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Items: 45


Forcing the reversibility of a mechanochemical reaction.

Beedle AEM, Mora M, Davis CT, Snijders AP, Stirnemann G, Garcia-Manyes S.

Nat Commun. 2018 Aug 8;9(1):3155. doi: 10.1038/s41467-018-05115-6.


DNA Binding Induces a Nanomechanical Switch in the RRM1 Domain of TDP-43.

Wang YJ, Rico-Lastres P, Lezamiz A, Mora M, Solsona C, Stirnemann G, Garcia-Manyes S.

J Phys Chem Lett. 2018 Jul 19;9(14):3800-3807. doi: 10.1021/acs.jpclett.8b01494. Epub 2018 Jun 28.


The force-dependent mechanism of DnaK-mediated mechanical folding.

Perales-Calvo J, Giganti D, Stirnemann G, Garcia-Manyes S.

Sci Adv. 2018 Feb 9;4(2):eaaq0243. doi: 10.1126/sciadv.aaq0243. eCollection 2018 Feb.


Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores.

Elosegui-Artola A, Andreu I, Beedle AEM, Lezamiz A, Uroz M, Kosmalska AJ, Oria R, Kechagia JZ, Rico-Lastres P, Le Roux AL, Shanahan CM, Trepat X, Navajas D, Garcia-Manyes S, Roca-Cusachs P.

Cell. 2017 Nov 30;171(6):1397-1410.e14. doi: 10.1016/j.cell.2017.10.008. Epub 2017 Oct 26.


Tailoring protein nanomechanics with chemical reactivity.

Beedle AEM, Mora M, Lynham S, Stirnemann G, Garcia-Manyes S.

Nat Commun. 2017 Jun 6;8:15658. doi: 10.1038/ncomms15658.


The Nanomechanics of Lipid Multibilayer Stacks Exhibits Complex Dynamics.

Relat-Goberna J, Beedle AEM, Garcia-Manyes S.

Small. 2017 Jun;13(24). doi: 10.1002/smll.201700147. Epub 2017 May 15.


Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection.

Pernigo S, Fukuzawa A, Beedle AEM, Holt M, Round A, Pandini A, Garcia-Manyes S, Gautel M, Steiner RA.

Structure. 2017 Jan 3;25(1):107-120. doi: 10.1016/j.str.2016.11.015. Epub 2016 Dec 15.


Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding.

Beedle AE, Lynham S, Garcia-Manyes S.

Nat Commun. 2016 Aug 22;7:12490. doi: 10.1038/ncomms12490.


Single-molecule Force Spectroscopy Predicts a Misfolded, Domain-swapped Conformation in human γD-Crystallin Protein.

Garcia-Manyes S, Giganti D, Badilla CL, Lezamiz A, Perales-Calvo J, Beedle AE, Fernández JM.

J Biol Chem. 2016 Feb 19;291(8):4226-35. doi: 10.1074/jbc.M115.673871. Epub 2015 Dec 24.


Mechanobiology - chemical origin of membrane mechanical resistance and force-dependent signaling.

Beedle AE, Williams A, Relat-Goberna J, Garcia-Manyes S.

Curr Opin Chem Biol. 2015 Dec;29:87-93. doi: 10.1016/j.cbpa.2015.09.019. Epub 2015 Oct 30. Review.


The Mechanochemistry of a Structural Zinc Finger.

Perales-Calvo J, Lezamiz A, Garcia-Manyes S.

J Phys Chem Lett. 2015 Sep 3;6(17):3335-40. doi: 10.1021/acs.jpclett.5b01371. Epub 2015 Aug 21.


The mechanochemistry of copper reports on the directionality of unfolding in model cupredoxin proteins.

Beedle AE, Lezamiz A, Stirnemann G, Garcia-Manyes S.

Nat Commun. 2015 Aug 3;6:7894. doi: 10.1038/ncomms8894.


Direct Observation of the Dynamics of Self-Assembly of Individual Solvation Layers in Molecularly Confined Liquids.

Relat-Goberna J, Garcia-Manyes S.

Phys Rev Lett. 2015 Jun 26;114(25):258303. Epub 2015 Jun 25.


Dividing cells regulate their lipid composition and localization.

Atilla-Gokcumen GE, Muro E, Relat-Goberna J, Sasse S, Bedigian A, Coughlin ML, Garcia-Manyes S, Eggert US.

