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Items: 1 to 50 of 207

1.

De novo design of potent and selective mimics of IL-2 and IL-15.

Silva DA, Yu S, Ulge UY, Spangler JB, Jude KM, Labão-Almeida C, Ali LR, Quijano-Rubio A, Ruterbusch M, Leung I, Biary T, Crowley SJ, Marcos E, Walkey CD, Weitzner BD, Pardo-Avila F, Castellanos J, Carter L, Stewart L, Riddell SR, Pepper M, Bernardes GJL, Dougan M, Garcia KC, Baker D.

Nature. 2019 Jan;565(7738):186-191. doi: 10.1038/s41586-018-0830-7. Epub 2019 Jan 9.

PMID:
30626941
2.

Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance.

Pervolaraki K, Rastgou Talemi S, Albrecht D, Bormann F, Bamford C, Mendoza JL, Garcia KC, McLauchlan J, Höfer T, Stanifer ML, Boulant S.

PLoS Pathog. 2018 Nov 28;14(11):e1007420. doi: 10.1371/journal.ppat.1007420. eCollection 2018 Nov.

3.

A polymorphic residue that attenuates the antiviral potential of interferon lambda 4 in hominid lineages.

Bamford CGG, Aranday-Cortes E, Filipe IC, Sukumar S, Mair D, Filipe ADS, Mendoza JL, Garcia KC, Fan S, Tishkoff SA, McLauchlan J.

PLoS Pathog. 2018 Oct 11;14(10):e1007307. doi: 10.1371/journal.ppat.1007307. eCollection 2018 Oct.

4.

A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Specific Regulation of Wnt Bioavailability.

Vallon M, Yuki K, Nguyen TD, Chang J, Yuan J, Siepe D, Miao Y, Essler M, Noda M, Garcia KC, Kuo CJ.

Cell Rep. 2018 Oct 9;25(2):339-349.e9. doi: 10.1016/j.celrep.2018.09.045.

5.

T cell receptor cross-reactivity expanded by dramatic peptide-MHC adaptability.

Riley TP, Hellman LM, Gee MH, Mendoza JL, Alonso JA, Foley KC, Nishimura MI, Vander Kooi CW, Garcia KC, Baker BM.

Nat Chem Biol. 2018 Oct;14(10):934-942. doi: 10.1038/s41589-018-0130-4. Epub 2018 Sep 17.

PMID:
30224695
6.

Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy.

Spangler JB, Trotta E, Tomala J, Peck A, Young TA, Savvides CS, Silveria S, Votavova P, Salafsky J, Pande VS, Kovar M, Bluestone JA, Garcia KC.

J Immunol. 2018 Oct 1;201(7):2094-2106. doi: 10.4049/jimmunol.1800578. Epub 2018 Aug 13.

PMID:
30104245
7.

Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.

Sibener LV, Fernandes RA, Kolawole EM, Carbone CB, Liu F, McAffee D, Birnbaum ME, Yang X, Su LF, Yu W, Dong S, Gee MH, Jude KM, Davis MM, Groves JT, Goddard WA 3rd, Heath JR, Evavold BD, Vale RD, Garcia KC.

Cell. 2018 Jul 26;174(3):672-687.e27. doi: 10.1016/j.cell.2018.06.017.

PMID:
30053426
8.

Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro.

Gee MH, Sibener LV, Birnbaum ME, Jude KM, Yang X, Fernandes RA, Mendoza JL, Glassman CR, Garcia KC.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7369-E7378. doi: 10.1073/pnas.1802746115. Epub 2018 Jul 18.

9.

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism.

Trotta E, Bessette PH, Silveria SL, Ely LK, Jude KM, Le DT, Holst CR, Coyle A, Potempa M, Lanier LL, Garcia KC, Crellin NK, Rondon IJ, Bluestone JA.

Nat Med. 2018 Jul;24(7):1005-1014. doi: 10.1038/s41591-018-0070-2. Epub 2018 Jun 25.

