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Items: 1 to 50 of 211

1.

Roles of the G protein-coupled receptor kinase 2 and Rab5 in α1B-adrenergic receptor function and internalization.

Hernández-Espinosa DA, Reyes-Cruz G, García-Sáinz JA.

Eur J Pharmacol. 2020 Jan 15;867:172846. doi: 10.1016/j.ejphar.2019.172846. Epub 2019 Dec 4.

PMID:
31811856
2.

The α1-adrenoceptor-mediated human hyperplastic prostate cells proliferation is impaired by EGF receptor inhibition.

Nascimento-Viana JB, Alcántara-Hernández R, Oliveira-Barros E, Castello Branco LA, Feijó PR, Soares Romeiro LA, Nasciutti LE, Noël F, García-Sáinz JA, Silva CLM.

Life Sci. 2019 Dec 15;239:117048. doi: 10.1016/j.lfs.2019.117048. Epub 2019 Nov 12.

PMID:
31730867
3.

Sites phosphorylated in human α1B-adrenoceptors in response to noradrenaline and phorbol myristate acetate.

Hernández-Espinosa DA, Carmona-Rosas G, Alfonzo-Méndez MA, Alcántara-Hernández R, García-Sáinz JA.

Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1509-1519. doi: 10.1016/j.bbamcr.2019.07.006. Epub 2019 Jul 17.

PMID:
31325464
4.

Receptor tyrosine kinase activation induces free fatty acid 4 receptor phosphorylation, β-arrestin interaction, and internalization.

Villegas-Comonfort S, Guzmán-Silva A, Romero-Ávila MT, Takei Y, Tsujimoto G, Hirasawa A, García-Sáinz JA.

Eur J Pharmacol. 2019 Jul 15;855:267-275. doi: 10.1016/j.ejphar.2019.05.018. Epub 2019 May 10.

PMID:
31078517
5.

Updates in the function and regulation of α1 -adrenoceptors.

Akinaga J, García-Sáinz JA, S Pupo A.

Br J Pharmacol. 2019 Jul;176(14):2343-2357. doi: 10.1111/bph.14617. Epub 2019 Apr 1. Review.

PMID:
30740663
6.

Distinct phosphorylation sites/clusters in the carboxyl terminus regulate α1D-adrenergic receptor subcellular localization and signaling.

Carmona-Rosas G, Hernández-Espinosa DA, Alcántara-Hernández R, Alfonzo-Méndez MA, García-Sainz JA.

Cell Signal. 2019 Jan;53:374-389. doi: 10.1016/j.cellsig.2018.11.003. Epub 2018 Nov 9.

PMID:
30419287
7.

S1P1 receptor phosphorylation, internalization, and interaction with Rab proteins: effects of sphingosine 1-phosphate, FTY720-P, phorbol esters, and paroxetine.

Martínez-Morales JC, Romero-Ávila MT, Reyes-Cruz G, García-Sáinz JA.

Biosci Rep. 2018 Dec 11;38(6). pii: BSR20181612. doi: 10.1042/BSR20181612. Print 2018 Dec 21.

8.

Free fatty acid receptor 4 agonists induce lysophosphatidic acid receptor 1 (LPA1 ) desensitization independent of LPA1 internalization and heterodimerization.

Meizoso-Huesca A, Villegas-Comonfort S, Romero-Ávila MT, García-Sáinz JA.

FEBS Lett. 2018 Aug;592(15):2612-2623. doi: 10.1002/1873-3468.13179. Epub 2018 Jul 16.

9.

Different phosphorylation patterns regulate α1D-adrenoceptor signaling and desensitization.

Alfonzo-Méndez MA, Carmona-Rosas G, Hernández-Espinosa DA, Romero-Ávila MT, García-Sáinz JA.

Biochim Biophys Acta Mol Cell Res. 2018 Jun;1865(6):842-854. doi: 10.1016/j.bbamcr.2018.03.006. Epub 2018 Mar 15.

10.

A549 cells as a model to study endogenous LPA1 receptor signaling and regulation.

Carmona-Rosas G, Alfonzo-Méndez MA, Hernández-Espinosa DA, Romero-Ávila MT, García-Sáinz JA.

Eur J Pharmacol. 2017 Nov 15;815:258-265. doi: 10.1016/j.ejphar.2017.09.013. Epub 2017 Sep 21.

PMID:
28943105
11.

Noradrenaline, oxymetazoline and phorbol myristate acetate induce distinct functional actions and phosphorylation patterns of α1A-adrenergic receptors.

Alcántara-Hernández R, Hernández-Méndez A, Romero-Ávila MT, Alfonzo-Méndez MA, Pupo AS, García-Sáinz JA.

Biochim Biophys Acta Mol Cell Res. 2017 Dec;1864(12):2378-2388. doi: 10.1016/j.bbamcr.2017.09.002. Epub 2017 Sep 6.

