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Plasma levels of the soluble form of the FcγRIIa receptor vary with receptor polymorphisms and are elevated in rheumatoid arthritis.

Qiao J, Dunne E, Wines B, Kenny D, McCarthy GM, Hogarth PM, Xu K, Andrews RK, Gardiner EE.

Platelets. 2019 Aug 4:1-7. doi: 10.1080/09537104.2019.1647527. [Epub ahead of print]


All-Trans Retinoic Acid Impairs Platelet Function and Thrombus Formation and Inhibits Protein Kinase CßI/δ Phosphorylation.

Luo Q, Wei G, Wang X, Xu X, Ju W, Li Z, Gardiner EE, Andrews RK, Zeng L, Xu K, Qiao J.

Thromb Haemost. 2019 Aug 1. doi: 10.1055/s-0039-1693737. [Epub ahead of print]


Parkin the bus to manage stress.

Kaur A, Gardiner EE.

EMBO Mol Med. 2019 Aug;11(8):e10968. doi: 10.15252/emmm.201910968. Epub 2019 Jul 17.


Novel Stenotic Microchannels to Study Thrombus Formation in Shear Gradients: Influence of Shear Forces and Human Platelet-Related Factors.

Lui M, Gardiner EE, Arthur JF, Pinar I, Lee WM, Ryan K, Carberry J, Andrews RK.

Int J Mol Sci. 2019 Jun 18;20(12). pii: E2967. doi: 10.3390/ijms20122967.


Adenosine and Forskolin Inhibit Platelet Aggregation by Collagen but not the Proximal Signalling Events.

Clark JC, Kavanagh DM, Watson S, Pike JA, Andrews RK, Gardiner EE, Poulter NS, Hill SJ, Watson SP.

Thromb Haemost. 2019 Jul;119(7):1124-1137. doi: 10.1055/s-0039-1688788. Epub 2019 May 26.


Autologous platelet-rich plasma for healing chronic venous leg ulcers: Clinical efficacy and potential mechanisms.

Weller CD, Gardiner EE, Arthur JF, Southey M, Andrews RK.

Int Wound J. 2019 Jun;16(3):788-792. doi: 10.1111/iwj.13098. Epub 2019 Mar 12.


Successful Renal Denervation Decreases the Platelet Activation Status in Hypertensive Patients.

Zaldivia MTK, Hering D, Marusic P, Sata Y, Lee R, Esler MD, Htun NM, Duval J, Hammond L, Flierl U, Wang X, Drummond GR, Walton A, Gardiner EE, Andrews RK, Schlaich MP, Peter K.

Cardiovasc Res. 2019 Feb 4. doi: 10.1093/cvr/cvz033. [Epub ahead of print]


Calpain cleaves phospholipid flippase ATP8A1 during apoptosis in platelets.

Jing W, Yabas M, Bröer A, Coupland L, Gardiner EE, Enders A, Bröer S.

Blood Adv. 2019 Feb 12;3(3):219-229. doi: 10.1182/bloodadvances.2018023473.


Platelet Ubiquitylation-It's Everywhere.

Gardiner EE, Andrews RK.

Thromb Haemost. 2019 Jan;119(1):6-8. doi: 10.1055/s-0038-1676650. Epub 2018 Dec 31.


SerpinB2 deficiency in mice reduces bleeding times via dysregulated platelet activation.

Schroder WA, Le TT, Gardner J, Andrews RK, Gardiner EE, Callaway L, Suhrbier A.

Platelets. 2019;30(5):658-663. doi: 10.1080/09537104.2018.1535702. Epub 2018 Nov 2.


Mechanisms of receptor shedding in platelets.

Montague SJ, Andrews RK, Gardiner EE.

Blood. 2018 Dec 13;132(24):2535-2545. doi: 10.1182/blood-2018-03-742668. Epub 2018 Oct 22. Review.


Dimeric FcγR ectodomains detect pathogenic anti-platelet factor 4-heparin antibodies in heparin-induced thromobocytopenia.

Wines BD, Tan CW, Duncan E, McRae S, Baker RI, Andrews RK, Esparon S, Gardiner EE, Hogarth PM.

J Thromb Haemost. 2018 Dec;16(12):2520-2525. doi: 10.1111/jth.14306. Epub 2018 Nov 20.


Monitoring the pulse of thrombus formation: Comment on "Modeling thrombosis in silico: Frontiers, challenges, unresolved problems and milestones" by A.V. Belyaev et al.

Andrews RK, Gardiner EE.

