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Items: 1 to 50 of 102

1.

Myc Is Required for Adaptive β-Cell Replication in Young Mice but Is Not Sufficient in One-Year-Old Mice Fed With a High-Fat Diet.

Rosselot C, Kumar A, Lakshmipathi J, Zhang P, Lu G, Katz LS, Prochownik EV, Stewart AF, Lambertini L, Scott DK, Garcia-Ocaña A.

Diabetes. 2019 Oct;68(10):1934-1949. doi: 10.2337/db18-1368. Epub 2019 Jul 10.

PMID:
31292135
2.

Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells.

Wang P, Karakose E, Liu H, Swartz E, Ackeifi C, Zlatanic V, Wilson J, González BJ, Bender A, Takane KK, Ye L, Harb G, Pagliuca F, Homann D, Egli D, Argmann C, Scott DK, Garcia-Ocaña A, Stewart AF.

Cell Metab. 2019 Mar 5;29(3):638-652.e5. doi: 10.1016/j.cmet.2018.12.005. Epub 2018 Dec 20.

PMID:
30581122
3.

Inhibition of Atypical Protein Kinase C Reduces Inflammation-Induced Retinal Vascular Permeability.

Lin CM, Titchenell PM, Keil JM, Garcia-Ocaña A, Bolinger MT, Abcouwer SF, Antonetti DA.

Am J Pathol. 2018 Oct;188(10):2392-2405. doi: 10.1016/j.ajpath.2018.06.020. Epub 2018 Sep 13.

4.

Circulating Levels of Bone and Inflammatory Markers in Gestational Diabetes Mellitus.

Eschler DC, Kulina G, Garcia-Ocana A, Li J, Kraus T, Levy CJ.

Biores Open Access. 2018 Aug 1;7(1):123-130. doi: 10.1089/biores.2018.0013. eCollection 2018.

5.

Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation.

Kumar A, Katz LS, Schulz AM, Kim M, Honig LB, Li L, Davenport B, Homann D, Garcia-Ocaña A, Herman MA, Haynes CM, Chipuk JE, Scott DK.

Diabetes. 2018 Aug;67(8):1561-1575. doi: 10.2337/db17-0943. Epub 2018 May 15.

6.

Lambert-Eaton myasthenic syndrome: mouse passive-transfer model illuminates disease pathology and facilitates testing therapeutic leads.

Meriney SD, Tarr TB, Ojala KS, Wu M, Li Y, Lacomis D, Garcia-Ocaña A, Liang M, Valdomir G, Wipf P.

Ann N Y Acad Sci. 2018 Jan;1412(1):73-81. doi: 10.1111/nyas.13512. Epub 2017 Nov 10. Review.

7.

CDK4/6 Inhibition on Glucose and Pancreatic Beta Cell Homeostasis in Young and Aged Rats.

Sacaan AI, Thibault S, Hong M, Kondegowda NG, Nichols T, Li R, Rosselot C, Evering W, Fenutria R, Vitsky A, Brown T, Finkelstein M, Garcia-Ocaña A, Khan N, Stewart AF, Vasavada RC.

Mol Cancer Res. 2017 Nov;15(11):1531-1541. doi: 10.1158/1541-7786.MCR-17-0172. Epub 2017 Jul 31.

8.

Parathyroid Hormone-Related Peptide (1-36) Enhances Beta Cell Regeneration and Increases Beta Cell Mass in a Mouse Model of Partial Pancreatectomy.

Mozar A, Lin H, Williams K, Chin C, Li R, Kondegowda NG, Stewart AF, Garcia-Ocaña A, Vasavada RC.

PLoS One. 2016 Jul 8;11(7):e0158414. doi: 10.1371/journal.pone.0158414. eCollection 2016.

9.

PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2.

Lakshmipathi J, Alvarez-Perez JC, Rosselot C, Casinelli GP, Stamateris RE, Rausell-Palamos F, O'Donnell CP, Vasavada RC, Scott DK, Alonso LC, Garcia-Ocaña A.

Diabetes. 2016 May;65(5):1283-96. doi: 10.2337/db15-1398. Epub 2016 Feb 11.

10.

SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction.