Cell. 2014 Jan 30;156(3):428-39. doi: 10.1016/j.cell.2013.12.015. Epub 2014 Jan 23.


Force dependency of biochemical reactions measured by single-molecule force-clamp spectroscopy.

Popa I, Kosuri P, Alegre-Cebollada J, Garcia-Manyes S, Fernandez JM.

Nat Protoc. 2013;8(7):1261-76. doi: 10.1038/nprot.2013.056. Epub 2013 Jun 6.


Rate limit of protein elastic response is tether dependent.

Berkovich R, Hermans RI, Popa I, Stirnemann G, Garcia-Manyes S, Berne BJ, Fernandez JM.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14416-21. doi: 10.1073/pnas.1212167109. Epub 2012 Aug 15.


Spontaneous dimerization of titin protein Z1Z2 domains induces strong nanomechanical anchoring.

Garcia-Manyes S, Badilla CL, Alegre-Cebollada J, Javadi Y, Fernández JM.

J Biol Chem. 2012 Jun 8;287(24):20240-7. doi: 10.1074/jbc.M112.355883. Epub 2012 Apr 21.


Direct quantification of the attempt frequency determining the mechanical unfolding of ubiquitin protein.

Popa I, Fernández JM, Garcia-Manyes S.

J Biol Chem. 2011 Sep 9;286(36):31072-9. doi: 10.1074/jbc.M111.264093. Epub 2011 Jul 16.


Single-molecule paleoenzymology probes the chemistry of resurrected enzymes.

Perez-Jimenez R, Inglés-Prieto A, Zhao ZM, Sanchez-Romero I, Alegre-Cebollada J, Kosuri P, Garcia-Manyes S, Kappock TJ, Tanokura M, Holmgren A, Sanchez-Ruiz JM, Gaucher EA, Fernandez JM.

Nat Struct Mol Biol. 2011 May;18(5):592-6. doi: 10.1038/nsmb.2020. Epub 2011 Apr 3.


Contrasting the individual reactive pathways in protein unfolding and disulfide bond reduction observed within a single protein.

Garcia-Manyes S, Kuo TL, Fernández JM.

J Am Chem Soc. 2011 Mar 9;133(9):3104-13. doi: 10.1021/ja109865z. Epub 2011 Feb 10.


Hopping around an entropic barrier created by force.

Berkovich R, Garcia-Manyes S, Klafter J, Urbakh M, Fernández JM.

Biochem Biophys Res Commun. 2010 Dec 3;403(1):133-7. doi: 10.1016/j.bbrc.2010.10.133. Epub 2010 Nov 2.


Single-molecule kinetics: Caught in the act.

Garcia-Manyes S.

Nat Chem. 2010 Nov;2(11):905-6. doi: 10.1038/nchem.882. No abstract available.


Nanomechanics of lipid bilayers: heads or tails?

Garcia-Manyes S, Redondo-Morata L, Oncins G, Sanz F.

J Am Chem Soc. 2010 Sep 22;132(37):12874-86. doi: 10.1021/ja1002185.


Probing static disorder in Arrhenius kinetics by single-molecule force spectroscopy.

Kuo TL, Garcia-Manyes S, Li J, Barel I, Lu H, Berne BJ, Urbakh M, Klafter J, Fernández JM.

Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11336-40. doi: 10.1073/pnas.1006517107. Epub 2010 Jun 8.


Collapse dynamics of single proteins extended by force.

Berkovich R, Garcia-Manyes S, Urbakh M, Klafter J, Fernandez JM.

Biophys J. 2010 Jun 2;98(11):2692-701. doi: 10.1016/j.bpj.2010.02.053.


Nanomechanics of lipid bilayers by force spectroscopy with AFM: a perspective.

Garcia-Manyes S, Sanz F.

Biochim Biophys Acta. 2010 Apr;1798(4):741-9. doi: 10.1016/j.bbamem.2009.12.019. Epub 2010 Jan 4. Review.


Modulation of titin-based stiffness by disulfide bonding in the cardiac titin N2-B unique sequence.

Grützner A, Garcia-Manyes S, Kötter S, Badilla CL, Fernandez JM, Linke WA.

Biophys J. 2009 Aug 5;97(3):825-34. doi: 10.1016/j.bpj.2009.05.037.


