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Items: 1 to 50 of 482

1.

Microglia, neurodegeneration and loss of neuroendocrine control.

Chowen JA, Garcia-Segura LM.

Prog Neurobiol. 2019 Nov 9:101720. doi: 10.1016/j.pneurobio.2019.101720. [Epub ahead of print] Review.

PMID:
31715222
2.

Sex differences in steroid levels and steroidogenesis in the nervous system: Physiopathological role.

Giatti S, Diviccaro S, Serafini MM, Caruso D, Garcia-Segura LM, Viviani B, Melcangi RC.

Front Neuroendocrinol. 2019 Nov 2:100804. doi: 10.1016/j.yfrne.2019.100804. [Epub ahead of print] Review.

PMID:
31689419
3.

Molecular mechanisms and cellular events involved in the neuroprotective actions of estradiol. Analysis of sex differences.

Azcoitia I, Barreto GE, Garcia-Segura LM.

Front Neuroendocrinol. 2019 Oct;55:100787. doi: 10.1016/j.yfrne.2019.100787. Epub 2019 Sep 9. Review.

PMID:
31513774
4.

Development of new treatments for Alzheimer's disease based on the modulation of translocator protein (TSPO).

Arbo BD, Ribeiro MF, Garcia-Segura LM.

Ageing Res Rev. 2019 Sep;54:100943. doi: 10.1016/j.arr.2019.100943. Epub 2019 Aug 17. Review.

PMID:
31430564
5.

Lipotoxicity, neuroinflammation, glial cells and oestrogenic compounds.

Hidalgo-Lanussa O, Baez-Jurado E, Echeverria V, Ashraf GM, Sahebkar A, Garcia-Segura LM, Melcangi RC, Barreto GE.

J Neuroendocrinol. 2019 Jul 23:e12776. doi: 10.1111/jne.12776. [Epub ahead of print] Review.

PMID:
31334878
6.

Sex differences and gonadal hormone regulation of brain cardiolipin, a key mitochondrial phospholipid.

Acaz-Fonseca E, Ortiz-Rodriguez A, Garcia-Segura LM, Astiz M.

J Neuroendocrinol. 2019 Jul 19:e12774. doi: 10.1111/jne.12774. [Epub ahead of print] Review.

PMID:
31323169
7.

Sex differences in the peripubertal response to a short-term, high-fat diet intake.

Freire-Regatillo A, Fernández-Gómez MJ, Díaz F, Barrios V, Sánchez-Jabonero I, Frago LM, Argente J, García-Segura LM, Chowen JA.

J Neuroendocrinol. 2019 Jun 10:e12756. doi: 10.1111/jne.12756. [Epub ahead of print]

PMID:
31179596
8.

Sexually Dimorphic Effect of Genistein on Hypothalamic Neuronal Differentiation in Vitro.

Marraudino M, Farinetti A, Arevalo MA, Gotti S, Panzica G, Garcia-Segura LM.

Int J Mol Sci. 2019 May 18;20(10). pii: E2465. doi: 10.3390/ijms20102465.

9.

Sex differences in the brain expression of steroidogenic molecules under basal conditions and after gonadectomy.

Giatti S, Diviccaro S, Garcia-Segura LM, Melcangi RC.

J Neuroendocrinol. 2019 Jun;31(6):e12736. doi: 10.1111/jne.12736. Epub 2019 May 29.

PMID:
31102564
10.

Editorial: Neuroprotection in Brain Hypoxia.

Otero-Losada M, Wandosell FG, Garcia-Segura LM, Capani F.

Front Neurosci. 2019 Mar 22;13:212. doi: 10.3389/fnins.2019.00212. eCollection 2019. No abstract available.

11.

Notch signaling in astrocytes mediates their morphological response to an inflammatory challenge.

Acaz-Fonseca E, Ortiz-Rodriguez A, Azcoitia I, Garcia-Segura LM, Arevalo MA.

Cell Death Discov. 2019 Apr 3;5:85. doi: 10.1038/s41420-019-0166-6. eCollection 2019.

12.

