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Items: 1 to 50 of 79


Mechanosensitive Junction Remodeling Promotes Robust Epithelial Morphogenesis.

Staddon MF, Cavanaugh KE, Munro EM, Gardel ML, Banerjee S.

Biophys J. 2019 Nov 5;117(9):1739-1750. doi: 10.1016/j.bpj.2019.09.027. Epub 2019 Sep 28.


High throughput discovery of functional protein modifications by Hotspot Thermal Profiling.

Huang JX, Lee G, Cavanaugh KE, Chang JW, Gardel ML, Moellering RE.

Nat Methods. 2019 Sep;16(9):894-901. doi: 10.1038/s41592-019-0499-3. Epub 2019 Aug 5.


Stress relaxation in F-actin solutions by severing.

Arzash S, McCall PM, Feng J, Gardel ML, MacKintosh FC.

Soft Matter. 2019 Aug 21;15(31):6300-6307. doi: 10.1039/c9sm01263j. Epub 2019 Jul 25.


Cofilin drives rapid turnover and fluidization of entangled F-actin.

McCall PM, MacKintosh FC, Kovar DR, Gardel ML.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12629-12637. doi: 10.1073/pnas.1818808116. Epub 2019 Jun 12.


Self-organizing motors divide active liquid droplets.

Weirich KL, Dasbiswas K, Witten TA, Vaikuntanathan S, Gardel ML.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11125-11130. doi: 10.1073/pnas.1814854116. Epub 2019 May 21.


Tunable structure and dynamics of active liquid crystals.

Kumar N, Zhang R, de Pablo JJ, Gardel ML.

Sci Adv. 2018 Oct 12;4(10):eaat7779. doi: 10.1126/sciadv.aat7779. eCollection 2018 Oct.


Force localization modes in dynamic epithelial colonies.

Schaumann EN, Staddon MF, Gardel ML, Banerjee S.

Mol Biol Cell. 2018 Nov 15;29(23):2835-2847. doi: 10.1091/mbc.E18-05-0336. Epub 2018 Sep 12.


Partitioning and Enhanced Self-Assembly of Actin in Polypeptide Coacervates.

McCall PM, Srivastava S, Perry SL, Kovar DR, Gardel ML, Tirrell MV.

Biophys J. 2018 Apr 10;114(7):1636-1645. doi: 10.1016/j.bpj.2018.02.020.


Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination.

Nekrasova O, Harmon RM, Broussard JA, Koetsier JL, Godsel LM, Fitz GN, Gardel ML, Green KJ.

Nat Commun. 2018 Mar 13;9(1):1053. doi: 10.1038/s41467-018-03414-6.


Lamellipodium is a myosin-independent mechanosensor.

Oakes PW, Bidone TC, Beckham Y, Skeeters AV, Ramirez-San Juan GR, Winter SP, Voth GA, Gardel ML.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2646-2651. doi: 10.1073/pnas.1715869115. Epub 2018 Feb 27.


Mechanical hysteresis in actin networks.

Majumdar S, Foucard LC, Levine AJ, Gardel ML.

Soft Matter. 2018 Mar 14;14(11):2052-2058. doi: 10.1039/c7sm01948c.


Dia1-dependent adhesions are required by epithelial tissues to initiate invasion.

Fessenden TB, Beckham Y, Perez-Neut M, Ramirez-San Juan G, Chourasia AH, Macleod KF, Oakes PW, Gardel ML.

J Cell Biol. 2018 Apr 2;217(4):1485-1502. doi: 10.1083/jcb.201703145. Epub 2018 Feb 5.


Interplay of structure, elasticity, and dynamics in actin-based nematic materials.

Zhang R, Kumar N, Ross JL, Gardel ML, de Pablo JJ.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E124-E133. doi: 10.1073/pnas.1713832115. Epub 2017 Dec 28.


Filament turnover tunes both force generation and dissipation to control long-range flows in a model actomyosin cortex.

McFadden WM, McCall PM, Gardel ML, Munro EM.

PLoS Comput Biol. 2017 Dec 18;13(12):e1005811. doi: 10.1371/journal.pcbi.1005811. eCollection 2017 Dec.


Filament rigidity and connectivity tune the deformation modes of active biopolymer networks.

Stam S, Freedman SL, Banerjee S, Weirich KL, Dinner AR, Gardel ML.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10037-E10045. doi: 10.1073/pnas.1708625114. Epub 2017 Nov 7.


Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres.

Oakes PW, Wagner E, Brand CA, Probst D, Linke M, Schwarz US, Glotzer M, Gardel ML.

