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Items: 1 to 50 of 67

1.

Author Correction: Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.

Klawitter S, Fuchs NV, Upton KR, Muñoz-Lopez M, Shukla R, Wang J, Garcia-Cañadas M, Lopez-Ruiz C, Gerhardt DJ, Sebe A, Grabundzija I, Merkert S, Gerdes P, Pulgarin JA, Bock A, Held U, Witthuhn A, Haase A, Sarkadi B, Löwer J, Wolvetang EJ, Martin U, Ivics Z, Izsvák Z, Garcia-Perez JL, Faulkner GJ, Schumann GG.

Nat Commun. 2018 Dec 19;9(1):5398. doi: 10.1038/s41467-018-07917-0.

2.

Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis.

Pereira GC, Sanchez L, Schaughency PM, Rubio-Roldán A, Choi JA, Planet E, Batra R, Turelli P, Trono D, Ostrow LW, Ravits J, Kazazian HH, Wheelan SJ, Heras SR, Mayer J, García-Pérez JL, Goodier JL.

Mob DNA. 2018 Dec 15;9:35. doi: 10.1186/s13100-018-0138-z. eCollection 2018.

3.

Reconstitution of the Ataxia-Telangiectasia Cellular Phenotype With Lentiviral Vectors.

Carranza D, Torres-Rusillo S, Ceballos-Pérez G, Blanco-Jimenez E, Muñoz-López M, García-Pérez JL, Molina IJ.

Front Immunol. 2018 Nov 20;9:2703. doi: 10.3389/fimmu.2018.02703. eCollection 2018.

4.

The IS2 Element Improves Transcription Efficiency of Integration-Deficient Lentiviral Vector Episomes.

Sánchez-Hernández S, Gutierrez-Guerrero A, Martín-Guerra R, Cortijo-Gutierrez M, Tristán-Manzano M, Rodriguez-Perales S, Sanchez L, Garcia-Perez JL, Chato-Astrain J, Fernandez-Valades R, Carrillo-Galvez AB, Anderson P, Montes R, Real PJ, Martin F, Benabdellah K.

Mol Ther Nucleic Acids. 2018 Dec 7;13:16-28. doi: 10.1016/j.omtn.2018.08.007. Epub 2018 Aug 18.

5.

Impact of non-LTR retrotransposons in the differentiation and evolution of anatomically modern humans.

Guichard E, Peona V, Malagoli Tagliazucchi G, Abitante L, Jagoda E, Musella M, Ricci M, Rubio-Roldán A, Sarno S, Luiselli D, Pettener D, Taccioli C, Pagani L, Garcia-Perez JL, Boattini A.

Mob DNA. 2018 Aug 15;9:28. doi: 10.1186/s13100-018-0133-4. eCollection 2018.

6.

Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s.

Warkocki Z, Krawczyk PS, Adamska D, Bijata K, Garcia-Perez JL, Dziembowski A.

Cell. 2018 Sep 6;174(6):1537-1548.e29. doi: 10.1016/j.cell.2018.07.022. Epub 2018 Aug 16.

7.

Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins.

Mayer J, Harz C, Sanchez L, Pereira GC, Maldener E, Heras SR, Ostrow LW, Ravits J, Batra R, Meese E, García-Pérez JL, Goodier JL.

Mol Neurodegener. 2018 Aug 2;13(1):39. doi: 10.1186/s13024-018-0275-3.

8.

RNase H2, mutated in Aicardi-Goutières syndrome, promotes LINE-1 retrotransposition.

Benitez-Guijarro M, Lopez-Ruiz C, Tarnauskaitė Ž, Murina O, Mian Mohammad M, Williams TC, Fluteau A, Sanchez L, Vilar-Astasio R, Garcia-Canadas M, Cano D, Kempen MH, Sanchez-Pozo A, Heras SR, Jackson AP, Reijns MA, Garcia-Perez JL.