IGF1 Gene Therapy Modifies Microglia in the Striatum of Senile Rats.

Falomir-Lockhart E, Dolcetti FJC, García-Segura LM, Hereñú CB, Bellini MJ.

Front Aging Neurosci. 2019 Mar 5;11:48. doi: 10.3389/fnagi.2019.00048. eCollection 2019.

13.

Tibolone attenuates inflammatory response by palmitic acid and preserves mitochondrial membrane potential in astrocytic cells through estrogen receptor beta.

González-Giraldo Y, Forero DA, Echeverria V, Garcia-Segura LM, Barreto GE.

Mol Cell Endocrinol. 2019 Apr 15;486:65-78. doi: 10.1016/j.mce.2019.02.017. Epub 2019 Feb 26.

PMID:
30822454
14.

Estrogen receptor beta and G protein-coupled estrogen receptor 1 are involved in the acute estrogenic regulation of arginine-vasopressin immunoreactive levels in the supraoptic and paraventricular hypothalamic nuclei of female rats.

Lagunas N, Marraudino M, de Amorim M, Pinos H, Collado P, Panzica G, Garcia-Segura LM, Grassi D.

Brain Res. 2019 Jun 1;1712:93-100. doi: 10.1016/j.brainres.2019.02.002. Epub 2019 Feb 4.

PMID:
30731078
15.

The sex differences of the behavior response to early Life immune stimulation: Microglia and astrocytes involvement.

Berkiks I, Garcia-Segura LM, Nassiri A, Mesfioui A, Ouichou A, Boulbaroud S, Bahbiti Y, Lopez-Rodriguez AB, Hasnaoui E, El Hessni A.

Physiol Behav. 2019 Feb 1;199:386-394. doi: 10.1016/j.physbeh.2018.11.037. Epub 2018 Dec 7.

PMID:
30529512
16.

The GLP-1 analog, liraglutide prevents the increase of proinflammatory mediators in the hippocampus of male rat pups submitted to maternal perinatal food restriction.

Diz-Chaves Y, Toba L, Fandiño J, González-Matías LC, Garcia-Segura LM, Mallo F.

J Neuroinflammation. 2018 Dec 5;15(1):337. doi: 10.1186/s12974-018-1370-7.

17.

Editorial: Hormones and Neural Aging: Lessons From Experimental Models.

Varela-Nieto I, Chowen JA, García-Segura LM.

Front Aging Neurosci. 2018 Nov 15;10:374. doi: 10.3389/fnagi.2018.00374. eCollection 2018. No abstract available.

18.

Astrocytes Mediate Protective Actions of Estrogenic Compounds after Traumatic Brain Injury.

Martin-Jiménez C, Gaitán-Vaca DM, Areiza N, Echeverria V, Ashraf GM, González J, Sahebkar A, Garcia-Segura LM, Barreto GE.

Neuroendocrinology. 2019;108(2):142-160. doi: 10.1159/000495078. Epub 2018 Nov 4. Review.

PMID:
30391959
19.

Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition.

Diviccaro S, Giatti S, Borgo F, Barcella M, Borghi E, Trejo JL, Garcia-Segura LM, Melcangi RC.

Psychoneuroendocrinology. 2019 Jan;99:206-215. doi: 10.1016/j.psyneuen.2018.09.021. Epub 2018 Sep 18.

PMID:
30265917
20.

Molecular mechanisms involved in the protective actions of Selective Estrogen Receptor Modulators in brain cells.

Baez-Jurado E, Rincón-Benavides MA, Hidalgo-Lanussa O, Guio-Vega G, Ashraf GM, Sahebkar A, Echeverria V, Garcia-Segura LM, Barreto GE.

Front Neuroendocrinol. 2019 Jan;52:44-64. doi: 10.1016/j.yfrne.2018.09.001. Epub 2018 Sep 14. Review.

PMID:
30223003
21.

Non-reproductive Functions of Aromatase in the Central Nervous System Under Physiological and Pathological Conditions.

Brocca ME, Garcia-Segura LM.

