub 2014 Dec 2.

26.

An optogenetic gene expression system with rapid activation and deactivation kinetics.

Motta-Mena LB, Reade A, Mallory MJ, Glantz S, Weiner OD, Lynch KW, Gardner KH.

Nat Chem Biol. 2014 Mar;10(3):196-202. doi: 10.1038/nchembio.1430. Epub 2014 Jan 12.

27.

Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides.

Salomon D, Guo Y, Kinch LN, Grishin NV, Gardner KH, Orth K.

Nat Commun. 2013;4:2973. doi: 10.1038/ncomms3973.

28.

Blue light-induced dimerization of a bacterial LOV-HTH DNA-binding protein.

Zoltowski BD, Motta-Mena LB, Gardner KH.

Biochemistry. 2013 Sep 24;52(38):6653-61. doi: 10.1021/bi401040m. Epub 2013 Sep 12.

29.

Tumor-induced osteomalacia resulting from primary cutaneous phosphaturic mesenchymal tumor: a case and review of the medical literature.

Gardner KH, Shon W, Folpe AL, Wieland CN, Tebben PJ, Baum CL.

J Cutan Pathol. 2013 Sep;40(9):780-4; quiz 779. doi: 10.1111/cup.12209. Review. No abstract available.

PMID:
23962115
30.

Blue light regulated two-component systems: enzymatic and functional analyses of light-oxygen-voltage (LOV)-histidine kinases and downstream response regulators.

Correa F, Ko WH, Ocasio V, Bogomolni RA, Gardner KH.

Biochemistry. 2013 Jul 9;52(27):4656-66. doi: 10.1021/bi400617y. Epub 2013 Jun 27.

31.

Comparative life cycle assessment (LCA) of construction and demolition (C&D) derived biomass and U.S. northeast forest residuals gasification for electricity production.

Nuss P, Gardner KH, Jambeck JR.

Environ Sci Technol. 2013 Apr 2;47(7):3463-71. doi: 10.1021/es304312f. Epub 2013 Mar 15.

PMID:
23496419
32.

Allosteric inhibition of hypoxia inducible factor-2 with small molecules.

Scheuermann TH, Li Q, Ma HW, Key J, Zhang L, Chen R, Garcia JA, Naidoo J, Longgood J, Frantz DE, Tambar UK, Gardner KH, Bruick RK.

Nat Chem Biol. 2013 Apr;9(4):271-6. doi: 10.1038/nchembio.1185. Epub 2013 Feb 24.

33.

Signaling mechanisms of LOV domains: new insights from molecular dynamics studies.

Freddolino PL, Gardner KH, Schulten K.

Photochem Photobiol Sci. 2013 Jul;12(7):1158-70. doi: 10.1039/c3pp25400c.

34.

Solution structure of the WNK1 autoinhibitory domain, a WNK-specific PF2 domain.

Moon TM, Correa F, Kinch LN, Piala AT, Gardner KH, Goldsmith EJ.

J Mol Biol. 2013 Apr 26;425(8):1245-52. doi: 10.1016/j.jmb.2013.01.031. Epub 2013 Jan 30.

PMID:
23376100
35.

Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor.

Rogers JL, Bayeh L, Scheuermann TH, Longgood J, Key J, Naidoo J, Melito L, Shokri C, Frantz DE, Bruick RK, Gardner KH, MacMillan JB, Tambar UK.

J Med Chem. 2013 Feb 28;56(4):1739-47. doi: 10.1021/jm301847z. Epub 2013 Feb 18.

36.

Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules.

Guo Y, Partch CL, Key J, Card PB, Pashkov V, Patel A, Bruick RK, Wurdak H, Gardner KH.

ACS Chem Biol. 2013 Mar 15;8(3):626-35. doi: 10.1021/cb300604u. Epub 2012 Dec 26.

37.

Identification of natural and artificial DNA substrates for light-activated LOV-HTH transcription factor EL222.

Rivera-Cancel G, Motta-Mena LB, Gardner KH.

Biochemistry. 2012 Dec 18;51(50):10024-34. doi: 10.1021/bi301306t. Epub 2012 Dec 10.

38.

Enlightening molecular mechanisms through study of protein interactions.

Rizo J, Rosen MK, Gardner KH.

J Mol Cell Biol. 2012 Oct;4(5):270-83. doi: 10.1093/jmcb/mjs036. Epub 2012 Jun 26. Review.

39.

Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms.

Chollangi S, Thompson JW, Ruiz JC, Gardner KH, Bruick RK.

J Biol Chem. 2012 Jul 6;287(28):23710-7. doi: 10.1074/jbc.M112.360404. Epub 2012 May 30.

40.

Plant science. How plants see the invisible.

Gardner KH, Correa F.

Science. 2012 Mar 23;335(6075):1451-2. doi: 10.1126/science.1220248. No abstract available.

PMID:
22442470
41.

Special issue as a tribute to Lewis E Kay on his 50th birthday.

Gardner KH, Mittermaier A, Mulder FA.

J Biomol NMR. 2011 Sep;51(1-2):3-207. doi: 10.1007/s10858-011-9561-x. No abstract available.

PMID:
21947910
42.

Variations in protein-flavin hydrogen bonding in a light, oxygen, voltage domain produce non-Arrhenius kinetics of adduct decay.

Zoltowski BD, Nash AI, Gardner KH.

Biochemistry. 2011 Oct 18;50(41):8771-9. doi: 10.1021/bi200976a. Epub 2011 Sep 21.

43.

Impacts of natural weathering on the transformation/neoformation processes in landfilled MSWI bottom ash: a geoenvironmental perspective.

Saffarzadeh A, Shimaoka T, Wei Y, Gardner KH, Musselman CN.

Waste Manag. 2011 Dec;31(12):2440-54. doi: 10.1016/j.wasman.2011.07.017. Epub 2011 Aug 27.

PMID:
21873042
44.

Mutational and structural studies of the PixD BLUF output signal that affects light-regulated interactions with PixE.

Yuan H, Dragnea V, Wu Q, Gardner KH, Bauer CE.

Biochemistry. 2011 Jul 26;50(29):6365-75. doi: 10.1021/bi200701d. Epub 2011 Jun 28.

45.

Structural basis of photosensitivity in a bacterial light-oxygen-voltage/helix-turn-helix (LOV-HTH) DNA-binding protein.

Nash AI, McNulty R, Shillito ME, Swartz TE, Bogomolni RA, Luecke H, Gardner KH.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9449-54. doi: 10.1073/pnas.1100262108. Epub 2011 May 23. Erratum in: Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5904.

46.

Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B.

Partch CL, Gardner KH.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7739-44. doi: 10.1073/pnas.1101357108. Epub 2011 Apr 21.

47.

Modulating LOV domain photodynamics with a residue alteration outside the chromophore binding site.

Song SH, Freddolino PL, Nash AI, Carroll EC, Schulten K, Gardner KH, Larsen DS.

Biochemistry. 2011 Apr 5;50(13):2411-23. doi: 10.1021/bi200198x. Epub 2011 Mar 1.

48.

The three Rs of transcription: recruit, retain, and recycle.

Motta-Mena LB, Partch CL, Gardner KH.

Mol Cell. 2010 Dec 22;40(6):855-8. doi: 10.1016/j.molcel.2010.12.010.

49.
50.

The third conformation of p38α MAP kinase observed in phosphorylated p38α and in solution.

Akella R, Min X, Wu Q, Gardner KH, Goldsmith EJ.

Structure. 2010 Dec 8;18(12):1571-8. doi: 10.1016/j.str.2010.09.015.

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