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Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice.

Kundu P, Lee HU, Garcia-Perez I, Tay EXY, Kim H, Faylon LE, Martin KA, Purbojati R, Drautz-Moses DI, Ghosh S, Nicholson JK, Schuster S, Holmes E, Pettersson S.

Sci Transl Med. 2019 Nov 13;11(518). pii: eaau4760. doi: 10.1126/scitranslmed.aau4760.


Development and validation of a high performance liquid chromatography-tandem mass spectrometry method for the absolute analysis of 17 α D-amino acids in cooked meals.

Barbas-Bernardos C, Garcia-Perez I, Lorenzo MP, Alonso-Herranz V, Nicholson J, Garcia A.

J Chromatogr A. 2020 Jan 25;1611:460598. doi: 10.1016/j.chroma.2019.460598. Epub 2019 Oct 4.


Distinct microbiome composition and metabolome exists across subgroups of elite Irish athletes.

O'Donovan CM, Madigan SM, Garcia-Perez I, Rankin A, O' Sullivan O, Cotter PD.

J Sci Med Sport. 2020 Jan;23(1):63-68. doi: 10.1016/j.jsams.2019.08.290. Epub 2019 Sep 18.


The gut microbiota influences skeletal muscle mass and function in mice.

Lahiri S, Kim H, Garcia-Perez I, Reza MM, Martin KA, Kundu P, Cox LM, Selkrig J, Posma JM, Zhang H, Padmanabhan P, Moret C, Gulyás B, Blaser MJ, Auwerx J, Holmes E, Nicholson J, Wahli W, Pettersson S.

Sci Transl Med. 2019 Jul 24;11(502). pii: eaan5662. doi: 10.1126/scitranslmed.aan5662.


A randomized controlled trial for overweight and obesity in preschoolers: the More and Less Europe study - an intervention within the STOP project.

Ek A, Delisle Nyström C, Chirita-Emandi A, Tur JA, Nordin K, Bouzas C, Argelich E, Martínez JA, Frost G, Garcia-Perez I, Saez M, Paul C, Löf M, Nowicka P.

BMC Public Health. 2019 Jul 15;19(1):945. doi: 10.1186/s12889-019-7161-y.


Effects of Fecal Microbiota Transplantation With Oral Capsules in Obese Patients.

Allegretti JR, Kassam Z, Mullish BH, Chiang A, Carrellas M, Hurtado J, Marchesi JR, McDonald JAK, Pechlivanis A, Barker GF, Blanco JM, Garcia-Perez I, Wong WF, Gerardin Y, Silverstein M, Kennedy K, Thompson C.

Clin Gastroenterol Hepatol. 2019 Jul 10. pii: S1542-3565(19)30739-6. doi: 10.1016/j.cgh.2019.07.006. [Epub ahead of print]


Spot and Cumulative Urine Samples Are Suitable Replacements for 24-Hour Urine Collections for Objective Measures of Dietary Exposure in Adults Using Metabolite Biomarkers.

Wilson T, Garcia-Perez I, Posma JM, Lloyd AJ, Chambers ES, Tailliart K, Zubair H, Beckmann M, Mathers JC, Holmes E, Frost G, Draper J.

J Nutr. 2019 Oct 1;149(10):1692-1700. doi: 10.1093/jn/nxz138.


Developing a Food Exposure and Urine Sampling Strategy for Dietary Exposure Biomarker Validation in Free-Living Individuals.

Lloyd AJ, Willis ND, Wilson T, Zubair H, Xie L, Chambers E, Garcia-Perez I, Tailliart K, Beckmann M, Mathers JC, Draper J.

Mol Nutr Food Res. 2019 Jun 3:e1900062. doi: 10.1002/mnfr.201900062. [Epub ahead of print]


Addressing the pitfalls when designing intervention studies to discover and validate biomarkers of habitual dietary intake.

Lloyd AJ, Willis ND, Wilson T, Zubair H, Chambers E, Garcia-Perez I, Xie L, Tailliart K, Beckmann M, Mathers JC, Draper J.

Metabolomics. 2019 May 2;15(5):72. doi: 10.1007/s11306-019-1532-3.