Cell Mol Neurobiol. 2019 May;39(4):473-481. doi: 10.1007/s10571-018-0607-4. Epub 2018 Aug 6. Review.

PMID:
30084008
22.

Neuroactive steroids, neurosteroidogenesis and sex.

Giatti S, Garcia-Segura LM, Barreto GE, Melcangi RC.

Prog Neurobiol. 2019 May;176:1-17. doi: 10.1016/j.pneurobio.2018.06.007. Epub 2018 Jul 4. Review.

PMID:
29981391
23.

Lipotoxic Effects of Palmitic Acid on Astrocytes Are Associated with Autophagy Impairment.

Ortiz-Rodriguez A, Acaz-Fonseca E, Boya P, Arevalo MA, Garcia-Segura LM.

Mol Neurobiol. 2019 Mar;56(3):1665-1680. doi: 10.1007/s12035-018-1183-9. Epub 2018 Jun 18.

PMID:
29916142
24.

Ovarian Function Modulates the Effects of Long-Chain Polyunsaturated Fatty Acids on the Mouse Cerebral Cortex.

Herrera JL, Ordoñez-Gutierrez L, Fabrias G, Casas J, Morales A, Hernandez G, Acosta NG, Rodriguez C, Prieto-Valiente L, Garcia-Segura LM, Alonso R, Wandosell FG.

Front Cell Neurosci. 2018 Apr 24;12:103. doi: 10.3389/fncel.2018.00103. eCollection 2018.

25.

Thymelaea lythroides extract attenuates microglial activation and depressive-like behavior in LPS-induced inflammation in adult male rats.

Berkiks I, Boulbaroud S, Garcia-Segura LM, Mesfioui A, Ouichou A, Mouden S, Benmhammed H, El Hasnaoui A, Nakache R, Bahbiti Y, El Hessni A.

Biomed Pharmacother. 2018 Mar;99:655-663. doi: 10.1016/j.biopha.2018.01.125. Epub 2018 Feb 20.

PMID:
29710462
26.

Estradiol Activates PI3K/Akt/GSK3 Pathway Under Chronic Neurodegenerative Conditions Triggered by Perinatal Asphyxia.

Saraceno GE, Bellini MJ, Garcia-Segura LM, Capani F.

Front Pharmacol. 2018 Apr 9;9:335. doi: 10.3389/fphar.2018.00335. eCollection 2018.

27.

The Synthetic Steroid Tibolone Decreases Reactive Gliosis and Neuronal Death in the Cerebral Cortex of Female Mice After a Stab Wound Injury.

Crespo-Castrillo A, Yanguas-Casás N, Arevalo MA, Azcoitia I, Barreto GE, Garcia-Segura LM.

Mol Neurobiol. 2018 Nov;55(11):8651-8667. doi: 10.1007/s12035-018-1008-x. Epub 2018 Mar 26.

PMID:
29582398
28.

A GABAergic cell type in the lateral habenula links hypothalamic homeostatic and midbrain motivation circuits with sex steroid signaling.

Zhang L, Hernández VS, Swinny JD, Verma AK, Giesecke T, Emery AC, Mutig K, Garcia-Segura LM, Eiden LE.

Transl Psychiatry. 2018 Feb 26;8(1):50. doi: 10.1038/s41398-018-0099-5.

29.

Axonal transport in a peripheral diabetic neuropathy model: sex-dimorphic features.

Pesaresi M, Giatti S, Spezzano R, Romano S, Diviccaro S, Borsello T, Mitro N, Caruso D, Garcia-Segura LM, Melcangi RC.

Biol Sex Differ. 2018 Jan 19;9(1):6. doi: 10.1186/s13293-018-0164-z.

30.

Diabetes induces mitochondrial dysfunction and alters cholesterol homeostasis and neurosteroidogenesis in the rat cerebral cortex.

Romano S, Mitro N, Giatti S, Diviccaro S, Pesaresi M, Spezzano R, Audano M, Garcia-Segura LM, Caruso D, Melcangi RC.

