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Items: 11

1.

Inhibitory effects of midostaurin and avapritinib on myeloid progenitors derived from patients with KIT D816V positive advanced systemic mastocytosis.

Lübke J, Naumann N, Kluger S, Schwaab J, Metzgeroth G, Evans E, Gardino AK, Lengauer C, Hofmann WK, Fabarius A, Cross NCP, Reiter A, Jawhar M.

Leukemia. 2019 May;33(5):1195-1205. doi: 10.1038/s41375-019-0450-8. Epub 2019 Mar 25.

PMID:
30911112
2.

Robust Activity of Avapritinib, Potent and Highly Selective Inhibitor of Mutated KIT, in Patient-derived Xenograft Models of Gastrointestinal Stromal Tumors.

Gebreyohannes YK, Wozniak A, Zhai ME, Wellens J, Cornillie J, Vanleeuw U, Evans E, Gardino AK, Lengauer C, Debiec-Rychter M, Sciot R, Schöffski P.

Clin Cancer Res. 2019 Jan 15;25(2):609-618. doi: 10.1158/1078-0432.CCR-18-1858. Epub 2018 Oct 1.

PMID:
30274985
3.

Targeting kinases with precision.

Gardino AK, Evans EK, Kim JL, Brooijmans N, Hodous BL, Wolf B, Lengauer C.

Mol Cell Oncol. 2018 Apr 11;5(3):e1435183. doi: 10.1080/23723556.2018.1435183. eCollection 2018.

4.

A precision therapy against cancers driven by KIT/PDGFRA mutations.

Evans EK, Gardino AK, Kim JL, Hodous BL, Shutes A, Davis A, Zhu XJ, Schmidt-Kittler O, Wilson D, Wilson K, DiPietro L, Zhang Y, Brooijmans N, LaBranche TP, Wozniak A, Gebreyohannes YK, Schöffski P, Heinrich MC, DeAngelo DJ, Miller S, Wolf B, Kohl N, Guzi T, Lydon N, Boral A, Lengauer C.

Sci Transl Med. 2017 Nov 1;9(414). pii: eaao1690. doi: 10.1126/scitranslmed.aao1690.

PMID:
29093181
5.

Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks.

Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, MacBeath G, Yaffe MB.

Cell. 2012 May 11;149(4):780-94. doi: 10.1016/j.cell.2012.03.031.

6.

14-3-3 proteins as signaling integration points for cell cycle control and apoptosis.

Gardino AK, Yaffe MB.

Semin Cell Dev Biol. 2011 Sep;22(7):688-95. doi: 10.1016/j.semcdb.2011.09.008. Epub 2011 Sep 14. Review.

7.

A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.

van Vugt MA, Gardino AK, Linding R, Ostheimer GJ, Reinhardt HC, Ong SE, Tan CS, Miao H, Keezer SM, Li J, Pawson T, Lewis TA, Carr SA, Smerdon SJ, Brummelkamp TR, Yaffe MB.

PLoS Biol. 2010 Jan 26;8(1):e1000287. doi: 10.1371/journal.pbio.1000287.

8.

Transient non-native hydrogen bonds promote activation of a signaling protein.

Gardino AK, Villali J, Kivenson A, Lei M, Liu CF, Steindel P, Eisenmesser EZ, Labeikovsky W, Wolf-Watz M, Clarkson MW, Kern D.

Cell. 2009 Dec 11;139(6):1109-18. doi: 10.1016/j.cell.2009.11.022.

9.

Functional dynamics of response regulators using NMR relaxation techniques.

Gardino AK, Kern D.

Methods Enzymol. 2007;423:149-65.

PMID:
17609130
11.

The NMR solution structure of BeF(3)(-)-activated Spo0F reveals the conformational switch in a phosphorelay system.

Gardino AK, Volkman BF, Cho HS, Lee SY, Wemmer DE, Kern D.

J Mol Biol. 2003 Aug 1;331(1):245-54.

PMID:
12875849

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