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The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies.

Stubbs MC, Burn TC, Sparks RB, Maduskuie T, Diamond S, Rupar M, Wen X, Volgina A, Zolotarjova N, Waeltz P, Favata M, Jalluri R, Liu H, Liu XM, Li J, Collins R, Falahatpisheh N, Polam P, DiMatteo D, Feldman P, Dostalik V, Thekkat P, Gardiner C, He X, Li Y, Covington M, Wynn R, Ruggeri B, Yeleswaram S, Xue C, Yao W, Combs AP, Huber R, Hollis G, Scherle P, Liu P.

Clin Cancer Res. 2018 Sep 11. pii: clincanres.0098.2018. doi: 10.1158/1078-0432.CCR-18-0098. [Epub ahead of print]


Assessing the Impact of Non-Urea Ruminant Urine Nitrogen Compounds on Urine Patch Nitrous Oxide Emissions.

Gardiner CA, Clough TJ, Cameron KC, Di HJ, Edwards GR, de Klein CAM.

J Environ Qual. 2018 Jul;47(4):812-819. doi: 10.2134/jeq2018.03.0112.


Reframing Global Palliative Care Advocacy for the Sustainable Development Goal Era: A Qualitative Study of the Views of International Palliative Care Experts.

Clark J, Barnes A, Gardiner C.

J Pain Symptom Manage. 2018 Sep;56(3):363-370. doi: 10.1016/j.jpainsymman.2018.06.009. Epub 2018 Jun 25.


Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice.

Loftus RM, Assmann N, Kedia-Mehta N, O'Brien KL, Garcia A, Gillespie C, Hukelmann JL, Oefner PJ, Lamond AI, Gardiner CM, Dettmer K, Cantrell DA, Sinclair LV, Finlay DK.

Nat Commun. 2018 Jun 14;9(1):2341. doi: 10.1038/s41467-018-04719-2.


Canonical TGF-β Signaling Pathway Represses Human NK Cell Metabolism.

Zaiatz-Bittencourt V, Finlay DK, Gardiner CM.

J Immunol. 2018 Jun 15;200(12):3934-3941. doi: 10.4049/jimmunol.1701461. Epub 2018 May 2.


Neural activation during delay discounting is associated with 6-month change in risky sexual behavior in adolescents.

Gardiner CK, Karoly HC, Thayer RE, Gillman AS, Sabbineni A, Bryan AD.

Ann Behav Med. 2018 Apr 19;52(5):356-366. doi: 10.1093/abm/kax028.


What is the cost of palliative care in the UK? A systematic review.

Gardiner C, Ryan T, Gott M.

BMJ Support Palliat Care. 2018 Sep;8(3):250-257. doi: 10.1136/bmjspcare-2018-001519. Epub 2018 Apr 13. Review.


Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI.

Montague SJ, Delierneux C, Lecut C, Layios N, Dinsdale RJ, Lee CS, Poulter NS, Andrews RK, Hampson P, Wearn CM, Maes N, Bishop J, Bamford A, Gardiner C, Lee WM, Iqbal T, Moiemen N, Watson SP, Oury C, Harrison P, Gardiner EE.

Blood Adv. 2018 Feb 13;2(3):240-251. doi: 10.1182/bloodadvances.2017011171.


Schistosomes and Microfilarial Parasites in Magellanic Penguins.

Vanstreels RET, Gardiner CH, Yabsley MJ, Swanepoel L, Kolesnikovas CKM, Silva-Filho RP, Ewbank AC, Catão-Dias JL.

J Parasitol. 2018 Jun;104(3):322-328. doi: 10.1645/17-154. Epub 2018 Feb 27.


Updating the MISEV minimal requirements for extracellular vesicle studies: building bridges to reproducibility.

Witwer KW, Soekmadji C, Hill AF, Wauben MH, Buzás EI, Di Vizio D, Falcon-Perez JM, Gardiner C, Hochberg F, Kurochkin IV, Lötvall J, Mathivanan S, Nieuwland R, Sahoo S, Tahara H, Torrecilhas AC, Weaver AM, Yin H, Zheng L, Gho YS, Quesenberry P, Théry C.

J Extracell Vesicles. 2017 Nov 15;6(1):1396823. doi: 10.1080/20013078.2017.1396823. eCollection 2017. No abstract available.


Body mass index, diet, and exercise: testing possible linkages to breast cancer risk via DNA methylation.

Gillman AS, Gardiner CK, Koljack CE, Bryan AD.

Breast Cancer Res Treat. 2018 Feb;168(1):241-248. doi: 10.1007/s10549-017-4573-1. Epub 2017 Nov 10.


Dirofilaria repens transmission in southeastern Finland.

Pietikäinen R, Nordling S, Jokiranta S, Saari S, Heikkinen P, Gardiner C, Kerttula AM, Kantanen T, Nikanorova A, Laaksonen S, Lavikainen A, Oksanen A.