10.

Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy.

Miles TF, Spiess K, Jude KM, Tsutsumi N, Burg JS, Ingram JR, Waghray D, Hjorto GM, Larsen O, Ploegh HL, Rosenkilde MM, Garcia KC.

Elife. 2018 Jun 8;7. pii: e35850. doi: 10.7554/eLife.35850.

11.

Deepening Attention to Social Location in Building Leader and Leadership Efficacy.

Turman NT, Garcia KCA, Howes S.

New Dir Stud Leadersh. 2018 Sep;2018(159):65-76. doi: 10.1002/yd.20298.

PMID:
29864233
12.

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells.

Fraietta JA, Nobles CL, Sammons MA, Lundh S, Carty SA, Reich TJ, Cogdill AP, Morrissette JJD, DeNizio JE, Reddy S, Hwang Y, Gohil M, Kulikovskaya I, Nazimuddin F, Gupta M, Chen F, Everett JK, Alexander KA, Lin-Shiao E, Gee MH, Liu X, Young RM, Ambrose D, Wang Y, Xu J, Jordan MS, Marcucci KT, Levine BL, Garcia KC, Zhao Y, Kalos M, Porter DL, Kohli RM, Lacey SF, Berger SL, Bushman FD, June CH, Melenhorst JJ.

Nature. 2018 Jun;558(7709):307-312. doi: 10.1038/s41586-018-0178-z. Epub 2018 May 30.

13.

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes.

Sockolosky JT, Trotta E, Parisi G, Picton L, Su LL, Le AC, Chhabra A, Silveria SL, George BM, King IC, Tiffany MR, Jude K, Sibener LV, Baker D, Shizuru JA, Ribas A, Bluestone JA, Garcia KC.

Science. 2018 Mar 2;359(6379):1037-1042. doi: 10.1126/science.aar3246.

14.

Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes.

Gee MH, Han A, Lofgren SM, Beausang JF, Mendoza JL, Birnbaum ME, Bethune MT, Fischer S, Yang X, Gomez-Eerland R, Bingham DB, Sibener LV, Fernandes RA, Velasco A, Baltimore D, Schumacher TN, Khatri P, Quake SR, Davis MM, Garcia KC.

Cell. 2018 Jan 25;172(3):549-563.e16. doi: 10.1016/j.cell.2017.11.043. Epub 2017 Dec 21.

15.

Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy.

Chheda ZS, Kohanbash G, Okada K, Jahan N, Sidney J, Pecoraro M, Yang X, Carrera DA, Downey KM, Shrivastav S, Liu S, Lin Y, Lagisetti C, Chuntova P, Watchmaker PB, Mueller S, Pollack IF, Rajalingam R, Carcaboso AM, Mann M, Sette A, Garcia KC, Hou Y, Okada H.

J Exp Med. 2018 Jan 2;215(1):141-157. doi: 10.1084/jem.20171046. Epub 2017 Dec 4.

16.

Inhibition of Delta-induced Notch signaling using fucose analogs.

Schneider M, Kumar V, Nordstrøm LU, Feng L, Takeuchi H, Hao H, Luca VC, Garcia KC, Stanley P, Wu P, Haltiwanger RS.

Nat Chem Biol. 2018 Jan;14(1):65-71. doi: 10.1038/nchembio.2520. Epub 2017 Nov 27.

17.

In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase.

Carbone CB, Kern N, Fernandes RA, Hui E, Su X, Garcia KC, Vale RD.

Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9338-E9345. doi: 10.1073/pnas.1710358114. Epub 2017 Oct 17.

18.

Localized CD47 blockade enhances immunotherapy for murine melanoma.

Ingram JR, Blomberg OS, Sockolosky JT, Ali L, Schmidt FI, Pishesha N, Espinosa C, Dougan SK, Garcia KC, Ploegh HL, Dougan M.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10184-10189. doi: 10.1073/pnas.1710776114. Epub 2017 Sep 5.

19.