Effects of Inulin Propionate Ester Incorporated into Palatable Food Products on Appetite and Resting Energy Expenditure: A Randomised Crossover Study.

Byrne CS, Chambers ES, Preston T, Tedford C, Brignardello J, Garcia-Perez I, Holmes E, Wallis GA, Morrison DJ, Frost GS.

Nutrients. 2019 Apr 16;11(4). pii: E861. doi: 10.3390/nu11040861.


Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial.

Chambers ES, Byrne CS, Morrison DJ, Murphy KG, Preston T, Tedford C, Garcia-Perez I, Fountana S, Serrano-Contreras JI, Holmes E, Reynolds CJ, Roberts JF, Boyton RJ, Altmann DM, McDonald JAK, Marchesi JR, Akbar AN, Riddell NE, Wallis GA, Frost GS.

Gut. 2019 Aug;68(8):1430-1438. doi: 10.1136/gutjnl-2019-318424. Epub 2019 Apr 10.


The effect of L-rhamnose on intestinal transit time, short chain fatty acids and appetite regulation: a pilot human study using combined 13CO2/H2 breath tests.

Byrne CS, Preston T, Brignardello J, Garcia-Perez I, Holmes E, Frost GS, Morrison DJ.

J Breath Res. 2018 Aug 6;12(4):046006. doi: 10.1088/1752-7163/aad3f1.


A Prospective Metagenomic and Metabolomic Analysis of the Impact of Exercise and/or Whey Protein Supplementation on the Gut Microbiome of Sedentary Adults.

Cronin O, Barton W, Skuse P, Penney NC, Garcia-Perez I, Murphy EF, Woods T, Nugent H, Fanning A, Melgar S, Falvey EC, Holmes E, Cotter PD, O'Sullivan O, Molloy MG, Shanahan F.

mSystems. 2018 Apr 24;3(3). pii: e00044-18. doi: 10.1128/mSystems.00044-18. eCollection 2018 May-Jun.


Optimized Phenotypic Biomarker Discovery and Confounder Elimination via Covariate-Adjusted Projection to Latent Structures from Metabolic Spectroscopy Data.

Posma JM, Garcia-Perez I, Ebbels TMD, Lindon JC, Stamler J, Elliott P, Holmes E, Nicholson JK.

J Proteome Res. 2018 Apr 6;17(4):1586-1595. doi: 10.1021/acs.jproteome.7b00879. Epub 2018 Feb 27.


Application of 1H NMR spectroscopy to the metabolic phenotyping of rodent brain extracts: A metabonomic study of gut microbial influence on host brain metabolism.

Swann JR, Garcia-Perez I, Braniste V, Wilson ID, Sidaway JE, Nicholson JK, Pettersson S, Holmes E.

J Pharm Biomed Anal. 2017 Sep 5;143:141-146. doi: 10.1016/j.jpba.2017.05.040. Epub 2017 May 31.


The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level.

Barton W, Penney NC, Cronin O, Garcia-Perez I, Molloy MG, Holmes E, Shanahan F, Cotter PD, O'Sullivan O.

Gut. 2018 Apr;67(4):625-633. doi: 10.1136/gutjnl-2016-313627. Epub 2017 Mar 30.


Metabolic Phenotyping of Diet and Dietary Intake.

Brignardello J, Holmes E, Garcia-Perez I.

Adv Food Nutr Res. 2017;81:231-270. doi: 10.1016/bs.afnr.2016.12.002. Epub 2017 Jan 23.


Integrated Analytical and Statistical Two-Dimensional Spectroscopy Strategy for Metabolite Identification: Application to Dietary Biomarkers.

Posma JM, Garcia-Perez I, Heaton JC, Burdisso P, Mathers JC, Draper J, Lewis M, Lindon JC, Frost G, Holmes E, Nicholson JK.

Anal Chem. 2017 Mar 21;89(6):3300-3309. doi: 10.1021/acs.analchem.6b03324. Epub 2017 Mar 10.


Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial.