EMBO J. 2018 Aug 1;37(15). pii: e98506. doi: 10.15252/embj.201798506. Epub 2018 Jun 29.

9.

Editorial: Mobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer.

Morrish TA, Garcia-Pérez JL.

Front Chem. 2017 Dec 4;5:108. doi: 10.3389/fchem.2017.00108. eCollection 2017. No abstract available.

10.

The TREX1 Dinosaur Bites the Brain through the LINE.

García Pérez JL, Alarcón-Riquelme ME.

Cell Stem Cell. 2017 Sep 7;21(3):287-288. doi: 10.1016/j.stem.2017.08.010.

11.

Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells.

MacLennan M, García-Cañadas M, Reichmann J, Khazina E, Wagner G, Playfoot CJ, Salvador-Palomeque C, Mann AR, Peressini P, Sanchez L, Dobie K, Read D, Hung CC, Eskeland R, Meehan RR, Weichenrieder O, García-Pérez JL, Adams IR.

Elife. 2017 Aug 14;6. pii: e26152. doi: 10.7554/eLife.26152.

12.

L1 Mosaicism in Mammals: Extent, Effects, and Evolution.

Faulkner GJ, Garcia-Perez JL.

Trends Genet. 2017 Nov;33(11):802-816. doi: 10.1016/j.tig.2017.07.004. Epub 2017 Aug 7. Review.

13.

Short term visual outcomes of a new trifocal intraocular lens.

García-Pérez JL, Gros-Otero J, Sánchez-Ramos C, Blázquez V, Contreras I.

BMC Ophthalmol. 2017 May 17;17(1):72. doi: 10.1186/s12886-017-0462-y.

14.

Heritable L1 retrotransposition in the mouse primordial germline and early embryo.

Richardson SR, Gerdes P, Gerhardt DJ, Sanchez-Luque FJ, Bodea GO, Muñoz-Lopez M, Jesuadian JS, Kempen MHC, Carreira PE, Jeddeloh JA, Garcia-Perez JL, Kazazian HH Jr, Ewing AD, Faulkner GJ.

Genome Res. 2017 Aug;27(8):1395-1405. doi: 10.1101/gr.219022.116. Epub 2017 May 8.

15.

Engineered LINE-1 retrotransposition in nondividing human neurons.

Macia A, Widmann TJ, Heras SR, Ayllon V, Sanchez L, Benkaddour-Boumzaouad M, Muñoz-Lopez M, Rubio A, Amador-Cubero S, Blanco-Jimenez E, Garcia-Castro J, Menendez P, Ng P, Muotri AR, Goodier JL, Garcia-Perez JL.

Genome Res. 2017 Mar;27(3):335-348. doi: 10.1101/gr.206805.116. Epub 2016 Dec 13.

16.

The impact of transposable elements on mammalian development.

Garcia-Perez JL, Widmann TJ, Adams IR.

Development. 2016 Nov 15;143(22):4101-4114. Review.

17.

Characterization of Engineered L1 Retrotransposition Events: The Recovery Method.

Cano D, Morell S, Pulgarin AJ, Amador S, Garcia-Pérez JL.

Methods Mol Biol. 2016;1400:165-82. doi: 10.1007/978-1-4939-3372-3_12.

PMID:
26895054
18.

Study of Transposable Elements and Their Genomic Impact.

Muñoz-Lopez M, Vilar-Astasio R, Tristan-Ramos P, Lopez-Ruiz C, Garcia-Pérez JL.

Methods Mol Biol. 2016;1400:1-19. doi: 10.1007/978-1-4939-3372-3_1.

PMID:
26895043
19.

Alu retrotransposons promote differentiation of human carcinoma cells through the aryl hydrocarbon receptor.

Morales-Hernández A, González-Rico FJ, Román AC, Rico-Leo E, Alvarez-Barrientos A, Sánchez L, Macia Á, Heras SR, García-Pérez JL, Merino JM, Fernández-Salguero PM.