Phys Life Rev. 2018 Nov;26-27:113-115. doi: 10.1016/j.plrev.2018.07.001. Epub 2018 Jul 24. No abstract available.


Matrix metalloproteinase-13 unlucky for the forming thrombus.

Montague SJ, Gardiner EE.

Res Pract Thromb Haemost. 2018 May 1;2(3):525-528. doi: 10.1002/rth2.12105. eCollection 2018 Jul. No abstract available.


Proteolytic processing of platelet receptors.

Gardiner EE.

Res Pract Thromb Haemost. 2018 Apr 10;2(2):240-250. doi: 10.1002/rth2.12096. eCollection 2018 Apr.


Anti-glycoprotein VI mediated immune thrombocytopenia: An under-recognized and significant entity?

Rabbolini DJ, Gardiner EE, Morel-Kopp MC, Dunkley S, Jahangiri A, Lee CS, Stevenson WS, Ward CM.

Res Pract Thromb Haemost. 2017 Aug 24;1(2):291-295. doi: 10.1002/rth2.12033. eCollection 2017 Oct.


NLRP3 regulates platelet integrin αIIbβ3 outside-in signaling, hemostasis and arterial thrombosis.

Qiao J, Wu X, Luo Q, Wei G, Xu M, Wu Y, Liu Y, Li X, Zi J, Ju W, Fu L, Chen C, Wu Q, Zhu S, Qi K, Li D, Li Z, Andrews RK, Zeng L, Gardiner EE, Xu K.

Haematologica. 2018 Sep;103(9):1568-1576. doi: 10.3324/haematol.2018.191700. Epub 2018 May 24.


Bone Marrow Defects and Platelet Function: A Focus on MDS and CLL.

Luu S, Gardiner EE, Andrews RK.

Cancers (Basel). 2018 May 18;10(5). pii: E147. doi: 10.3390/cancers10050147. Review.


Significant Hypo-Responsiveness to GPVI and CLEC-2 Agonists in Pre-Term and Full-Term Neonatal Platelets and following Immune Thrombocytopenia.

Hardy AT, Palma-Barqueros V, Watson SK, Malcor JD, Eble JA, Gardiner EE, Blanco JE, Guijarro-Campillo R, Delgado JL, Lozano ML, Teruel-Montoya R, Vicente V, Watson SP, Rivera J, Ferrer-Marín F.

Thromb Haemost. 2018 Jun;118(6):1009-1020. doi: 10.1055/s-0038-1646924. Epub 2018 Apr 25.


An exit strategy for new platelets.

Rivera J, Gardiner EE.

Blood. 2018 Mar 8;131(10):1041-1042. doi: 10.1182/blood-2018-01-826453. No abstract available.


High contrast imaging and flexible photomanipulation for quantitative in vivo multiphoton imaging with polygon scanning microscope.

Li Y, Montague SJ, Brüstle A, He X, Gillespie C, Gaus K, Gardiner EE, Lee WM.

J Biophotonics. 2018 Jul;11(7):e201700341. doi: 10.1002/jbio.201700341. Epub 2018 Apr 10.


Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI.

Montague SJ, Delierneux C, Lecut C, Layios N, Dinsdale RJ, Lee CS, Poulter NS, Andrews RK, Hampson P, Wearn CM, Maes N, Bishop J, Bamford A, Gardiner C, Lee WM, Iqbal T, Moiemen N, Watson SP, Oury C, Harrison P, Gardiner EE.

Blood Adv. 2018 Feb 13;2(3):240-251. doi: 10.1182/bloodadvances.2017011171.


Soluble glycoprotein VI, a specific marker of platelet activation is increased in the plasma of subjects with seropositive rheumatoid arthritis.

Stack JR, Madigan A, Helbert L, Dunne E, Gardiner EE, Andrews RK, Finan R, Smyth E, Kenny D, McCarthy GM.

PLoS One. 2017 Nov 15;12(11):e0188027. doi: 10.1371/journal.pone.0188027. eCollection 2017.


Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: comment.

Flierl U, Nero TL, Lim B, Andrews RK, Parker MW, Gardiner EE, Peter K.

J Thromb Haemost. 2018 Jan;16(1):181-185. doi: 10.1111/jth.13877. Epub 2017 Nov 16. No abstract available.


Mechanisms of Platelet Dysfunction in Patients with Implantable Devices.

Casan J, Andrews RK, Gardiner EE, Davis AK.

Semin Thromb Hemost. 2018 Feb;44(1):12-19. doi: 10.1055/s-0037-1605572. Epub 2017 Sep 12. Review.


