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UntRIG(er)ing lncRNAs.

Garcin D.

Mol Cell. 2018 Jul 5;71(1):6-7. doi: 10.1016/j.molcel.2018.06.026.


IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission.

Klinkhammer J, Schnepf D, Ye L, Schwaderlapp M, Gad HH, Hartmann R, Garcin D, Mahlakõiv T, Staeheli P.

Elife. 2018 Apr 13;7. pii: e33354. doi: 10.7554/eLife.33354.


Viral chimeras decrypt the role of enterovirus capsid proteins in viral tropism, acid sensitivity and optimal growth temperature.

Royston L, Essaidi-Laziosi M, Pérez-Rodríguez FJ, Piuz I, Geiser J, Krause KH, Huang S, Constant S, Kaiser L, Garcin D, Tapparel C.

PLoS Pathog. 2018 Apr 9;14(4):e1006962. doi: 10.1371/journal.ppat.1006962. eCollection 2018 Apr.


Severe viral respiratory infections in children with IFIH1 loss-of-function mutations.

Asgari S, Schlapbach LJ, Anchisi S, Hammer C, Bartha I, Junier T, Mottet-Osman G, Posfay-Barbe KM, Longchamp D, Stocker M, Cordey S, Kaiser L, Riedel T, Kenna T, Long D, Schibler A, Telenti A, Tapparel C, McLaren PJ, Garcin D, Fellay J.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8342-8347. doi: 10.1073/pnas.1704259114. Epub 2017 Jul 17.


Loss of Sendai virus C protein leads to accumulation of RIG-I immunostimulatory defective interfering RNA.

Sánchez-Aparicio MT, Garcin D, Rice CM, Kolakofsky D, García-Sastre A, Baum A.

J Gen Virol. 2017 Jun;98(6):1282-1293. doi: 10.1099/jgv.0.000815. Epub 2017 Jun 20.


Both exo- and endo-nucleolytic activities of RNase J1 from Staphylococcus aureus are manganese dependent and active on triphosphorylated 5'-ends.

Hausmann S, Guimarães VA, Garcin D, Baumann N, Linder P, Redder P.

RNA Biol. 2017 Oct 3;14(10):1431-1443. doi: 10.1080/15476286.2017.1300223. Epub 2017 Mar 1.


A Short Double-Stapled Peptide Inhibits Respiratory Syncytial Virus Entry and Spreading.

Gaillard V, Galloux M, Garcin D, Eléouët JF, Le Goffic R, Larcher T, Rameix-Welti MA, Boukadiri A, Héritier J, Segura JM, Baechler E, Arrell M, Mottet-Osman G, Nyanguile O.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02241-16. doi: 10.1128/AAC.02241-16. Print 2017 Apr.


HSV1 Pulls the Deamidation tRIGger.

Garcin D.

Cell Host Microbe. 2016 Dec 14;20(6):698-700. doi: 10.1016/j.chom.2016.11.011.


The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing.

Pourcelot M, Zemirli N, Silva Da Costa L, Loyant R, Garcin D, Vitour D, Munitic I, Vazquez A, Arnoult D.

BMC Biol. 2016 Aug 18;14:69. doi: 10.1186/s12915-016-0292-z.


Mismatches in the Influenza A Virus RNA Panhandle Prevent Retinoic Acid-Inducible Gene I (RIG-I) Sensing by Impairing RNA/RIG-I Complex Formation.

Anchisi S, Guerra J, Mottet-Osman G, Garcin D.

J Virol. 2015 Oct 7;90(1):586-90. doi: 10.1128/JVI.01671-15. Print 2016 Jan 1.


TLR3-Mediated CD8+ Dendritic Cell Activation Is Coupled with Establishment of a Cell-Intrinsic Antiviral State.

Széles L, Meissner F, Dunand-Sauthier I, Thelemann C, Hersch M, Singovski S, Haller S, Gobet F, Fuertes Marraco SA, Mann M, Garcin D, Acha-Orbea H, Reith W.

J Immunol. 2015 Aug 1;195(3):1025-33. doi: 10.4049/jimmunol.1402033. Epub 2015 Jun 22.


γHV68 vGAT: a viral pseudoenzyme pimping for PAMPs.

Kolakofsky D, Garcin D.

Mol Cell. 2015 Apr 2;58(1):3-4. doi: 10.1016/j.molcel.2015.03.021.


RIG-I ATPase activity and discrimination of self-RNA versus non-self-RNA.

Anchisi S, Guerra J, Garcin D.