Parasit Vectors. 2017 Nov 10;10(1):561. doi: 10.1186/s13071-017-2499-4.


Sugar or Fat?-Metabolic Requirements for Immunity to Viral Infections.

Shehata HM, Murphy AJ, Lee MKS, Gardiner CM, Crowe SM, Sanjabi S, Finlay DK, Palmer CS.

Front Immunol. 2017 Oct 16;8:1311. doi: 10.3389/fimmu.2017.01311. eCollection 2017. Review.


Predictors of patient-related benefit, burden and feeling safe in relation to hospital admissions in palliative care: A cross-sectional survey.

Robinson J, Gott M, Frey R, Gardiner C, Ingleton C.

Palliat Med. 2018 Jan;32(1):167-171. doi: 10.1177/0269216317731991. Epub 2017 Sep 27.


Srebp-controlled glucose metabolism is essential for NK cell functional responses.

Assmann N, O'Brien KL, Donnelly RP, Dyck L, Zaiatz-Bittencourt V, Loftus RM, Heinrich P, Oefner PJ, Lynch L, Gardiner CM, Dettmer K, Finlay DK.

Nat Immunol. 2017 Nov;18(11):1197-1206. doi: 10.1038/ni.3838. Epub 2017 Sep 18.



Brereton L, Wahlster P, Mozygemba K, Lysdahl KB, Burns J, Polus S, Tummers M, Refolo P, Sacchini D, Leppert W, Chilcott J, Ingleton C, Gardiner C, Goyder E.

Int J Technol Assess Health Care. 2017 Jan;33(5):552-561. doi: 10.1017/S026646231700068X. Epub 2017 Sep 4.


Circulating endothelial cell-derived extracellular vesicles mediate the acute phase response and sickness behaviour associated with CNS inflammation.

Couch Y, Akbar N, Roodselaar J, Evans MC, Gardiner C, Sargent I, Romero IA, Bristow A, Buchan AM, Haughey N, Anthony DC.

Sci Rep. 2017 Aug 29;7(1):9574. doi: 10.1038/s41598-017-09710-3.


Specialist palliative care nursing and the philosophy of palliative care: a critical discussion.

Robinson J, Gott M, Gardiner C, Ingleton C.

Int J Palliat Nurs. 2017 Jul 2;23(7):352-358. doi: 10.12968/ijpn.2017.23.7.352. Review.


A performance evaluation of a novel human recombinant tissue factor prothrombin time reagent (Revohem PT).

Gardiner C, Kohama K, Patel I, Lane P, Dwyer S, Machin SJ, Mackie IJ.

Int J Lab Hematol. 2017 Oct;39(5):532-538. doi: 10.1111/ijlh.12691. Epub 2017 Jun 12.


Body mass is positively associated with neural response to sweet taste, but not alcohol, among drinkers.

Gardiner CK, YorkWilliams SL, Bryan AD, Hutchison KE.

Behav Brain Res. 2017 Jul 28;331:131-134. doi: 10.1016/j.bbr.2017.05.046. Epub 2017 May 23.


What Fuels Natural Killers? Metabolism and NK Cell Responses.

Gardiner CM, Finlay DK.

Front Immunol. 2017 Apr 3;8:367. doi: 10.3389/fimmu.2017.00367. eCollection 2017. Review.


Challenges in building interpersonal care in organized hospital stroke units: The perspectives of stroke survivors, family caregivers and the multidisciplinary team.

Ryan T, Harrison M, Gardiner C, Jones A.

J Adv Nurs. 2017 Oct;73(10):2351-2360. doi: 10.1111/jan.13313. Epub 2017 May 11.


What do we know about different models of providing palliative care? Findings from a systematic review of reviews.

Brereton L, Clark J, Ingleton C, Gardiner C, Preston L, Ryan T, Goyder E.

Palliat Med. 2017 Oct;31(9):781-797. doi: 10.1177/0269216317701890. Epub 2017 Apr 5. Review.


Impact of haemostatic mechanisms on pathophysiology of preeclampsia.

Gardiner C, Vatish M.

Thromb Res. 2017 Mar;151 Suppl 1:S48-S52. doi: 10.1016/S0049-3848(17)30067-1. Review.


Hypovitaminosis A in extensively grazed beef cattle.

Parker EM, Gardiner CP, Kessell AE, Parker AJ.

Aust Vet J. 2017 Mar;95(3):80-84. doi: 10.1111/avj.12560.


Costs of Family Caregiving in Palliative Care (COFAC) questionnaire: development and piloting of a new survey tool.

Gardiner C, McDermott C, Hulme C.

