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Diazepam and ethanol differently modulate neuronal activity in organotypic cortical cultures.

Kreuzer M, García PS, Brucklacher-Waldert V, Claassen R, Schneider G, Antkowiak B, Drexler B.

BMC Neurosci. 2019 Dec 10;20(1):58. doi: 10.1186/s12868-019-0540-6.


American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on the Role of Neuromonitoring in Perioperative Outcomes: Electroencephalography.

Chan MTV, Hedrick TL, Egan TD, García PS, Koch S, Purdon PL, Ramsay MA, Miller TE, McEvoy MD, Gan TJ; Perioperative Quality Initiative (POQI) 6 Workgroup.

Anesth Analg. 2019 Nov 18. doi: 10.1213/ANE.0000000000004502. [Epub ahead of print]


Structure, Function, and Evolution of the Pseudomonas aeruginosa Lysine Decarboxylase LdcA.

Kandiah E, Carriel D, Garcia PS, Felix J, Banzhaf M, Kritikos G, Bacia-Verloop M, Brochier-Armanet C, Elsen S, Gutsche I.

Structure. 2019 Dec 3;27(12):1842-1854.e4. doi: 10.1016/j.str.2019.10.003. Epub 2019 Oct 22.


Effect of General Anesthetics on Caspase-3 Levels in Patients With Aneurysmal Subarachnoid Hemorrhage: A Preliminary Study.

Balasubramanian M, Kuberan A, Rawat A, Dhandapani S, Panda N, Kumar A, Sahoo AK, Kumar M, Sharma T, Garcia PS, Bhagat H.

J Neurosurg Anesthesiol. 2019 Oct 9. doi: 10.1097/ANA.0000000000000648. [Epub ahead of print]


The SUF system: an ABC ATPase-dependent protein complex with a role in Fe-S cluster biogenesis.

Garcia PS, Gribaldo S, Py B, Barras F.

Res Microbiol. 2019 Nov - Dec;170(8):426-434. doi: 10.1016/j.resmic.2019.08.001. Epub 2019 Aug 14.


Corrigendum to "Association of electroencephalogram trajectories during emergence from anaesthesia with delirium in the postanaesthesia care unit: an early sign of postoperative complications" (Br J Anaesth 2019; 122: 622-634).

Hesse S, Kreuzer M, Hight D, Gaskell A, Davari P, Singh D, Taylor NB, Whalin MK, Lee S, Sleigh JW, Garcıá PS.

Br J Anaesth. 2019 Aug;123(2):255. doi: 10.1016/j.bja.2019.05.033. Epub 2019 Jun 14. No abstract available.


Peptide-Conjugated Silver Nanoparticle for Autoantibody Recognition.

Higa AM, Mambrini GP, Ierich JCM, Garcia PS, Scramin JA, Peroni LA, Okuda-Shinagawa NM, Teresa Machini M, Trivinho-Strixino F, Leite FL.

J Nanosci Nanotechnol. 2019 Dec 1;19(12):7564-7573. doi: 10.1166/jnn.2019.16734.


RocS drives chromosome segregation and nucleoid protection in Streptococcus pneumoniae.

Mercy C, Ducret A, Slager J, Lavergne JP, Freton C, Nagarajan SN, Garcia PS, Noirot-Gros MF, Dubarry N, Nourikyan J, Veening JW, Grangeasse C.

Nat Microbiol. 2019 Oct;4(10):1661-1670. doi: 10.1038/s41564-019-0472-z. Epub 2019 Jun 10.


Chronic Calcineurin Inhibition via Cyclosporine A Impairs Visuospatial Learning After Isoflurane Anesthesia.

Speigel IA, Ma CM, Bichler EK, Gooch JL, García PS.

Anesth Analg. 2019 Jul;129(1):192-203. doi: 10.1213/ANE.0000000000004183.


Transient electroencephalographic alpha power loss during maintenance of general anaesthesia.

Hight DF, Gaskell AL, Kreuzer M, Voss LJ, García PS, Sleigh JW.

Br J Anaesth. 2019 May;122(5):635-642. doi: 10.1016/j.bja.2018.11.029. Epub 2019 Jan 30.


Association of electroencephalogram trajectories during emergence from anaesthesia with delirium in the postanaesthesia care unit: an early sign of postoperative complications.

Hesse S, Kreuzer M, Hight D, Gaskell A, Devari P, Singh D, Taylor NB, Whalin MK, Lee S, Sleigh JW, García PS.

Br J Anaesth. 2019 May;122(5):622-634. doi: 10.1016/j.bja.2018.09.016. Epub 2018 Oct 25. Erratum in: Br J Anaesth. 2019 Aug;123(2):255.