MBio. 2015 Mar 3;6(2):e02349. doi: 10.1128/mBio.02349-14.


MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors.

Castanier C, Zemirli N, Portier A, Garcin D, Bidère N, Vazquez A, Arnoult D.

BMC Biol. 2012 May 24;10:44. doi: 10.1186/1741-7007-10-44.


Induction of influenza-specific mucosal immunity by an attenuated recombinant Sendai virus.

Le TV, Mironova E, Garcin D, Compans RW.

PLoS One. 2011 Apr 18;6(4):e18780. doi: 10.1371/journal.pone.0018780.


Recombinant Sendai viruses expressing fusion proteins with two furin cleavage sites mimic the syncytial and receptor-independent infection properties of respiratory syncytial virus.

Rawling J, Cano O, Garcin D, Kolakofsky D, Melero JA.

J Virol. 2011 Mar;85(6):2771-80. doi: 10.1128/JVI.02065-10. Epub 2011 Jan 12.


Short double-stranded RNAs with an overhanging 5' ppp-nucleotide, as found in arenavirus genomes, act as RIG-I decoys.

Marq JB, Hausmann S, Veillard N, Kolakofsky D, Garcin D.

J Biol Chem. 2011 Feb 25;286(8):6108-16. doi: 10.1074/jbc.M110.186262. Epub 2010 Dec 15.


Human parainfluenza virus type 2 L protein regions required for interaction with other viral proteins and mRNA capping.

Nishio M, Tsurudome M, Garcin D, Komada H, Ito M, Le Mercier P, Nosaka T, Kolakofsky D.

J Virol. 2011 Jan;85(2):725-32. doi: 10.1128/JVI.01226-10. Epub 2010 Nov 10.


Hepatitis C virus controls interferon production through PKR activation.

Arnaud N, Dabo S, Maillard P, Budkowska A, Kalliampakou KI, Mavromara P, Garcin D, Hugon J, Gatignol A, Akazawa D, Wakita T, Meurs EF.

PLoS One. 2010 May 11;5(5):e10575. doi: 10.1371/journal.pone.0010575.


Unpaired 5' ppp-nucleotides, as found in arenavirus double-stranded RNA panhandles, are not recognized by RIG-I.

Marq JB, Kolakofsky D, Garcin D.

J Biol Chem. 2010 Jun 11;285(24):18208-16. doi: 10.1074/jbc.M109.089425. Epub 2010 Apr 16.


Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway.

Castanier C, Garcin D, Vazquez A, Arnoult D.

EMBO Rep. 2010 Feb;11(2):133-8. doi: 10.1038/embor.2009.258. Epub 2009 Dec 18.


The double-stranded RNA binding domain of the vaccinia virus E3L protein inhibits both RNA- and DNA-induced activation of interferon beta.

Marq JB, Hausmann S, Luban J, Kolakofsky D, Garcin D.

J Biol Chem. 2009 Sep 18;284(38):25471-8. doi: 10.1074/jbc.M109.018895. Epub 2009 Jul 7.


RIG-I and dsRNA-induced IFNbeta activation.

Hausmann S, Marq JB, Tapparel C, Kolakofsky D, Garcin D.

PLoS One. 2008;3(12):e3965. doi: 10.1371/journal.pone.0003965. Epub 2008 Dec 30.


Genetic and biochemical analysis of yeast and human cap trimethylguanosine synthase: functional overlap of 2,2,7-trimethylguanosine caps, small nuclear ribonucleoprotein components, pre-mRNA splicing factors, and RNA decay pathways.

Hausmann S, Zheng S, Costanzo M, Brost RL, Garcin D, Boone C, Shuman S, Schwer B.

J Biol Chem. 2008 Nov 14;283(46):31706-18. doi: 10.1074/jbc.M806127200. Epub 2008 Sep 5.


Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties of novel indeno[2,1-c]quinolin-7-one and indeno[1,2-c]isoquinolin-5,11-dione derivatives.

Ryckebusch A, Garcin D, Lansiaux A, Goossens JF, Baldeyrou B, Houssin R, Bailly C, Hénichart JP.

J Med Chem. 2008 Jun 26;51(12):3617-29. doi: 10.1021/jm800017u. Epub 2008 May 29.


Activation of the beta interferon promoter by unnatural Sendai virus infection requires RIG-I and is inhibited by viral C proteins.

Strähle L, Marq JB, Brini A, Hausmann S, Kolakofsky D, Garcin D.

J Virol. 2007 Nov;81(22):12227-37. Epub 2007 Sep 5.


