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Items: 42

1.

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice.

Loftus RM, Assmann N, Kedia-Mehta N, O'Brien KL, Garcia A, Gillespie C, Hukelmann JL, Oefner PJ, Lamond AI, Gardiner CM, Dettmer K, Cantrell DA, Sinclair LV, Finlay DK.

Nat Commun. 2018 Jun 14;9(1):2341. doi: 10.1038/s41467-018-04719-2.

2.

Canonical TGF-β Signaling Pathway Represses Human NK Cell Metabolism.

Zaiatz-Bittencourt V, Finlay DK, Gardiner CM.

J Immunol. 2018 Jun 15;200(12):3934-3941. doi: 10.4049/jimmunol.1701461. Epub 2018 May 2.

PMID:
29720425
3.

Sugar or Fat?-Metabolic Requirements for Immunity to Viral Infections.

Shehata HM, Murphy AJ, Lee MKS, Gardiner CM, Crowe SM, Sanjabi S, Finlay DK, Palmer CS.

Front Immunol. 2017 Oct 16;8:1311. doi: 10.3389/fimmu.2017.01311. eCollection 2017. Review.

4.

Srebp-controlled glucose metabolism is essential for NK cell functional responses.

Assmann N, O'Brien KL, Donnelly RP, Dyck L, Zaiatz-Bittencourt V, Loftus RM, Heinrich P, Oefner PJ, Lynch L, Gardiner CM, Dettmer K, Finlay DK.

Nat Immunol. 2017 Nov;18(11):1197-1206. doi: 10.1038/ni.3838. Epub 2017 Sep 18.

PMID:
28920951
5.

What Fuels Natural Killers? Metabolism and NK Cell Responses.

Gardiner CM, Finlay DK.

Front Immunol. 2017 Apr 3;8:367. doi: 10.3389/fimmu.2017.00367. eCollection 2017. Review.

6.

Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults.

Deac OM, Mills JL, Gardiner CM, Shane B, Quinn L, Midttun Ø, McCann A, Meyer K, Ueland PM, Fan R, Lu Z, Brody LC, Molloy AM.

J Nutr. 2016 Sep;146(9):1801-6. doi: 10.3945/jn.116.230698. Epub 2016 Aug 3.

7.

Human Natural Killer cell expression of ULBP2 is associated with a mature functional phenotype.

Brennan K, McSharry BP, Keating S, Petrasca A, O'Reilly VP, Keane J, Doherty DG, Gardiner CM.

Hum Immunol. 2016 Oct;77(10):876-885. doi: 10.1016/j.humimm.2016.06.018. Epub 2016 Jun 24.

PMID:
27349945
8.

The cells that mediate innate immune memory and their functional significance in inflammatory and infectious diseases.

Gardiner CM, Mills KH.

Semin Immunol. 2016 Aug;28(4):343-50. doi: 10.1016/j.smim.2016.03.001. Epub 2016 Mar 12. Review.

PMID:
26979658
9.

Metabolic Reprogramming Supports IFN-γ Production by CD56bright NK Cells.

Keating SE, Zaiatz-Bittencourt V, Loftus RM, Keane C, Brennan K, Finlay DK, Gardiner CM.

J Immunol. 2016 Mar 15;196(6):2552-60. doi: 10.4049/jimmunol.1501783. Epub 2016 Feb 12.

10.

NK cell function and receptor diversity in the context of HCV infection.

Gardiner CM.

Front Microbiol. 2015 Sep 30;6:1061. doi: 10.3389/fmicb.2015.01061. eCollection 2015. Review.

11.

Natural killer cells from psoriasis vulgaris patients have reduced levels of cytotoxicity associated degranulation and cytokine production.

Dunphy SE, Sweeney CM, Kelly G, Tobin AM, Kirby B, Gardiner CM.

Clin Immunol. 2017 Apr;177:43-49. doi: 10.1016/j.clim.2015.10.004. Epub 2015 Oct 20.

PMID:
26477484
12.

Increased frequencies of the killer immunoglobulin-like receptor genes KIR2DL2 and KIR2DS2 are associated with neuroblastoma.

Keating SE, Ní Chorcora C, Dring MM, Stallings RL, O'Meara A, Gardiner CM.