BMJ Support Palliat Care. 2017 Feb 17. pii: bmjspcare-2016-001202. doi: 10.1136/bmjspcare-2016-001202. [Epub ahead of print]


Differences in the nutrient concentrations, in vitro methanogenic potential and other fermentative traits of tropical grasses and legumes for beef production systems in northern Australia.

Durmic Z, Ramírez-Restrepo CA, Gardiner C, O'Neill CJ, Hussein E, Vercoe PE.

J Sci Food Agric. 2017 Sep;97(12):4075-4086. doi: 10.1002/jsfa.8274. Epub 2017 Mar 22.


Effectiveness of differing levels of support for family meals on obesity prevention among head start preschoolers: the simply dinner study.

Brophy-Herb HE, Horodynski M, Contreras D, Kerver J, Kaciroti N, Stein M, Lee HJ, Motz B, Hebert S, Prine E, Gardiner C, Van Egeren LA, Lumeng JC.

BMC Public Health. 2017 Feb 10;17(1):184. doi: 10.1186/s12889-017-4074-5.


Monetary Incentive Interventions Can Enhance Psychological Factors Related to Fruit and Vegetable Consumption.

Gardiner CK, Bryan AD.

Ann Behav Med. 2017 Aug;51(4):599-609. doi: 10.1007/s12160-017-9882-4.


Structural analysis of pathogenic mutations in the DYRK1A gene in patients with developmental disorders.

Evers JM, Laskowski RA, Bertolli M, Clayton-Smith J, Deshpande C, Eason J, Elmslie F, Flinter F, Gardiner C, Hurst JA, Kingston H, Kini U, Lampe AK, Lim D, Male A, Naik S, Parker MJ, Price S, Robert L, Sarkar A, Straub V, Woods G, Thornton JM; DDD Study, Wright CF.

Hum Mol Genet. 2017 Feb 1;26(3):519-526. doi: 10.1093/hmg/ddw409.


Single particle analysis: Methods for detection of platelet extracellular vesicles in suspension (excluding flow cytometry).

Buzás EI, Gardiner C, Lee C, Smith ZJ.

Platelets. 2017 May;28(3):249-255. doi: 10.1080/09537104.2016.1260704. Epub 2016 Dec 29. Review.


A Comparison of Different Methodologies for the Measurement of Extracellular Vesicles and Milk-derived Particles in Raw Milk from Cows.

Pollott G, Brito A, Gardiner C, Lawson C.

Biomark Insights. 2016 Dec 13;11:147-155. doi: 10.4137/BMI.S38438. eCollection 2016.


Changes in Body Composition in the Two Years after Initiation of Haemodialysis: A Retrospective Cohort Study.

Keane D, Gardiner C, Lindley E, Lines S, Woodrow G, Wright M.

Nutrients. 2016 Nov 4;8(11). pii: E702.


Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey.

Gardiner C, Di Vizio D, Sahoo S, Théry C, Witwer KW, Wauben M, Hill AF.

J Extracell Vesicles. 2016 Oct 31;5:32945. doi: 10.3402/jev.v5.32945. eCollection 2016.


Adaptation to Stressors by Systemic Protein Amyloidogenesis.

Audas TE, Audas DE, Jacob MD, Ho JJ, Khacho M, Wang M, Perera JK, Gardiner C, Bennett CA, Head T, Kryvenko ON, Jorda M, Daunert S, Malhotra A, Trinkle-Mulcahy L, Gonzalgo ML, Lee S.

Dev Cell. 2016 Oct 24;39(2):155-168. doi: 10.1016/j.devcel.2016.09.002. Epub 2016 Oct 6.


What cost components are relevant for economic evaluations of palliative care, and what approaches are used to measure these costs? A systematic review.

Gardiner C, Ingleton C, Ryan T, Ward S, Gott M.

Palliat Med. 2017 Apr;31(4):323-337. doi: 10.1177/0269216316670287. Epub 2016 Sep 27. Review.


Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults.

Deac OM, Mills JL, Gardiner CM, Shane B, Quinn L, Midttun Ø, McCann A, Meyer K, Ueland PM, Fan R, Lu Z, Brody LC, Molloy AM.

J Nutr. 2016 Sep;146(9):1801-6. doi: 10.3945/jn.116.230698. Epub 2016 Aug 3.


International palliative care research in the context of global development: a systematic mapping review.

Clark J, Gardiner C, Barnes A.

BMJ Support Palliat Care. 2018 Mar;8(1):7-18. doi: 10.1136/bmjspcare-2015-001008. Epub 2016 Aug 2. Review.


The 'problematisation' of palliative care in hospital: an exploratory review of international palliative care policy in five countries.

Robinson J, Gott M, Gardiner C, Ingleton C.

BMC Palliat Care. 2016 Jul 25;15:64. doi: 10.1186/s12904-016-0137-0.


Commentary: Differential associations between obesity and behavioral measures of impulsivity.