Garcia-Perez I, Posma JM, Gibson R, Chambers ES, Hansen TH, Vestergaard H, Hansen T, Beckmann M, Pedersen O, Elliott P, Stamler J, Nicholson JK, Draper J, Mathers JC, Holmes E, Frost G.

Lancet Diabetes Endocrinol. 2017 Mar;5(3):184-195. doi: 10.1016/S2213-8587(16)30419-3. Epub 2017 Jan 13.


Multiplatform serum metabolic phenotyping combined with pathway mapping to identify biochemical differences in smokers.

Kaluarachchi MR, Boulangé CL, Garcia-Perez I, Lindon JC, Minet EF.

Bioanalysis. 2016 Oct;8(19):2023-43. doi: 10.4155/bio-2016-0108. Epub 2016 Sep 16.


NMR-Based Metabonomic Analysis of Physiological Responses to Starvation and Refeeding in the Rat.

Serrano-Contreras JI, García-Pérez I, Meléndez-Camargo ME, Zepeda LG.

J Proteome Res. 2016 Sep 2;15(9):3241-54. doi: 10.1021/acs.jproteome.6b00433. Epub 2016 Aug 22.


Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods.

Byrne CS, Chambers ES, Alhabeeb H, Chhina N, Morrison DJ, Preston T, Tedford C, Fitzpatrick J, Irani C, Busza A, Garcia-Perez I, Fountana S, Holmes E, Goldstone AP, Frost GS.

Am J Clin Nutr. 2016 Jul;104(1):5-14. doi: 10.3945/ajcn.115.126706. Epub 2016 May 11.


An Analytical Pipeline for Quantitative Characterization of Dietary Intake: Application To Assess Grape Intake.

Garcia-Perez I, Posma JM, Chambers ES, Nicholson JK, C Mathers J, Beckmann M, Draper J, Holmes E, Frost G.

J Agric Food Chem. 2016 Mar 23;64(11):2423-31. doi: 10.1021/acs.jafc.5b05878. Epub 2016 Mar 8.


NMR-based metabonomic analysis of normal rat urine and faeces in response to (±)-venlafaxine treatment.

Serrano-Contreras JI, García-Pérez I, Meléndez-Camargo ME, Zepeda-Vallejo LG.

J Pharm Biomed Anal. 2016 May 10;123:82-92. doi: 10.1016/j.jpba.2016.01.044. Epub 2016 Feb 1.


Randomised controlled pilot study to assess the feasibility of a Mediterranean Portfolio dietary intervention for cardiovascular risk reduction in HIV dyslipidaemia: a study protocol.

Stradling C, Thomas GN, Hemming K, Frost G, Garcia-Perez I, Redwood S, Taheri S.

BMJ Open. 2016 Feb 8;6(2):e010821. doi: 10.1136/bmjopen-2015-010821.


Multiplatform characterization of dynamic changes in breast milk during lactation.

Andreas NJ, Hyde MJ, Gomez-Romero M, Lopez-Gonzalvez MA, Villaseñor A, Wijeyesekera A, Barbas C, Modi N, Holmes E, Garcia-Perez I.

Electrophoresis. 2015 Sep;36(18):2269-2285. doi: 10.1002/elps.201500011. Epub 2015 Jun 25.


Urinary metabolic signatures of human adiposity.

Elliott P, Posma JM, Chan Q, Garcia-Perez I, Wijeyesekera A, Bictash M, Ebbels TM, Ueshima H, Zhao L, van Horn L, Daviglus M, Stamler J, Holmes E, Nicholson JK.

Sci Transl Med. 2015 Apr 29;7(285):285ra62. doi: 10.1126/scitranslmed.aaa5680. Epub 2015 Apr 29.


Application of CE-MS to a metabonomics study of human urine from cigarette smokers and non-smokers.

Garcia-Perez I, Lindon JC, Minet E.

Bioanalysis. 2014 Oct;6(20):2733-49. doi: 10.4155/bio.14.136.


The urinary proteome and metabonome differ from normal in adults with mitochondrial disease.

