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Items: 1 to 50 of 54

1.

Ischemic preconditioning induces cortical microglial proliferation and a transcriptomic program of robust cell cycle activation.

McDonough A, Noor S, Lee RV, Dodge R 3rd, Strosnider JS, Shen J, Davidson S, Möller T, Garden GA, Weinstein JR.

Glia. 2020 Jan;68(1):76-94. doi: 10.1002/glia.23701. Epub 2019 Aug 17.

PMID:
31420975
2.

Alternative splicing in a presenilin 2 variant associated with Alzheimer disease.

Braggin JE, Bucks SA, Course MM, Smith CL, Sopher B, Osnis L, Shuey KD, Domoto-Reilly K, Caso C, Kinoshita C, Scherpelz KP, Cross C, Grabowski T, Nik SHM, Newman M, Garden GA, Leverenz JB, Tsuang D, Latimer C, Gonzalez-Cuyar LF, Keene CD, Morrison RS, Rhoads K, Wijsman EM, Dorschner MO, Lardelli M, Young JE, Valdmanis PN, Bird TD, Jayadev S.

Ann Clin Transl Neurol. 2019 Mar 10;6(4):762-777. doi: 10.1002/acn3.755. eCollection 2019 Apr.

3.

Neuronal susceptibility to beta-amyloid toxicity and ischemic injury involves histone deacetylase-2 regulation of endophilin-B1.

Wang DB, Kinoshita C, Kinoshita Y, Sopher BL, Uo T, Lee RJ, Kim JK, Murphy SP, Dirk Keene C, Garden GA, Morrison RS.

Brain Pathol. 2019 Mar;29(2):164-175. doi: 10.1111/bpa.12647. Epub 2018 Oct 5.

PMID:
30028551
4.

Modulation of Hematopoietic Lineage Specification Impacts TREM2 Expression in Microglia-Like Cells Derived From Human Stem Cells.

Amos PJ, Fung S, Case A, Kifelew J, Osnis L, Smith CL, Green K, Naydenov A, Aloi M, Hubbard JJ, Ramakrishnan A, Garden GA, Jayadev S.

ASN Neuro. 2017 Jul-Aug;9(4):1759091417716610. doi: 10.1177/1759091417716610.

5.

Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate.

Adams Waldorf KM, Stencel-Baerenwald JE, Kapur RP, Studholme C, Boldenow E, Vornhagen J, Baldessari A, Dighe MK, Thiel J, Merillat S, Armistead B, Tisoncik-Go J, Green RR, Davis MA, Dewey EC, Fairgrieve MR, Gatenby JC, Richards T, Garden GA, Diamond MS, Juul SE, Grant RF, Kuller L, Shaw DW, Ogle J, Gough GM, Lee W, English C, Hevner RF, Dobyns WB, Gale M Jr, Rajagopal L.

Nat Med. 2016 Nov;22(11):1256-1259. doi: 10.1038/nm.4193. Epub 2016 Sep 12.

6.

Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.

Möller T, Bard F, Bhattacharya A, Biber K, Campbell B, Dale E, Eder C, Gan L, Garden GA, Hughes ZA, Pearse DD, Staal RG, Sayed FA, Wes PD, Boddeke HW.

Glia. 2016 Oct;64(10):1788-94. doi: 10.1002/glia.23007. Epub 2016 Jun 1. Review.

PMID:
27246804
7.

Glial biomarkers in human central nervous system disease.

Garden GA, Campbell BM.

Glia. 2016 Oct;64(10):1755-71. doi: 10.1002/glia.22998. Epub 2016 May 26. Review.

8.

The p53 Transcriptional Network Influences Microglia Behavior and Neuroinflammation.

Aloi MS, Su W, Garden GA.

Crit Rev Immunol. 2015;35(5):401-15. Review.

9.

MicroRNAs mediating CNS inflammation: Small regulators with powerful potential.

Su W, Aloi MS, Garden GA.

Brain Behav Immun. 2016 Feb;52:1-8. doi: 10.1016/j.bbi.2015.07.003. Epub 2015 Jul 3. Review.

10.

R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study.

Korvatska O, Leverenz JB, Jayadev S, McMillan P, Kurtz I, Guo X, Rumbaugh M, Matsushita M, Girirajan S, Dorschner MO, Kiianitsa K, Yu CE, Brkanac Z, Garden GA, Raskind WH, Bird TD.