Sex effects on behavioral markers of emergence from propofol and isoflurane anesthesia in rats.

Mansouri MT, Fidler JA, Meng QC, Eckenhoff RG, García PS.

Behav Brain Res. 2019 Jul 23;367:59-67. doi: 10.1016/j.bbr.2019.03.029. Epub 2019 Mar 18.


Escape From Oblivion: Neural Mechanisms of Emergence From General Anesthesia.

Kelz MB, García PS, Mashour GA, Solt K.

Anesth Analg. 2019 Apr;128(4):726-736. doi: 10.1213/ANE.0000000000004006.


A Preoperative Cognitive Screening Test Predicts Increased Length of Stay in a Frail Population: A Retrospective Case-Control Study.

O'Reilly-Shah VN, Hemani S, Davari P, Glowka L, Gebhardt E, Hill L, Lee S, Master VA, Rodriguez AD, García PS.

Anesth Analg. 2019 Nov;129(5):1283-1290. doi: 10.1213/ANE.0000000000004103.


Antibody-mediated biorecognition of myelin oligodendrocyte glycoprotein: computational evidence of demyelination-related epitopes.

Ierich JCM, Brum DG, Moraes AS, Higa AM, Garcia PS, Miyazaki CM, Ferreira M, Peroni LA, Oliveira GS, Franca EF, Freitas LCG, Leite FL.

Sci Rep. 2019 Feb 14;9(1):2033. doi: 10.1038/s41598-018-36578-8.


Understanding the Effects of General Anesthetics on Cortical Network Activity Using Ex Vivo Preparations.

Voss LJ, García PS, Hentschke H, Banks MI.

Anesthesiology. 2019 Jun;130(6):1049-1063. doi: 10.1097/ALN.0000000000002554.


An update on postoperative delirium: Clinical features, neuropathogenesis, and perioperative management.

Safavynia SA, Arora S, Pryor KO, García PS.

Curr Anesthesiol Rep. 2018 Jul 4;8(3):252-262.


Faster emergence behavior from ketamine/xylazine anesthesia with atipamezole versus yohimbine.

Mees L, Fidler J, Kreuzer M, Fu J, Pardue MT, García PS.

PLoS One. 2018 Oct 29;13(10):e0199087. doi: 10.1371/journal.pone.0199087. eCollection 2018.


GeneSpy, a user-friendly and flexible genomic context visualizer.

Garcia PS, Jauffrit F, Grangeasse C, Brochier-Armanet C.

Bioinformatics. 2019 Jan 15;35(2):329-331. doi: 10.1093/bioinformatics/bty459.


Inattentive Delirium vs. Disorganized Thinking: A New Axis to Subcategorize PACU Delirium.

Hight DF, Sleigh J, Winders JD, Voss LJ, Gaskell AL, Rodriguez AD, García PS.

Front Syst Neurosci. 2018 May 23;12:22. doi: 10.3389/fnsys.2018.00022. eCollection 2018.


Central Disorders of Hypersomnolence, Restless Legs Syndrome, and Surgery With General Anesthesia: Patient Perceptions.

LaBarbera V, García PS, Bliwise DL, Trotti LM.

Front Hum Neurosci. 2018 Mar 20;12:99. doi: 10.3389/fnhum.2018.00099. eCollection 2018.


Durable pectin/chitosan membranes with self-assembling, water resistance and enhanced mechanical properties.

Martins JG, de Oliveira AC, Garcia PS, Kipper MJ, Martins AF.

Carbohydr Polym. 2018 May 15;188:136-142. doi: 10.1016/j.carbpol.2018.01.112. Epub 2018 Feb 5.


Phosphorylation-dependent activation of the cell wall synthase PBP2a in Streptococcus pneumoniae by MacP.

Fenton AK, Manuse S, Flores-Kim J, Garcia PS, Mercy C, Grangeasse C, Bernhardt TG, Rudner DZ.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2812-2817. doi: 10.1073/pnas.1715218115. Epub 2018 Feb 27.


Influences of 12-Week Physical Activity Interventions on TMS Measures of Cortical Network Inhibition and Upper Extremity Motor Performance in Older Adults-A Feasibility Study.

McGregor KM, Crosson B, Mammino K, Omar J, García PS, Nocera JR.

Front Aging Neurosci. 2018 Jan 4;9:422. doi: 10.3389/fnagi.2017.00422. eCollection 2017.


Propofol and Sevoflurane Differentially Modulate Cortical Depolarization following Electric Stimulation of the Ventrobasal Thalamus.