Regulation of platelet activation and thrombus formation by reactive oxygen species.

Qiao J, Arthur JF, Gardiner EE, Andrews RK, Zeng L, Xu K.

Redox Biol. 2018 Apr;14:126-130. doi: 10.1016/j.redox.2017.08.021. Epub 2017 Sep 8. Review.


Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.

Schoenwaelder SM, Darbousset R, Cranmer SL, Ramshaw HS, Orive SL, Sturgeon S, Yuan Y, Yao Y, Krycer JR, Woodcock J, Maclean J, Pitson S, Zheng Z, Henstridge DC, van der Wal D, Gardiner EE, Berndt MC, Andrews RK, James DE, Lopez AF, Jackson SP.

Nat Commun. 2017 Aug 30;8:16125. doi: 10.1038/ncomms16125.


The influence of platelet membranes on tumour cell behaviour.

Coupland LA, Hindmarsh EJ, Gardiner EE, Parish CR.

Cancer Metastasis Rev. 2017 Jun;36(2):215-224. doi: 10.1007/s10555-017-9671-3. Review.


The cutting edge of platelets.

Andrews RK, Gardiner EE.

Platelets. 2017 Jun;28(4):317-318. doi: 10.1080/09537104.2017.1338397. No abstract available.


An absence of platelet activation following thalidomide treatment in vitro or in vivo.

Qiao J, Wu Y, Wu X, Liu Y, Li X, Ju W, Qi K, Li D, Gardiner EE, Andrews RK, Zeng L, Xu K.

Oncotarget. 2017 May 30;8(22):35776-35782. doi: 10.18632/oncotarget.16205.


Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets.

Poulter NS, Pollitt AY, Owen DM, Gardiner EE, Andrews RK, Shimizu H, Ishikawa D, Bihan D, Farndale RW, Moroi M, Watson SP, Jung SM.

J Thromb Haemost. 2017 Mar;15(3):549-564. doi: 10.1111/jth.13613. Epub 2017 Feb 16.


Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals.

Trevillyan JM, Gardiner EE, Andrews RK, Maisa A, Hearps AC, Al-Tamimi M, Crowe SM, Hoy JF.

Platelets. 2017 May;28(3):301-304. doi: 10.1080/09537104.2016.1237627. Epub 2016 Nov 16.


Basic mechanisms of platelet receptor shedding.

Andrews RK, Gardiner EE.

Platelets. 2017 Jun;28(4):319-324. doi: 10.1080/09537104.2016.1235690. Epub 2016 Oct 25. Review.


Mechanical circulatory support is associated with loss of platelet receptors glycoprotein Ibα and glycoprotein VI.

Lukito P, Wong A, Jing J, Arthur JF, Marasco SF, Murphy DA, Bergin PJ, Shaw JA, Collecutt M, Andrews RK, Gardiner EE, Davis AK.

J Thromb Haemost. 2016 Nov;14(11):2253-2260. doi: 10.1111/jth.13497. Epub 2016 Oct 20.


14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.

Schoenwaelder SM, Darbousset R, Cranmer SL, Ramshaw HS, Orive SL, Sturgeon S, Yuan Y, Yao Y, Krycer JR, Woodcock J, Maclean J, Pitson S, Zheng Z, Henstridge DC, van der Wal D, Gardiner EE, Berndt MC, Andrews RK, James DE, Lopez AF, Jackson SP.

Nat Commun. 2016 Sep 27;7:12862. doi: 10.1038/ncomms12862. Erratum in: Nat Commun. 2017 Aug 30;8:16125.


Metalloproteolytic receptor shedding…platelets "acting their age".

Andrews RK, Gardiner EE.

Platelets. 2016 Sep;27(6):512-8. doi: 10.1080/09537104.2016.1212001. Epub 2016 Jul 26. Review.


M1761K mutation in the von Willebrand factor A3 domain associated with impaired collagen binding and without platelet dysfunction.

Ong DM, Aumann H, Andrews RK, Gardiner EE, Rodgers SE, Davis AK.

Haemophilia. 2016 Jul;22(4):e345-6. doi: 10.1111/hae.12976. Epub 2016 Jun 28. No abstract available.


Colocalization of neutrophils, extracellular DNA and coagulation factors during NETosis: Development and utility of an immunofluorescence-based microscopy platform.

Healy LD, Puy C, Itakura A, Chu T, Robinson DK, Bylund A, Phillips KG, Gardiner EE, McCarty OJ.