Nat Commun. 2017 Jun 12;8:15817. doi: 10.1038/ncomms15817.


When Is "Enough" Enough?

Suarez C, McCall PM, Gardel ML, Kovar DR.

Cell Syst. 2017 May 24;4(5):480-482. doi: 10.1016/j.cels.2017.05.007.


Cholesterol depletion impairs contractile machinery in neonatal rat cardiomyocytes.

Hissa B, Oakes PW, Pontes B, Ramírez-San Juan G, Gardel ML.

Sci Rep. 2017 Mar 3;7:43764. doi: 10.1038/srep43764.


Contact guidance requires spatial control of leading-edge protrusion.

Ramirez-San Juan GR, Oakes PW, Gardel ML.

Mol Biol Cell. 2017 Apr 15;28(8):1043-1053. doi: 10.1091/mbc.E16-11-0769. Epub 2017 Feb 22.


Liquid behavior of cross-linked actin bundles.

Weirich KL, Banerjee S, Dasbiswas K, Witten TA, Vaikuntanathan S, Gardel ML.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2131-2136. doi: 10.1073/pnas.1616133114. Epub 2017 Feb 15.


Forcing cells into shape: the mechanics of actomyosin contractility.

Murrell M, Oakes PW, Lenz M, Gardel ML.

Nat Rev Mol Cell Biol. 2015 Aug;16(8):486-98. doi: 10.1038/nrm4012. Epub 2015 Jul 1. Review.


Actin Mechanics and Fragmentation.

De La Cruz EM, Gardel ML.

J Biol Chem. 2015 Jul 10;290(28):17137-44. doi: 10.1074/jbc.R115.636472. Epub 2015 May 8. Review.


Isoforms Confer Characteristic Force Generation and Mechanosensation by Myosin II Filaments.

Stam S, Alberts J, Gardel ML, Munro E.

Biophys J. 2015 Apr 21;108(8):1997-2006. doi: 10.1016/j.bpj.2015.03.030.


Model-based traction force microscopy reveals differential tension in cellular actin bundles.

Soiné JR, Brand CA, Stricker J, Oakes PW, Gardel ML, Schwarz US.

PLoS Comput Biol. 2015 Mar 6;11(3):e1004076. doi: 10.1371/journal.pcbi.1004076. eCollection 2015 Mar.


Moving beyond molecular mechanisms.

Gardel ML.

J Cell Biol. 2015 Jan 19;208(2):143-5. doi: 10.1083/jcb.201412143.


Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation.

Cetera M, Ramirez-San Juan GR, Oakes PW, Lewellyn L, Fairchild MJ, Tanentzapf G, Gardel ML, Horne-Badovinac S.

Nat Commun. 2014 Nov 21;5:5511. doi: 10.1038/ncomms6511.


Cutting through the noise: the mechanics of intracellular transport.

Stam S, Gardel ML.

Dev Cell. 2014 Aug 25;30(4):365-6. doi: 10.1016/j.devcel.2014.08.013.


Geometry regulates traction stresses in adherent cells.

Oakes PW, Banerjee S, Marchetti MC, Gardel ML.

Biophys J. 2014 Aug 19;107(4):825-33. doi: 10.1016/j.bpj.2014.06.045.


Protrusive activity guides changes in cell-cell tension during epithelial cell scattering.

Maruthamuthu V, Gardel ML.

Biophys J. 2014 Aug 5;107(3):555-563. doi: 10.1016/j.bpj.2014.06.028.


Stressing the limits of focal adhesion mechanosensitivity.

Oakes PW, Gardel ML.

Curr Opin Cell Biol. 2014 Oct;30:68-73. doi: 10.1016/ Epub 2014 Jul 5. Review.


Attenuation of lipopolysaccharide-induced lung vascular stiffening by lipoxin reduces lung inflammation.

Meng F, Mambetsariev I, Tian Y, Beckham Y, Meliton A, Leff A, Gardel ML, Allen MJ, Birukov KG, Birukova AA.

Am J Respir Cell Mol Biol. 2015 Feb;52(2):152-61. doi: 10.1165/rcmb.2013-0468OC.


Arp2/3 inhibition induces amoeboid-like protrusions in MCF10A epithelial cells by reduced cytoskeletal-membrane coupling and focal adhesion assembly.

Beckham Y, Vasquez RJ, Stricker J, Sayegh K, Campillo C, Gardel ML.

PLoS One. 2014 Jun 26;9(6):e100943. doi: 10.1371/journal.pone.0100943. eCollection 2014.


Actomyosin sliding is attenuated in contractile biomimetic cortices.

Murrell M, Gardel ML.