Lai YC, Tabima DM, Dube JJ, Hughan KS, Vanderpool RR, Goncharov DA, St Croix CM, Garcia-Ocaña A, Goncharova EA, Tofovic SP, Mora AL, Gladwin MT.

Circulation. 2016 Feb 23;133(8):717-31. doi: 10.1161/CIRCULATIONAHA.115.018935. Epub 2016 Jan 26.

11.

Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor.

Stamateris RE, Sharma RB, Kong Y, Ebrahimpour P, Panday D, Ranganath P, Zou B, Levitt H, Parambil NA, O'Donnell CP, García-Ocaña A, Alonso LC.

Diabetes. 2016 Apr;65(4):981-95. doi: 10.2337/db15-0529. Epub 2016 Jan 6.

12.

FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice.

Zhang T, Kim DH, Xiao X, Lee S, Gong Z, Muzumdar R, Calabuig-Navarro V, Yamauchi J, Harashima H, Wang R, Bottino R, Alvarez-Perez JC, Garcia-Ocaña A, Gittes G, Dong HH.

Endocrinology. 2016 Mar;157(3):1055-70. doi: 10.1210/en.2015-1852. Epub 2016 Jan 4.

13.

Targeted delivery of HGF to the skeletal muscle improves glucose homeostasis in diet-induced obese mice.

Sanchez-Encinales V, Cozar-Castellano I, Garcia-Ocaña A, Perdomo G.

J Physiol Biochem. 2015 Dec;71(4):795-805. doi: 10.1007/s13105-015-0444-6. Epub 2015 Oct 27.

PMID:
26507644
14.

Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway.

Kondegowda NG, Fenutria R, Pollack IR, Orthofer M, Garcia-Ocaña A, Penninger JM, Vasavada RC.

Cell Metab. 2015 Jul 7;22(1):77-85. doi: 10.1016/j.cmet.2015.05.021. Epub 2015 Jun 18.

15.

Human β-cell proliferation and intracellular signaling: part 3.

Stewart AF, Hussain MA, García-Ocaña A, Vasavada RC, Bhushan A, Bernal-Mizrachi E, Kulkarni RN.

Diabetes. 2015 Jun;64(6):1872-85. doi: 10.2337/db14-1843. Review.

16.

MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism.

Shroff EH, Eberlin LS, Dang VM, Gouw AM, Gabay M, Adam SJ, Bellovin DI, Tran PT, Philbrick WM, Garcia-Ocana A, Casey SC, Li Y, Dang CV, Zare RN, Felsher DW.

Proc Natl Acad Sci U S A. 2015 May 26;112(21):6539-44. doi: 10.1073/pnas.1507228112. Epub 2015 May 11.

17.

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.

Wang P, Alvarez-Perez JC, Felsenfeld DP, Liu H, Sivendran S, Bender A, Kumar A, Sanchez R, Scott DK, Garcia-Ocaña A, Stewart AF.

Nat Med. 2015 Apr;21(4):383-8. doi: 10.1038/nm.3820. Epub 2015 Mar 9.

18.

Anti-incretin, Anti-proliferative Action of Dopamine on β-Cells.

Maffei A, Segal AM, Alvarez-Perez JC, Garcia-Ocaña A, Harris PE.

Mol Endocrinol. 2015 Apr;29(4):542-57. doi: 10.1210/me.2014-1273. Epub 2015 Mar 9.

19.

Diabetes mellitus--advances and challenges in human β-cell proliferation.

Wang P, Fiaschi-Taesch NM, Vasavada RC, Scott DK, García-Ocaña A, Stewart AF.

Nat Rev Endocrinol. 2015 Apr;11(4):201-12. doi: 10.1038/nrendo.2015.9. Epub 2015 Feb 17. Review.

PMID:
25687999
20.

Phospho-BAD BH3 mimicry protects β cells and restores functional β cell mass in diabetes.

Ljubicic S, Polak K, Fu A, Wiwczar J, Szlyk B, Chang Y, Alvarez-Perez JC, Bird GH, Walensky LD, Garcia-Ocaña A, Danial NN.

Cell Rep. 2015 Feb 3;10(4):497-504. doi: 10.1016/j.celrep.2014.12.056. Epub 2015 Jan 29.

21.

Hepatocyte growth factor ameliorates hyperglycemia and corrects β-cell mass in IRS2-deficient mice.