J Steroid Biochem Mol Biol. 2018 Apr;178:108-116. doi: 10.1016/j.jsbmb.2017.11.009. Epub 2017 Nov 26.

PMID:
29183767
31.

Sex differences in the phagocytic and migratory activity of microglia and their impairment by palmitic acid.

Yanguas-Casás N, Crespo-Castrillo A, de Ceballos ML, Chowen JA, Azcoitia I, Arevalo MA, Garcia-Segura LM.

Glia. 2018 Mar;66(3):522-537. doi: 10.1002/glia.23263. Epub 2017 Nov 15.

PMID:
29139169
32.

Estradiol Uses Different Mechanisms in Astrocytes from the Hippocampus of Male and Female Rats to Protect against Damage Induced by Palmitic Acid.

Frago LM, Canelles S, Freire-Regatillo A, Argente-Arizón P, Barrios V, Argente J, Garcia-Segura LM, Chowen JA.

Front Mol Neurosci. 2017 Oct 24;10:330. doi: 10.3389/fnmol.2017.00330. eCollection 2017.

33.

Interaction of sex chromosome complement, gonadal hormones and neuronal steroid synthesis on the sexual differentiation of mammalian neurons.

Cambiasso MJ, Cisternas CD, Ruiz-Palmero I, Scerbo MJ, Arevalo MA, Azcoitia I, Garcia-Segura LM.

J Neurogenet. 2017 Dec;31(4):300-306. doi: 10.1080/01677063.2017.1390572. Epub 2017 Oct 27. Review.

PMID:
29078716
34.

The Hypothalamic Inflammatory/Gliosis Response to Neonatal Overnutrition Is Sex and Age Dependent.

Argente-Arizón P, Díaz F, Ros P, Barrios V, Tena-Sempere M, García-Segura LM, Argente J, Chowen JA.

Endocrinology. 2018 Jan 1;159(1):368-387. doi: 10.1210/en.2017-00539.

PMID:
29077836
35.

Sex differences in Parkinson's disease: Features on clinical symptoms, treatment outcome, sexual hormones and genetics.

Jurado-Coronel JC, Cabezas R, Ávila Rodríguez MF, Echeverria V, García-Segura LM, Barreto GE.

Front Neuroendocrinol. 2018 Jul;50:18-30. doi: 10.1016/j.yfrne.2017.09.002. Epub 2017 Sep 30. Review.

PMID:
28974386
36.

Tibolone Reduces Oxidative Damage and Inflammation in Microglia Stimulated with Palmitic Acid through Mechanisms Involving Estrogen Receptor Beta.

Hidalgo-Lanussa O, Ávila-Rodriguez M, Baez-Jurado E, Zamudio J, Echeverria V, Garcia-Segura LM, Barreto GE.

Mol Neurobiol. 2018 Jul;55(7):5462-5477. doi: 10.1007/s12035-017-0777-y. Epub 2017 Sep 25.

PMID:
28948468
37.

Hormonal and genetic factors interact to control aromatase expression in the developing brain.

Cisternas CD, Garcia-Segura LM, Cambiasso MJ.

J Neuroendocrinol. 2018 Feb;30(2). doi: 10.1111/jne.12535. Review.

PMID:
28891264
38.

Regulation of aromatase expression in the anterior amygdala of the developing mouse brain depends on ERβ and sex chromosome complement.

Cisternas CD, Cabrera Zapata LE, Arevalo MA, Garcia-Segura LM, Cambiasso MJ.

Sci Rep. 2017 Jul 13;7(1):5320. doi: 10.1038/s41598-017-05658-6.

39.

Tibolone Preserves Mitochondrial Functionality and Cell Morphology in Astrocytic Cells Treated with Palmitic Acid.

González-Giraldo Y, Garcia-Segura LM, Echeverria V, Barreto GE.

Mol Neurobiol. 2018 May;55(5):4453-4462. doi: 10.1007/s12035-017-0667-3. Epub 2017 Jun 30.

PMID:
28667487
40.

4'-Chlorodiazepam is neuroprotective against amyloid-beta in organotypic hippocampal cultures.