Mol Biol Cell. 2014 Jun 15;25(12):1845-53. doi: 10.1091/mbc.E13-08-0450. Epub 2014 Apr 23.


Determinants of fluidlike behavior and effective viscosity in cross-linked actin networks.

Kim T, Gardel ML, Munro E.

Biophys J. 2014 Feb 4;106(3):526-34. doi: 10.1016/j.bpj.2013.12.031.


Distribution of directional change as a signature of complex dynamics.

Burov S, Tabei SM, Huynh T, Murrell MP, Philipson LH, Rice SA, Gardel ML, Scherer NF, Dinner AR.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19689-94. doi: 10.1073/pnas.1319473110. Epub 2013 Nov 18.


Myosin II-mediated focal adhesion maturation is tension insensitive.

Stricker J, Beckham Y, Davidson MW, Gardel ML.

PLoS One. 2013 Jul 29;8(7):e70652. doi: 10.1371/journal.pone.0070652. Print 2013.


Actin assembly factors regulate the gelation kinetics and architecture of F-actin networks.

Falzone TT, Oakes PW, Sees J, Kovar DR, Gardel ML.

Biophys J. 2013 Apr 16;104(8):1709-19. doi: 10.1016/j.bpj.2013.01.017.


Thick filament length and isoform composition determine self-organized contractile units in actomyosin bundles.

Thoresen T, Lenz M, Gardel ML.

Biophys J. 2013 Feb 5;104(3):655-65. doi: 10.1016/j.bpj.2012.12.042.


Observation and characterization of the vestige of the jamming transition in a thermal three-dimensional system.

Caswell TA, Zhang Z, Gardel ML, Nagel SR.

Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Jan;87(1):012303. Epub 2013 Jan 3.


Materials science: Synthetic polymers with biological rigidity.

Gardel ML.

Nature. 2013 Jan 31;493(7434):618-9. doi: 10.1038/nature11855. Epub 2013 Jan 23. No abstract available.


Endothelial barrier disruption and recovery is controlled by substrate stiffness.

Birukova AA, Tian X, Cokic I, Beckham Y, Gardel ML, Birukov KG.

Microvasc Res. 2013 May;87:50-7. doi: 10.1016/j.mvr.2012.12.006. Epub 2013 Jan 5.


F-actin buckling coordinates contractility and severing in a biomimetic actomyosin cortex.

Murrell MP, Gardel ML.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20820-5. doi: 10.1073/pnas.1214753109. Epub 2012 Dec 3.


Requirements for contractility in disordered cytoskeletal bundles.

Lenz M, Gardel ML, Dinner AR.

New J Phys. 2012 Mar 1;14. pii: 033037. Epub 2012 Mar 28.


Living matter--nexus of physics and biology in the 21st century.

Gardel ML.

Mol Biol Cell. 2012 Nov;23(21):4165-6. doi: 10.1091/mbc.E12-05-0353.


Stiffness-controlled three-dimensional extracellular matrices for high-resolution imaging of cell behavior.

Fischer RS, Myers KA, Gardel ML, Waterman CM.

Nat Protoc. 2012 Nov;7(11):2056-66. doi: 10.1038/nprot.2012.127. Epub 2012 Oct 25.


Contractile units in disordered actomyosin bundles arise from F-actin buckling.

Lenz M, Thoresen T, Gardel ML, Dinner AR.

Phys Rev Lett. 2012 Jun 8;108(23):238107. Epub 2012 Jun 8.


Self-organization of myosin II in reconstituted actomyosin bundles.

Stachowiak MR, McCall PM, Thoresen T, Balcioglu HE, Kasiewicz L, Gardel ML, O'Shaughnessy B.

Biophys J. 2012 Sep 19;103(6):1265-74. doi: 10.1016/j.bpj.2012.08.028.


United we stand: integrating the actin cytoskeleton and cell-matrix adhesions in cellular mechanotransduction.

Schwarz US, Gardel ML.

J Cell Sci. 2012 Jul 1;125(Pt 13):3051-60. doi: 10.1242/jcs.093716. Epub 2012 Jul 13. Review.


Assembly kinetics determine the architecture of α-actinin crosslinked F-actin networks.

Falzone TT, Lenz M, Kovar DR, Gardel ML.

Nat Commun. 2012 May 29;3:861. doi: 10.1038/ncomms1862.


Tension is required but not sufficient for focal adhesion maturation without a stress fiber template.

Oakes PW, Beckham Y, Stricker J, Gardel ML.

J Cell Biol. 2012 Feb 6;196(3):363-74. doi: 10.1083/jcb.201107042. Epub 2012 Jan 30.

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