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Items: 20

1.

High-throughput peptide-MHC complex generation and kinetic screenings of TCRs with peptide-receptive HLA-A*02:01 molecules.

Moritz A, Anjanappa R, Wagner C, Bunk S, Hofmann M, Pszolla G, Saikia A, Garcia-Alai M, Meijers R, Rammensee HG, Springer S, Maurer D.

Sci Immunol. 2019 Jul 19;4(37). pii: eaav0860. doi: 10.1126/sciimmunol.aav0860.

PMID:
31324691
2.

Empty peptide-receptive MHC class I molecules for efficient detection of antigen-specific T cells.

Saini SK, Tamhane T, Anjanappa R, Saikia A, Ramskov S, Donia M, Svane IM, Jakobsen SN, Garcia-Alai M, Zacharias M, Meijers R, Springer S, Hadrup SR.

Sci Immunol. 2019 Jul 19;4(37). pii: eaau9039. doi: 10.1126/sciimmunol.aau9039.

PMID:
31324690
3.

High-throughput stability screening for detergent-solubilized membrane proteins.

Kotov V, Bartels K, Veith K, Josts I, Subhramanyam UKT, Günther C, Labahn J, Marlovits TC, Moraes I, Tidow H, Löw C, Garcia-Alai MM.

Sci Rep. 2019 Jul 17;9(1):10379. doi: 10.1038/s41598-019-46686-8.

4.

Novel CaM-binding motif in its NudT9H domain contributes to temperature sensitivity of TRPM2.

Gattkowski E, Johnsen A, Bauche A, Möckl F, Kulow F, Garcia Alai M, Rutherford TJ, Fliegert R, Tidow H.

Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1162-1170. doi: 10.1016/j.bbamcr.2018.12.010. Epub 2018 Dec 22.

5.

Structure and stability of the Human respiratory syncytial virus M2-1 RNA-binding core domain reveals a compact and cooperative folding unit.

Molina IG, Josts I, Almeida Hernandez Y, Esperante S, Salgueiro M, Garcia Alai MM, de Prat-Gay G, Tidow H.

Acta Crystallogr F Struct Biol Commun. 2018 Jan 1;74(Pt 1):23-30. doi: 10.1107/S2053230X17017381. Epub 2017 Dec 15.

6.

Epsin and Sla2 form assemblies through phospholipid interfaces.

Garcia-Alai MM, Heidemann J, Skruzny M, Gieras A, Mertens HDT, Svergun DI, Kaksonen M, Uetrecht C, Meijers R.

Nat Commun. 2018 Jan 23;9(1):328. doi: 10.1038/s41467-017-02443-x.

7.

Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex.

Andersen JL, Schrøder TJ, Christensen S, Strandbygård D, Pallesen LT, García-Alai MM, Lindberg S, Langgård M, Eskildsen JC, David L, Tagmose L, Simonsen KB, Maltas PJ, Rønn LC, de Jong IE, Malik IJ, Egebjerg J, Karlsson JJ, Uppalanchi S, Sakumudi DR, Eradi P, Watson SP, Thirup S.

Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):451-60. doi: 10.1107/S1399004713030149. Epub 2014 Jan 29.

8.

Genetically directing ɛ-N, N-dimethyl-L-lysine in recombinant histones.

Nguyen DP, Garcia Alai MM, Virdee S, Chin JW.

Chem Biol. 2010 Oct 29;17(10):1072-6. doi: 10.1016/j.chembiol.2010.07.013.

9.

The structure of the FYR domain of transforming growth factor beta regulator 1.

García-Alai MM, Allen MD, Joerger AC, Bycroft M.

Protein Sci. 2010 Jul;19(7):1432-8. doi: 10.1002/pro.404.

10.

Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome.

Neumann H, Wang K, Davis L, Garcia-Alai M, Chin JW.

Nature. 2010 Mar 18;464(7287):441-4. doi: 10.1038/nature08817. Epub 2010 Feb 14.

PMID:
20154731
11.

The human papillomavirus E7-E2 interaction mechanism in vitro reveals a finely tuned system for modulating available E7 and E2 proteins.

Smal C, Wetzler DE, Dantur KI, Chemes LB, Garcia-Alai MM, Dellarole M, Alonso LG, Gaston K, de Prat-Gay G.

Biochemistry. 2009 Dec 22;48(50):11939-49. doi: 10.1021/bi901415k.

PMID:
19899811
12.

Genetically encoding N(epsilon)-methyl-L-lysine in recombinant histones.

Nguyen DP, Garcia Alai MM, Kapadnis PB, Neumann H, Chin JW.

J Am Chem Soc. 2009 Oct 14;131(40):14194-5. doi: 10.1021/ja906603s.

PMID:
19772323
13.

The novel p53 isoform "delta p53" is a misfolded protein and does not bind the p21 promoter site.

García-Alai MM, Tidow H, Natan E, Townsley FM, Veprintsev DB, Fersht AR.

Protein Sci. 2008 Oct;17(10):1671-8. doi: 10.1110/ps.036996.108. Epub 2008 Jul 11.

14.

The N-terminal module of HPV16 E7 is an intrinsically disordered domain that confers conformational and recognition plasticity to the oncoprotein.

García-Alai MM, Alonso LG, de Prat-Gay G.

Biochemistry. 2007 Sep 18;46(37):10405-12. Epub 2007 Aug 23.

PMID:
17715947
15.

High-risk HPV E6 oncoproteins assemble into large oligomers that allow localization of endogenous species in prototypic HPV-transformed cell lines.

García-Alai MM, Dantur KI, Smal C, Pietrasanta L, de Prat-Gay G.

Biochemistry. 2007 Jan 16;46(2):341-9.

PMID:
17209544
16.

Molecular basis for phosphorylation-dependent, PEST-mediated protein turnover.

García-Alai MM, Gallo M, Salame M, Wetzler DE, McBride AA, Paci M, Cicero DO, de Prat-Gay G.

Structure. 2006 Feb;14(2):309-19.

17.

Chaperone holdase activity of human papillomavirus E7 oncoprotein.

Alonso LG, Smal C, Garcia-Alai MM, Chemes L, Salame M, de Prat-Gay G.

Biochemistry. 2006 Jan 24;45(3):657-67.

PMID:
16411741
18.

The HPV16 E7 viral oncoprotein self-assembles into defined spherical oligomers.

Alonso LG, García-Alai MM, Smal C, Centeno JM, Iacono R, Castaño E, Gualfetti P, de Prat-Gay G.

Biochemistry. 2004 Mar 30;43(12):3310-7.

PMID:
15035602
19.

Casein Kinase II phosphorylation-induced conformational switch triggers degradation of the papillomavirus E2 protein.

Penrose KJ, Garcia-Alai M, de Prat-Gay G, McBride AA.

J Biol Chem. 2004 May 21;279(21):22430-9. Epub 2004 Mar 9.

20.

High-risk (HPV16) human papillomavirus E7 oncoprotein is highly stable and extended, with conformational transitions that could explain its multiple cellular binding partners.

Alonso LG, García-Alai MM, Nadra AD, Lapeña AN, Almeida FL, Gualfetti P, Prat-Gay GD.

Biochemistry. 2002 Aug 20;41(33):10510-8.

PMID:
12173938

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