Deconstruction of the beaten Path-Sidestep interaction network provides insights into neuromuscular system development.

Li H, Watson A, Olechwier A, Anaya M, Sorooshyari SK, Harnett DP, Lee HP, Vielmetter J, Fares MA, Garcia KC, Özkan E, Labrador JP, Zinn K.

Elife. 2017 Aug 15;6. pii: e28111. doi: 10.7554/eLife.28111.

20.

CD47 blockade enhances therapeutic activity of TCR mimic antibodies to ultra-low density cancer epitopes.

Mathias MD, Sockolosky JT, Chang AY, Tan KS, Liu C, Garcia KC, Scheinberg DA.

Leukemia. 2017 Oct;31(10):2254-2257. doi: 10.1038/leu.2017.223. Epub 2017 Jul 12. No abstract available.

21.

Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments.

Richter D, Moraga I, Winkelmann H, Birkholz O, Wilmes S, Schulte M, Kraich M, Kenneweg H, Beutel O, Selenschik P, Paterok D, Gavutis M, Schmidt T, Garcia KC, Müller TD, Piehler J.

Nat Commun. 2017 Jul 14;8:15976. doi: 10.1038/ncomms15976.

22.

Bacteriophage use to control Salmonella biofilm on surfaces present in chicken slaughterhouses.

Garcia KCOD, Corrêa IMO, Pereira LQ, Silva TM, Mioni MSR, Izidoro ACM, Bastos IHV, Gonçalves GAM, Okamoto AS, Andreatti Filho RL.

Poult Sci. 2017 Sep 1;96(9):3392-3398. doi: 10.3382/ps/pex124.

PMID:
28595324
23.

The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands.

Hilton HG, McMurtrey CP, Han AS, Djaoud Z, Guethlein LA, Blokhuis JH, Pugh JL, Goyos A, Horowitz A, Buchli R, Jackson KW, Bardet W, Bushnell DA, Robinson PJ, Mendoza JL, Birnbaum ME, Nielsen M, Garcia KC, Hildebrand WH, Parham P.

Cell Rep. 2017 May 16;19(7):1394-1405. doi: 10.1016/j.celrep.2017.04.059.

24.

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers.

Moraga I, Spangler JB, Mendoza JL, Gakovic M, Wehrman TS, Krutzik P, Garcia KC.

Elife. 2017 May 12;6. pii: e22882. doi: 10.7554/eLife.22882.

25.

Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer.

Lim JS, Ibaseta A, Fischer MM, Cancilla B, O'Young G, Cristea S, Luca VC, Yang D, Jahchan NS, Hamard C, Antoine M, Wislez M, Kong C, Cain J, Liu YW, Kapoun AM, Garcia KC, Hoey T, Murriel CL, Sage J.

Nature. 2017 May 18;545(7654):360-364. doi: 10.1038/nature22323. Epub 2017 May 10.

26.

Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal.

Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J, Davies PS, Ueno H, von Furstenberg RJ, Belgrader P, Ziraldo SB, Ordonez H, Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC, Kuo CJ.

Nature. 2017 May 11;545(7653):238-242. doi: 10.1038/nature22313. Epub 2017 May 3.

27.

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling.

Janda CY, Dang LT, You C, Chang J, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li X, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, Kuo CJ, Garcia KC.

Nature. 2017 May 11;545(7653):234-237. doi: 10.1038/nature22306. Epub 2017 May 3.

28.

The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity.

Mendoza JL, Schneider WM, Hoffmann HH, Vercauteren K, Jude KM, Xiong A, Moraga I, Horton TM, Glenn JS, de Jong YP, Rice CM, Garcia KC.

Immunity. 2017 Mar 21;46(3):379-392. doi: 10.1016/j.immuni.2017.02.017.

29.

Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.

Kim AR, Ulirsch JC, Wilmes S, Unal E, Moraga I, Karakukcu M, Yuan D, Kazerounian S, Abdulhay NJ, King DS, Gupta N, Gabriel SB, Lander ES, Patiroglu T, Ozcan A, Ozdemir MA, Garcia KC, Piehler J, Gazda HT, Klein DE, Sankaran VG.