12.

[Conference Dr. Ignacio Chávez. Moving towards molecular medicine].

García-Sáinz JA.

Gac Med Mex. 2017 May-Jun;153(3):379-382. Spanish.

13.

Effects of arachidonic acid on FFA4 receptor: Signaling, phosphorylation and internalization.

Villegas-Comonfort S, Takei Y, Tsujimoto G, Hirasawa A, García-Sáinz JA.

Prostaglandins Leukot Essent Fatty Acids. 2017 Feb;117:1-10. doi: 10.1016/j.plefa.2017.01.013. Epub 2017 Jan 26.

PMID:
28237082
14.

Protein Kinase C Activation Promotes α1B-Adrenoceptor Internalization and Late Endosome Trafficking through Rab9 Interaction. Role in Heterologous Desensitization.

Alfonzo-Méndez MA, Hernández-Espinosa DA, Carmona-Rosas G, Romero-Ávila MT, Reyes-Cruz G, García-Sáinz JA.

Mol Pharmacol. 2017 Apr;91(4):296-306. doi: 10.1124/mol.116.106583. Epub 2017 Jan 12.

PMID:
28082304
15.

Novel Structural Approaches to Study GPCR Regulation.

Alfonzo-Méndez MA, Alcántara-Hernández R, García-Sáinz JA.

Int J Mol Sci. 2016 Dec 23;18(1). pii: E27. doi: 10.3390/ijms18010027. Review.

16.

A Latin American Perspective on G Protein-Coupled Receptors.

Pupo AS, García-Sáinz JA.

Mol Pharmacol. 2016 Nov;90(5):570-572.

PMID:
27754900
17.

Carboxyl terminus-truncated α1D-adrenoceptors inhibit the ERK pathway.

Alfonzo-Méndez MA, Castillo-Badillo JA, Romero-Ávila MT, Rivera R, Chun J, García-Sáinz JA.

Naunyn Schmiedebergs Arch Pharmacol. 2016 Aug;389(8):911-20. doi: 10.1007/s00210-016-1254-2. Epub 2016 May 5.

18.

Agonists and protein kinase C-activation induce phosphorylation and internalization of FFA1 receptors.

Sosa-Alvarado C, Hernández-Méndez A, Romero-Ávila MT, Sánchez-Reyes OB, Takei Y, Tsujimoto G, Hirasawa A, García-Sáinz JA.

Eur J Pharmacol. 2015 Dec 5;768:108-15. doi: 10.1016/j.ejphar.2015.10.038. Epub 2015 Oct 23.

PMID:
26526350
19.

New Multi-target Antagonists of α1A-, α1D-Adrenoceptors and 5-HT1A Receptors Reduce Human Hyperplastic Prostate Cell Growth and the Increase of Intraurethral Pressure.

Nascimento-Viana JB, Carvalho AR, Nasciutti LE, Alcántara-Hernández R, Chagas-Silva F, Souza PA, Romeiro LA, García-Sáinz JA, Noël F, Silva CL.

J Pharmacol Exp Ther. 2016 Jan;356(1):212-22. doi: 10.1124/jpet.115.227066. Epub 2015 Oct 22.

PMID:
26493747
20.

Phosphorylation and Internalization of Lysophosphatidic Acid Receptors LPA1, LPA2, and LPA3.

Alcántara-Hernández R, Hernández-Méndez A, Campos-Martínez GA, Meizoso-Huesca A, García-Sáinz JA.

PLoS One. 2015 Oct 16;10(10):e0140583. doi: 10.1371/journal.pone.0140583. eCollection 2015.

21.

α1B-adrenergic receptors differentially associate with Rab proteins during homologous and heterologous desensitization.

Castillo-Badillo JA, Sánchez-Reyes OB, Alfonzo-Méndez MA, Romero-Ávila MT, Reyes-Cruz G, García-Sáinz JA.

PLoS One. 2015 Mar 23;10(3):e0121165. doi: 10.1371/journal.pone.0121165. eCollection 2015.

22.

The phosphoinositide-dependent protein kinase 1 inhibitor, UCN-01, induces fragmentation: possible role of metalloproteinases.

Alcántara-Hernández R, Hernández-Méndez A, García-Sáinz JA.

Eur J Pharmacol. 2014 Oct 5;740:88-96. doi: 10.1016/j.ejphar.2014.06.057. Epub 2014 Jul 10.

PMID:
25016091
23.

Visualizing G protein-coupled receptors in action through confocal microscopy techniques.

Castillo-Badillo JA, Cabrera-Wrooman A, García-Sáinz JA.

Arch Med Res. 2014 May;45(4):283-93. doi: 10.1016/j.arcmed.2014.03.009. Epub 2014 Apr 18. Review.

PMID:
24751328
24.