Hall AM, Vilasi A, Garcia-Perez I, Lapsley M, Alston CL, Pitceathly RD, McFarland R, Schaefer AM, Turnbull DM, Beaumont NJ, Hsuan JJ, Cutillas PR, Lindon JC, Holmes E, Unwin RJ, Taylor RW, Gorman GS, Rahman S, Hanna MG.

Kidney Int. 2015 Mar;87(3):610-22. doi: 10.1038/ki.2014.297. Epub 2014 Sep 10.


Breast milk metabolome characterization in a single-phase extraction, multiplatform analytical approach.

Villaseñor A, Garcia-Perez I, Garcia A, Posma JM, Fernández-López M, Nicholas AJ, Modi N, Holmes E, Barbas C.

Anal Chem. 2014 Aug 19;86(16):8245-52. doi: 10.1021/ac501853d. Epub 2014 Aug 6.


Earthworms produce phytochelatins in response to arsenic.

Liebeke M, Garcia-Perez I, Anderson CJ, Lawlor AJ, Bennett MH, Morris CA, Kille P, Svendsen C, Spurgeon DJ, Bundy JG.

PLoS One. 2013 Nov 22;8(11):e81271. doi: 10.1371/journal.pone.0081271. eCollection 2013.


Dietary and urinary metabonomic factors possibly accounting for higher blood pressure of black compared with white Americans: results of International Collaborative Study on macro-/micronutrients and blood pressure.

Stamler J, Brown IJ, Yap IK, Chan Q, Wijeyesekera A, Garcia-Perez I, Chadeau-Hyam M, Ebbels TM, De Iorio M, Posma J, Daviglus ML, Carnethon M, Holmes E, Nicholson JK, Elliott P; INTERMAP Research Group.

Hypertension. 2013 Dec;62(6):1074-80. doi: 10.1161/HYPERTENSIONAHA.113.01810. Epub 2013 Oct 7.


The role of metabonomics as a tool for augmenting nutritional information in epidemiological studies.

Ismail NA, Posma JM, Frost G, Holmes E, Garcia-Perez I.

Electrophoresis. 2013 Oct;34(19):2776-86. doi: 10.1002/elps.201300066. Epub 2013 Sep 10. Review.


Subset optimization by reference matching (STORM): an optimized statistical approach for recovery of metabolic biomarker structural information from 1H NMR spectra of biofluids.

Posma JM, Garcia-Perez I, De Iorio M, Lindon JC, Elliott P, Holmes E, Ebbels TM, Nicholson JK.

Anal Chem. 2012 Dec 18;84(24):10694-701. doi: 10.1021/ac302360v. Epub 2012 Dec 4.


Molecular validation of the acute phencyclidine rat model for schizophrenia: identification of translational changes in energy metabolism and neurotransmission.

Ernst A, Ma D, Garcia-Perez I, Tsang TM, Kluge W, Schwarz E, Guest PC, Holmes E, Sarnyai Z, Bahn S.

J Proteome Res. 2012 Jul 6;11(7):3704-14. doi: 10.1021/pr300197d. Epub 2012 Jun 1.


Urinary metabolic phenotyping the slc26a6 (chloride-oxalate exchanger) null mouse model.

Garcia-Perez I, Villaseñor A, Wijeyesekera A, Posma JM, Jiang Z, Stamler J, Aronson P, Unwin R, Barbas C, Elliott P, Nicholson J, Holmes E.

J Proteome Res. 2012 Sep 7;11(9):4425-35. doi: 10.1021/pr2012544. Epub 2012 Aug 28.


HER2 status in breast cancer: experience of a Spanish National Reference Centre.

Cuadros M, Cano C, López FJ, Talavera P, García-Peréz I, Blanco A, Concha Á.

Clin Transl Oncol. 2011 May;13(5):335-40. doi: 10.1007/s12094-011-0663-4.


Metabolome-wide association study identifies multiple biomarkers that discriminate north and south Chinese populations at differing risks of cardiovascular disease: INTERMAP study.

Yap IK, Brown IJ, Chan Q, Wijeyesekera A, Garcia-Perez I, Bictash M, Loo RL, Chadeau-Hyam M, Ebbels T, De Iorio M, Maibaum E, Zhao L, Kesteloot H, Daviglus ML, Stamler J, Nicholson JK, Elliott P, Holmes E.