Kratzer S, Mattusch C, Garcia PS, Schmid S, Kochs E, Rammes G, Schneider G, Kreuzer M, Haseneder R.

Front Comput Neurosci. 2017 Dec 11;11:109. doi: 10.3389/fncom.2017.00109. eCollection 2017.


PASTA repeats of the protein kinase StkP interconnect cell constriction and separation of Streptococcus pneumoniae.

Zucchini L, Mercy C, Garcia PS, Cluzel C, Gueguen-Chaignon V, Galisson F, Freton C, Guiral S, Brochier-Armanet C, Gouet P, Grangeasse C.

Nat Microbiol. 2018 Feb;3(2):197-209. doi: 10.1038/s41564-017-0069-3. Epub 2017 Dec 4.


Waking Up to a New Model for Studying Neural Systems: What Emergence from Unconscious States Can Reveal about Brain Organization.

Garcia PS, Rothman DL, Fitzpatrick SM.

Front Syst Neurosci. 2017 Oct 17;11:78. doi: 10.3389/fnsys.2017.00078. eCollection 2017. No abstract available.


The Influence of Regional Distribution and Pharmacologic Specificity of GABAAR Subtype Expression on Anesthesia and Emergence.

Speigel I, Bichler EK, García PS.

Front Syst Neurosci. 2017 Aug 22;11:58. doi: 10.3389/fnsys.2017.00058. eCollection 2017. Review.


Post-anaesthesia care unit delirium: incidence, risk factors and associated adverse outcomes.

Hernandez BA, Lindroth H, Rowley P, Boncyk C, Raz A, Gaskell A, García PS, Sleigh J, Sanders RD.

Br J Anaesth. 2017 Aug 1;119(2):288-290. doi: 10.1093/bja/aex197. No abstract available.


Cognitive Impairment and Overall Survival in Frail Surgical Patients.

Makhani SS, Kim FY, Liu Y, Ye Z, Li JL, Revenig LM, Vaughan CP, Johnson TM 2nd, García PS, Ogan K, Master VA.

J Am Coll Surg. 2017 Nov;225(5):590-600.e1. doi: 10.1016/j.jamcollsurg.2017.07.1066. Epub 2017 Aug 4.


In vitro and Ex vivo Neurotoxic Effects of Efavirenz are Greater than Those of Other Common Antiretrovirals.

Ciavatta VT, Bichler EK, Speigel IA, Elder CC, Teng SL, Tyor WR, García PS.

Neurochem Res. 2017 Nov;42(11):3220-3232. doi: 10.1007/s11064-017-2358-x. Epub 2017 Aug 2.


The RNA-binding protein, ZC3H14, is required for proper poly(A) tail length control, expression of synaptic proteins, and brain function in mice.

Rha J, Jones SK, Fidler J, Banerjee A, Leung SW, Morris KJ, Wong JC, Inglis GAS, Shapiro L, Deng Q, Cutler AA, Hanif AM, Pardue MT, Schaffer A, Seyfried NT, Moberg KH, Bassell GJ, Escayg A, García PS, Corbett AH.

Hum Mol Genet. 2017 Oct 1;26(19):3663-3681. doi: 10.1093/hmg/ddx248.


Changes in Alpha Frequency and Power of the Electroencephalogram during Volatile-Based General Anesthesia.

Hight D, Voss LJ, Garcia PS, Sleigh J.

Front Syst Neurosci. 2017 May 29;11:36. doi: 10.3389/fnsys.2017.00036. eCollection 2017.


Rigor, reproducibility, and in vitro cerebrospinal fluid assays: The devil in the details.

Moody OA, Talwar S, Jenkins MA, Freeman AA, Trotti LM, García PS, Bliwise D, Lynch JW, Cherson B, Hernandez EM, Feldman N, Saini P, Rye DB, Jenkins A.

Ann Neurol. 2017 Jun;81(6):904-907. doi: 10.1002/ana.24940. Epub 2017 Jun 1. No abstract available.


Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity.

Gooch JL, King C, Francis CE, Garcia PS, Bai Y.

PLoS One. 2017 Apr 17;12(4):e0175242. doi: 10.1371/journal.pone.0175242. eCollection 2017.


The Input Is Reflected in the Output: Evaluating Neurophysiologic Monitors With Simulated Data.

Kreuzer M, Schneider G, García PS.

Anesth Analg. 2017 May;124(5):1734-1735. doi: 10.1213/ANE.0000000000001958. No abstract available.


Infrared pupillometry helps to detect and predict delirium in the post-anesthesia care unit.

Yang E, Kreuzer M, Hesse S, Davari P, Lee SC, García PS.