J Immunol Methods. 2016 Aug;435:77-84. doi: 10.1016/j.jim.2016.06.002. Epub 2016 Jun 7.


Longitudinal changes in hemostatic parameters and reduced pulsatility contribute to non-surgical bleeding in patients with centrifugal continuous-flow left ventricular assist devices.

Muthiah K, Connor D, Ly K, Gardiner EE, Andrews RK, Qiao J, Rutgers D, Robson D, Low J, Jarvis S, Macdonald P, Dhital K, Jansz P, Joseph J, Hayward CS.

J Heart Lung Transplant. 2016 Jun;35(6):743-51. doi: 10.1016/j.healun.2015.12.024. Epub 2016 Jan 7.


Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood.

French SL, Arthur JF, Lee H, Nesbitt WS, Andrews RK, Gardiner EE, Hamilton JR.

J Thromb Haemost. 2016 Aug;14(8):1642-54. doi: 10.1111/jth.13293. Epub 2016 Jun 22.


A-Disintegrin-And-Metalloproteinase (ADAM) 10 Activity on Resting and Activated Platelets.

Facey A, Pinar I, Arthur JF, Qiao J, Jing J, Mado B, Carberry J, Andrews RK, Gardiner EE.

Biochemistry. 2016 Mar 1;55(8):1187-94. doi: 10.1021/acs.biochem.5b01102. Epub 2016 Feb 16.


Methods to Determine the Lagrangian Shear Experienced by Platelets during Thrombus Growth.

Pinar IP, Arthur JF, Andrews RK, Gardiner EE, Ryan K, Carberry J.

PLoS One. 2015 Dec 14;10(12):e0144860. doi: 10.1371/journal.pone.0144860. eCollection 2015.


Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα.

Carrim N, Arthur JF, Hamilton JR, Gardiner EE, Andrews RK, Moran N, Berndt MC, Metharom P.

Redox Biol. 2015 Dec;6:640-647. doi: 10.1016/j.redox.2015.10.009. Epub 2015 Oct 28.


Effects of abacavir administration on structural and functional markers of platelet activation.

Trevillyan JM, Arthur JF, Jing J, Andrews RK, Gardiner EE, Hoy JF.

AIDS. 2015 Nov;29(17):2309-13. doi: 10.1097/QAD.0000000000000848.


The platelet Fc receptor, FcγRIIa.

Qiao J, Al-Tamimi M, Baker RI, Andrews RK, Gardiner EE.

Immunol Rev. 2015 Nov;268(1):241-52. doi: 10.1111/imr.12370. Review.


Low levels of CD9 coincidental with a novel nonsense mutation in glycoprotein Ibβ in a patient with Bernard-Soulier syndrome.

Qiao J, Davis AK, Morel-Kopp MC, Ward CM, Gardiner EE, Andrews RK.

Ann Hematol. 2015 Dec;94(12):2069-71. doi: 10.1007/s00277-015-2473-1. Epub 2015 Aug 16. No abstract available.


An atypical IgM class platelet cold agglutinin induces GPVI-dependent aggregation of human platelets.

Sánchez Guiu IM, Martínez-Martinez I, Martínez C, Navarro-Fernandez J, García-Candel F, Ferrer-Marín F, Vicente V, Watson SP, Andrews RK, Gardiner EE, Lozano ML, Rivera J.

Thromb Haemost. 2015 Aug;114(2):313-24. doi: 10.1160/TH14-11-0945. Epub 2015 May 21.


Editorial: ADAMs control inflammation from afar.

Andrews RK, Gardiner EE.

J Leukoc Biol. 2015 Mar;97(3):437-8. doi: 10.1189/jlb.3CE1114-528R. No abstract available.


Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators.

Flierl U, Nero TL, Lim B, Arthur JF, Yao Y, Jung SM, Gitz E, Pollitt AY, Zaldivia MT, Jandrot-Perrus M, Schäfer A, Nieswandt B, Andrews RK, Parker MW, Gardiner EE, Peter K.

J Exp Med. 2015 Feb 9;212(2):129-37. doi: 10.1084/jem.20140391. Epub 2015 Feb 2.


Extracorporeal membrane oxygenation-hemostatic complications.

Murphy DA, Hockings LE, Andrews RK, Aubron C, Gardiner EE, Pellegrino VA, Davis AK.

Transfus Med Rev. 2015 Apr;29(2):90-101. doi: 10.1016/j.tmrv.2014.12.001. Epub 2014 Dec 18. Review.


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