JAMA Neurol. 2015 Aug;72(8):920-7. doi: 10.1001/jamaneurol.2015.0979.

11.

Loss of endophilin-B1 exacerbates Alzheimer's disease pathology.

Wang DB, Kinoshita Y, Kinoshita C, Uo T, Sopher BL, Cudaback E, Keene CD, Bilousova T, Gylys K, Case A, Jayadev S, Wang HG, Garden GA, Morrison RS.

Brain. 2015 Jul;138(Pt 7):2005-19. doi: 10.1093/brain/awv128. Epub 2015 May 16.

12.

Glia: guardians, gluttons, or guides for the maintenance of neuronal connectivity?

Jebelli J, Su W, Hopkins S, Pocock J, Garden GA.

Ann N Y Acad Sci. 2015 Sep;1351:1-10. doi: 10.1111/nyas.12711. Epub 2015 Mar 9. Review.

13.

Recombinant adeno-associated viral (rAAV) vectors mediate efficient gene transduction in cultured neonatal and adult microglia.

Su W, Kang J, Sopher B, Gillespie J, Aloi MS, Odom GL, Hopkins S, Case A, Wang DB, Chamberlain JS, Garden GA.

J Neurochem. 2016 Jan;136 Suppl 1:49-62. doi: 10.1111/jnc.13081. Epub 2015 Mar 20.

14.

miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation.

Hu R, Kagele DA, Huffaker TB, Runtsch MC, Alexander M, Liu J, Bake E, Su W, Williams MA, Rao DS, Möller T, Garden GA, Round JL, O'Connell RM.

Immunity. 2014 Oct 16;41(4):605-19. doi: 10.1016/j.immuni.2014.09.015.

15.

Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.

Cortes CJ, Miranda HC, Frankowski H, Batlevi Y, Young JE, Le A, Ivanov N, Sopher BL, Carromeu C, Muotri AR, Garden GA, La Spada AR.

Nat Neurosci. 2014 Sep;17(9):1180-9. doi: 10.1038/nn.3787. Epub 2014 Aug 10.

16.

CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120.

Maung R, Hoefer MM, Sanchez AB, Sejbuk NE, Medders KE, Desai MK, Catalan IC, Dowling CC, de Rozieres CM, Garden GA, Russo R, Roberts AJ, Williams R, Kaul M.

J Immunol. 2014 Aug 15;193(4):1895-910. doi: 10.4049/jimmunol.1302915. Epub 2014 Jul 16.

17.

Bax interacting factor-1 promotes survival and mitochondrial elongation in neurons.

Wang DB, Uo T, Kinoshita C, Sopher BL, Lee RJ, Murphy SP, Kinoshita Y, Garden GA, Wang HG, Morrison RS.

J Neurosci. 2014 Feb 12;34(7):2674-83. doi: 10.1523/JNEUROSCI.4074-13.2014.

18.

The p53 transcription factor modulates microglia behavior through microRNA-dependent regulation of c-Maf.

Su W, Hopkins S, Nesser NK, Sopher B, Silvestroni A, Ammanuel S, Jayadev S, Möller T, Weinstein J, Garden GA.

J Immunol. 2014 Jan 1;192(1):358-66. doi: 10.4049/jimmunol.1301397. Epub 2013 Dec 6.

19.

Epigenetics and the modulation of neuroinflammation.

Garden GA.

Neurotherapeutics. 2013 Oct;10(4):782-8. doi: 10.1007/s13311-013-0207-4. Review.

20.

Presenilin 2 influences miR146 level and activity in microglia.

Jayadev S, Case A, Alajajian B, Eastman AJ, Möller T, Garden GA.

J Neurochem. 2013 Dec;127(5):592-9. doi: 10.1111/jnc.12400. Epub 2013 Sep 30.

21.

Declines in Drp1 and parkin expression underlie DNA damage-induced changes in mitochondrial length and neuronal death.

Wang DB, Garden GA, Kinoshita C, Wyles C, Babazadeh N, Sopher B, Kinoshita Y, Morrison RS.

J Neurosci. 2013 Jan 23;33(4):1357-65. doi: 10.1523/JNEUROSCI.3365-12.2013.

22.