Direct observation of an ensemble of stable collapsed states in the mechanical folding of ubiquitin.

Garcia-Manyes S, Dougan L, Badilla CL, Brujic J, Fernández JM.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10534-9. doi: 10.1073/pnas.0901213106. Epub 2009 Jun 16.


Osmolyte-induced separation of the mechanical folding phases of ubiquitin.

Garcia-Manyes S, Dougan L, Fernández JM.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10540-5. doi: 10.1073/pnas.0902090106. Epub 2009 Jun 16.


Force-activated reactivity switch in a bimolecular chemical reaction.

Garcia-Manyes S, Liang J, Szoszkiewicz R, Kuo TL, Fernández JM.

Nat Chem. 2009 Jun;1(3):236-42. doi: 10.1038/nchem.207. Epub 2009 May 10.


Mechanical characterization of protein L in the low-force regime by electromagnetic tweezers/evanescent nanometry.

Liu R, Garcia-Manyes S, Sarkar A, Badilla CL, Fernández JM.

Biophys J. 2009 May 6;96(9):3810-21. doi: 10.1016/j.bpj.2009.01.043.


Arsenic speciation in contaminated soils.

Garcia-Manyes S, Jiménez G, Padró A, Rubio R, Rauret G.

Talanta. 2002 Aug 16;58(1):97-109.


Thermal response of Langmuir-Blodgett films of dipalmitoylphosphatidylcholine studied by atomic force microscopy and force spectroscopy.

Oncins G, Picas L, Hernández-Borrell J, Garcia-Manyes S, Sanz F.

Biophys J. 2007 Oct 15;93(8):2713-25. Epub 2007 Jun 22.


Force-clamp spectroscopy of single-protein monomers reveals the individual unfolding and folding pathways of I27 and ubiquitin.

Garcia-Manyes S, Brujić J, Badilla CL, Fernández JM.

Biophys J. 2007 Oct 1;93(7):2436-46. Epub 2007 Jun 1.


Atomic force microscopy and force spectroscopy study of Langmuir-Blodgett films formed by heteroacid phospholipids of biological interest.

Garcia-Manyes S, Domènech O, Sanz F, Montero MT, Hernandez-Borrell J.

Biochim Biophys Acta. 2007 May;1768(5):1190-8. Epub 2007 Feb 14.


Dwell-time distribution analysis of polyprotein unfolding using force-clamp spectroscopy.

Brujic J, Hermans RI, Garcia-Manyes S, Walther KA, Fernandez JM.

Biophys J. 2007 Apr 15;92(8):2896-903. Epub 2007 Jan 26.


Mechanical unfolding pathways of the enhanced yellow fluorescent protein revealed by single molecule force spectroscopy.

Perez-Jimenez R, Garcia-Manyes S, Ainavarapu SR, Fernandez JM.

J Biol Chem. 2006 Dec 29;281(52):40010-4. Epub 2006 Nov 2.


Nanoindentation: Toward the sensing of atomic interactions.

Fraxedas J, Garcia-Manyes S, Gorostiza P, Sanz F.

Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5228-32. Epub 2002 Apr 9.


Nanomechanics of silicon surfaces with atomic force microscopy: an insight to the first stages of plastic deformation.

Garcia-Manyes S, Güell AG, Gorostiza P, Sanz F.

J Chem Phys. 2005 Sep 15;123(11):114711.


Titration force microscopy on supported lipid bilayers.

Garcia-Manyes S, Gorostiza P, Sanz F.

Anal Chem. 2006 Jan 1;78(1):61-70.


Proteoglycan mechanics studied by single-molecule force spectroscopy of allotypic cell adhesion glycans.

Garcia-Manyes S, Bucior I, Ros R, Anselmetti D, Sanz F, Burger MM, Fernàndez-Busquets X.

J Biol Chem. 2006 Mar 3;281(9):5992-9. Epub 2005 Dec 22.


Effect of temperature on the nanomechanics of lipid bilayers studied by force spectroscopy.

Garcia-Manyes S, Oncins G, Sanz F.

Biophys J. 2005 Dec;89(6):4261-74. Epub 2005 Sep 8.


Alkali halide nanocrystal growth and etching studied by AFM and modeled by MD simulations.

Garcia-Manyes S, Verdaguer A, Gorostiza P, Sanz F.

J Chem Phys. 2004 Feb 8;120(6):2963-71.


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