Nucleic Acids Res. 2016 Jun 2;44(10):4665-83. doi: 10.1093/nar/gkw095. Epub 2016 Feb 15.

20.

Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells.

Klawitter S, Fuchs NV, Upton KR, Muñoz-Lopez M, Shukla R, Wang J, Garcia-Cañadas M, Lopez-Ruiz C, Gerhardt DJ, Sebe A, Grabundzija I, Merkert S, Gerdes P, Pulgarin JA, Bock A, Held U, Witthuhn A, Haase A, Sarkadi B, Löwer J, Wolvetang EJ, Martin U, Ivics Z, Izsvák Z, Garcia-Perez JL, Faulkner GJ, Schumann GG.

Nat Commun. 2016 Jan 8;7:10286. doi: 10.1038/ncomms10286. Erratum in: Nat Commun. 2018 Dec 19;9(1):5398.

21.

Localization of a bacterial group II intron-encoded protein in human cells.

Reinoso-Colacio M, García-Rodríguez FM, García-Cañadas M, Amador-Cubero S, García Pérez JL, Toro N.

Sci Rep. 2015 Aug 5;5:12716. doi: 10.1038/srep12716.

22.

The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes.

Richardson SR, Doucet AJ, Kopera HC, Moldovan JB, Garcia-Perez JL, Moran JV.

Microbiol Spectr. 2015 Apr;3(2):MDNA3-0061-2014. doi: 10.1128/microbiolspec.MDNA3-0061-2014. Review.

23.

Stenotrophomonas maltophilia keratitis treated with trimethoprim-sulfamethoxazole.

Díez-Álvarez L, Lumbreras-Fernández B, García-Pérez JL.

Arch Soc Esp Oftalmol. 2015 Nov;90(11):539-41. doi: 10.1016/j.oftal.2015.03.001. Epub 2015 May 23. English, Spanish.

PMID:
26008926
24.

Control of mammalian retrotransposons by cellular RNA processing activities.

Heras SR, Macias S, Cáceres JF, Garcia-Perez JL.

Mob Genet Elements. 2014 Mar 6;4:e28439. eCollection 2014.

25.

Retrotransposons in pluripotent cells: Impact and new roles in cellular plasticity.

Macia A, Blanco-Jimenez E, García-Pérez JL.

Biochim Biophys Acta. 2015 Apr;1849(4):417-26. doi: 10.1016/j.bbagrm.2014.07.007. Epub 2014 Jul 17. Review.

PMID:
25042909
26.

Role of BRD4 in hematopoietic differentiation of embryonic stem cells.

Rodriguez RM, Suarez-Alvarez B, Salvanés R, Huidobro C, Toraño EG, Garcia-Perez JL, Lopez-Larrea C, Fernandez AF, Bueno C, Menendez P, Fraga MF.

Epigenetics. 2014 Apr;9(4):566-78. doi: 10.4161/epi.27711. Epub 2014 Jan 20.

27.

Wiping DNA methylation: Wip1 regulates genomic fluidity on cancer.

Muñoz-Lopez M, Medina PP, Garcia-Perez JL.

Cancer Cell. 2013 Oct 14;24(4):405-7. doi: 10.1016/j.ccr.2013.10.002.

28.

The Microprocessor controls the activity of mammalian retrotransposons.

Heras SR, Macias S, Plass M, Fernandez N, Cano D, Eyras E, Garcia-Perez JL, Cáceres JF.

Nat Struct Mol Biol. 2013 Oct;20(10):1173-81. doi: 10.1038/nsmb.2658. Epub 2013 Sep 1.

29.

Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma.

Shukla R, Upton KR, Muñoz-Lopez M, Gerhardt DJ, Fisher ME, Nguyen T, Brennan PM, Baillie JK, Collino A, Ghisletti S, Sinha S, Iannelli F, Radaelli E, Dos Santos A, Rapoud D, Guettier C, Samuel D, Natoli G, Carninci P, Ciccarelli FD, Garcia-Perez JL, Faivre J, Faulkner GJ.