J Proteome Res. 2010 Dec 3;9(12):6647-54. doi: 10.1021/pr100798r. Epub 2010 Nov 2.


Chemometric and biological validation of a capillary electrophoresis metabolomic experiment of Schistosoma mansoni infection in mice.

Garcia-Perez I, Angulo S, Utzinger J, Holmes E, Legido-Quigley C, Barbas C.

Electrophoresis. 2010 Jul;31(14):2338-48. doi: 10.1002/elps.200900523.


Chemometric analysis of urine fingerprints acquired by liquid chromatography-mass spectrometry and capillary electrophoresis: application to the schistosomiasis mouse model.

Garcia-Perez I, Earll ME, Angulo S, Barbas C, Legido-Quigley C.

Electrophoresis. 2010 Jul;31(14):2349-55. doi: 10.1002/elps.200900492.


Real-time RT-PCR analysis for evaluating the Her2/neu status in breast cancer.

Cuadros M, Talavera P, López FJ, García-Peréz I, Blanco A, Concha A.

Pathobiology. 2010;77(1):38-45. doi: 10.1159/000272953. Epub 2010 Feb 25.


Bidirectional correlation of NMR and capillary electrophoresis fingerprints: a new approach to investigating Schistosoma mansoni infection in a mouse model.

Garcia-Perez I, Couto Alves A, Angulo S, Li JV, Utzinger J, Ebbels TM, Legido-Quigley C, Nicholson JK, Holmes E, Barbas C.

Anal Chem. 2010 Jan 1;82(1):203-10. doi: 10.1021/ac901728w.


[Usefulness of urokinase in intraabdominal abscesses].

García Pérez I, González Vega A.

Cir Esp. 2010 Jul;88(1):53-4. doi: 10.1016/j.ciresp.2009.04.017. Epub 2009 Sep 23. Spanish. No abstract available.


The autocorrelation matrix probing biochemical relationships after metabolic fingerprinting with CE.

Angulo S, García-Pérez I, Legido-Quigley C, Barbas C.

Electrophoresis. 2009 Apr;30(7):1221-7. doi: 10.1002/elps.200800554.


[Epiploic appendagitis as a cause of acute abdominal pain].

González Vega A, García Pérez I, Alvarez Alvarez D, Rizzo Ramos A, García Muñiz JL, Pérez Ricarte P.

Rev Esp Enferm Dig. 2008 Dec;100(12):800-1. Spanish. No abstract available.


Fingerprinting of human bile during liver transplantation by capillary electrophoresis.

Papaspyridonos K, Garcia-Perez I, Angulo S, Domann PJ, Vilca-Melendez H, Heaton N, Murphy GM, Holmes E, Barbas C, Legido-Quigley C.

J Sep Sci. 2008 Sep;31(16-17):3058-64. doi: 10.1002/jssc.200800194.


Metabolic fingerprinting with capillary electrophoresis.

García-Pérez I, Vallejo M, García A, Legido-Quigley C, Barbas C.

J Chromatogr A. 2008 Sep 19;1204(2):130-9. doi: 10.1016/j.chroma.2008.07.025. Epub 2008 Jul 12. Review.


Metabolic fingerprinting of Schistosoma mansoni infection in mice urine with capillary electrophoresis.

García-Pérez I, Whitfield P, Bartlett A, Angulo S, Legido-Quigley C, Hanna-Brown M, Barbas C.

Electrophoresis. 2008 Aug;29(15):3201-6. doi: 10.1002/elps.200800031.


[Esophagodiverticulostomy for the treatment of Zenker's diverticulum].

García Pérez I, Pozo Fidalgo F, Ricarte Pérez P, García-Morán M.

Rev Esp Enferm Dig. 2002 Mar;94(3):172-3. Spanish. No abstract available.


[On the isotopic localization of parathyroid adenomas].

García Pérez I, Pozo Fidalgo F, Ricarte Pérez P, García-Morán M.

Rev Esp Med Nucl. 2002 Apr;21(2):126-7. Spanish. No abstract available.


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