Cell. 2017 Mar 9;168(6):1053-1064.e15. doi: 10.1016/j.cell.2017.02.026.

30.

Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.

Ho CCM, Chhabra A, Starkl P, Schnorr PJ, Wilmes S, Moraga I, Kwon HS, Gaudenzio N, Sibilano R, Wehrman TS, Gakovic M, Sockolosky JT, Tiffany MR, Ring AM, Piehler J, Weissman IL, Galli SJ, Shizuru JA, Garcia KC.

Cell. 2017 Mar 9;168(6):1041-1052.e18. doi: 10.1016/j.cell.2017.02.011.

31.

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity.

Luca VC, Kim BC, Ge C, Kakuda S, Wu D, Roein-Peikar M, Haltiwanger RS, Zhu C, Ha T, Garcia KC.

Science. 2017 Mar 24;355(6331):1320-1324. doi: 10.1126/science.aaf9739. Epub 2017 Mar 2.

32.

Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling.

You C, Marquez-Lago TT, Richter CP, Wilmes S, Moraga I, Garcia KC, Leier A, Piehler J.

Sci Adv. 2016 Dec 2;2(12):e1600452. eCollection 2016 Dec.

33.

Improvement of the enzymatic synthesis of ethyl valerate by esterification reaction in a solvent system.

Corradini MC, Costa BM, Bressani AP, Garcia KC, Pereira EB, Mendes AA.

Prep Biochem Biotechnol. 2017 Jan 2;47(1):100-109. doi: 10.1080/10826068.2016.1181084. Epub 2016 May 2.

PMID:
27136358
34.

Genetic variation in MHC proteins is associated with T cell receptor expression biases.

Sharon E, Sibener LV, Battle A, Fraser HB, Garcia KC, Pritchard JK.

Nat Genet. 2016 Sep;48(9):995-1002. doi: 10.1038/ng.3625. Epub 2016 Aug 1.

35.

Salmonella Infection Enhances Erythropoietin Production by the Kidney and Liver, Which Correlates with Elevated Bacterial Burdens.

Li LX, Benoun JM, Weiskopf K, Garcia KC, McSorley SJ.

Infect Immun. 2016 Sep 19;84(10):2833-41. doi: 10.1128/IAI.00337-16. Print 2016 Oct.

36.

CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer.

Weiskopf K, Jahchan NS, Schnorr PJ, Cristea S, Ring AM, Maute RL, Volkmer AK, Volkmer JP, Liu J, Lim JS, Yang D, Seitz G, Nguyen T, Wu D, Jude K, Guerston H, Barkal A, Trapani F, George J, Poirier JT, Gardner EE, Miles LA, de Stanchina E, Lofgren SM, Vogel H, Winslow MM, Dive C, Thomas RK, Rudin CM, van de Rijn M, Majeti R, Garcia KC, Weissman IL, Sage J.

J Clin Invest. 2016 Jul 1;126(7):2610-20. doi: 10.1172/JCI81603. Epub 2016 Jun 13.

37.

Durable antitumor responses to CD47 blockade require adaptive immune stimulation.

Sockolosky JT, Dougan M, Ingram JR, Ho CC, Kauke MJ, Almo SC, Ploegh HL, Garcia KC.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2646-54. doi: 10.1073/pnas.1604268113. Epub 2016 Apr 18.

38.

Data publication with the structural biology data grid supports live analysis.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.

Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882.

39.

Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes.

Ng CT, Mendoza JL, Garcia KC, Oldstone MB.

Cell. 2016 Jan 28;164(3):349-52. doi: 10.1016/j.cell.2015.12.027. Review.

40.

Control of Synaptic Connectivity by a Network of Drosophila IgSF Cell Surface Proteins.

