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Items: 1 to 50 of 53

1.

Telomere length and genetic variant associations with interstitial lung disease progression and survival.

Newton CA, Oldham JM, Ley B, Anand V, Adegunsoye A, Liu G, Batra K, Torrealba J, Kozlitina J, Glazer C, Strek ME, Wolters PJ, Noth I, Garcia CK.

Eur Respir J. 2019 Apr 11;53(4). pii: 1801641. doi: 10.1183/13993003.01641-2018. Print 2019 Apr.

2.

Telomere Length and Use of Immunosuppressive Medications in Idiopathic Pulmonary Fibrosis.

Newton CA, Zhang D, Oldham JM, Kozlitina J, Ma SF, Martinez FJ, Raghu G, Noth I, Garcia CK.

Am J Respir Crit Care Med. 2019 Aug 1;200(3):336-347. doi: 10.1164/rccm.201809-1646OC.

PMID:
30566847
3.

Homozygous Rare PARN Missense Mutation in Familial Pulmonary Fibrosis.

Zhang D, Zhou Z, Abu-Hijleh M, Batra K, Xing C, Garcia CK.

Am J Respir Crit Care Med. 2019 Mar 15;199(6):797-799. doi: 10.1164/rccm.201809-1632LE. No abstract available.

PMID:
30525901
4.

Whole-Exome Sequencing in Adults With Chronic Kidney Disease.

Kiryluk K, Groopman E, Rasouly H, Garcia CK, Gharavi AG.

Ann Intern Med. 2018 Jul 17;169(2):132-133. doi: 10.7326/L18-0207. No abstract available.

PMID:
30014107
5.

Sex-dependent responses to exertional heat stroke in mice.

Garcia CK, Mattingly AJ, Robinson GP, Laitano O, King MA, Dineen SM, Leon LR, Clanton TL.

J Appl Physiol (1985). 2018 Sep 1;125(3):841-849. doi: 10.1152/japplphysiol.00220.2018. Epub 2018 Jun 14.

6.

Insights from human genetic studies of lung and organ fibrosis.

Garcia CK.

J Clin Invest. 2018 Jan 2;128(1):36-44. doi: 10.1172/JCI93556. Epub 2018 Jan 2. Review.

7.

Whole-Exome Sequencing in Adults With Chronic Kidney Disease: A Pilot Study.

Lata S, Marasa M, Li Y, Fasel DA, Groopman E, Jobanputra V, Rasouly H, Mitrotti A, Westland R, Verbitsky M, Nestor J, Slater LM, D'Agati V, Zaniew M, Materna-Kiryluk A, Lugani F, Caridi G, Rampoldi L, Mattoo A, Newton CA, Rao MK, Radhakrishnan J, Ahn W, Canetta PA, Bomback AS, Appel GB, Antignac C, Markowitz GS, Garcia CK, Kiryluk K, Sanna-Cherchi S, Gharavi AG.

Ann Intern Med. 2018 Jan 16;168(2):100-109. doi: 10.7326/M17-1319. Epub 2017 Dec 5. Erratum in: Ann Intern Med. 2018 Feb 20;168(4):308.

8.

Xiphoid Surface Temperature Predicts Mortality in a Murine Model of Septic Shock.

Laitano O, Van Steenbergen D, Mattingly AJ, Garcia CK, Robinson GP, Murray KO, Clanton TL, Nunamaker EA.

Shock. 2018 Aug;50(2):226-232. doi: 10.1097/SHK.0000000000001007.

9.

Whole-Exome Sequencing Insights into Adult Pulmonary Fibrosis. Repeating the Telomere Theme.

Garcia CK.

Am J Respir Crit Care Med. 2017 Jul 1;196(1):7-9. doi: 10.1164/rccm.201701-0194ED. No abstract available.

10.

The MUC5B promoter polymorphism and telomere length in patients with chronic hypersensitivity pneumonitis: an observational cohort-control study.

Ley B, Newton CA, Arnould I, Elicker BM, Henry TS, Vittinghoff E, Golden JA, Jones KD, Batra K, Torrealba J, Garcia CK, Wolters PJ.

Lancet Respir Med. 2017 Aug;5(8):639-647. doi: 10.1016/S2213-2600(17)30216-3. Epub 2017 Jun 22.

11.

Pleuroparenchymal fibroelastosis associated with telomerase reverse transcriptase mutations.

Newton CA, Batra K, Torrealba J, Meyer K, Raghu G, Garcia CK.

Eur Respir J. 2017 May 11;49(5). pii: 1700696. doi: 10.1183/13993003.00696-2017. Print 2017 May. No abstract available.

12.

Telomere length in patients with pulmonary fibrosis associated with chronic lung allograft dysfunction and post-lung transplantation survival.

Newton CA, Kozlitina J, Lines JR, Kaza V, Torres F, Garcia CK.