Conventional protein kinase C isoforms mediate phorbol ester-induced lysophosphatidic acid LPA1 receptor phosphorylation.

Hernández-Méndez A, Alcántara-Hernández R, Acosta-Cervantes GC, Martínez-Ortiz J, Avendaño-Vázquez SE, García-Sáinz JA.

Eur J Pharmacol. 2014 Jan 15;723:124-30. doi: 10.1016/j.ejphar.2013.11.043. Epub 2013 Dec 16.

PMID:
24355769
25.

Isoforms of protein kinase C involved in phorbol ester-induced sphingosine 1-phosphate receptor 1 phosphorylation and desensitization.

Morquecho-León MA, Bazúa-Valenti S, Romero-Ávila MT, García-Sáinz JA.

Biochim Biophys Acta. 2014 Feb;1843(2):327-34. doi: 10.1016/j.bbamcr.2013.11.002. Epub 2013 Nov 13.

26.

Free fatty acids and protein kinase C activation induce GPR120 (free fatty acid receptor 4) phosphorylation.

Sánchez-Reyes OB, Romero-Ávila MT, Castillo-Badillo JA, Takei Y, Hirasawa A, Tsujimoto G, Villalobos-Molina R, García-Sáinz JA.

Eur J Pharmacol. 2014 Jan 15;723:368-74. doi: 10.1016/j.ejphar.2013.11.003. Epub 2013 Nov 12.

PMID:
24239485
27.

Differential phosphorylation, desensitization, and internalization of α1A-adrenoceptors activated by norepinephrine and oxymetazoline.

Akinaga J, Lima V, Kiguti LR, Hebeler-Barbosa F, Alcántara-Hernández R, García-Sáinz JA, Pupo AS.

Mol Pharmacol. 2013 Apr;83(4):870-81. doi: 10.1124/mol.112.082313. Epub 2013 Jan 30.

PMID:
23364786
28.

Roles of phosphoinositide-dependent kinase-1 in α1B-adrenoceptor phosphorylation and desensitization.

Alcántara Hernández R, García-Sáinz JA.

Eur J Pharmacol. 2012 Jan 15;674(2-3):179-87. doi: 10.1016/j.ejphar.2011.11.021. Epub 2011 Nov 21.

PMID:
22134004
29.

Sphingosine 1-phosphate-mediated α1B-adrenoceptor desensitization and phosphorylation. Direct and paracrine/autocrine actions.

Castillo-Badillo JA, Molina-Muñoz T, Romero-Ávila MT, Vázquez-Macías A, Rivera R, Chun J, García-Sáinz JA.

Biochim Biophys Acta. 2012 Feb;1823(2):245-54. doi: 10.1016/j.bbamcr.2011.10.002. Epub 2011 Oct 13.

30.

EGF and angiotensin II modulate lysophosphatidic acid LPA(1) receptor function and phosphorylation state.

Colín-Santana CC, Avendaño-Vázquez SE, Alcántara-Hernández R, García-Sáinz JA.

Biochim Biophys Acta. 2011 Dec;1810(12):1170-7. doi: 10.1016/j.bbagen.2011.08.016. Epub 2011 Sep 2.

PMID:
21914461
31.

Mechanisms involved in α1B-adrenoceptor desensitization.

García-Sáinz JA, Romero-Ávila MT, Alcántara-Hernández R.

IUBMB Life. 2011 Oct;63(10):811-5. doi: 10.1002/iub.519. Epub 2011 Aug 3. Review.

32.

α(1D)-Adrenergic receptors constitutive activity and reduced expression at the plasma membrane.

García-Sáinz JA, Romero-Ávila MT, Medina Ldel C.

Methods Enzymol. 2010;484:109-25. doi: 10.1016/B978-0-12-381298-8.00006-X.

PMID:
21036229
33.

Roles of the α1A-adrenergic receptor carboxyl tail in protein kinase C-induced phosphorylation and desensitization.

Cabrera-Wrooman A, Romero-Ávila MT, García-Sáinz JA.

Naunyn Schmiedebergs Arch Pharmacol. 2010 Dec;382(5-6):499-510. doi: 10.1007/s00210-010-0569-7. Epub 2010 Oct 5.

PMID:
20922361
34.

Dissecting how receptor tyrosine kinases modulate G protein-coupled receptor function.

García-Sáinz JA, Romero-Ávila MT, Medina Ldel C.

Eur J Pharmacol. 2010 Dec 1;648(1-3):1-5. doi: 10.1016/j.ejphar.2010.08.049. Epub 2010 Sep 7. Review.

PMID:
20828551
35.

Signaling properties of human alpha(1D)-adrenoceptors lacking the carboxyl terminus: intrinsic activity, agonist-mediated activation, and desensitization.

Rodríguez-Pérez CE, Romero-Avila MT, Reyes-Cruz G, García-Sáinz JA.