Tissue Antigens. 2015 Sep;86(3):172-7. doi: 10.1111/tan.12608. Epub 2015 Jul 22.

PMID:
26202659
13.

2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells.

Dunphy SE, Guinan KJ, Chorcora CN, Jayaraman J, Traherne JA, Trowsdale J, Pende D, Middleton D, Gardiner CM.

Genes Immun. 2015 Jul-Aug;16(5):301-10. doi: 10.1038/gene.2015.15. Epub 2015 May 7.

PMID:
25950617
14.

mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function.

Donnelly RP, Loftus RM, Keating SE, Liou KT, Biron CA, Gardiner CM, Finlay DK.

J Immunol. 2014 Nov 1;193(9):4477-84. doi: 10.4049/jimmunol.1401558. Epub 2014 Sep 26.

15.

IFNL cytokines do not modulate human or murine NK cell functions.

Morrison MH, Keane C, Quinn LM, Kelly A, O'Farrelly C, Bergin C, Gardiner CM.

Hum Immunol. 2014 Sep;75(9):996-1000. doi: 10.1016/j.humimm.2014.06.016. Epub 2014 Jun 30.

PMID:
24994459
16.

Variation in both IL28B and KIR2DS3 genes influence pegylated interferon and ribavirin hepatitis C treatment outcome in HIV-1 co-infection.

Keane C, O'Shea D, Reiberger T, Peck-Radosavljevic M, Farrell G, Bergin C, Gardiner CM.

PLoS One. 2013 Jun 24;8(6):e66831. doi: 10.1371/journal.pone.0066831. Print 2013.

17.

NK cells and psoriasis.

Dunphy S, Gardiner CM.

J Biomed Biotechnol. 2011;2011:248317. doi: 10.1155/2011/248317. Epub 2011 May 26. Review.

18.

Common HIV-1 peptide variants mediate differential binding of KIR3DL1 to HLA-Bw4 molecules.

Fadda L, O'Connor GM, Kumar S, Piechocka-Trocha A, Gardiner CM, Carrington M, McVicar DW, Altfeld M.

J Virol. 2011 Jun;85(12):5970-4. doi: 10.1128/JVI.00412-11. Epub 2011 Apr 6.

19.

Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection.

Dring MM, Morrison MH, McSharry BP, Guinan KJ, Hagan R; Irish HCV Research Consortium, O'Farrelly C, Gardiner CM.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5736-41. doi: 10.1073/pnas.1016358108. Epub 2011 Mar 14.

20.

Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors.

Medina JR, Becker CJ, Blackledge CW, Duquenne C, Feng Y, Grant SW, Heerding D, Li WH, Miller WH, Romeril SP, Scherzer D, Shu A, Bobko MA, Chadderton AR, Dumble M, Gardiner CM, Gilbert S, Liu Q, Rabindran SK, Sudakin V, Xiang H, Brady PG, Campobasso N, Ward P, Axten JM.

J Med Chem. 2011 Mar 24;54(6):1871-95. doi: 10.1021/jm101527u. Epub 2011 Feb 22.

PMID:
21341675
21.

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin.

Knight SD, Adams ND, Burgess JL, Chaudhari AM, Darcy MG, Donatelli CA, Luengo JI, Newlander KA, Parrish CA, Ridgers LH, Sarpong MA, Schmidt SJ, Van Aller GS, Carson JD, Diamond MA, Elkins PA, Gardiner CM, Garver E, Gilbert SA, Gontarek RR, Jackson JR, Kershner KL, Luo L, Raha K, Sherk CS, Sung CM, Sutton D, Tummino PJ, Wegrzyn RJ, Auger KR, Dhanak D.

ACS Med Chem Lett. 2010 Jan 19;1(1):39-43. doi: 10.1021/ml900028r. eCollection 2010 Apr 8.

22.

Signatures of natural selection and coevolution between killer cell immunoglobulin-like receptors (KIR) and HLA class I genes.

Guinan KJ, Cunningham RT, Meenagh A, Gonzalez A, Dring MM, McGuinness BW, Middleton D, Gardiner CM.

Genes Immun. 2010 Sep;11(6):467-78. doi: 10.1038/gene.2010.9. Epub 2010 Mar 4.

PMID:
20200544
23.