J Heart Lung Transplant. 2017 Aug;36(8):845-853. doi: 10.1016/j.healun.2017.02.005. Epub 2017 Feb 4.

13.

Somatic mutations in telomerase promoter counterbalance germline loss-of-function mutations.

Maryoung L, Yue Y, Young A, Newton CA, Barba C, van Oers NS, Wang RC, Garcia CK.

J Clin Invest. 2017 Mar 1;127(3):982-986. doi: 10.1172/JCI91161. Epub 2017 Feb 13.

14.

Pulmonary fibrosis in the era of stratified medicine.

Mathai SK, Newton CA, Schwartz DA, Garcia CK.

Thorax. 2016 Dec;71(12):1154-1160. doi: 10.1136/thoraxjnl-2016-209172. Epub 2016 Oct 31. Review.

15.

Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive.

Newton CA, Batra K, Torrealba J, Kozlitina J, Glazer CS, Aravena C, Meyer K, Raghu G, Collard HR, Garcia CK.

Eur Respir J. 2016 Dec;48(6):1710-1720. doi: 10.1183/13993003.00308-2016. Epub 2016 Aug 18.

16.

Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia.

Fingerlin TE, Zhang W, Yang IV, Ainsworth HC, Russell PH, Blumhagen RZ, Schwarz MI, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch DA, Groshong S, Collard HR, Wolters PJ, Bradford WZ, Kossen K, Seiwert SD, du Bois RM, Garcia CK, Devine MS, Gudmundsson G, Isaksson HJ, Kaminski N, Zhang Y, Gibson KF, Lancaster LH, Maher TM, Molyneaux PL, Wells AU, Moffatt MF, Selman M, Pardo A, Kim DS, Crapo JD, Make BJ, Regan EA, Walek DS, Daniel JJ, Kamatani Y, Zelenika D, Murphy E, Smith K, McKean D, Pedersen BS, Talbert J, Powers J, Markin CR, Beckman KB, Lathrop M, Freed B, Langefeld CD, Schwartz DA.

BMC Genet. 2016 Jun 7;17(1):74. doi: 10.1186/s12863-016-0377-2.

17.

Epigenetic inheritance of telomere length obscures identification of causative PARN locus.

Xing C, Garcia CK.

J Med Genet. 2016 May;53(5):356-8. doi: 10.1136/jmedgenet-2015-103685. Epub 2016 Feb 23. No abstract available.

18.

Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity.

Raj P, Rai E, Song R, Khan S, Wakeland BE, Viswanathan K, Arana C, Liang C, Zhang B, Dozmorov I, Carr-Johnson F, Mitrovic M, Wiley GB, Kelly JA, Lauwerys BR, Olsen NJ, Cotsapas C, Garcia CK, Wise CA, Harley JB, Nath SK, James JA, Jacob CO, Tsao BP, Pasare C, Karp DR, Li QZ, Gaffney PM, Wakeland EK.

Elife. 2016 Feb 15;5. pii: e12089. doi: 10.7554/eLife.12089.

19.

Clinical outcomes of lung transplant recipients with telomerase mutations.

Tokman S, Singer JP, Devine MS, Westall GP, Aubert JD, Tamm M, Snell GI, Lee JS, Goldberg HJ, Kukreja J, Golden JA, Leard LE, Garcia CK, Hays SR.

J Heart Lung Transplant. 2015 Oct;34(10):1318-24. doi: 10.1016/j.healun.2015.05.002. Epub 2015 May 11.

20.

Running short on time: lung transplant evaluation for telomere-related pulmonary fibrosis.

Garcia CK.

Chest. 2015 Jun;147(6):1450-1452. doi: 10.1378/chest.15-0077. No abstract available.

21.

Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening.

Stuart BD, Choi J, Zaidi S, Xing C, Holohan B, Chen R, Choi M, Dharwadkar P, Torres F, Girod CE, Weissler J, Fitzgerald J, Kershaw C, Klesney-Tait J, Mageto Y, Shay JW, Ji W, Bilguvar K, Mane S, Lifton RP, Garcia CK.

Nat Genet. 2015 May;47(5):512-7. doi: 10.1038/ng.3278. Epub 2015 Apr 13.

22.

Effect of leukocyte telomere length on total and regional brain volumes in a large population-based cohort.

King KS, Kozlitina J, Rosenberg RN, Peshock RM, McColl RW, Garcia CK.

JAMA Neurol. 2014 Oct;71(10):1247-54. doi: 10.1001/jamaneurol.2014.1926. Erratum in: JAMA Neurol. 2014 Dec;71(12):1580.

23.

Effect of telomere length on survival in patients with idiopathic pulmonary fibrosis: an observational cohort study with independent validation.