Carrillo RA, Özkan E, Menon KP, Nagarkar-Jaiswal S, Lee PT, Jeon M, Birnbaum ME, Bellen HJ, Garcia KC, Zinn K.

Cell. 2015 Dec 17;163(7):1770-1782. doi: 10.1016/j.cell.2015.11.022.

41.

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency.

Moraga I, Richter D, Wilmes S, Winkelmann H, Jude K, Thomas C, Suhoski MM, Engleman EG, Piehler J, Garcia KC.

Sci Signal. 2015 Nov 10;8(402):ra114. doi: 10.1126/scisignal.aab2677.

42.

Cost-Effectiveness of Apixaban Versus Other New Oral Anticoagulants And Warfarin for Stroke Prevention In Atrial Fibrillation In Venezuela.

Fernández Ávila Y, Garcia KC, Garrido Lecca S, Donato BM, Juarez-Garcia A.

Value Health. 2015 Nov;18(7):A829. doi: 10.1016/j.jval.2015.09.309. Epub 2015 Oct 20. No abstract available.

43.

Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity.

Adams JJ, Narayanan S, Birnbaum ME, Sidhu SS, Blevins SJ, Gee MH, Sibener LV, Baker BM, Kranz DM, Garcia KC.

Nat Immunol. 2016 Jan;17(1):87-94. doi: 10.1038/ni.3310. Epub 2015 Nov 2.

44.

Gelatin and galactomannan-based scaffolds: Characterization and potential for tissue engineering applications.

Siqueira NM, Paiva B, Camassola M, Rosenthal-Kim EQ, Garcia KC, dos Santos FP, Soares RM.

Carbohydr Polym. 2015 Nov 20;133:8-18. doi: 10.1016/j.carbpol.2015.06.039. Epub 2015 Jun 20.

PMID:
26344248
45.

Effects of 5-hydroxytryptophan and m-hydroxybenzylhydrazine associated to Lactobacillus spp. on the humoral response of broilers challenged with Salmonella Enteritidis.

Donato TC, Baptista AA, Garcia KC, Smaniotto BD, Okamoto AS, Sequeira JL, Andreatti Filho RL.

Poult Sci. 2015 Sep;94(9):2081-7. doi: 10.3382/ps/pev206. Epub 2015 Jul 20.

PMID:
26195810
46.

Sexuality Education Websites for Adolescents: A Framework-Based Content Analysis.

Marques SS, Lin JS, Starling MS, Daquiz AG, Goldfarb ES, Garcia KC, Constantine NA.

J Health Commun. 2015;20(11):1310-9. doi: 10.1080/10810730.2015.1018621. Epub 2015 Jul 6.

PMID:
26147453
47.

Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo.

Spiess K, Jeppesen MG, Malmgaard-Clausen M, Krzywkowski K, Dulal K, Cheng T, Hjortø GM, Larsen O, Burg JS, Jarvis MA, Garcia KC, Zhu H, Kledal TN, Rosenkilde MM.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8427-32. doi: 10.1073/pnas.1509392112. Epub 2015 Jun 15.

48.

Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.

Mitra S, Ring AM, Amarnath S, Spangler JB, Li P, Ju W, Fischer S, Oh J, Spolski R, Weiskopf K, Kohrt H, Foley JE, Rajagopalan S, Long EO, Fowler DH, Waldmann TA, Garcia KC, Leonard WJ.

Immunity. 2015 May 19;42(5):826-38. doi: 10.1016/j.immuni.2015.04.018.

49.

Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms.

Spangler JB, Tomala J, Luca VC, Jude KM, Dong S, Ring AM, Votavova P, Pepper M, Kovar M, Garcia KC.

Immunity. 2015 May 19;42(5):815-25. doi: 10.1016/j.immuni.2015.04.015.

50.

Wnt acylation and its functional implication in Wnt signalling regulation.

Janda CY, Garcia KC.

Biochem Soc Trans. 2015 Apr;43(2):211-6. doi: 10.1042/BST20140249. Review.

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