Gardiner CK, Karoly HC, Bryan AD.

Front Psychol. 2016 Jun 21;7:949. doi: 10.3389/fpsyg.2016.00949. eCollection 2016. No abstract available.


Interventions to reduce social isolation and loneliness among older people: an integrative review.

Gardiner C, Geldenhuys G, Gott M.

Health Soc Care Community. 2018 Mar;26(2):147-157. doi: 10.1111/hsc.12367. Epub 2016 Jul 13. Review.


Human Natural Killer cell expression of ULBP2 is associated with a mature functional phenotype.

Brennan K, McSharry BP, Keating S, Petrasca A, O'Reilly VP, Keane J, Doherty DG, Gardiner CM.

Hum Immunol. 2016 Oct;77(10):876-885. doi: 10.1016/j.humimm.2016.06.018. Epub 2016 Jun 24.


Psychological and emotional needs, assessment, and support post-stroke: a multi-perspective qualitative study.

Harrison M, Ryan T, Gardiner C, Jones A.

Top Stroke Rehabil. 2017 Mar;24(2):119-125. doi: 10.1080/10749357.2016.1196908. Epub 2016 Jun 16.


Lay and professional stakeholder involvement in scoping palliative care issues: Methods used in seven European countries.

Brereton L, Ingleton C, Gardiner C, Goyder E, Mozygemba K, Lysdahl KB, Tummers M, Sacchini D, Leppert W, Blaževičienė A, van der Wilt GJ, Refolo P, De Nicola M, Chilcott J, Oortwijn W.

Palliat Med. 2017 Feb;31(2):181-192. doi: 10.1177/0269216316649154. Epub 2016 Jul 10.


Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection.

Fischer J, Weber ANR, Böhm S, Dickhöfer S, El Maadidi S, Deichsel D, Knop V, Klinker H, Möller B, Rasenack J, Wang L, Sharma M, Hinrichsen H, Spengler U, Buggisch P, Sarrazin C, Pawlita M, Waterboer T, Wiese M, Probst-Müller E, Malinverni R, Bochud PY, Gardiner C, O'Farrelly C, Berg T.

Gut. 2017 Oct;66(10):1829-1837. doi: 10.1136/gutjnl-2015-310239. Epub 2016 Apr 21.


Genetic Analysis of 'PAX6-Negative' Individuals with Aniridia or Gillespie Syndrome.

Ansari M, Rainger J, Hanson IM, Williamson KA, Sharkey F, Harewood L, Sandilands A, Clayton-Smith J, Dollfus H, Bitoun P, Meire F, Fantes J, Franco B, Lorenz B, Taylor DS, Stewart F, Willoughby CE, McEntagart M, Khaw PT, Clericuzio C, Van Maldergem L, Williams D, Newbury-Ecob R, Traboulsi EI, Silva ED, Madlom MM, Goudie DR, Fleck BW, Wieczorek D, Kohlhase J, McTrusty AD, Gardiner C, Yale C, Moore AT, Russell-Eggitt I, Islam L, Lees M, Beales PL, Tuft SJ, Solano JB, Splitt M, Hertz JM, Prescott TE, Shears DJ, Nischal KK, Doco-Fenzy M, Prieur F, Temple IK, Lachlan KL, Damante G, Morrison DA, van Heyningen V, FitzPatrick DR.

PLoS One. 2016 Apr 28;11(4):e0153757. doi: 10.1371/journal.pone.0153757. eCollection 2016.


Methodological considerations for researching the financial costs of family caregiving within a palliative care context.

Gardiner C, Allen R, Moeke-Maxwell T, Robinson J, Gott M.

BMJ Support Palliat Care. 2016 Dec;6(4):445-451. doi: 10.1136/bmjspcare-2015-001046. Epub 2016 Apr 26.


The cells that mediate innate immune memory and their functional significance in inflammatory and infectious diseases.

Gardiner CM, Mills KH.

Semin Immunol. 2016 Aug;28(4):343-50. doi: 10.1016/j.smim.2016.03.001. Epub 2016 Mar 12. Review.


The 2nd United Kingdom Extracellular Vesicle Forum Meeting Abstracts: 15 December 2015, Hadyn Ellis Building, Cardiff University.

Clayton A, Lawson C, Gardiner C, Harrison P, Carter D.

J Extracell Vesicles. 2016 Feb 23;5:30924. doi: 10.3402/jev.v5.30924. eCollection 2016.


Metabolic Reprogramming Supports IFN-γ Production by CD56bright NK Cells.

Keating SE, Zaiatz-Bittencourt V, Loftus RM, Keane C, Brennan K, Finlay DK, Gardiner CM.

J Immunol. 2016 Mar 15;196(6):2552-60. doi: 10.4049/jimmunol.1501783. Epub 2016 Feb 12.

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