Alvarez-Perez JC, Rosa TC, Casinelli GP, Valle SR, Lakshmipathi J, Rosselot C, Rausell-Palamos F, Vasavada RC, García-Ocaña A.

Mol Endocrinol. 2014 Dec;28(12):2038-48. doi: 10.1210/me.2014-1207.

22.

"RAS"ling β cells to proliferate for diabetes: why do we need MEN?

García-Ocaña A, Stewart AF.

J Clin Invest. 2014 Sep;124(9):3698-700. doi: 10.1172/JCI77764. Epub 2014 Aug 18.

23.

Functional roles of the nuclear localization signal of parathyroid hormone-related protein (PTHrP) in osteoblastic cells.

García-Martín A, Ardura JA, Maycas M, Lozano D, López-Herradón A, Portal-Núñez S, García-Ocaña A, Esbrit P.

Mol Endocrinol. 2014 Jun;28(6):925-34. doi: 10.1210/me.2013-1225. Epub 2014 Apr 11.

24.

Human β-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map.

Bernal-Mizrachi E, Kulkarni RN, Scott DK, Mauvais-Jarvis F, Stewart AF, Garcia-Ocaña A.

Diabetes. 2014 Mar;63(3):819-31. doi: 10.2337/db13-1146. Review.

25.

Hepatocyte growth factor/c-Met signaling is required for β-cell regeneration.

Alvarez-Perez JC, Ernst S, Demirci C, Casinelli GP, Mellado-Gil JM, Rausell-Palamos F, Vasavada RC, Garcia-Ocaña A.

Diabetes. 2014 Jan;63(1):216-23. doi: 10.2337/db13-0333. Epub 2013 Oct 2.

26.

Exogenous glucose administration impairs glucose tolerance and pancreatic insulin secretion during acute sepsis in non-diabetic mice.

Watanabe Y, Singamsetty S, Zou B, Guo L, Stefanovski D, Alonso LC, Garcia-Ocana A, O'Donnell CP, McVerry BJ.

PLoS One. 2013 Jun 24;8(6):e67716. doi: 10.1371/journal.pone.0067716. Print 2013.

27.

A comparison of parathyroid hormone-related protein (1-36) and parathyroid hormone (1-34) on markers of bone turnover and bone density in postmenopausal women: the PrOP study.

Horwitz MJ, Augustine M, Khan L, Martin E, Oakley CC, Carneiro RM, Tedesco MB, Laslavic A, Sereika SM, Bisello A, Garcia-Ocaña A, Gundberg CM, Cauley JA, Stewart AF.

J Bone Miner Res. 2013 Nov;28(11):2266-76. doi: 10.1002/jbmr.1978. Erratum in: J Bone Miner Res. 2014 Mar;29(3):770. Kahn, Leila [corrected to Khan, Leila].

28.

Time-dependent changes in glucose and insulin regulation during intermittent hypoxia and continuous hypoxia.

Lee EJ, Alonso LC, Stefanovski D, Strollo HC, Romano LC, Zou B, Singamsetty S, Yester KA, McGaffin KR, Garcia-Ocana A, O'Donnell CP.

Eur J Appl Physiol. 2013 Feb;113(2):467-78. doi: 10.1007/s00421-012-2452-3. Epub 2012 Jul 17.

29.

ChREBP mediates glucose-stimulated pancreatic β-cell proliferation.

Metukuri MR, Zhang P, Basantani MK, Chin C, Stamateris RE, Alonso LC, Takane KK, Gramignoli R, Strom SC, O'Doherty RM, Stewart AF, Vasavada RC, Garcia-Ocaña A, Scott DK.

Diabetes. 2012 Aug;61(8):2004-15. doi: 10.2337/db11-0802. Epub 2012 May 14.

30.

Sex-specific effect of estrogen sulfotransferase on mouse models of type 2 diabetes.

Gao J, He J, Shi X, Stefanovic-Racic M, Xu M, O'Doherty RM, Garcia-Ocana A, Xie W.

Diabetes. 2012 Jun;61(6):1543-51. doi: 10.2337/db11-1152. Epub 2012 Mar 20.

31.

Loss of HGF/c-Met signaling in pancreatic β-cells leads to incomplete maternal β-cell adaptation and gestational diabetes mellitus.