Receptor systems controlling natural killer cell function are genetically stratified in Europe.

Guinan KJ, Cunningham RT, Meenagh A, Dring MM, Middleton D, Gardiner CM.

Genes Immun. 2010 Jan;11(1):67-78. doi: 10.1038/gene.2009.60. Epub 2009 Aug 20.

PMID:
19693090
24.

Activation of human NK cells by the bacterial pathogen-associated molecular pattern muramyl dipeptide.

Athié-Morales V, O'Connor GM, Gardiner CM.

J Immunol. 2008 Mar 15;180(6):4082-9.

25.

Killer cell immunoglobulin-like receptors on NK cells: the how, where and why.

Gardiner CM.

Int J Immunogenet. 2008 Feb;35(1):1-8. Epub 2007 Dec 18. Review.

PMID:
18093180
26.

Natural Killer cells from long-term non-progressor HIV patients are characterized by altered phenotype and function.

O'Connor GM, Holmes A, Mulcahy F, Gardiner CM.

Clin Immunol. 2007 Sep;124(3):277-83. Epub 2007 Jul 3.

PMID:
17611161
27.

Functional polymorphism of the KIR3DL1/S1 receptor on human NK cells.

O'Connor GM, Guinan KJ, Cunningham RT, Middleton D, Parham P, Gardiner CM.

J Immunol. 2007 Jan 1;178(1):235-41.

28.

Putting the natural killer cell in its place.

O'Connor GM, Hart OM, Gardiner CM.

Immunology. 2006 Jan;117(1):1-10. Review.

29.

TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production.

Hart OM, Athie-Morales V, O'Connor GM, Gardiner CM.

J Immunol. 2005 Aug 1;175(3):1636-42.

31.

Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B.

Gómez-Lozano N, Gardiner CM, Parham P, Vilches C.

Immunogenetics. 2002 Aug;54(5):314-9. Epub 2002 Jun 26.

PMID:
12185535
32.

Genetic control of human NK cell repertoire.

Shilling HG, Young N, Guethlein LA, Cheng NW, Gardiner CM, Tyan D, Parham P.

J Immunol. 2002 Jul 1;169(1):239-47.

33.

Allelic polymorphism synergizes with variable gene content to individualize human KIR genotype.

Shilling HG, Guethlein LA, Cheng NW, Gardiner CM, Rodriguez R, Tyan D, Parham P.

J Immunol. 2002 Mar 1;168(5):2307-15.

34.

Different NK cell surface phenotypes defined by the DX9 antibody are due to KIR3DL1 gene polymorphism.

Gardiner CM, Guethlein LA, Shilling HG, Pando M, Carr WH, Rajalingam R, Vilches C, Parham P.

J Immunol. 2001 Mar 1;166(5):2992-3001.

35.

Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors.

Rajalingam R, Gardiner CM, Canavez F, Vilches C, Parham P.

Tissue Antigens. 2001 Jan;57(1):22-31.

PMID:
11169255
36.

Discovery of two novel variants of KIR2DS5 reveals this gene to be a common component of human KIR 'B' haplotypes.

Vilches C, Pando MJ, Rajalingam R, Gardiner CM, Parham P.

Tissue Antigens. 2000 Nov;56(5):453-6.

PMID:
11144295
37.

Gene structure and promoter variation of expressed and nonexpressed variants of the KIR2DL5 gene.

Vilches C, Gardiner CM, Parham P.

J Immunol. 2000 Dec 1;165(11):6416-21.

38.

KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains.

Vilches C, Rajalingam R, Uhrberg M, Gardiner CM, Young NT, Parham P.

J Immunol. 2000 Jun 1;164(11):5797-804.

39.

Natural killer cells.

Gardiner CM.

Curr Biol. 1999 Oct 7;9(19):R716. Review. No abstract available.

40.
41.

Differential cytotoxicity of cord blood and bone marrow-derived natural killer cells.

Gardiner CM, Meara AO, Reen DJ.

Blood. 1998 Jan 1;91(1):207-13.

42.

Recognition of unusual presentation of natural killer cell leukemia.

Gardiner CM, Reen DJ, O'Meara A.

Am J Hematol. 1995 Oct;50(2):133-9.

PMID:
7572992

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