J Clin Monit Comput. 2018 Apr;32(2):359-368. doi: 10.1007/s10877-017-0009-z. Epub 2017 Mar 8.


Anesthetic Management of a Patient With Multiple Previous Episodes of Postanesthesia Care Unit Delirium: A Case Report.

Kreuzer M, Whalin MK, Hesse SDW, Riso MA, García PS.

A A Case Rep. 2017 Jun 15;8(12):311-315. doi: 10.1213/XAA.0000000000000497.


Monitoring depth of sedation: evaluating the agreement between the Bispectral Index, qCON and the Entropy Module's State Entropy during flexible bronchoscopy.

Müller JN, Kreuzer M, García PS, Schneider G, Hautmann H.

Minerva Anestesiol. 2017 Jun;83(6):563-573. doi: 10.23736/S0375-9393.17.11262-9. Epub 2017 Feb 8.


In Reply.

Safavynia SA, Keating G, Speigel I, Fidler JA, Kreuzer M, Rye DB, Jenkins A, García PS.

Anesthesiology. 2017 Feb;126(2):352-353. doi: 10.1097/ALN.0000000000001446. No abstract available.


Clarithromycin increases neuronal excitability in CA3 pyramidal neurons through a reduction in GABAergic signaling.

Bichler EK, Elder CC, García PS.

J Neurophysiol. 2017 Jan 1;117(1):93-103. doi: 10.1152/jn.00134.2016. Epub 2016 Oct 12.


Cell division of Streptococcus pneumoniae: think positive!

Garcia PS, Simorre JP, Brochier-Armanet C, Grangeasse C.

Curr Opin Microbiol. 2016 Dec;34:18-23. doi: 10.1016/j.mib.2016.07.014. Epub 2016 Aug 4. Review.


Electromyographic activation reveals cortical and sub-cortical dissociation during emergence from general anesthesia.

Hight DF, Voss LJ, García PS, Sleigh JW.

J Clin Monit Comput. 2017 Aug;31(4):813-823. doi: 10.1007/s10877-016-9911-z. Epub 2016 Jul 21.


The A-S-C-O classification identifies cardioembolic phenotypes in a high proportion of embolic stroke of undetermined source (ESUS).

Montero MV, Pastor AG, Cano BC, García PS, Mohedano AI, Otero FD, Alén PV, Buzo EL, Cámara PS, Campo PS, Gómez MÁ, Bullido YF, Osorio JA, Núñez AG.

J Neurol Sci. 2016 Aug 15;367:32-3. doi: 10.1016/j.jns.2016.05.029. Epub 2016 May 14. No abstract available.


Anesthetic Suppression of Thalamic High-Frequency Oscillations: Evidence that the Thalamus Is More Than Just a Gateway to Consciousness?

Berger M, García PS.

Anesth Analg. 2016 Jun;122(6):1737-9. doi: 10.1213/ANE.0000000000001207. No abstract available.


Effects of γ-Aminobutyric Acid Type A Receptor Modulation by Flumazenil on Emergence from General Anesthesia.

Safavynia SA, Keating G, Speigel I, Fidler JA, Kreuzer M, Rye DB, Jenkins A, García PS.

Anesthesiology. 2016 Jul;125(1):147-58. doi: 10.1097/ALN.0000000000001134.


Postanesthesia Care for the Elderly Patient.

García PS, Duggan EW, McCullough IL, Lee SC, Fishman D.

Clin Ther. 2015 Dec 1;37(12):2651-65. doi: 10.1016/j.clinthera.2015.10.018. Epub 2015 Nov 17. Review.


Honokiol for the Treatment of Neonatal Pain and Prevention of Consequent Neurobehavioral Disorders.

Woodbury A, Yu SP, Chen D, Gu X, Lee JH, Zhang J, Espinera A, García PS, Wei L.

J Nat Prod. 2015 Nov 25;78(11):2531-6. doi: 10.1021/acs.jnatprod.5b00225. Epub 2015 Nov 5.


Missed Opportunities for Intervention in a Patient With Prolonged Postoperative Delirium.

Whalin MK, Kreuzer M, Halenda KM, García PS.

Clin Ther. 2015 Dec 1;37(12):2706-10. doi: 10.1016/j.clinthera.2015.09.012. Epub 2015 Oct 20.


Complementary and alternative medicine therapies for the anesthesiologist and pain practitioner: a narrative review.

Woodbury A, Soong SN, Fishman D, García PS.

Can J Anaesth. 2016 Jan;63(1):69-85. doi: 10.1007/s12630-015-0506-9. Epub 2015 Oct 14. Review.


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