Demirci C, Ernst S, Alvarez-Perez JC, Rosa T, Valle S, Shridhar V, Casinelli GP, Alonso LC, Vasavada RC, García-Ocana A.

Diabetes. 2012 May;61(5):1143-52. doi: 10.2337/db11-1154. Epub 2012 Mar 16.

32.

Lactogens protect rodent and human beta cells against glucolipotoxicity-induced cell death through Janus kinase-2 (JAK2)/signal transducer and activator of transcription-5 (STAT5) signalling.

Kondegowda NG, Mozar A, Chin C, Otero A, Garcia-Ocaña A, Vasavada RC.

Diabetologia. 2012 Jun;55(6):1721-32. doi: 10.1007/s00125-012-2501-9. Epub 2012 Mar 3.

PMID:
22382519
33.

Free fatty acids block glucose-induced β-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18.

Pascoe J, Hollern D, Stamateris R, Abbasi M, Romano LC, Zou B, O'Donnell CP, Garcia-Ocana A, Alonso LC.

Diabetes. 2012 Mar;61(3):632-41. doi: 10.2337/db11-0991. Epub 2012 Feb 14.

34.

Simultaneous measurement of insulin sensitivity, insulin secretion, and the disposition index in conscious unhandled mice.

Alonso LC, Watanabe Y, Stefanovski D, Lee EJ, Singamsetty S, Romano LC, Zou B, Garcia-Ocaña A, Bergman RN, O'Donnell CP.

Obesity (Silver Spring). 2012 Jul;20(7):1403-12. doi: 10.1038/oby.2012.36. Epub 2012 Feb 14.

35.

Activation of protein kinase C-ζ in pancreatic β-cells in vivo improves glucose tolerance and induces β-cell expansion via mTOR activation.

Velazquez-Garcia S, Valle S, Rosa TC, Takane KK, Demirci C, Alvarez-Perez JC, Mellado-Gil JM, Ernst S, Scott DK, Vasavada RC, Alonso LC, Garcia-Ocaña A.

Diabetes. 2011 Oct;60(10):2546-59. doi: 10.2337/db10-1783. Epub 2011 Sep 12.

36.

Mechanisms in the adaptation of maternal β-cells during pregnancy.

Ernst S, Demirci C, Valle S, Velazquez-Garcia S, Garcia-Ocaña A.

Diabetes Manag (Lond). 2011 Mar 1;1(2):239-248.

37.

Systemic and acute administration of parathyroid hormone-related peptide(1-36) stimulates endogenous beta cell proliferation while preserving function in adult mice.

Williams K, Abanquah D, Joshi-Gokhale S, Otero A, Lin H, Guthalu NK, Zhang X, Mozar A, Bisello A, Stewart AF, Garcia-Ocaña A, Vasavada RC.

Diabetologia. 2011 Nov;54(11):2867-77. doi: 10.1007/s00125-011-2260-z. Epub 2011 Jul 29.

PMID:
21800111
38.

A 7-day continuous infusion of PTH or PTHrP suppresses bone formation and uncouples bone turnover.

Horwitz MJ, Tedesco MB, Sereika SM, Prebehala L, Gundberg CM, Hollis BW, Bisello A, Garcia-Ocaña A, Carneiro RM, Stewart AF.

J Bone Miner Res. 2011 Sep;26(9):2287-97. doi: 10.1002/jbmr.415.

39.

Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes.

Mellado-Gil J, Rosa TC, Demirci C, Gonzalez-Pertusa JA, Velazquez-Garcia S, Ernst S, Valle S, Vasavada RC, Stewart AF, Alonso LC, Garcia-Ocaña A.

Diabetes. 2011 Feb;60(2):525-36. doi: 10.2337/db09-1305. Epub 2010 Oct 27.

40.

Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-severe combined immunodeficiency (SCID) mice.

Levitt HE, Cyphert TJ, Pascoe JL, Hollern DA, Abraham N, Lundell RJ, Rosa T, Romano LC, Zou B, O'Donnell CP, Stewart AF, Garcia-Ocaña A, Alonso LC.

Diabetologia. 2011 Mar;54(3):572-82. doi: 10.1007/s00125-010-1919-1. Epub 2010 Oct 9.

41.