Cell. 2013 Mar 28;153(1):101-11. doi: 10.1016/j.cell.2013.02.032.

30.

Microarray analysis of LTR retrotransposon silencing identifies Hdac1 as a regulator of retrotransposon expression in mouse embryonic stem cells.

Reichmann J, Crichton JH, Madej MJ, Taggart M, Gautier P, Garcia-Perez JL, Meehan RR, Adams IR.

PLoS Comput Biol. 2012;8(4):e1002486. doi: 10.1371/journal.pcbi.1002486. Epub 2012 Apr 26.

31.

Analysis of LINE-1 expression in human pluripotent cells.

Muñoz-Lopez M, Garcia-Cañadas M, Macia A, Morell S, Garcia-Perez JL.

Methods Mol Biol. 2012;873:113-25. doi: 10.1007/978-1-61779-794-1_7.

PMID:
22528351
32.

Microcephaly, intellectual impairment, bilateral vesicoureteral reflux, distichiasis, and glomuvenous malformations associated with a 16q24.3 contiguous gene deletion and a Glomulin mutation.

Butler MG, Dagenais SL, Garcia-Perez JL, Brouillard P, Vikkula M, Strouse P, Innis JW, Glover TW.

Am J Med Genet A. 2012 Apr;158A(4):839-49. doi: 10.1002/ajmg.a.35229. Epub 2012 Mar 9.

33.

Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells.

Coufal NG, Garcia-Perez JL, Peng GE, Marchetto MC, Muotri AR, Mu Y, Carson CT, Macia A, Moran JV, Gage FH.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20382-7. doi: 10.1073/pnas.1100273108. Epub 2011 Dec 9.

34.

An epi [c] genetic battle: LINE-1 retrotransposons and intragenomic conflict in humans.

Muñoz-Lopez M, Macia A, Garcia-Cañadas M, Badge RM, Garcia-Perez JL.

Mob Genet Elements. 2011 Jul;1(2):122-127. Epub 2011 Jul 1.

35.

Reprogramming somatic cells into iPS cells activates LINE-1 retroelement mobility.

Wissing S, Muñoz-Lopez M, Macia A, Yang Z, Montano M, Collins W, Garcia-Perez JL, Moran JV, Greene WC.

Hum Mol Genet. 2012 Jan 1;21(1):208-18. doi: 10.1093/hmg/ddr455. Epub 2011 Oct 11.

36.

Similarities between long interspersed element-1 (LINE-1) reverse transcriptase and telomerase.

Kopera HC, Moldovan JB, Morrish TA, Garcia-Perez JL, Moran JV.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20345-50. doi: 10.1073/pnas.1100275108. Epub 2011 Sep 22.

37.

Endogenous APOBEC3B restricts LINE-1 retrotransposition in transformed cells and human embryonic stem cells.

Wissing S, Montano M, Garcia-Perez JL, Moran JV, Greene WC.

J Biol Chem. 2011 Oct 21;286(42):36427-37. doi: 10.1074/jbc.M111.251058. Epub 2011 Aug 30.

38.

LINE-1 elements in structural variation and disease.

Beck CR, Garcia-Perez JL, Badge RM, Moran JV.

Annu Rev Genomics Hum Genet. 2011;12:187-215. doi: 10.1146/annurev-genom-082509-141802. Review.

39.

Enrichment of human ESC-derived multipotent mesenchymal stem cells with immunosuppressive and anti-inflammatory properties capable to protect against experimental inflammatory bowel disease.

Sánchez L, Gutierrez-Aranda I, Ligero G, Rubio R, Muñoz-López M, García-Pérez JL, Ramos V, Real PJ, Bueno C, Rodríguez R, Delgado M, Menendez P.

Stem Cells. 2011 Feb;29(2):251-62. doi: 10.1002/stem.569.

40.

[Effect on ocular blood flow of Combigan® versus placebo in patients with ocular hypertension].