Arbo BD, Hoppe JB, Rodrigues K, Garcia-Segura LM, Salbego CG, Ribeiro MF.

J Steroid Biochem Mol Biol. 2017 Jul;171:281-287. doi: 10.1016/j.jsbmb.2017.04.010. Epub 2017 Apr 23.

41.

Neural-derived estradiol regulates brain plasticity.

Azcoitia I, Arevalo MA, Garcia-Segura LM.

J Chem Neuroanat. 2018 Apr;89:53-59. doi: 10.1016/j.jchemneu.2017.04.004. Epub 2017 Apr 13. Review.

PMID:
28414121
42.

Non-Neuronal Cells in the Hypothalamic Adaptation to Metabolic Signals.

Freire-Regatillo A, Argente-Arizón P, Argente J, García-Segura LM, Chowen JA.

Front Endocrinol (Lausanne). 2017 Mar 21;8:51. doi: 10.3389/fendo.2017.00051. eCollection 2017. Review.

43.

Developmental Sex Differences in the Metabolism of Cardiolipin in Mouse Cerebral Cortex Mitochondria.

Acaz-Fonseca E, Ortiz-Rodriguez A, Lopez-Rodriguez AB, Garcia-Segura LM, Astiz M.

Sci Rep. 2017 Mar 6;7:43878. doi: 10.1038/srep43878.

44.

4'-Chlorodiazepam modulates the development of primary hippocampal neurons in a sex-dependent manner.

Arbo BD, Vieira-Marques C, Ruiz-Palmero I, Ortiz-Rodriguez A, Arevalo MA, Garcia-Segura LM, Ribeiro MF.

Neurosci Lett. 2017 Feb 3;639:98-102. doi: 10.1016/j.neulet.2016.12.067. Epub 2016 Dec 29.

45.

Short-term effects of diabetes on neurosteroidogenesis in the rat hippocampus.

Romano S, Mitro N, Diviccaro S, Spezzano R, Audano M, Garcia-Segura LM, Caruso D, Melcangi RC.

J Steroid Biochem Mol Biol. 2017 Mar;167:135-143. doi: 10.1016/j.jsbmb.2016.11.019. Epub 2016 Nov 23.

PMID:
27890531
46.

Glial cells and energy balance.

Argente-Arizón P, Guerra-Cantera S, Garcia-Segura LM, Argente J, Chowen JA.

J Mol Endocrinol. 2017 Jan;58(1):R59-R71. Epub 2016 Nov 18. Review.

PMID:
27864453
47.

NADPH-Diaphorase Colocalizes with GPER and Is Modulated by the GPER Agonist G1 in the Supraoptic and Paraventricular Nuclei of Ovariectomized Female Rats.

Grassi D, Lagunas N, Pinos H, Panzica G, Garcia-Segura LM, Collado P.

Neuroendocrinology. 2017;104(1):94-104. Epub 2016 Mar 9.

PMID:
26954778
48.

Short-Term High-Fat Diet Feeding Provides Hypothalamic but Not Hippocampal Protection against Acute Infection in Male Mice.

Astiz M, Pernía O, Barrios V, Garcia-Segura LM, Diz-Chaves Y.

Neuroendocrinology. 2017;104(1):40-50. Epub 2016 Feb 11.

PMID:
26862917
49.

Selective Oestrogen Receptor Agonists Rescued Hippocampus Parameters in Male Spontaneously Hypertensive Rats.

Pietranera L, Correa J, Brocca ME, Roig P, Lima A, Di Giorgio N, Garcia-Segura LM, De Nicola AF.

J Neuroendocrinol. 2016 Oct;28(10). doi: 10.1111/jne.12415.

PMID:
27517478
50.

Protection by Neuroglobin Expression in Brain Pathologies.

Baez E, Echeverria V, Cabezas R, Ávila-Rodriguez M, Garcia-Segura LM, Barreto GE.

Front Neurol. 2016 Sep 12;7:146. doi: 10.3389/fneur.2016.00146. eCollection 2016. Review.

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