Parathyroid hormone-related protein enhances human ß-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression.

Guthalu Kondegowda N, Joshi-Gokhale S, Harb G, Williams K, Zhang XY, Takane KK, Zhang P, Scott DK, Stewart AF, Garcia-Ocaña A, Vasavada RC.

Diabetes. 2010 Dec;59(12):3131-8. doi: 10.2337/db09-1796. Epub 2010 Sep 28.

42.

Deficiency of Atf3, an adaptive-response gene, protects islets and ameliorates inflammation in a syngeneic mouse transplantation model.

Zmuda EJ, Viapiano M, Grey ST, Hadley G, Garcia-Ocaña A, Hai T.

Diabetologia. 2010 Jul;53(7):1438-50. doi: 10.1007/s00125-010-1696-x. Epub 2010 Mar 28.

43.

Novel proapoptotic effect of hepatocyte growth factor: synergy with palmitate to cause pancreatic {beta}-cell apoptosis.

González-Pertusa JA, Dubé J, Valle SR, Rosa TC, Takane KK, Mellado-Gil JM, Perdomo G, Vasavada RC, García-Ocaña A.

Endocrinology. 2010 Apr;151(4):1487-98. doi: 10.1210/en.2009-0975. Epub 2010 Feb 22.

44.

Parathyroid hormone-related protein for the treatment of postmenopausal osteoporosis: defining the maximal tolerable dose.

Horwitz MJ, Tedesco MB, Garcia-Ocaña A, Sereika SM, Prebehala L, Bisello A, Hollis BW, Gundberg CM, Stewart AF.

J Clin Endocrinol Metab. 2010 Mar;95(3):1279-87. doi: 10.1210/jc.2009-0233. Epub 2010 Jan 8.

45.

Plasma membrane subdomain compartmentalization contributes to distinct mechanisms of ceramide action on insulin signaling.

Blouin CM, Prado C, Takane KK, Lasnier F, Garcia-Ocana A, Ferré P, Dugail I, Hajduch E.

Diabetes. 2010 Mar;59(3):600-10. doi: 10.2337/db09-0897. Epub 2009 Dec 3.

46.

Hyperinsulinemia predicts survival in a hyperglycemic mouse model of critical illness.

Woodske ME, Yokoe T, Zou B, Romano LC, Rosa TC, Garcia-Ocana A, Alonso LC, O'Donnell CP, McVerry BJ.

Crit Care Med. 2009 Sep;37(9):2596-603. doi: 10.1097/CCM.0b013e3181a9338a.

47.

Marginal mass islet transplantation with autologous mesenchymal stem cells promotes long-term islet allograft survival and sustained normoglycemia.

Solari MG, Srinivasan S, Boumaza I, Unadkat J, Harb G, Garcia-Ocana A, Feili-Hariri M.

J Autoimmun. 2009 Mar;32(2):116-24. doi: 10.1016/j.jaut.2009.01.003. Epub 2009 Feb 12.

PMID:
19217258
48.

Autologous bone marrow-derived rat mesenchymal stem cells promote PDX-1 and insulin expression in the islets, alter T cell cytokine pattern and preserve regulatory T cells in the periphery and induce sustained normoglycemia.

Boumaza I, Srinivasan S, Witt WT, Feghali-Bostwick C, Dai Y, Garcia-Ocana A, Feili-Hariri M.

J Autoimmun. 2009 Feb;32(1):33-42. doi: 10.1016/j.jaut.2008.10.004. Epub 2008 Dec 4.

PMID:
19062254
49.

Hepatocyte growth factor enhances engraftment and function of nonhuman primate islets.

Fiaschi-Taesch NM, Berman DM, Sicari BM, Takane KK, Garcia-Ocaña A, Ricordi C, Kenyon NS, Stewart AF.

Diabetes. 2008 Oct;57(10):2745-54. doi: 10.2337/db08-1085.

50.

Hepatocyte growth factor is a novel stimulator of glucose uptake and metabolism in skeletal muscle cells.

Perdomo G, Martinez-Brocca MA, Bhatt BA, Brown NF, O'Doherty RM, Garcia-Ocaña A.

J Biol Chem. 2008 May 16;283(20):13700-6. doi: 10.1074/jbc.M707551200. Epub 2008 Mar 24.

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