Stuart BD, Lee JS, Kozlitina J, Noth I, Devine MS, Glazer CS, Torres F, Kaza V, Girod CE, Jones KD, Elicker BM, Ma SF, Vij R, Collard HR, Wolters PJ, Garcia CK.

Lancet Respir Med. 2014 Jul;2(7):557-65. doi: 10.1016/S2213-2600(14)70124-9. Epub 2014 Jun 16.

24.

Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report.

Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE Jr, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP.

Am J Respir Crit Care Med. 2014 Jan 15;189(2):214-22. doi: 10.1164/rccm.201306-1141WS.

25.

Lung fibrosis-associated surfactant protein A1 and C variants induce latent transforming growth factor β1 secretion in lung epithelial cells.

Maitra M, Dey M, Yuan WC, Nathanielsz PW, Garcia CK.

J Biol Chem. 2013 Sep 20;288(38):27159-71. doi: 10.1074/jbc.M113.475335. Epub 2013 Aug 7. Retraction in: J Biol Chem. 2015 Aug 28;290(35):21407.

26.

Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.

Fingerlin TE, Murphy E, Zhang W, Peljto AL, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch D, Groshong S, Collard HR, Wolters PJ, Bradford WZ, Kossen K, Seiwert SD, du Bois RM, Garcia CK, Devine MS, Gudmundsson G, Isaksson HJ, Kaminski N, Zhang Y, Gibson KF, Lancaster LH, Cogan JD, Mason WR, Maher TM, Molyneaux PL, Wells AU, Moffatt MF, Selman M, Pardo A, Kim DS, Crapo JD, Make BJ, Regan EA, Walek DS, Daniel JJ, Kamatani Y, Zelenika D, Smith K, McKean D, Pedersen BS, Talbert J, Kidd RN, Markin CR, Beckman KB, Lathrop M, Schwarz MI, Schwartz DA.

Nat Genet. 2013 Jun;45(6):613-20. doi: 10.1038/ng.2609. Epub 2013 Apr 14. Erratum in: Nat Genet. 2013 Nov;45(11):1409.

27.

Association of cardiac troponin I with disease severity and outcomes in patients with pulmonary hypertension.

Vélez-Martínez M, Ayers C, Mishkin JD, Bartolome SB, García CK, Torres F, Drazner MH, de Lemos JA, Turer AT, Chin KM.

Am J Cardiol. 2013 Jun 15;111(12):1812-7. doi: 10.1016/j.amjcard.2013.02.036. Epub 2013 Mar 27.

PMID:
23540547
28.

Long-range PCR based sequencing of the highly homologous genes, SFTPA1 and SFTPA2.

Horton CJ, Mitui M, Leos NK, Garcia CK, Park JY.

Mol Cell Probes. 2013 Jun-Aug;27(3-4):115-7. doi: 10.1016/j.mcp.2013.01.001. Epub 2013 Jan 23.

PMID:
23354021
29.

Red blood cell size is inversely associated with leukocyte telomere length in a large multi-ethnic population.

Kozlitina J, Garcia CK.

PLoS One. 2012;7(12):e51046. doi: 10.1371/journal.pone.0051046. Epub 2012 Dec 4.

30.

Mutant surfactant A2 proteins associated with familial pulmonary fibrosis and lung cancer induce TGF-β1 secretion.

Maitra M, Cano CA, Garcia CK.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21064-9. doi: 10.1073/pnas.1217069110. Epub 2012 Dec 5. Retraction in: Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):E5222.

31.

Lung fibrosis, premature graying, and macrocytosis.

Chambers DC, Clarke BE, McGaughran J, Garcia CK.

Am J Respir Crit Care Med. 2012 Sep 1;186(5):e8-9. doi: 10.1164/rccm.201112-2175IM. No abstract available.

32.

Genetic interstitial lung disease.

Devine MS, Garcia CK.

Clin Chest Med. 2012 Mar;33(1):95-110. doi: 10.1016/j.ccm.2011.11.001. Epub 2011 Dec 6. Review.

33.

Rapid and progressive pulmonary fibrosis in 2 families with DNA repair deficiencies of undetermined etiology.

Vece TJ, Schecter MG, Gatti RA, Tunuguntla R, Garcia CK, Langston C, Dishop MK, Moore RH, Fan LL.

J Pediatr. 2012 Apr;160(4):700-702.e3. doi: 10.1016/j.jpeds.2011.12.001. Epub 2012 Jan 10.

34.

Interactions between smoking, pulmonary surfactant protein B, and atherosclerosis in the general population: the Dallas Heart Study.

Nguyen AB, Rohatgi A, Garcia CK, Ayers CR, Das SR, Lakoski SG, Berry JD, Khera A, McGuire DK, de Lemos JA.

Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):2136-43. doi: 10.1161/ATVBAHA.111.228692. Epub 2011 Aug 4.

35.