Puerto-Hernández B, Rebolleda G, García-Pérez JL, Muñoz-Negrete FJ, González-Gordaliza C.

Arch Soc Esp Oftalmol. 2011 Feb;86(2):42-6. doi: 10.1016/j.oftal.2010.07.005. Spanish.

PMID:
21440829
41.

[Pars plana vitrectomy as anti-inflammatory therapy for intermediate uveitis in children].

Figueroa MS, Noval S, Contreras I, Arruabarrena C, García-Pérez JL, Sales M, Gil-Cazorla R.

Arch Soc Esp Oftalmol. 2010 Dec;85(12):390-4. doi: 10.1016/j.oftal.2010.10.004. Epub 2011 Feb 16. Spanish.

PMID:
21354506
42.

Epigenetic control of retrotransposon expression in human embryonic stem cells.

Macia A, Muñoz-Lopez M, Cortes JL, Hastings RK, Morell S, Lucena-Aguilar G, Marchal JA, Badge RM, Garcia-Perez JL.

Mol Cell Biol. 2011 Jan;31(2):300-16. doi: 10.1128/MCB.00561-10. Epub 2010 Nov 1.

43.

DNA transposons: nature and applications in genomics.

Muñoz-López M, García-Pérez JL.

Curr Genomics. 2010 Apr;11(2):115-28. doi: 10.2174/138920210790886871.

44.

[Evaluation of the effect of bimatoprost/timolol fixed combination on ocular blood flow in patients with ocular hypertension using colour Doppler imaging. Preliminary study].

García-Pérez JL, Puerto-Hernández B, Rebolleda Fernández G, Muñoz-Negrete FJ, González-Gordaliza C.

Arch Soc Esp Oftalmol. 2010 Apr;85(4):131-7. Spanish.

PMID:
20858400
45.

iPSC lines that do not silence the expression of the ectopic reprogramming factors may display enhanced propensity to genomic instability.

Ramos-Mejia V, Muñoz-Lopez M, Garcia-Perez JL, Menendez P.

Cell Res. 2010 Oct;20(10):1092-5. doi: 10.1038/cr.2010.125. Epub 2010 Sep 7.

PMID:
20820191
46.

Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells.

Garcia-Perez JL, Morell M, Scheys JO, Kulpa DA, Morell S, Carter CC, Hammer GD, Collins KL, O'Shea KS, Menendez P, Moran JV.

Nature. 2010 Aug 5;466(7307):769-73. doi: 10.1038/nature09209.

47.

Enhanced transfection efficiency of human embryonic stem cells by the incorporation of DNA liposomes in extracellular matrix.

Villa-Diaz LG, Garcia-Perez JL, Krebsbach PH.

Stem Cells Dev. 2010 Dec;19(12):1949-57. doi: 10.1089/scd.2009.0505. Epub 2010 Sep 29.

48.

Central retinal vein occlusion after nonperforating sclerectomy without mitomycin.

Pérez-López M, Nozal CC, López MM, García-Pérez JL, Negrete FM.

Can J Ophthalmol. 2009 Dec;44(6):718-9. doi: 10.1139/i09-164. No abstract available.

PMID:
20029501
49.

L1 retrotransposition in human neural progenitor cells.

Coufal NG, Garcia-Perez JL, Peng GE, Yeo GW, Mu Y, Lovci MT, Morell M, O'Shea KS, Moran JV, Gage FH.

Nature. 2009 Aug 27;460(7259):1127-31. doi: 10.1038/nature08248. Epub 2009 Aug 5.

50.

Etoposide induces MLL rearrangements and other chromosomal abnormalities in human embryonic stem cells.

Bueno C, Catalina P, Melen GJ, Montes R, Sánchez L, Ligero G, García-Pérez JL, Menendez P.

Carcinogenesis. 2009 Sep;30(9):1628-37. doi: 10.1093/carcin/bgp169. Epub 2009 Jul 8.

PMID:
19587093

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