Sendai virus budding in the course of an infection does not require Alix and VPS4A host factors.

Gosselin-Grenet AS, Marq JB, Abrami L, Garcin D, Roux L.

Virology. 2007 Aug 15;365(1):101-12. Epub 2007 Apr 27.


Sendai virus RNA polymerase scanning for mRNA start sites at gene junctions.

Plattet P, Strahle L, le Mercier P, Hausmann S, Garcin D, Kolakofsky D.

Virology. 2007 Jun 5;362(2):411-20. Epub 2007 Feb 14.


Targeting of the Sendai virus C protein to the plasma membrane via a peptide-only membrane anchor.

Marq JB, Brini A, Kolakofsky D, Garcin D.

J Virol. 2007 Apr;81(7):3187-97. Epub 2007 Jan 17.


Suppression of the Sendai virus M protein through a novel short interfering RNA approach inhibits viral particle production but does not affect viral RNA synthesis.

Mottet-Osman G, Iseni F, Pelet T, Wiznerowicz M, Garcin D, Roux L.

J Virol. 2007 Mar;81(6):2861-8. Epub 2006 Dec 27.


Sendai virus defective-interfering genomes and the activation of interferon-beta.

Strahle L, Garcin D, Kolakofsky D.

Virology. 2006 Jul 20;351(1):101-11. Epub 2006 May 2.


Paramyxovirus mRNA editing, the "rule of six" and error catastrophe: a hypothesis.

Kolakofsky D, Roux L, Garcin D, Ruigrok RW.

J Gen Virol. 2005 Jul;86(Pt 7):1869-77. Review.


Identification of paramyxovirus V protein residues essential for STAT protein degradation and promotion of virus replication.

Nishio M, Tsurudome M, Ito M, Garcin D, Kolakofsky D, Ito Y.

J Virol. 2005 Jul;79(13):8591-601.


Functional analysis of CLPT1, a Rab/GTPase required for protein secretion and pathogenesis in the plant fungal pathogen Colletotrichum lindemuthianum.

Siriputthaiwan P, Jauneau A, Herbert C, Garcin D, Dumas B.

J Cell Sci. 2005 Jan 15;118(Pt 2):323-9. Epub 2004 Dec 22.


Viral DNA polymerase scanning and the gymnastics of Sendai virus RNA synthesis.

Kolakofsky D, Le Mercier P, Iseni F, Garcin D.

Virology. 2004 Jan 20;318(2):463-73. Review.


Competition between the Sendai virus N mRNA start site and the genome 3'-end promoter for viral RNA polymerase.

Le Mercier P, Garcin D, Garcia E, Kolakofsky D.

J Virol. 2003 Sep;77(17):9147-55.


Sendai virus targets inflammatory responses, as well as the interferon-induced antiviral state, in a multifaceted manner.

Strähle L, Garcin D, Le Mercier P, Schlaak JF, Kolakofsky D.

J Virol. 2003 Jul;77(14):7903-13.


Sendai virus trailer RNA binds TIAR, a cellular protein involved in virus-induced apoptosis.

Iseni F, Garcin D, Nishio M, Kedersha N, Anderson P, Kolakofsky D.

EMBO J. 2002 Oct 1;21(19):5141-50.


Sendai virus, a murine parainfluenza virus type 1, replicates to a level similar to human PIV1 in the upper and lower respiratory tract of African green monkeys and chimpanzees.

Skiadopoulos MH, Surman SR, Riggs JM, Elkins WR, St Claire M, Nishio M, Garcin D, Kolakofsky D, Collins PL, Murphy BR.

Virology. 2002 May 25;297(1):153-60.


All four Sendai Virus C proteins bind Stat1, but only the larger forms also induce its mono-ubiquitination and degradation.

Garcin D, Marq JB, Strahle L, le Mercier P, Kolakofsky D.

Virology. 2002 Apr 10;295(2):256-65.


Ambisense sendai viruses are inherently unstable but are useful to study viral RNA synthesis.

Le Mercier P, Garcin D, Hausmann S, Kolakofsky D.

J Virol. 2002 Jun;76(11):5492-502.


Sendai virus C proteins counteract the interferon-mediated induction of an antiviral state.

Garcin D, Latorre P, Kolakofsky D.

J Virol. 1999 Aug;73(8):6559-65.


The versatility of paramyxovirus RNA polymerase stuttering.

Hausmann S, Garcin D, Delenda C, Kolakofsky D.

J Virol. 1999 Jul;73(7):5568-76.

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