Reduction of mutant ataxin-7 expression restores motor function and prevents cerebellar synaptic reorganization in a conditional mouse model of SCA7.

Furrer SA, Waldherr SM, Mohanachandran MS, Baughn TD, Nguyen KT, Sopher BL, Damian VA, Garden GA, La Spada AR.

Hum Mol Genet. 2013 Mar 1;22(5):890-903. doi: 10.1093/hmg/dds495. Epub 2012 Nov 29.

23.

Intercellular (mis)communication in neurodegenerative disease.

Garden GA, La Spada AR.

Neuron. 2012 Mar 8;73(5):886-901. doi: 10.1016/j.neuron.2012.02.017. Review.

24.

Emerging roles of p53 in glial cell function in health and disease.

Jebelli JD, Hooper C, Garden GA, Pocock JM.

Glia. 2012 Apr;60(4):515-25. doi: 10.1002/glia.22268. Epub 2011 Nov 21.

25.

Spinocerebellar ataxia type 7 cerebellar disease requires the coordinated action of mutant ataxin-7 in neurons and glia, and displays non-cell-autonomous bergmann glia degeneration.

Furrer SA, Mohanachandran MS, Waldherr SM, Chang C, Damian VA, Sopher BL, Garden GA, La Spada AR.

J Neurosci. 2011 Nov 9;31(45):16269-78. doi: 10.1523/JNEUROSCI.4000-11.2011.

26.

Transcription factor p53 influences microglial activation phenotype.

Jayadev S, Nesser NK, Hopkins S, Myers SJ, Case A, Lee RJ, Seaburg LA, Uo T, Murphy SP, Morrison RS, Garden GA.

Glia. 2011 Oct;59(10):1402-13. doi: 10.1002/glia.21178. Epub 2011 May 19.

27.

Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release.

Jayadev S, Case A, Eastman AJ, Nguyen H, Pollak J, Wiley JC, Möller T, Morrison RS, Garden GA.

PLoS One. 2010 Dec 29;5(12):e15743. doi: 10.1371/journal.pone.0015743.

28.

A simple composite phenotype scoring system for evaluating mouse models of cerebellar ataxia.

Guyenet SJ, Furrer SA, Damian VM, Baughan TD, La Spada AR, Garden GA.

J Vis Exp. 2010 May 21;(39). pii: 1787. doi: 10.3791/1787.

29.

Predictors of surface disruption with MR imaging in asymptomatic carotid artery stenosis.

Underhill HR, Yuan C, Yarnykh VL, Chu B, Oikawa M, Dong L, Polissar NL, Garden GA, Cramer SC, Hatsukami TS.

AJNR Am J Neuroradiol. 2010 Mar;31(3):487-93. doi: 10.3174/ajnr.A1842. Epub 2009 Oct 15.

30.

Autophagy activation and enhanced mitophagy characterize the Purkinje cells of pcd mice prior to neuronal death.

Chakrabarti L, Eng J, Ivanov N, Garden GA, La Spada AR.

Mol Brain. 2009 Jul 29;2:24. doi: 10.1186/1756-6606-2-24.

31.

Host and viral factors influencing the pathogenesis of HIV-associated neurocognitive disorders.

Jayadev S, Garden GA.

J Neuroimmune Pharmacol. 2009 Jun;4(2):175-89. doi: 10.1007/s11481-009-9154-6. Epub 2009 Apr 17. Review.

32.

Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk.

Young JE, Garden GA, Martinez RA, Tanaka F, Sandoval CM, Smith AC, Sopher BL, Lin A, Fischbeck KH, Ellerby LM, Morrison RS, Taylor JP, La Spada AR.

J Neurosci. 2009 Feb 18;29(7):1987-97. doi: 10.1523/JNEUROSCI.4072-08.2009.

33.

Molecular pathogenesis and cellular pathology of spinocerebellar ataxia type 7 neurodegeneration.

Garden GA, La Spada AR.

Cerebellum. 2008;7(2):138-49. doi: 10.1007/s12311-008-0027-y. Review.

34.

The glial response to CNS HIV infection includes p53 activation and increased expression of p53 target genes.

Jayadev S, Yun B, Nguyen H, Yokoo H, Morrison RS, Garden GA.

J Neuroimmune Pharmacol. 2007 Dec;2(4):359-70. Epub 2007 Oct 20.