Naunyn Schmiedebergs Arch Pharmacol. 2009 Aug;380(2):99-107. doi: 10.1007/s00210-009-0428-6. Epub 2009 May 21.

PMID:
19458937
36.

Receptor tyrosine kinases regulate alpha1D-adrenoceptor signaling properties: phosphorylation and desensitization.

Rodríguez-Pérez CE, Calvo-Ochoa E, Kalashnikova EV, Reyes-Cruz G, Romero-Avila MT, García-Sáinz JA.

Int J Biochem Cell Biol. 2009 Jun;41(6):1276-83. doi: 10.1016/j.biocel.2008.10.030. Epub 2008 Nov 6.

PMID:
19038360
37.

Roles of c-Src in alpha1B-adrenoceptor phosphorylation and desensitization.

Alcántara-Hernández R, Casas-González P, García-Sáinz JA.

Auton Autacoid Pharmacol. 2008 Jan;28(1):29-39. doi: 10.1111/j.1474-8673.2007.00414.x.

PMID:
18257749
38.

Regulation of LPA receptor function by estrogens.

González-Arenas A, Avendaño-Vázquez SE, Cabrera-Wrooman A, Tapia-Carrillo D, Larrea F, García-Becerra R, García-Sáinz JA.

Biochim Biophys Acta. 2008 Feb;1783(2):253-62. doi: 10.1016/j.bbamcr.2007.11.014. Epub 2007 Dec 5.

39.

Phosphorylation, desensitization and internalization of human alpha1B-adrenoceptors induced by insulin-like growth factor-I.

Molina-Muñoz T, Romero-Avila MT, Avendaño-Vázquez SE, García-Sáinz JA.

Eur J Pharmacol. 2008 Jan 6;578(1):1-10. Epub 2007 Sep 19.

PMID:
17915215
40.

Role of epidermal growth factor receptor transactivation in alpha1B-adrenoceptor phosphorylation.

Casas-González P, García-Sáinz JA.

Eur J Pharmacol. 2006 Aug 7;542(1-3):31-6. Epub 2006 May 27.

PMID:
16828079
41.

Insulin-like growth factor-I induces alpha(1B)-adrenergic receptor phosphorylation through G beta gamma and epidermal growth factor receptor transactivation.

Molina-Muñoz T, Romero-Avila MT, García-Sáinz JA.

Mol Endocrinol. 2006 Nov;20(11):2773-83. Epub 2006 Jun 27.

PMID:
16803866
42.

Estrogens cross-talk to alpha1b-adrenergic receptors.

González-Arenas A, Aguilar-Maldonado B, Avendaño-Vázquez SE, García-Sáinz JA.

Mol Pharmacol. 2006 Jul;70(1):154-62. Epub 2006 Apr 25.

PMID:
16638969
43.

Okadaic acid increases the phosphorylation state of alpha1A-adrenoceptors and induces receptor desensitization.

Alcántara-Hernández R, García-Sáinz JA.

Eur J Pharmacol. 2005 Nov 21;525(1-3):18-23. Epub 2005 Nov 17.

PMID:
16297906
44.

Agonist-induced interactions between angiotensin AT1 and epidermal growth factor receptors.

Olivares-Reyes JA, Shah BH, Hernández-Aranda J, García-Caballero A, Farshori MP, García-Sáinz JA, Catt KJ.

Mol Pharmacol. 2005 Aug;68(2):356-64. Epub 2005 May 19.

PMID:
15905421
45.

The elusive alpha(1D)-adrenoceptor: molecular and cellular characteristics and integrative roles.

García-Sáinz JA, Villalobos-Molina R.

Eur J Pharmacol. 2004 Oct 1;500(1-3):113-20. Review.

PMID:
15464025
46.

Phosphorylation and desensitization of the lysophosphatidic acid receptor LPA1.

Avendaño-Vázquez SE, García-Caballero A, García-Sáinz JA.

Biochem J. 2005 Feb 1;385(Pt 3):677-84.

47.

Insulin induces alpha1B-adrenergic receptor phosphorylation and desensitization.

García-Sáinz JA, Romero-Avila MT, Molina-Muñoz T, Medina Ldel C.

Life Sci. 2004 Sep 3;75(16):1937-47.

PMID:
15306161
48.

Human alpha1D-adrenoceptor phosphorylation and desensitization.

García-Sáinz JA, Rodríguez-Pérez CE, Romero-Avila MT.

Biochem Pharmacol. 2004 May 15;67(10):1853-8.

PMID:
15130762
49.

Peroxovanadate induces alpha 1B-adrenoceptor phosphorylation and association with protein kinase C.

Alcántara-Hernández R, Medina Ldel C, García-Sáinz JA.

Eur J Pharmacol. 2004 Feb 6;485(1-3):61-7.

PMID:
14757124
50.

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