Quantification of regional interstitial lung disease from CT-derived fractional tissue volume: a lung tissue research consortium study.

Yilmaz C, Watharkar SS, Diaz de Leon A, Garcia CK, Patel NC, Jordan KG, Hsia CC.

Acad Radiol. 2011 Aug;18(8):1014-23. doi: 10.1016/j.acra.2011.03.004. Epub 2011 May 18.

36.

Idiopathic pulmonary fibrosis: update on genetic discoveries.

Garcia CK.

Proc Am Thorac Soc. 2011 May;8(2):158-62. doi: 10.1513/pats.201008-056MS.

37.

Subclinical lung disease, macrocytosis, and premature graying in kindreds with telomerase (TERT) mutations.

Diaz de Leon A, Cronkhite JT, Yilmaz C, Brewington C, Wang R, Xing C, Hsia CCW, Garcia CK.

Chest. 2011 Sep;140(3):753-763. doi: 10.1378/chest.10-2865. Epub 2011 Feb 24.

38.

Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations.

Diaz de Leon A, Cronkhite JT, Katzenstein AL, Godwin JD, Raghu G, Glazer CS, Rosenblatt RL, Girod CE, Garrity ER, Xing C, Garcia CK.

PLoS One. 2010 May 19;5(5):e10680. doi: 10.1371/journal.pone.0010680.

39.

Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress.

Maitra M, Wang Y, Gerard RD, Mendelson CR, Garcia CK.

J Biol Chem. 2010 Jul 16;285(29):22103-13. doi: 10.1074/jbc.M110.121467. Epub 2010 May 13.

40.

Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer.

Wang Y, Kuan PJ, Xing C, Cronkhite JT, Torres F, Rosenblatt RL, DiMaio JM, Kinch LN, Grishin NV, Garcia CK.

Am J Hum Genet. 2009 Jan;84(1):52-9. doi: 10.1016/j.ajhg.2008.11.010. Epub 2008 Dec 18.

41.

Telomere shortening in familial and sporadic pulmonary fibrosis.

Cronkhite JT, Xing C, Raghu G, Chin KM, Torres F, Rosenblatt RL, Garcia CK.

Am J Respir Crit Care Med. 2008 Oct 1;178(7):729-37. doi: 10.1164/rccm.200804-550OC. Epub 2008 Jul 17.

42.

Human diseases of telomerase dysfunction: insights into tissue aging.

Garcia CK, Wright WE, Shay JW.

Nucleic Acids Res. 2007;35(22):7406-16. Epub 2007 Oct 2. Review.

43.

Adult-onset pulmonary fibrosis caused by mutations in telomerase.

Tsakiri KD, Cronkhite JT, Kuan PJ, Xing C, Raghu G, Weissler JC, Rosenblatt RL, Shay JW, Garcia CK.

Proc Natl Acad Sci U S A. 2007 May 1;104(18):7552-7. Epub 2007 Apr 25.

44.

Familial spontaneous pneumothorax.

Chiu HT, Garcia CK.

Curr Opin Pulm Med. 2006 Jul;12(4):268-72. Review.

PMID:
16825879
45.

Nonsense mutations in folliculin presenting as isolated familial spontaneous pneumothorax in adults.

Graham RB, Nolasco M, Peterlin B, Garcia CK.

Am J Respir Crit Care Med. 2005 Jul 1;172(1):39-44. Epub 2005 Apr 1.

PMID:
15805188
46.

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

Cohen J, Pertsemlidis A, Kotowski IK, Graham R, Garcia CK, Hobbs HH.

Nat Genet. 2005 Feb;37(2):161-5. Epub 2005 Jan 16. Erratum in: Nat Genet. 2005 Mar;37(3):328.

PMID:
15654334
47.

Inherited interstitial lung disease.

Garcia CK, Raghu G.

Clin Chest Med. 2004 Sep;25(3):421-33, v. Review. Erratum in: Clin Chest Med. 2004 Dec;25(4):xi.

PMID:
15331184
48.

Sequence diversity in genes of lipid metabolism.

Garcia CK, Mues G, Liao Y, Hyatt T, Patil N, Cohen JC, Hobbs HH.

Genome Res. 2001 Jun;11(6):1043-52.

49.

Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein.

Garcia CK, Wilund K, Arca M, Zuliani G, Fellin R, Maioli M, Calandra S, Bertolini S, Cossu F, Grishin N, Barnes R, Cohen JC, Hobbs HH.

Science. 2001 May 18;292(5520):1394-8. Epub 2001 Apr 26.

50.

Structure and localization of the human gene encoding SR-BI/CLA-1. Evidence for transcriptional control by steroidogenic factor 1.

Cao G, Garcia CK, Wyne KL, Schultz RA, Parker KL, Hobbs HH.

J Biol Chem. 1997 Dec 26;272(52):33068-76.

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