PMID:
18040854
35.

Microglia biology in health and disease.

Garden GA, Möller T.

J Neuroimmune Pharmacol. 2006 Jun;1(2):127-37. Epub 2006 Mar 25. Review.

PMID:
18040779
36.
37.

Potential applications and limitations of proteomics in the study of neurological disease.

Kinoshita Y, Uo T, Jayadev S, Garden GA, Conrads TP, Veenstra TD, Morrison RS.

Arch Neurol. 2006 Dec;63(12):1692-6. Review. No abstract available.

PMID:
17172608
38.

Predictors of carotid atherosclerotic plaque progression as measured by noninvasive magnetic resonance imaging.

Saam T, Yuan C, Chu B, Takaya N, Underhill H, Cai J, Tran N, Polissar NL, Neradilek B, Jarvik GP, Isaac C, Garden GA, Maravilla KR, Hashimoto B, Hatsukami TS.

Atherosclerosis. 2007 Oct;194(2):e34-42. Epub 2006 Sep 15.

39.

Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport.

Custer SK, Garden GA, Gill N, Rueb U, Libby RT, Schultz C, Guyenet SJ, Deller T, Westrum LE, Sopher BL, La Spada AR.

Nat Neurosci. 2006 Oct;9(10):1302-11. Epub 2006 Aug 27.

PMID:
16936724
40.

Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI--initial results.

Takaya N, Yuan C, Chu B, Saam T, Underhill H, Cai J, Tran N, Polissar NL, Isaac C, Ferguson MS, Garden GA, Cramer SC, Maravilla KR, Hashimoto B, Hatsukami TS.

Stroke. 2006 Mar;37(3):818-23. Epub 2006 Feb 9.

41.

The multiple roles of p53 in the pathogenesis of HIV associated dementia.

Garden GA, Morrison RS.

Biochem Biophys Res Commun. 2005 Jun 10;331(3):799-809.

PMID:
15865935
42.

HIV associated neurodegeneration requires p53 in neurons and microglia.

Garden GA, Guo W, Jayadev S, Tun C, Balcaitis S, Choi J, Montine TJ, Möller T, Morrison RS.

FASEB J. 2004 Jul;18(10):1141-3. Epub 2004 May 20.

PMID:
15155568
43.

Acyclovir responsive brain stem disease after the Ramsay Hunt syndrome.

Hu S, Walker M, Czartoski T, Cheng A, Forghani B, Gilden DH, Garden GA.

J Neurol Sci. 2004 Jan 15;217(1):111-3.

PMID:
14675618
44.

p53-dependent cell death signaling in neurons.

Morrison RS, Kinoshita Y, Johnson MD, Guo W, Garden GA.

Neurochem Res. 2003 Jan;28(1):15-27. Review.

PMID:
12587660
45.

Microglia in human immunodeficiency virus-associated neurodegeneration.

Garden GA.

Glia. 2002 Nov;40(2):240-51. Review.

PMID:
12379911
46.

Polyglutamine-expanded ataxin-7 promotes non-cell-autonomous purkinje cell degeneration and displays proteolytic cleavage in ataxic transgenic mice.

Garden GA, Libby RT, Fu YH, Kinoshita Y, Huang J, Possin DE, Smith AC, Martinez RA, Fine GC, Grote SK, Ware CB, Einum DD, Morrison RS, Ptacek LJ, Sopher BL, La Spada AR.

J Neurosci. 2002 Jun 15;22(12):4897-905.

47.

Caspase cascades in human immunodeficiency virus-associated neurodegeneration.

Garden GA, Budd SL, Tsai E, Hanson L, Kaul M, D'Emilia DM, Friedlander RM, Yuan J, Masliah E, Lipton SA.

J Neurosci. 2002 May 15;22(10):4015-24.

48.

Pathways to neuronal injury and apoptosis in HIV-associated dementia.

Kaul M, Garden GA, Lipton SA.

Nature. 2001 Apr 19;410(6831):988-94. Review.

PMID:
11309629
49.
50.

Protein masking of a ribosomal RNA epitope is an early event in afferent deprivation-induced neuronal death.

Garden GA, Hartlage-Rübsamen M, Rubel EW, Bothwell MA.

Mol Cell Neurosci. 1995 Jun;6(3):293-310.

PMID:
7496633

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